JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 17
·7456-7468
·
IF 4.5
Zhang Ning,Wang Zongliang,Zeng Yuqi,Guo Yueming,Wang Liqiang,Liu Jianguo,Wang Yu,Zhang Peibiao
Preformed three-dimensional scaffolds with insufficient mechanical properties, poor surgical performance, and morphological mismatch to defects with irregular shape have shown drawbacks in animal evaluations and clinical applications. This motivates the development of novel injectable systems to ideally fill bone defects, allowing in situ solidification within the host tissues while retaining high initial mechanical strength and appropriate porosity. In this study, an in situ forming scaffold with time-dependent pore formation inspired by the metamorphosis of a butterfly was fabricated by incorporating gelatin microspheres (GMs) into a poly(lactic-co-glycolic acid) (PLGA)-based injectable implant. After optimizing solvent, molecular weight and solution concentration of PLGA matrix, the injectable mixture could be easily injected into both aqueous solution and random-shaped grooves while in situ solidified instantaneously. The injectability enabled an in situ morphological match within an irregular bone defect, providing high initial strength in the early period. The toughness of the injectable implant also allowed them to be easily bent into a ring without breaking. Time-dependent pore formation was accomplished by gradual degradation of GMs, generating appropriate space for tissue ingrowth in the scaffold. It is expected that the injectable in situ forming implant would aid the bone healing process by maintaining initial mechanical support and creating a spatiotemporally evolutionary microstructure during bone tissue regeneration.
研究领域:
生物材料学
·
组织工程
·
骨科学
·
再生医学
·
高分子科学
·
药物递送系统
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DOI
高影响因子
IONICS
·
2022
·Vol. 28
·期 8
·3655-3659
·
IF 2.961
Zuo Zhaoyang,Dong Sanfeng,Meng Dongrong
Although the lithium-sulfur batteries have high specific capacity and energy density, it is still a challenge to achieve the wide commercial applications due to the severe polysulfide migration and poor electronic conductivity of the element sulfur. To this context, we developed porous carbon/MnO 2 (PCMO) composites as sulfur host materials to increase the adsorption ability between the PCMO host and polysulfide. The MnO 2 particles embedded on the porous carbon severe as active sites to effectively adsorb and catalyze the polysulfide, therefore improving the redox kinetics and reducing shuttle effect. More importantly, the porous structure of the carbon can provide pathways for the lithium-ion diffusion, which accelerates the ion transport through the electrode. Owing to these merits, the as-prepared PCMO/S cathode exhibits high capacity, stable cycle performance and excellent rate capability.
研究领域:
储能
·
材料科学
·
电化学
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DOI
高影响因子
Eye and Vision
·
2021
·Vol. 8
·期 1
·9
·
IF 3.257
Wang Junjie,Lopes Bernardo T.,Li Hechen,Vinciguerra Riccardo,Cao Si,Wu Songan,Zhu Rong,Wang Qinmei,Zheng Xiaobo,Bao Fangjun,Elsheikh Ahmed
Background Corneal refractive surgery has become reliable for correcting refractive errors, but it can induce unintended ocular changes that alter refractive outcomes. This study is to evaluate the unintended changes in ocular biometric parameters over a 6-month follow-up period after femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) and small incision lenticule extraction (SMILE). Methods 156 consecutive myopic patients scheduled for FS-LASIK and SMILE were included in this study. Central corneal thickness (CCT), mean curvature of the corneal posterior surface (K pm ), internal anterior chamber depth (IACD) and the length from corneal endothelium to retina (ER) were evaluated before and after surgery over a 6-month period. Results Both the FS-LASIK and SMILE groups (closely matched at the pre-surgery stage) experienced flatter K pm , shallower IACD and decreased ER 1 week post-surgery ( P < 0.01), and these changes were larger in FS-LASIK than in SMILE group. During the 1 week to 6 months follow up period, K pm , IACD and ER remained stable unlike CCT which increased significantly ( P < 0.05), more in the FS-LASIK group. Conclusions During the follow up, the posterior corneal surface became flatter and shifted posteriorly, the anterior chamber depth and the length from the corneal endothelium to retina decreased significantly compared with the pre-surgery stage. These unintended changes in ocular biometric parameters were greater in patients undergoing FS-LASIK than SMILE. The changes present clear challenges for IOL power calculations and should be considered to avoid affecting the outcome of cataract surgery.
研究领域:
眼科学
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屈光手术
·
生物测量
·
临床研究
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DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2014
·Vol. 174
·期 6
·2236-2244
·
IF 1.687
Dai Yong,Shao Rong,Qi Gang,Ding Bin-Bin
In this study, it was the first report that the Brevibacterium lutescens CCZU12-1 was employed as a sulfur removing bacteria. Using dibenzothiophene (DBT) as the sole sulfur source, B. lutescens could selectively degrade DBT into 2-hydroxybiphenyl (2-HBP) via the “4S” pathway. In the basal salt medium (BSM) supplemented with 0.25 mM DBT and 0.5 g/L Tween-80, high desulfurization rate (100 %) was obtained by growth cells after 60 h. Furthermore, the n -octane–water (10:90, v / v ) biphasic system was built for the biodesulfurization by resting cells. Moreover, a combination of magnetic nano Fe 3 O 4 particles with calcium alginate immobilization was used for enhancing biodesulfurization. In this n -octane–water biphasic system, immobilized B. lutescens cells could be reused for not less than four times. Therefore, B. lutescens CCZU12-1 shows high potential in the biodesulfurization.
研究领域:
生物脱硫
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环境生物技术
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微生物技术
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石油生物炼制
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应用微生物学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 6
·5925-5933
·
IF 1.798
Peng Linghui,Guo Ronghui,Lan Jianwu,Jiang Shouxiang,Wang Xiang,Li Chao,Li Juan
Silver nanoparticles were synthesized on bamboo pulp fabric with pretreatment of plasma under microwave radiation. The silver nanoparticles coated bamboo pulp fabrics were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, thermogravimetric analysis and X-ray diffraction. Color characteristics and contact angles of silver coated bamboo pulp fabrics were evaluated. Adhesive strength of silver nanoparticles on bamboo pulp fabrics without and with pretreatment of plasma was investigated. Compared with silver nanoparticles coated bamboo pulp fabric without pretreatment of plasma, more silver nanoparticles are coated on the bamboo pulp fabric with pretreatment of plasma. Bamboo pulp fabrics are evenly covered with silver nanoparticles with pretreatment of plasma. In addition, influences of distance between the plasma source and the fabric and treating time on deposition amounts of silver nanoparticles were investigated. Color strength values decrease and increase with the rise of distance and treatment time, respectively. The silver nanoparticles coated bamboo pulp fabric pretreatment of plasma has excellent UV protection, good fastness to laundering and hydrophobicity.
研究领域:
材料科学
·
纳米技术
·
纺织工程
·
表面化学
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DOI
高影响因子
Journal of Coatings Technology and Research
·
2026
·
IF 3.4
Jia Caixia,Yang Tianyu,Wang Qian,Li Zhixin,Yan Chao,Liu Xin
This study investigated an epoxy indicative coating designed to reveal the degree of damage through changes in its cracking characteristics after low-energy impact. Thickness was a critical factor in the pattern of crack extension and distribution of the indicative coating upon impact. Therefore, experiments and finite element analysis were used to reveal the correspondence between epoxy coating (EC) thickness and the damage indications in terms of the number of cracks, the direct cracking area, and the energy absorption-to-mass ratio. Results showed that EC of different thicknesses from 0.5 to 1.0 mm all had the function of indicating damage. The number of cracks and the direct cracking area both increased with impact energy from 1.0 to 3.0 J. The former was relatively independent of coating thickness, whereas the latter was largely influenced. Meanwhile, the coating’s ability to absorb energy also enhanced with its thickness. However, if the effects of weight increase and crack clarity were taken into account, a suitable coating thickness should be selected. For instance, in this study, the 0.8 mm EC achieved an energy consumption effect close to the 1.0 mm EC, but with a lower weight, as well as better regularity and clarity in its crack distribution.
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DOI
高影响因子
npj Materials Degradation
·
2026
·
IF 7.5
Liu Xiangju,Liu Nazhen,Ma Zheng,Wang Yuanxia,Dai Yongchao,Li Chengtao,Song Lijun,Jiang Quantong,Duan Jizhou,Hou Baorong
Hydrogen atom generation and permeation on nuclear waste storage canister surfaces threaten disposal safety. This study investigated the corrosion behavior of hydrogen-charged and non-charged copper in an anoxic, sulfide-containing groundwater environment simulating nuclear waste disposal conditions in Beishan, China. Chloride ions induced pitting corrosion in non-charged copper. The mass transfer rate of \(\text{Cu}{\text{Cl}}_{2}^{-}\) species within pitting pores was higher compared to that of Cu⁺ through the Cu 2 S layer, resulting in excessive thickening of corrosion products at pitting sites. By contrast, porous corrosion products on hydrogen-charged copper formed non-passivating films, leading to uniform substrate corrosion. The corrosion product thickness exhibited sub-parabolic growth over time. This predictable sub-parabolic growth pattern is crucial for reliable service life assessment of deep geological repositories rather than unpredictable pitting corrosion.
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DOI
高影响因子
Communications Chemistry
·
2026
·
IF 6.9
Zhang Chengyu,Wang Longyu,Ndayisenga Fabrice,Jalil Anam,Zhang Yiming,Yu Zhisheng
The hydrogen evolution reaction (HER) is critical for clean energy conversion, yet achieving efficient and durable electrocatalysis across a wide pH range remains a major challenge. Modulating the electronic structure of metal single atoms has shown promise, but is often constrained by weak metal–support interactions in conventional carbon matrices. Here, we report a pH–universal HER electrocatalyst comprising atomically dispersed Ru sites and carbon–confined Ru nanoparticles, synthesized via one–step pyrolysis of biomass–derived precursors. The catalyst delivered low overpotentials of 176 mV (Tafel slope: 23 mV dec –1 ) in acidic and 241 mV (40 mV dec –1 ) in alkaline media at 200 mA cm –2 , along with outstanding operational stability exceeding 500 hours—outperforming commercial Pt/C. This performance arises from electron–rich Ru single atoms (RuN 4 ) modulated by neighboring Ru nanoparticles, synergistically embedded within a hydrophilic and porous carbon scaffold. Density functional theory (DFT) calculations revealed a near–optimal hydrogen adsorption free energy (ΔG H* = –0.25 eV) in acidic conditions and a moderate water dissociation barrier (0.94 eV) in alkaline media. Our findings demonstrate a viable strategy for integrating nanoparticles and single atoms to achieve both high activity and durability, while highlighting the upcycling of biomass into advanced HER catalysts via rational interface engineering.
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DOI
PubMed
高影响因子
BMC MICROBIOLOGY
·
2026
·Vol. 26
·期 1
·282
·
IF 5.4
Zhang Dongdong,Li Haotian,Ye Anqiang,Lian Xiang,Cui Hongtu,Cheng Zhenshun,Guo Feng-Biao
Background The scarcity of effective antibiotics against drug-resistant pathogens has intensified the need for alternative antibacterial development strategies. Drug repurposing (DR) offers a practical solution; herein, we present detailed experimental workflows and in vitro results to validate the feasibility of a DR-based strategy for new antibacterial development. Methods Using Vina-GPU, we performed molecular docking between 125 highly conserved bacterial essential proteins and 2,027 approved non-antibacterials drugs to predict drug-target interactions. As preliminary screening, 14 candidate drugs were tested for inhibitory activity against six bacterial strains ( Escherichia coli MC4100, Pseudomonas aeruginosa PAO1, Acinetobacter baumannii ATCC 19606, Salmonella enterica Typhi CMCC 50071, Salmonella enterica Typhimurium ATCC 14028, and Klebsiella oxytoca ATCC 13182) at 100 μg/ml. Subsequently, lower-concentration assays (combined with Polymyxin B nonapeptide, PMBN) were conducted for preliminarily active drugs. The FLUOStar Omega was used to measure bacterial suspension optical density (OD₆₀₀) and calculate drug inhibition rates. Surface plasmon resonance (SPR), MD simulation, and folate rescue experiments were used to further validate the mechanism of the drug. Results Among the 2,027 non-antibacterials drugs, several exhibited antibacterial activities. Additionally, 173 existing antibacterials were clustered into two groups based on their binding affinity similarity to the 125 essential proteins, with the two groups showing distinct antibacterial activities. Notably, multiple repurposed drugs inhibited the growth of multiple bacterial species. Conclusion Our study revealed that the combination of 8 μg/ml lifitegrast and PMBN can effectively inhibit six gram-negative bacteria. Folate rescue experiments showed that the preliminary antibacterial mechanism of lifitegrast is to inhibit the function of FolA. In addition, future research should explore the structure–activity relationship of lifitegrast and its impact on antibacterial activity. Graphical abstract The alternative text for this image may have been generated using AI.
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DOI
高影响因子
ONCOGENE
·
2026
·
IF 9.1
Tian Shuai,Gu Shuchen,Sun Shuangwu,Wang Zhaoyang,Zhao Yingming,Yuan Bo,Liu Xia,Zhao Bin,Xu Pinglong,Cao Jin,Xiao Mu,Yu Yi,Feng Xin-Hua
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell proliferation, differentiation, migration, and apoptosis. It is generally accepted that TGF-β induces cellular responses through Smad-dependent gene transcription. However, the underlying mechanisms that modulate the transcriptional activities of Smads are not yet fully understood. Here, we identify BRD2, a member of the bromodomain and extraterminal (BET) family, as a key transcriptional coactivator for Smad3. BRD2 physically interacts with Smad3 through a newly identified Smad3-binding region (SBR). This BRD2-Smad interaction enhances Smad’s association with chromatin and amplifies its transcriptional activity, playing a vital role in TGF-β transcriptional and tumor-suppressive responses. Our findings establish BRD2 as an important modulator of TGF-β signaling and suggest that it may serve as a potential target for TGF-β-related diseases.
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 14
·6185-6202
·
IF 4.5
Xin Qingping,Gao Lei,Ma Faxin,Wang Shaofei,Xuan Guangyu,Ma Xiaohua,Wei Mengting,Zhang Lei,Zhang Yuzhong
In this study, functionalized MOF (Azo@MOF-199) is prepared by introducing azo molecules into the pores of MOF-199 by vacuum assisted method, and the effects of the molecular structure of MOF material and its affinity with the modified material on the SO 2 permeability and SO 2 /N 2 selectivity of the prepared mixed matrix membrane are explored. The MOF-199 with higher porosity and specific surface area introduced in Pebax matrix has constructed rich SO 2 transport channel, the –NH 2 as SO 2 -facilitated groups and open metal sites in functionalized MOF increase the affinity to SO 2 . The SO 2 adsorption capacity of Azo@MOF-199 reached 580 mg/g at 0 °C/Vis. The SO 2 permeability and SO 2 /N 2 selectivity of the prepared mixed matrix membrane are significantly improved, which are 3204.2 Barrer and 930, respectively. The prepared membrane has a long-term stability of more than 120 h. In particular, under different light conditions (UV and Vis), Pebax/Azo@MOF-199 membrane is used to investigate the SO 2 separation process with light response, and the change of membrane properties caused by the change of light conditions is reversible. Graphical abstract
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产品关联
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2023
·Vol. 30
·期 5
·1735-1751
·
IF 2.6
Hui Yao,Liu Rukuan,Li Liuzemu,Sun Qingqing,Xiao Zhihong,Xu Airong,Liu Sisi
Ecofriendly adsorbent materials for the rapid and efficient removal of pollutant dyes are highly desired on account of concerns about environmental pollution and human health. Herein, novel magnetic HC/Fe 3 O 4 spherical materials have been constructed via crosslinking hydroxyethyl cellulose (HC) by poly(ethylene glycol) diglycidyl ether (PGDE) followed by the introduction of magnetic Fe 3 O 4 by a facile and effective strategy developed in this work. The morphology, structure and magnetic behavior, point of zero-charge (pH z pc) and Brunauer-Emmet-Teller (BET) of the spherical materials have been systematically investigated. Further, the spherical materials were utilized to remove congo red (CR-SO 3 Na) from aqueous solution under varying adsorption conditions. Meanwhile, the adsorption kinetics, thermodynamics and isothermics have been achieved to explore the adsorption process and possible adsorption mechanism of CR-SO 3 Na by the spherical materials. The materials show not only an efficient capacity of CR-SO 3 Na removal from aqueous solution, but also a sufficient magnetic property of the recovery of the materials from aqueous solution after adsorption. The spherical materials have great potential to be used as efficient adsorbents for the removal of dye-containing effluent.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）