JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
·
IF 4.6
Guangli Li,Nayu Chen,Yafeng Zhang,Tianyu Wang,Rui Zhu,Yuan Jin,Nanke Ma
Rhodamine B (RhB) is highly carcinogenic and is therefore prohibited as a food colorant. Hence, it is necessary to establish a simple but effective technique for the sensitive determination of RhB in foodstuff. Herein, an efficient voltammetric platform was established for the detection of RhB in chili oil based on flower-like β-Bi 2 O 3 microsphere/multiwalled carbon nanotube composites (β-Bi 2 O 3 /MWCNTs). Various microscopic and spectroscopic techniques confirmed the successful formation of β-Bi 2 O 3 /MWCNTs. Owing to the synergistic effect from β-Bi 2 O 3 microspheres and MWCNTs, the β-Bi 2 O 3 /MWCNTs demonstrated superior electrocatalytic activity for the oxidation of RhB as compared to the individual components. Electrochemical kinetics tests confirmed that the RhB electrooxidation was governed by an irreversible and adsorption-controlled process, and involved two electrons one proton transfer pathway. The oxidation peak currents of RhB were linearly correlated with RhB concentrations ranging from 0.05 to 100 μM with a low limit of detection (0.002 μM). The β-Bi 2 O 3 /MWCNT demonstrated strong anti-interfering ability against other azo colorants, and retained robust voltammetric responses for at least 14 days. Moreover, the concentrations of RhB in chili oil were accurately detected by the β-Bi 2 O 3 /MWCNT via second-order derivative linear scan voltammetry with satisfactory recovery. Overall, the β-Bi 2 O 3 /MWCNT/GCE shows great potential for in-situ analysis of trace amounts of RhB in various food matrices.
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Nanoscale
·
2025
·
IF 5.1
Jiasheng Wang,Tianyu Zhang,Jiliang Song,Fengxin Zhang,Hong Liu,Wan-Hui Wang,Ming Bao
Unsaturated alcohols (UOLs) are important fine chemical intermediates. Thus, it is of great significance to design and prepare catalysts for highly selective hydrogenation of CO of α,β-unsaturated aldehydes (UALs). In this paper, a fluffy mesoporous Al2O3-supported Ag–In2O3 catalyst (Ag-In2O3/f-m-Al2O3) was synthesized by employing a two-solvent method, in which Ag and In2O3 form a Mott–Schottky junction and lead to electron transfer from In2O3 to Ag. Electron-rich Ag repels the CC bond owing to “four-electron repulsion”, and electron-deficient In2O3 acts as the electrophilic site to adsorb the O atom of the CO bond, thus improving the selectivity towards UOLs. In addition to a larger specific surface area and smaller mass transfer resistance, the fluffy mesopore Al2O3 exhibits a large number of Lewis acid sites, which can further improve UOL selectivity. With the help of Ag–In2O3/f-m-Al2O3, high UOL selectivity can be obtained from UALs containing aliphatic, aromatic and heterocyclic groups. This elaborate design of the catalyst could contribute to the highly selective hydrogenation of UALs to UOLs.
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高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
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EXPERIMENTAL CELL RESEARCH
·
2024
·
IF 3.3
Zhen Xu,Yilin Guo,Lu Wang,Jinquan Cui
HECW1 belongs to ubiquitin ligase (E3) HECT family, and is found to be involved in tumorigenesis and tumor progression. However, the function of HECW1 in cervical cancer (CC) remains unknown. Clinical analysis showed that HECW1 is significantly decreased in CC tumor tissues. Ectopic expression of HECW1 suppressed cell growth, promoting cell cycle arrest and apoptosis in CC cells, while downregulation of HECW1 reversed these trends, impeded proliferation and accelerated cell cycle progression of CC cells. Overexpressing of HECW1 reduced mitochondrial membrane potential and the protein expression of voltage-dependent anion channel 1 (VDAC1). In addition, upregulation of HECW1 inhibited nuclear β-catenin accumulation, downregulated β-catenin/TCF/LEF-mediated transcriptional activity and the expression of downstream gene c-Myc, whereas inhibition of HECW1 received opposite results. Further results confirmed HECW1 affects the protein expression of dishevelled-1 (DVL1), a potent activator of Wnt/β‐catenin, and inhibition of HECW1 inhibited the ubiquitination of DVL1, upregulating its expression. Inhibition of DVL1 restrained the promotion effect of HECW1 suppression on cell proliferation. In vivo experiments also verified that HECW1 suppression promoted the tumor formation of CC cells. Summary, we demonstrated that HECW1 inhibits CC cell proliferation and tumor formation by downregulating DVL1 induced Wnt/β‐catenin signaling pathway activation.
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Regenerative Biomaterials
·
2024
·
IF 5.6
Lin Qiaoxia,Zhang Yonggang,Chen Luhua,Zhang Haoyue,An Chuanfeng,Li Chengze,Wang Qifan,Song Jinhui,He Wei,Wang Huanan
Development of piezoelectric biomaterials with high piezoelectric performance, while possessing excellent flexibility, biocompatibility, and biodegradability still remains a great challenge. Herein, a flexible, biocompatible and biodegradable piezoelectric β-glycine-alginate-glycerol (Gly-Alg-Glycerol) film with excellent in vitro and in vivo sensing performance was developed. Remarkably, a single, monolithic β-glycine spherulite, instead of more commonly observed multiple spherulites, was formed in alginate matrix, thereby resulting in outstanding piezoelectric property, including high piezoelectric constant (7.2 pC/N) and high piezoelectric sensitivity (1.97 mV/kPa). The Gly-Alg-Glycerol film exhibited superior flexibility, enabling complex shape-shifting, e.g. origami pigeon, 40% tensile strain, and repeated bending and folding deformation without fracture. In vitro, the flexible Gly-Alg-Glycerol film sensor could detect subtle pulse signal, sound wave, and recognize shear stress applied from different directions. In addition, we have demonstrated that the Gly-Alg-Glycerol film sensor sealed by polylactic acid and beeswax could serve as an in vivo sensor to monitor physiological pressure signals such as heartbeat, respiration, and muscle movement. Finally, the Gly-Alg-Glycerol film possessed good biocompatibility, supporting the attachment and proliferation of rat mesenchymal stromal cells, and biodegradability, thereby showing great potential as biodegradable piezoelectric biomaterials for biomedical sensing applications.
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MATERIALS RESEARCH BULLETIN
·
2025
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IF 5.7
Lanfei Wei,Jiaquan Liu,Qiuman Zhou,Shaolong Liu,Zhifeng Su,Yurong Yan
Bismuth trioxide (Bi 2 O 3 ) acts as an ideal material for supercapacitors because of its high theoretical specific capacity, but its crystal form and compact accumulation limit its specific capacitance below its theoretical value of 1370 F g -1 . In this study, a specific kapok fiber@chitosan-derived carbon (KCC) doping inside β/α hybrid-crystal Bi 2 O 3 (KCC-Bi 2 O 3 ) was constructed by KCC assisting to enhance the contact area between Bi-MOF and air during calcination. A specific capacitance of 1135 F g -1 at 1 A g -1 was obtained for KCC-Bi 2 O 3 , which matched 82.3 % of its theoretical value. An asymmetric capacitor, with KCC-Bi 2 O 3 as a negative electrode and NiCo-LDH as a positive electrode, exhibits a potential window of 1.6 V and an energy density of 17.3 Wh kg -1 at 800 W kg -1 . The result demonstrates that incorporating a KCC carbon source can significantly enhance the capacitance of mixed crystal form Bi 2 O 3 , highlighting its potential in supercapacitor applications.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 4
·1558
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IF 4.9
Jiabin Huang,Haotian Wu,Ranran Gao,Lan Wu,Mengyue Wang,Yang Chu,Yuhua Shi,Li Xiang,Qinggang Yin
L-ascorbic acid (vitamin C, AA) is widely present in plants, but humans lack the ability to synthesize it independently. As a potent reducing agent, AA is susceptible to oxidation, making the enhancement of its stability crucial. 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG) is a stable natural derivative of AA with glycosylation, initially discovered in the fruits ofLycium barbarum. Understanding the biosynthesis of AA-2βG is crucial for enhancing its production inL. barbarum. While the established biosynthesis pathway of AA constitutes the upstream of AA-2βG biosynthesis, the conclusive step of β-glycosylation remains unclear. We identified aL. barbarumcultivar by UPLC, ZN01, with a high content of AA-2βG, and compared its leaves, immature fruits, and mature fruits to a normal AA-2βG contentL. barbarumcultivar for metabolomic and transcriptomic analysis. The RNA-seq and RT-qPCR analysis revealed that the expression levels of genes involved in the AA biosynthesis pathway did not consistently correlate with AA-2βG content, suggesting that the final glycosylation step may be a key determinant of AA-2βG accumulation. Subsequently, utilizing phylogenetic and co-expression analysis, we identified ten UDP-glycosyltransferases (UGTs) and three β-glucosidases (BGLUs) which may be involved in the crucial step of the conversion from AA to AA-2βG, and the UGTs’ activities were predicted through molecular docking. Lastly, we speculated that the presence of the glycosylation process of AA might have a crucial role in maintaining AA homeostasis inL. barbarum, and deliberated on potential correlations between AA, carotenoids, and anthocyanins. Our integrated multi-omics analysis provides valuable insights into AA-2βG biosynthesis inL. barbarum, identifying thirteen candidate genes and highlighting the complex interplay between AA, carotenoids, and anthocyanins. These findings have implications for improving AA-2βG content inL. barbarum.
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ANALYTICAL BIOCHEMISTRY
·
2024
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IF 2.6
Cheng Li,Qinghui Chen,Jinqiao Rong,Houde He,Yu Lu,Yuxia Liu,Zhongfu Wang
As the main active glycoprotein of egg white, the biological functions of chicken ovomucin α- and β-subunit are closely related to the structure of glycans. However, the exact composition and structure of the subunit glycans are still unknown. We obtained highly pure chicken ovomucin α-subunit and β-subunit protein bands by the strategy combined with two-step isoelectric precipitation and SDS-PAGE gel electrophoresis. The ammonia-catalyzed one-pot procedure was then used to release and capture α-and β-subunit protein glycans with 1-phenyl- 3-Methyl-5-pyrazolone (PMP). The N / O -glycans of bis-PMP derivatives were purified and analyzed by LC-MS. More importantly, an effective dual modification was performed to accurately quantify neutral and sialylated O -glycans through methylamidation of sialic acid residues and simultaneously through carbonyl condensation reactions of reducing ends with PMP. We first showed that the α-subunit protein has only N -glycosylation modification, and the β-subunit only O -glycosylation, a total of 22 N -glycans and 20 O -glycans were identified in the α- and β-subunit, respectively. In addition, the complex N -glycan (47 %) and the sialylated O -glycan (77 %) are each major types of the above subunits. Such findings in this study provide a basis for studying the functional and biological activities of chicken ovomucin glycans.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Jiaqiao Yuan,Yamin Li,Zhan Ding,Anmei Yu,Yijie Zhang,Shuming Wen,Shaojun Bai
It is difficult to realize an effective separating of chalcopyrite and pyrite without using any depressants due to their similar physicochemical properties . Herein, a cyclic oligosaccharide carboxymethyl-β-cyclodextrin (CMCD) with carboxyl and hydroxyl groups was introduced for the first time as a novel environmentally friendly depressant for separating chalcopyrite from pyrite. The depression performance and adsorption mechanism of CMCD in the flotation separation of chalcopyrite and pyrite were investigated through micro-flotation experiments, molecular dynamics (MD) simulations, and a series of characterization tests. The flotation findings manifested that under weakly acidic conditions (pH=6.5±0.2), a high-quality copper concentrate with a copper recovery of 73.15 % and a grade of 28.06 % was obtained. CMCD exhibited superior inhibition of pyrite compared with other traditional inhibitors. The adsorption density of CMCD onto the pyrite surface was significantly higher than that of chalcopyrite, and the pre-treatment with CMCD hindered the attachment of sodium butyl xanthate (SBX) on pyrite but had a minor effect on chalcopyrite, as confirmed by contact angle, adsorption amount, and Atomic Force Microscope analyses. Moreover, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analyses robustly demonstrated that the carboxyl and hydroxyl groups in the CMCD molecule primarily reacted with the metal hydroxides on the pyrite surface through hydrogen bonding, leading to a more hydrophilic surface. MD simulations further confirmed at the molecular level that the affinity of CMCD for the pyrite surface was much greater than for chalcopyrite. In summary, CMCD shows promising potential as a depressant for separating chalcopyrite from pyrite.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Jian Zhu,Yunyan Lai,Yinhua Wu,Jiali Wang,Jiaqi Wei,Hanhong Xu
We screened the contact activity of 32 commercial essential oils (EOs) and their synergistic effect with β-cypermethrin against Blattella germanica. Results showed that the most effective EOs against B. germanica were from Illicium verum, Syzygium aromaticum, and Cinnamomum camphora, with LD50 values of less than 500 μg/insect. The most potent synergistic effects of β-cypermethrin on B. germanica were from Dysphania ambrosioides and Mentha canadensis. Both oils have a co-toxic factor of 133.33. The results of the major compound testing of the EOs showed that trans-anisaldehyde and thymol have the best insecticidal activity against B. germanica, with LD50 values of 141.30 and 138.61 μg/insect, respectively. The compounds with the best synergistic effect on β-cypermethrin were γ-terpinene and linalool at a concentration of 0.5%. The co-toxic factors for γ-terpinene and linalool were 150 and 133.33, respectively, which were similar to the synergistic effect observed with 2% piperonyl butoxide.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yunfei Sun,Yaping Wang,Yun Chen,Junchao Qian,Feng Chen,Zelong Zhou,Chaoya Han,Yu Shi,Xiaowang Lu,Chaoying Ni
Bisphenol A (BPA), a prevalent organic pollutant found in wastewater environment, is notorious for its resistance to natural degradation, raising significant ecological and human health concerns. In this study, a “signal-on” photoelectrochemical aptasensing system was designed for detecting BPA in real water samples with high specificity and sensitivity. One-dimensional (1D) β-FeOOH nanobelts were synthesized on a two-dimensional (2D) porous carbon nitride (g-C 3 N 4 ) through an in-situ growth procedure. The β-FeOOH/g-C 3 N 4 nanocomposites demonstrated superior photoelectric conversion efficiency due to several factors: (i) The 1D nanobelt-like structure of β-FeOOH shortens the charge transfer path within the nanocomposite, enabling directional and rapid migration of photoinduced charges from the interior to the surface. (ii) β-FeOOH possesses strong visible absorption capabilities, enhancing the utilization of g-C 3 N 4 under photoexcitation, resulting in the generation of numerous photo-induced carriers. (iii) The in-situ formation of the β-FeOOH/g-C 3 N 4 heterojunction establishes an intimate interfacial contact, facilitating the rapid separation and transfer of charges between β-FeOOH and g-C 3 N 4 . A photoelectrochemical aptasensing platform based on the photoactive material of β-FeOOH/g-C 3 N 4 detects BPA with reduced photocurrent owing to the presence of BPA-aptamer macromolecules on the electrode surface. This BPA detection system exhibits excellent linearity over a wide concentration range from 10 pM to 10 nM, with high sensitivity (a detection limit of 3.5 pM), stability, specificity, and repeatability. Furthermore, this research offers a straightforward and rapid sensing platform for monitoring BPA enriched water environments.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 2
·1-14
·
IF 21.8
Xi Tingting,Li Chaojian,Yu Yaqian,Wei Weiqi,Wang Sha,Xu Tingting,Xiao Huining,Dai Hongqi,Zhou Xuelian,Bian Huiyang
Enhancing the dispersibility and recoverability of powdered catalysts is essential for developing efficient and cost-effective photocatalytic systems. Herein, β -FeOOH nanoparticles were in-situ deposited on commercially available filter paper (FP) to construct paper-based composite material ( β -FeOOH@FP). Results showed that the rod-like β -FeOOH nanoparticles were uniformly distributed in the FP matrix without destroying the crystalline structure of cellulose. The resulting β -FeOOH synthesized at 3 h presented the highest photoelectrochemical response and exhibited better suppression of electron–hole recombination, allowing more photogenerated electrons to participate in the reaction. The β -FeOOH@FP catalyst achieved a 94.1% photocatalytic degradation rate of tetracycline (TC) within 120 min compared to the pure β -FeOOH (42.2%) and FP (20.1%) under simulated visible light irradiation. Photocatalytic degradation kinetics also demonstrated that the rate constant of β -FeOOH@FP was 9.6 × 10 −3 min −1 , much higher than that of others. In addition, the resulting β -FeOOH@FP composite material exhibited excellent stability and reusability with a photocatalytic efficiency of over 90% after five cycles. These findings provide a simple and cost-effective strategy to improve the degradation performance of powdered semiconductor catalysts and pave a new way to develop cellulose-based nanocomposites with high photocatalytic efficiency.
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