International Journal of Electrochemical Science
·
2023
·
IF 1.5
Chuan Lai,Hongxia Yang,Xiaogang Guo,Xiulan Su,Lvshan Zhou,Lei Zhang,Bin Xie
The new organic corrosion inhibitor of 2-( p -bromobenzylthio)-1 H -benzimidazole (Br-BBD) was synthesized in this work. After prepared, the adsorption and corrosion inhibition performance of Br-BBD for Q235 steel in HCl solution were studied using EIS, SEM, polarization measurement and WLM (weight loss measurement). The results exhibit that Br-BBD acts as an excellent corrosion inhibitor for Q235 steel in HCl solution, and the inhibition efficiency can reach up to 98.07% when the Br-BBD concentration is 50 mg L -1 in 1.0 M HCl at 25°C. In addition, the adsorption of the mixed-type inhibitor of Br-BBD on Q235 steel surface obey Langmuir adsorption isotherm, which is governed by spontaneous chemisorption mechanism.
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CATALYSIS LETTERS
·
2013
·Vol. 143
·期 5
·463-468
·
IF 2.244
Zhu Anlian,Li Qianqian,Li Lingjun,Wang Jianji
Abstract A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO 4 ] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO 4 ] > [Choline] [HSO 4 ] > [DMEA][H 2 PO 4 ] > [Choline] [H 2 PO 4 ] .
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Natural Product Communications
·
2025
·
IF 1.4
Longwei Fang,Zhen Ni,Yanglei Shen,Feng Gao,La Yang,Nanling Liu,Zhuoma Duoji,Dongzhi Zhuoma,Wangdui Suolang,Zhuoma Basang
ObjectiveTo study the chemical constituents of Synotis solidaginea (SS) from Tibet. In our previous research, it was found that the extract of Synotis solidaginea stems has potential inhibitory activity against the proliferation of melanoma cells. Therefore, we hope to separate, extract and structurally identify the extracts of Synotis solidaginea stems, and determine the main components that exert potential inhibitory activity on the proliferation of melanoma cells.MethodsThe compounds were separated and purified using silica gel, polyamide, reversed phase C18 column chromatography, and preparative high performance liquid chromatography. The structure of each compound was identified based on the spectral data and literature comparisons. To verify the inhibitory activity of each component against melanoma cells, cell and enzyme assay were conducted.ResultsA total of 7 compounds were isolated from the dichloromethane extract of Synotis solidaginea. The irimofen lactone structure compound SS-1 and SS-5 were isolated from Synotis solidaginea for the first time. Among these, irimofin sesquiterpenoid compound SS-2 exhibited strong inhibitory activity against B16F10 of melanoma cells. Meanwhile, the iremorphene sesquiterpenoid SS-2 exhibited significant tyrosinase inhibitory activity, and the docking results explained the mechanism of its action.DiscussionSolidaginea has laid the foundation for the prevention and treatment of melanoma with the active ingredients of Tibetan medicine.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Hailiang Chu,Nianpu Li,Xueying Qiu,Yu Wang,Shujun Qiu,Ju-Lan Zeng,Yongjin Zou,Fen Xu,Lixian Sun
In this work, poly( N -vinyl-2-pyrrolidone) (PVP)-stabilized ruthenium nanoparticles (NPs) supported on bamboo leaf-derived porous carbon (Ru/BC) has been synthesized via a one-step procedure. The structure and morphology of the as-synthesized samples were characterized by means of X-ray diffraction (XRD), X-ray photoelectron spectrometry (XPS), scanning electron microscope (SEM) and transmission electron microscope (TEM). As a catalyst for hydrogen generation from the hydrolysis of ammonia-borane (AB, NH 3 BH 3 ) at room temperature, Ru/BC stabilized with 1 mg of PVP exhibited high activity (TOF = 718 mol H2 ·mol Ru −1 ·min −1 ) and low activation energy ( E a = 22.8 kJ mol −1 ). In addition, the catalyst could be easily recovered and showed fairly good recyclability with 55.6% of the initial catalytic activity retained after ten experimental cycles, which confirmed that PVP could stabilize the Ru NPs and prevent their agglomeration on BC surface. Our results suggest that PVP-stabilized Ru/BC is a highly efficient catalyst for the hydrolysis of AB.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Qimeng Tian,Hong Jiang,Yajun Luan,Jingge Sun,Yihang Sui,Ling Chen,Yongxiang Wang,Ninghua Tan
Ethnopharmacological relevance Suhuang antitussive capsule (SH) is the only clinically approved traditional Chinese patent medicine for the treatment of post-infectious cough (PIC). During the past decade, our lab has conducted intensive researches on SH, including its efficacy and mechanism on PIC, and determined that SH has favorable anti-inflammatory, antitussive, expectorant, and anti-asthmatic pharmacological effects. Recently, we found that vicenin-2 (VIC-2) could be detected in SH and showed activity in vitro primary screening on PIC. Aim of the study To investigate the therapeutic effects of VIC-2 on PIC and its potential mechanisms, and want to elucidate VIC-2 as one of the efficacious components of SH. Materials and methods The PIC mouse model was established with lipopolysaccharide (LPS)-induced combined cigarette smoke (CS)-exposed ICR mice, while the in vitro assay was constructed to induce BEAS-2B cells with cigarette smoke extract (CSE). The therapeutic effects of VIC-2 on PIC in vitro and in vivo were assessed by pathological sections, cough assay, immune cell counting, and quantitative-polymerase chain reaction (Q-PCR). The mechanisms of VIC-2 on ferroptosis and mitophagy in PIC were further explored by cell viability assay, Prussian blue staining, lipid peroxidation assessment, confocal laser scanning microscopy, and western blotting. Subsequently, virtual docking, cellular thermal shift assay (CETSA), and drug affinity responsive target stability (DARTS) verified the target relationship between VIC-2 and LDL receptor-related protein 1 (LRP1). In addition, the link between LRP1 and mitophagy-dependent ferroptosis was explored by knocking down LRP1. Results VIC-2 significantly improved lung inflammation, oxidative stress, and airway remodeling in PIC and inhibited mitophagy-dependent ferroptosis, confirming that it is one of the antitussive components of SH for the treatment of PIC. LRP1 is one of the pharmacological targets of VIC-2, in which VIC-2 exerted the above effects through up-regulating LRP1 by influencing the LRP1-Parkin interaction. The blockade of LRP1 reversed the both in vitro and in vivo pharmacological activities of VIC-2 . Furthermore, our results showed for the first time that defects in LRP1 lead to ferroptosis. Conclusion This study demonstrates that VIC-2 inhibits mitophagy-dependent ferroptosis via LRP1 for the treatment of PIC, constituting one of the antitussive components of SH.
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高影响因子
SOLAR ENERGY
·
2025
·
IF 6.6
Jiachen Li,Biao Hu,Hui Wang,Jinxin Yang,Chunwang Li,Xin Du
A eutectic hydrate salt phase change material composed of NH 4 Al(SO 4 ) 2 ·12H 2 O-CH 3 COONa·3H 2 O was prepared. The eutectic composition, determined experimentally to consist of 92.5 wt% NH 4 Al(SO 4 ) 2 ·12H 2 O and 7.5 wt% CH 3 COONa·3H 2 O, deviated significantly from predictions made by the Scholar’s equation, highlighting the need for optimization of theoretical prediction methods. The eutectic material exhibited promising thermal storage properties, but a significant supercooling degree of 12.98 K was observed. To mitigate this issue, 14 different nucleating agents were evaluated and five nucleating agents were identified as effective in reducing the supercooling degree to below 1 °C. Furthermore, the thermophysical properties of the eutectic phase change materials with five preferred nucleating agents, including phase change temperature, latent heat, volume expansion ratio and thermal storage density, were characterized using differential scanning calorimetry, T-history, and solid–liquid density testing. Among the five preferred nucleating agents, Nano Cu demonstrated the best performance, achieving a high thermal storage density of 223.45 kJ/kg and a minimal volume expansion ratio of 4.92 %. Future studies will focus on optimizing heat transfer characterization and integrating this material into renewable energy-based heating systems such as heat pumps, solar heating systems, and valley electric heating systems to achieve sustainable and efficient heating solutions.
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Laser & Photonics Reviews
·
2025
·Vol. 19
·期 12
·2402164
·
IF 10
Fengyang Ma,Kaixin Liu,Zhongyao Yan,Liang Yu,Yanru Yang,Wuyan Zhao,Feilong Wang,Yaohua Li,Shuyu Zhang,Songyou Wang,Jian Sun,Ming Lu
Silicon (Si) light source has profound significance in monolithic integrated Si photonics. However, its luminance remains too low to meet practical use that usually requires > 10000 cd m⁻ 2 . Here, an all-inorganic Si nanocrystal (SiNC) white light-emitting diode (WLED) with a continuous emission spectrum spanning ≈400–900 nm in wavelength, is reported. The architecture of the WLED comprises front electrode of Ag grids and transparent-conducting-oxide/electron transport layer (ETL) of ZnO/front charge confinement layer (CCL) of SiO 2 /active layer of low-resistivity SiNC composite thin film/rear CCL of SiO 2 /hole transport layer (HTL) of MoO 3 /textured p-Si substrate/rear electrode of aluminum/heat radiator. The main procedures for achieving high luminance here include combined applications of high-pressure ammonia passivation of the active layer, which enhances its photoluminescence quantum yield significantly, and texturing of p-Si substrate, which boosts the light extraction and charge injection effectively. With an optimized combination of passivation and texturing, luminance of 10751 cd m⁻ 2 is achieved with external quantum efficiency (EQE) of 0.26%. After a Peltier cooler is further applied, luminance of 12363 cd m⁻ 2 is attained with EQE of 0.30%. Following further technical iterations, this highly bright SiNC WLED shall find applications in monolithic integrated Si photonics and even Si general lighting.
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JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Wenzhi Su,Mengyu Zhang,Chuancheng Zhang,Yong Zou,Wenpeng Liu,Shoujun Ding
Upconversion (UC) fluorescence intensity ratio (FIR) technology has emerged as a promising approach for optical thermometry due to its ability to provide non-contact, high-precision temperature measurements. Unlike conventional UC phosphor-based systems, single-crystal UC materials offer enhanced responsiveness and sensitivity for thermal detection, thanks to their structural stability and superior thermal conductivity. In this study, we successfully synthesized an Yb 3+ , Ho 3 ⁺:NaBi(MoO 4 ) 2 (NBM) single crystal with exceptional optical quality using the Czochralski (Cz) growth technique. Comprehensive structural characterization was carried out using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). The results confirmed that Yb 3+ , Ho 3+ :NBM crystallizes in a tetragonal structure with the space group I4 1 /a. The emission of different visible light colors under various excitation wavelengths was found to be due to the multiphonon relaxation process. Systematic analysis of power-dependent up-conversion emission spectra conclusively showed that the green and red up-conversion emissions arise from two-photon excitation processes. Moreover, temperature-dependent spectral evolution in the range of 300–500 K was quantitatively analyzed, allowing the calculation of both absolute sensitivity ( S ₐ) and relative sensitivity ( S ᵣ) parameters to evaluate the material's optical thermometric performance. These findings highlight the promising potential of Yb 3+ , Ho 3+ :NBM single crystal for developing high-performance optical thermometry devices.
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MOLECULES
·
2025
·Vol. 30
·期 11
·2400
·
IF 4.6
Ming Yuan,Huai Wang,Mingjun Yu,Sen Yao,Risheng Yao
Cisplatin (CIS) is a widely used chemotherapeutic agent that is highly effective against various cancers. However, its clinical application is frequently limited by its substantial nephrotoxic side effects. The gastrin-releasing peptide receptor (GRPR), a critical regulator in inflammatory diseases, has been identified as a promising therapeutic target. Our previous studies have demonstrated that the GRPR antagonists PD176252 and RH-1402 can mitigate CIS-induced nephrotoxicity through anti-inflammatory mechanisms. Based on these findings, we designed and synthesized a series of 2-arylpropanoic acid-L-tryptophan derivatives to enhance the therapeutic effects. Among these compounds,3mexhibited superior renal protection by significantly improving mouse renal tubular epithelial cell (mRTEC) viability from 50.2 ± 2.6% to 80.5 ± 3.9%, surpassing PD176252 (70.8 ± 1.4%) and RH-1402 (73.9 ± 3.7%). Moreover, compound3mmarkedly reduced the expression of kidney injury molecule-1 (KIM-1) and inflammatory cytokines [Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), Monocyte Chemoattractant Protein-1 (MCP-1)]. Finally, molecular docking results revealed that3mexhibited a high binding affinity for GRPR. Computational predictions using SwissADME further indicated that3mpossesses favorable drug-like properties, thereby supporting its potential as a promising candidate for mitigating CIS-induced nephrotoxicity.
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Small
·
2025
·
IF 12.1
Xin Chen,Jiahui Wu,Jingyao Zeng,Caiyan Shen,Yuejun Wang,Yangyang Xie,Guorong Hu,Ke Du,Zhongdong Peng,Yanbing Cao
Due to the strong electronegativity of P in the anion group and the strong P─O covalent bond, NFPP exhibits low electronic and ionic conductivity, hindering its rate capability. A doping modification strategy of selecting La 3+ with a large ion radius at Na site has been designed, and the nano-micro architectural Na 4-3x La x □ 2x Fe 3 (PO 4 ) 2 (P 2 O 7 )/C (0≤x≤0.04) cathode material with Na vacancies is successfully synthesized via a scalable preparation route. Introducing positively charged substitutional point defects and charged vacancies through doping La 3+ not only broadens the Na + transport channels but also reduces lattice stress and stabilizes the crystal bulk structure during long-term cycling for La 3+ as pillars. Additionally, high valence La 3+ doping enhances the effective charge carrier concentration and improves material conductivity. Consequently, the kinetic performance of Na + migration is significantly enhanced. The optimal Na 3.91 La 0.03 □ 0.06 Fe 3 (PO 4 ) 2 (P 2 O 7 )/C (NFPP/C-La3) exhibits the best electrochemical performance. The synthesized NFPP/C-La3 exhibits excellent rate performance (99.45 mAh g −1 at 20 C) and long-term cycle stability (92.36% of capacity retention over 1000 cycles at 10 C). These results provide the importance and prospect of the high valence ion doping for NFPP/C with high rate stability.
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2025
·
IF 2.7
Fei Yuan,Yiyuan Xin,Caifeng Yuan,Zhuo Chen,Tongling Qin,Wenxia Hu,Jiahuan Duan,E Tang
A simple, exogenous-base-free, and NBS-mediated C-selenocyanation/cyclization reaction of enaminones with KSeCN under mild conditions, providing a facile route to 2-aminoselenazole products, has been developed. This efficient protocol is postulated to first undergo the NBS-oxidated polarity reversal of the reactive SeCN- anion to form N-selenocyanosuccinimide as an electrophilic selenium source, which can induce the C-selenocyanation of enaminones and enamino esters, followed by a nucleophilic cyclization promoted by in-situ yielded HBr.
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MOLECULAR DIVERSITY
·
2025
·
IF 3.8
Miao Wenjun,Yang Meixian,Peng Zhiping,Xia Zhu,Zhang Xiaoyang,Chen Yi,Jia Jianhua
Cyclooxygenase-2 (COX-2) plays vital roles in promoting angiogenesis, tissue invasion, and resistance to apoptosis, so it has become an attractive biomarker for imaging and therapy of cancer. Numerous radio-tracers for detection of COX-2 in vivo have been reported, but no one has been successfully applied in clinic. In this study, the radiosynthesis and evaluation of [ 18 F] 6 , containing a 1,5-diarylpyrrole structure, as a radiotracer for imaging of COX-2 is described. [ 18 F] 6 was prepared within 90 min synthesis time with radiochemical yields (RCYs) of 2–6% (n = 7, decay corrected) from [ 18 F]fluoride by a one-step 18 F-trifluoromethylation reaction. After purification by high performance liquid chromatography (HPLC), its radiochemical purity (RCP) was higher than 98%, and the molar activity was 156–210 MBq/mmol. The stability of [ 18 F] 6 was determined by incubation in saline and fetal bovine serum (FBS) in vitro, showing excellent stability in 4 h. The specific binding of [ 18 F] 6 was evaluated using MCF-7 cells (COX-2 positive cells) in vitro, where the radiotracer uptake was blocked in the presence of Celecoxib (a commonly used COX-2 inhibitor). However, no tumor accumulation of [ 18 F] 6 could be observed by micro-PET/CT studies on MCF-7 tumor-bearing mice in vivo. This may be due to the insufficient molar activity of [ 18 F] 6, or inadequate expression of COX-2 in MCF-7. In conclusion, optimizations of radiosynthesis and evaluations of specific binding in suitable model are further still needed to verify the potential of [ 18 F] 6 as a COX-2 imaging agent.
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