ACS Sustainable Chemistry & Engineering
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2024
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IF 7.1
Bo Yang,Wentao Sun,Xinhe Liu,Ming-zhu Ding,Xudong Feng,Chun Li
Glycyrrhetinic acid 3-O-monoglucuronide (GAMG) and glycyrrhizin (GL) are typical pentacyclic triterpenoid saponins present in licorice roots that exhibit important pharmacological properties. GAMG and GL are sourced primarily from licorice, namely, “digging roots and extracting acid”, which results in ecological imbalance and environmental pollution. To overcome these issues, it is an eco-friendly and sustainable alternative to de novo synthesize GAMG and GL in Saccharomyces cerevisiae by coupling UDP-glucuronic acid and glycyrrhetinic acid (GA) under the catalysis of glycosyltransferases. However, the reported productivity is too low for industrial production. The primary limiting factors include insufficient supply of precursors, poor activity, and low specificity of the glycosyltransferases. In this study, we reconstructed the GA-producing platform strain in which GA was mainly accumulated intracellularly, making it suitable for subsequent glycosylation modifications. Different glycosyltransferases were tested and selected in the platform strain for achieving the efficient and specific synthesis of GAMG and GL. Protein engineering of rate-limiting enzyme cUGT73P12 was performed to further facilitate the conversion from GAMG to GL. The glycosylation capacity of this system was assessed in vivo, uncovering that the insufficient supply of precursor GA limited glycosylation modifications. Correspondingly, multiple metabolic engineering strategies were applied to optimize the carbon flux distribution, increasing the titers of GAMG and GL by 115.6 and 50.2%, respectively. Finally, 552.9 mg/L GAMG and 476.6 mg/L GL were produced in the 5 L fed-batch fermentation, which were 238- and 79-fold higher than previously reported values, respectively. The strategy described herein can serve as a reference for the glycosylation of triterpenoids in a cost-effective manner.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Xingxing Yu,Faxun Wang,Huakang Zong,Yufei Gan,Guotao Duan,Yuanyuan Luo
The modification of ionic liquid electrolytes is of particular importance for the development of high-performance electrochemical oxygen sensors with zero power consumption but still quite challenging. Herein, we designed and synthesized an electrochemical oxygen sensor based on the modified Pt/CMK-3-COOH-[EMIM][OAc] ionic liquid as composite electrolyte, where the -COOH functional group was introduced by acidifying CMK to provide hydrogen protons, and then Pt nanoparticles with different contents were loaded to improve the activity of the sensor towards O 2 gas as well as the conductivity of ionic liquid. Such composite ionic liquid sensor exhibits excellent O 2 detection ability with high sensitivity (0.58 μA/[%O 2 ]), high stability, wide detection range (0.4-10%), and zero-power consumption, along with the detection limit as low as 0.4%. Furthermore, it has humidity-independent gas-sensing characteristic. Moreover, density functional theory (DFT) calculations combined with experimental results were applied to deeply unveil the improved O 2 sensing mechanism. Compared with CMK, the introduction of Pt/CMK-3-COOH material increases the conductivity of the ionic liquid, decreases the adsorption energy of the sensor for O 2 and hydrogen protons, promotes the oxygen reduction reaction, and simulates the transfer of effective charge, thereby significantly improving O 2 sensing. This work provides a high-performance ionic liquid oxygen sensor, showing potential application in zero-power consumption and low concentration O 2 detection.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2019
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IF 8.355
Jing Zeng,Dongzheng Wu,Xin Wang,Junnan Wu,Jiyang Li,Jing Wang,Jinbao Zhao
The high-voltage cathode material based on the sodium super ionic conductor (NASICON) structured Na 3 V 2 (PO 4 ) 3 (NVP) has been found to be a potential candidate for Mg storage. In this work, to improve its electrochemical performance, we construct honeycomb-like structured NVP/C/G with faster electronic and ionic transport by a convenient and universal spray-drying method for the first time. After electrochemically desodiating two Na from the NVP/C/G (ED-NVP/C/G), the ED-NVP/C/G is tested in highly anhydrous Mg electrolyte, and the insights into its Mg storage property and mechanism are carefully studied. An initial capacity of 87 mAh g −1 with a relatively high average discharge voltage of 2.47 V vs. Mg 2+ /Mg is obtained at 0.1 C. The X-ray diffraction (XRD) results show that the inserted Mg 2+ ions tend to occupy the Na2 (at 18e sites) vacant sites. The investigation of kinetic process by galvanostatic intermittent titration technique (GITT) reveals that the Mg diffusion kinetics is faster during the demagnesiation process. The electrochemical reaction bases on two-phase transition mechanism, and the R ct value shows a positive relationship to the formation of NaV 2 (PO 4 ) 3 phase. Finally, a Mg full cell prototype based on the ED-NVP/C/G cathode with Mg metal anode is built. The rational structure design of NVP/C/G improves the electrochemical performance for Mg storage, and our work also gives new understanding into the Mg storage mechanism in the ED-NVP/C/G structure.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2011
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IF 3.37
Tao Liu,Haichao Su,Xiangjin Qu,Peng Ju,Lin Cui,Shiyun Ai
A novel amperometric biosensor based on immobilizing acetylcholinesterase on 3-carboxyphenylboronic/reduced graphene oxide–gold nanocomposites modified electrode was developed for the detection of organophosphorus and carbamate pesticides . Acetylcholinesterase was successfully immobilized on the electrode with relatively high activity by the specific binding between the boronic acid group of 3-carboxyphenylboronic and the glycosyl of acetylcholinesterase. The biosensor enjoyed good sensitivity owing to the excellent properties of gold nanoparticles and reduced graphene oxide , which promoted electron transfer reaction and enhanced the electrochemical response. Parameters affecting the biosensor response such as pH, applied potential, enzyme loading and inhibition time were optimized. Based on the inhibition of an organophosphorus insecticide on the enzymatic activity of AChE, organophosphorus and carbamate pesticides were determined with satisfactory results in the presence of acetylthiocholine chloride as a substrate. Moreover, the fabricated biosensor had good repeatability and high stability.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2014
·Vol. 131
·期 13
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IF 1.64
Zhan-Lin Gong,Lan Cen,Shu-Ting Wang,Fu-Lin Chen
Maleated glycidyl 3-pentadecenyl phenyl ether (M-GPPE) was synthesized from glycidyl 3-pentadecenyl phenyl ether (GPPE), a renewable derivative from cardanol, with maleic anhydride (MAH) by grafting copolymerization. The resulting M-GPPE was used as a functionalized plasticizer for a styrene–butadiene rubber (SBR)/carbon black (CB)/silica composite. The effects of M-GPPE on the development of the filler network, the extent of silica dispersion, the curing characteristics, and the mechanical performance of the composites were studied. Meanwhile, a comparative study was performed between M-GPPE and aromatic oil, a traditional plasticizer used in SBR filler formulations. Gel permeation chromatography and IR and 1 H-NMR analysis results confirmed the occurrence of the grafting reaction between GPPE and MAH and the potential structure of M-GPPE. The thermostability of GPPE was improved by grafting copolymerization with MAH, as shown by thermogravimetric analysis results. The presence of M-GPPE resulted in a shorter curing time and better aging properties in the SBR composite compared with GPPE. The mechanical properties, dynamic mechanical analysis, and transmission electron microscopy analysis showed that the maleate of GPPE could enhance the compatibility between SBR and silica, improve the dispersion of silica in SBR, and partially replace the aromatic oil in the SBR/CB/silica composite formulation. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40462.
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高影响因子
Journal of Energy Storage
·
2024
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IF 8.9
Xueting Yang,Haoyu Deng,Jie Xu,Dezhan Ye,Xiancai Jiang,Yazhou Chen,Ke Sun,Zengjin Liu
1,3-dioxolane (DOL) shows low interfacial impedance and high Coulombic efficiency, thus its polymer electrolytes have attracted extensive attention. In order to initiate DOL polymerization, catalyst amount of LiPF 6 is usually used rather than as the main lithium salt . Totally replacement of LiTFSI with low cost of LiPF 6 could bring the heat explosion and high viscosity when mixing DOL with 0.9 M LiPF 6 electrolyte (carbonate ester solvent). Here, based on the Lewis acid-base interaction, a new type of Lewis base, pyridine, is added to control the explosive polymerization of 1,3-dioxolane in LiPF 6 electrolyte. Through tuning the pyridine content, the gelling process and electrochemical properties could be controlled. It is demonstrated that the optimized monomer conversion and electrochemical window are up to 85.2 % and 4.6 V; meanwhile, the optimized conductivity and transfer number are 0.99 × 10 −3 S/cm (25 °C) and 0.68, respectively. The stable interface between PDOL and lithium metal anode could be proved by the stable over-potential (50mv, 700 h) at current density of 0.5 mA cm −2 . After 500 cycles at 2C, the assembled Li/PDOL@py 0.125 /LiFePO 4 battery delivers 115 mAh/g and 90 % capacity retention, with high average Coulombic efficiency of 99.83 %. The present results demonstrate the heat suppression role of pyridine toward mixing DOL with 0.9 M LiPF 6 electrolyte, which solves the heat and viscosity problems for PDOL based gelling polymer electrolytes .
研究领域:
电化学
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高分子化学
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能源材料
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锂离子电池
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界面化学
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功能材料
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 16
·118714
·
IF 6.3
Yuan Liu,Jin Wang,Qing Tao,Xi Zhang,Junxia Wang
In this work, Sr 0.5 Zr 2 (PO 4 ) 3 –high-entropy ( Ln 1/ n )PO 4 monazite dual-phase ceramics with n = 5, 6, and 7 were prepared by microwave-assisted sintering for high-level waste immobilization, where Ln 1/5 = (La, Nd, Sm, Eu, Gd) 1/5 , Ln 1/6 = (La, Nd, Sm, Eu, Gd, Dy) 1/6 , and Ln 1/7 = (La, Nd, Sm, Eu, Gd, Dy, Ho) 1/7 . After 28 days of leaching at pH 4.0, 6.2, and 10.0, the LR Sr and LR Ln-average values for the n = 5 samples were 10 −4 –10 −3 and ∼10 −6 g·m −2 ·d −1 , respectively. Both phases exhibited optimal chemical durability at pH 6.2, and Sr and Ln release mechanisms were pH-dependent. After 28 days of leaching in deionized water, the LR Sr and LR Ln-average values for the n = 5, 6, and 7 samples were 10 −4 –10 −3 and 10 −7 –10 −6 g·m −2 ·d −1 , respectively. Increasing configurational entropy in the high-entropy ( Ln 1/ n )PO 4 monazite phase indirectly reduced Sr release through phase-coupled effects, whereas average Ln release remained nearly unchanged.
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高影响因子
Biomaterials Research
·
2026
·
IF 9.8
Yiqiong Yang,Rui Zuo,Yi Wang,Rumeng Liu,Yi Zhou,Jun Wang
Sepsis-induced acute kidney injury (AKI) is characterized by mitochondrial dysfunction and dysregulated inflammation, with a lack of effective therapies. Studies have found that down-regulation of Sirtuin 3 (Sirt3) expression in renal tubular epithelial cells is associated with mitochondrial imbalance, suggesting its potential as a therapeutic target. Based on this, the research team developed a targeted nanodelivery system: black phosphorus nanosheets loaded with a cortistatin agonist were encapsulated with macrophage membranes modified with (KKEEE)₃K peptides to specifically deliver Sirt3-activating components to the kidneys. This nanosystem demonstrated favorable stability and biocompatibility. Ex vivo experiments confirmed its ability to alleviate lipopolysaccharide-induced oxidative stress, apoptosis, and inflammation in HK-2 cells, while restoring mitochondrial function. Mechanistically, the nanomaterial regulates mitochondrial homeostasis by activating the Sirt3–YME1L1 deacetylation axis. This study provides a novel nano-therapeutic strategy for sepsis-induced AKI, combining targeting capability with metabolism regulation, and holds broad implications for the treatment of inflammatory organ damage.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Zengchen Liu,Wenping Zhu,Ruilan Liu,Hongyu Chen,Yahong Chen,Yaling Zhao,Yanxia Li,Baodui Wang
Copper is one transition metal element, which plays important roles in nature and living organisms. Especially, when copper in the industrial process is released into biological chain, it can pose heavy metal pollution and seriously endangers human health. Recently, membrane materials for adsorbing Cu 2+ have received sufficient attention and made encouraging progress. However, due to the interference from some coexisting ions like Pb 2+ , Cd 2+ , Co 2+ , et al., how to achieve selective and efficient Cu 2+ adsorption holds certain research value. Herein, we synthesize a novel organic molecule based on quinolince-2-one-3-carbaldehyde dihydrorhodizidine (QDO), which contains active hydrogen atoms and heteroatoms. According to self-assembly interaction with important biological carrier chitosan, an adsorption membrane containing a large number of nano particles is constructed. By taking advantage of the rapid Cu 2+ binding property of organic molecules, the membrane can efficiently and quickly adsorb Cu 2+ in water solution. At pH = 6.5, the adsorption reaches equilibrium state within 150 min, and according to following the thermodynamics and kinetics model, maximum adsorption capacities of 214.4763 mg/g for Cu 2+ are confirmed. We conclude the adsorption process is primarily governed by homogeneous chemisorption. The absorption membrane provides potentially promising prospects for highly selective and effective Cu 2+ treatment.
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PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2026
·
IF 5.2
Rawiyah Alkahtani,Ahmad Iqbal,M.S. Al-Buriahi,Muhammad Ali Hamza Shahbaz,Amir Muhammad Afzal,Nora Mobark Farhan,Sohail Mumtaz,Abhinav Kumar
A MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO was successfully synthesized through hydrothermal and modified Hummers' methods. • The integration of porous MIL-53(Al) and conductive rGO enhanced charge transport and electroactive site accessibility. • The MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO electrode delivered a high specific capacity of 1189.23C g −1 . • The hybrid SC achieved an energy density of 45 Wh kg −1 and a power density of 2773 W kg −1 . • The ternary electrode showed a low overpotential of 46 mV and a Tafel slope of 49 mV dec −1 . The rising requirement of sustainable and multifunctional electrodes for energy storage and production has stimulated significant interest in advanced electrode architectures. In this study, a MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO composite was fabricated by means of combined hydrothermal and modified Hummers approach. The composite was rationally designed by integrating the MIL-53(Al), the favorable ionic transport characteristics of NASICON-type KTi 2 (PO 4 ) 3 , and the highly conductive network of rGO, there by promoting efficient charge and ion transport. Electrochemical evaluation in a three-electrode cell demonstrated a high specific capacity of 1189.23C g −1 . When assembled into a two-electrode supercapacitor device, the material delivered an energy density of 45 Wh kg −1 at a power density of 2773 W kg −1 . The device also maintained 92% of its initial capacity with a Coulombic efficiency of 97% after 10,000 consecutive charge–discharge cycles, indicating strong electrochemical durability. In addition to its energy storage performance, the MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO electrode demonstrated promising catalytic activity for the hydrogen evolution reaction, requiring only 46 mV overpotential to achieve the targeted current density and exhibiting a Tafel slope of 49 mV dec −1 . These results highlight the synergistic contribution of the MOF, NASICON phosphate, and rGO components and establish MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO as a promising multifunctional platform for advanced supercapacitor systems and electrocatalytic hydrogen production.
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高影响因子
LANGMUIR
·
2026
·
IF 4.4
Ziyi Wan,Chunxi Hai,Yanxia Sun,Shengde Dong,Luxiang Ma,Qi Xu,Xin He,Yuan Zhou
Na3V2(PO4)3 has garnered significant attention as a promising cathode material for sodium-ion batteries due to its excellent ionic conductivity and robust structural stability. However, its further large-scale practical application has been hindered by its low electrical conductivity and poor interface kinetics. Therefore, it is reported in this study that the discharging/charging cycling and rate performance of Na3V2(PO4)3 cathodes are dramatically improved by the uniformly formed 3D carbon networks. Evidently, the Na3V2(PO4)3 cathode material prepared under the optimized conditions exhibited a relatively high initial capacity of 109.30 mAh/g at 0.1C with an initial Coulombic efficiency (ICE) of 99% and achieved an appreciable capacity of 99.42 mAh/g with a capacity retention of 96.39% after 400 cycles at 2C. Based on different characterizations and electrochemical performances, both the formation and sodium storage mechanism of Na3V2(PO4)3-based composite cathodes were initially concluded, which is significant and important for improving electrical conductivity and designing practical carbon-cladding strategies for Na-ion batteries.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jiahong Xie,Shiyu Liu,Yang Xu,Boyu Song,Jingli Liu,Guangyi Du,Lianghua Xie,Wei Chen
Alcoholic liver disease (ALD) is one of the most prevalent liver diseases worldwide. There are currently no FDA approved pharmacological therapies specifically designed to prevent or treat ALD. Targeted nutritional interventions offer a promising avenue for ALD management. Cyanidin-3-O-glucoside (C3G), a natural anthocyanin, has shown potential in mitigating alcoholic liver injury, but its therapeutic utility is limited by poor stability and inadequate liver targeting. Here, we report a galactosylated chitosan-modified nanoplatform for the encapsulation and hepatic targeted delivery of C3G. The fabricated nanonutriosomes (C3G@GC-NS) exhibited favorable physicochemical stability, biosafety, and enhanced C3G accumulation in the liver. In a mice model of alcoholic liver injury induced by 15-day ethanol feeding, oral administration of C3G@GC-NS at a dose of 150 mg /kg (C3G equivalent) daily significantly alleviated liver injury. C3G@GC-NS outperformed free C3G in ameliorating steatosis, inflammation, and metabolic dysfunction. Mechanistically, the nanotherapeutic activates the AMPK signaling pathway, regulates PPARα-driven lipid and ethanol metabolism, and restores alcohol-induced gut microbiota dysbiosis. This study presents a rationally designed nanoplatform that enhances the therapeutic efficacy of C3G through coordinated modulation of hepatic metabolism and the gut-liver axis, offering a novel strategy for the treatment of ALD.
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高影响因子
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