TALANTA
·
2019
·
IF 4.916
Yuanjie Teng,Zeyu Ren,Yuchao Zhang,Zhenni Wang,Zaifa Pan,Kang Shao,Yuanbin She
As the concentration of Zn 2+ in patients with prostate cancer is much less than that in healthy persons, Zn 2+ concentration can be used as a marker to expediently screen prostate cancer. In this study, a sensitive and highly selective surface-enhanced Raman scattering (SERS) method to detect Zn 2+ concentration in human prostatic fluids by utilizing water-insoluble 2-carboxyl-2′-hydroxyl-5′-sulfoformazylbenze (Zincon) as a SERS probe based on self-assembled Au nanoarrays at a liquid–liquid interface between n-hexane and Au colloids was proposed. Zincon showed remarkably different SERS bands before and after coordinating Zn 2+ in the controlled conditions (70 μL of ethanol, 500 μL of n-hexane, pH value of 7.1 and 10 s of vortex mixing time), which can be used in quantifying Zn 2+ with characteristic peaks. The proposed SERS method presented a good linear relationship ranging from 0.5 to 10 μmol/L and a satisfactory detection limit of 0.1 μmol/L as well as low interference with other metal ions . Moreover, the detection results are close to those of the conventional standard atomic absorption spectroscopy (AAS) method.
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Analytical Methods
·
2019
·Vol. 12
·期 1
·104-111
·
IF 2.378
Jianmin Wang,Wei Yang,Qiling Peng,Daobin Han,Liangsheng Kong,Lu Fan,Min Zhao,Shijia Ding
Rapid and simple detection of carbapenem-resistant Enterobacteriaceae (CRE) is important to manage infection and prevent the spread of these bacteria. In this work, we utilize pH response to detect CRE in urine rapidly. By using vancomycin-modified Fe3O4@Au nanoparticles (Fe3O4@Au@VanNPs), CRE in urine were enriched and separated efficiently via vancomycin–cell wall interaction. More importantly, carbapenemases released via CRE lysis were detected using a pH metre which responded to hydrogen ions generated from imipenem hydrolysis. Thus, the concentration of CRE in urine was detected via the carbapenemase hydrolysis reaction. The proposed method demonstrated a good linear relationship in the range of 104–108 cfu mL−1 for CRE with the limit of detection estimated to be 1.0 × 103 cfu mL−1. More importantly, this method successfully detected clinically isolated CRE strains in urine samples within 3.5 h. Thus, this biosensing strategy might have the potential for practical application in the rapid detection of various resistant bacteria.
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FOOD AND AGRICULTURAL IMMUNOLOGY
·
2019
·
IF 2.398
Fan He,Tingting Zou,Jinyi Yang,Hong Wang,Lihua Deng,Yuanxin Tian,Zhenlin Xu,Yuanming Sun,Hongtao Lei,Xuecai Tan,Yudong Shen
In this work, a rapid, convenient and sensitive Au nanoparticle-based immunochromatographic sensor (AuNPs-ICS) for simultaneous detection of various tadalafil adulterants in health food was established for the first time, based on one high affinity and broad-spectrum antibody through skeleton-specific hapten design according to the common structure of tadalafil drugs. This immunochromatographic sensor was developed by the polyclonal antibody conjugated with AuNPs and the IC50 was 10.04 ng mL−1 for tadalafil and 9.55, 11.46, 17.01 ng mL−1 for amino tadalafil, acetamino tadalafil and nortadalafil, respectively. The limit of detection results could be obtained visually by naked eyes for and computationally by the hand-held immunochromatography reader. The sensor could specially detect Tadalafil and its analogs within 10 min in health food samples, and the close correlation with UPLC-MS/MS method showed the sensor was accurate and reliable, which could apply to on site detection Tadalafil and its analogs rapidly and accurately.
研究领域:
分析化学
·
药物检测
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Sheng Wan,Rong Xie,Jianhong Fan,Kewen Tang
Gold (Au) and palladium (Pd) play an increasing role in the production and human life, therefore, it is of great significance to study their recovery. A 5,11,17,23-tetra-ethylthio-25,26,27,28-tetra-hydroxyl thiacalix[4]arene (TCAET) was synthesized specifically for the capture of Au(Ⅲ) and Pd(Ⅱ) from HCl medium by liquid–liquid extraction. In a 0.1 mol·L –1 HCl medium, the transfer of Au(Ⅲ) and Pd(Ⅱ) from the aqueous phase to the organic phase was highly efficient, with a transfer ratio of 100% for Au(Ⅲ) and 98% for Pd(Ⅱ). Furthermore, the extraction equilibrium time for Au(Ⅲ) was just 5 min. Job's method data demonstrated that TCAET formed complexes with Au(III) and Pd(II) in a ratio of 2:3 and 1:1, respectively, during the extraction process. TCAET showed high selectivity toward Pd(II) and Au(III) over other competing metal ions. Moreover, both Au(Ⅲ) and Pd(II) could be successfully stripped from the loaded organic phases with a 1.0 mol·L –1 thiourea in 0.5 mol·L –1 HCl and 0.5 mol·L –1 thiourea in 0.5 mol·L –1 HCl, respectively. Results obtained from five consecutive extraction-stripping cycles showed good reusability of TCAET toward Au(Ⅲ) and Pd(Ⅱ) recovery. The conclusion can provide a certain reference for thiacalixarene in the recovery of precious metal species.
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Chemical Science
·
2023
·Vol. 14
·期 46
·13518-13529
·
IF 8.4
Jie Liu,Yu Xie,Yiqiao Wang,Kai Yang,Shuping Su,Yun Ling,Pinghua Chen
The challenge of synergistically optimizing different mechanisms limits the further improvement of plasmon-mediated photocatalytic activities. In this work, an Au/Bi24O31Br10 composite, combining an interface ohmic contact and localized surface plasmon resonance (LSPR), is prepared by a thermal reduction method. The LSPR effect induces the local resonance energy transfer effect and the local electric field enhancement effect, while the interface ohmic contact forms a stronger interface electric field. The novel synergistic interaction between the interface ohmic contact and LSPR drives effective charge separation and provides more active sites for the adsorption and activation of CO2 with improved photocatalytic efficiency. The optimized 0.6 wt% Au (5.7 nm) over Bi24O31Br10 nanosheets showed an apparently improved photocatalytic activity without any sacrificial reagents, specifically CO and O2 yields of 44.92 and 17.83 μmol g−1 h−1, and demonstrated superior stability (only lost 6%) after continuous reaction for 48 h, nearly 5-fold enhanced compared to Bi24O31Br10 and a great advantage compared with other bismuth-based photocatalysts.
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LANGMUIR
·
2023
·
IF 3.9
Haoran Li,Daqing Chen,Wen Zhou,Donghao Cheng,Danhua Ge,Xiaojun Chen
Monitoring l-cysteine (l-Cys) is of importance for human health and food safety. Herein, we designed a novel strategy for bimetallic Au and Ag/AgCl anchoring on Ni-doped ZIF-67 to form core–shell nanocubes (Ni-ZIF-67/AuAg/AgCl) using the galvanic replacement processes. The unique properties of ZIF-67 nanocubes were conducive to generating strong synergistic catalytic effects with Au and Ag/AgCl, particularly when Ni-ZIF-67/AuAg/AgCl composites were employed as oxidase mimics for catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB). The Ni-ZIF-67/AuAg/AgCl composites displayed strong affinity toward TMB, displaying a lower Michaelis constant Km value of 0.25 mM and a higher maximum initial rate Vmax of 9 × 10–8 M s–1. By virtue of the nanozyme, the colorimetric sensor was constructed for l-Cys detection with a relatively low detection limit of 0.051 μM. The superior catalytic performance of the as-prepared Ni-ZIF-67/AuAg/AgCl composites can be ascribed to the core–shell structure, large specific surface area, and strong synergistic catalytic effects, which are beneficial for exposing more active sites and enhancing the conductivity to further boost their catalytic activity.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 10
·1-11
·
IF 5.7
Tian Jiangman,Zhu Qihao,Huang Xiaojing,Li Yuan
A novel sandwich-type “on-off” electrochemiluminescence (ECL) biosensor for the determination of α(2,3)-sial-Gs was designed. Specifically, amino-functionalized porous silica nanoparticles (HPSNs-NH 2 ) were first prepared and then decorated with gold nanoparticles (Au NPs) to form HPSNs-NH 2 @Au NP nanocomposite, which exhibited a strong ability to enhance ECL intensity with K 2 S 2 O 8 as co-reactant (signal-on) and could immobilize the target-specific binding molecules of maackia amurensis lectin (MAL). Additionally, AuPdPt trimetallic nanoparticles were prepared to serve as a quenched ECL signal indicator (signal-off) with the ability of capturing the target non-specific binding molecules of 3-aminophenylboronic acid (APBA) to form a signal label. The sandwich-type ECL biosensor was constructed based on the structure of MAL-α(2,3)-sial-Gs-APBA and achieved a determination toward α(2,3)-sial-Gs with a wide linear range from 1 fg mL −1 to 10 ng mL −1 and a low detection limit of 0.5 fg mL −1 . Furthermore, the proposed ECL biosensor showed satisfactory selectivity, stability, and reproducibility for α(2,3)-sial-Gs determination. Graphical Abstract
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MATERIALS RESEARCH BULLETIN
·
2023
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IF 5.4
Miaomiao Li,Tong Wu,Yiting Wang,Wei Zhang,Ruinian Hua
Biothiols are biologically important targets because their transport and metabolism are closely related to the activities of many proteins and biological enzymes. In this paper, a kind of biological probe based on the fluorescence resonance energy transfer between lanthanide oxysulfide and gold nanoparticles was developed for the detection of cysteine. Ln 2 O 2 S:Tb 3+ and Ln 2 O 2 S:Eu 3+ nanoparticles were prepared by a thermolysis method. The as-prepared fluorescent nanoparticles were modified by polyethylenimine ligand exchange to increase their hydrophilicity. Then, Au nanoparticles were added to form fluorescence resonance energy transfer systems in which Au NPs and La 2 O 2 S:Ln 3+ act as the acceptor and donor, respectively. Among the Ln 2 O 2 S:Tb 3+ and Ln 2 O 2 S:Eu 3+ systems, the cysteine content and fluorescence intensity showed good proportional proportionality, with detection limits of 6.75 nM and 14.09 nM in the range of 50∼1500 nM, respectively. The results of anti-interference experiments showed that this biological probe is highly selective for cysteine detection.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·
IF 3.1
Xiang Shuang,Guo Yong,Liu Xiaohui,Wang Yanqin
The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis reactions. Herein, we create the Au-CoO-O V interface in the 1.0%Au/Co 3 O 4 -Rod-250 catalyst, which could dissociate H 2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF). The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-O V surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen (signals of Au—D and O—D vibration) compared with bare CoO (Co 3 O 4 -Rod-250). This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Honghong Feng,Yangjing Zhao,Yeping Li,Xueyong Qi,Song Shen,Shengwang Zhou
Nanotechnology provides the platform to develop functional nanocomposites with outstanding features, such as persistent luminescence (PL), photothermal conversion, magnetic resonance (MR), and so on, that has been incorporated in nanomedicine for diagnosis and therapy. Herein, the nanocomposites of ZnGa2O4:Cr3+ embedded in mesoporous silica coating surrounding gold nanorods (cGNR@MSNs) were developed for the codelivery of chemotherapeutic drugs and anti-CD40 antibodies. The nanocomposites were functionalized with tetrazaheterocycle linking divinylpyrimidine derivatives (DOTVs), which covalently capture anti-CD40 by disulfide re-bridging on the surface of cGNR@MSNs. The anti-CD40-mediated dual drug delivery system simultaneously realized the combination of chemo-, immuno-, and photothermal therapies, enhancing the synergistic effect of combination therapy for multiple tumor cells. Moreover, the nanodrug delivery system achieved multimodality imaging with fluorescence, PL, and MR modes for precise diagnosis. This study provides fascinating insights into the development of nanocomposite-based multimodality imaging strategies and imaging-guided combination therapies.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Zhipeng Zhao,Qian Zhao,Le Zhou,Yi Wei,Biao Lei,Hongwen Zhang,Weiping Cai
Styrene , a prevalent volatile organic compounds (VOCs), is very harmful to atmosphere and humans. Consequently, the development of efficient detection technologies for styrene is of high importance, which is still in challenge! In this work, we crafted a layered double hydroxide (LDH) porous film-coated gold nanoarray, designed to act as a surface enhanced Raman spectroscopy (SERS) chip for the efficient and portable detection of gaseous styrene. This chip features a covering layer composed of cross-linked LDH nanosheets , notable for their porous structure and high specific surface area. When the covering layer is 100–300 nm in thickness, this composite chip has significant enrichment effect and strong SERS performance to gaseous styrene with a lowest detectable concentration below 1 ppb (4.64 ×10 -3 mg/m 3 ), and can response within 10 s, showing the rapid response and high sensitivity. Additionally, the chip has strong anti-interference capabilities and maintains excellent response to styrene, even in mixed benzene-VOCs gases. The exceptional SERS performances of this chip is ascribed to its LDH covering layer-induced styrene-enrichment and structurally-enhanced SERS performances. This study provides a simple route and practical chip for the rapid and ultrasensitive SERS-based detection of gaseous styrene, which is also potentially beneficial for the detection of other gaseous VOCs.
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MOLECULES
·
2023
·Vol. 28
·期 14
·5355
·
IF 4.6
Keyan Chen,Shiqi Fu,Chenyu Jin,Fan Guo,Yu He,Qi Ren,Xuesheng Wang
Smartphone-assisted fluorescence and colorimetric methods for the on-site detection of Hg2+and Cl−were established based on the oxidase-like activity of the Au–Hg alloy on the surface of Au/Cu/Ti3C2NSs. The Au nanoparticles (NPs) were constructed via in-situ growth on the surface of Cu/Ti3C2NSs and characterized by different characterization techniques. After the addition of Hg2+, the formation of Hg–Au alloys could promote the oxidization of o-phenylenediamine (OPD) to generate a new fluorescence emission peak of 2,3-diaminopenazine (ADP) at 570 nm. Therefore, a turn-on fluorescence method for the detection of Hg2+was established. As the addition of Cl−can influence the fluorescence of ADP, the fluorescence intensity was constantly quenched to achieve the continuous quantitative detection of Cl−. Therefore, a turn-off fluorescence method for the detection of Cl−was established. This method had good linear ranges for the detection of Hg2+and Cl−in 8.0–200.0 nM and 5.0–350.0 µM, with a detection limit of 0.8 nM and 27 nM, respectively. Depending on the color change with the detection of Hg2+and Cl−, a convenient on-site colorimetric method for an analysis of Hg2+and Cl−was achieved by using digital images combined with smartphones (color recognizers). The digital picture sensor could analyze RGB values in concentrations of Hg2+or Cl−via a smartphone app. In summary, the proposed Au/Cu/Ti3C2NSs-based method provided a novel and more comprehensive application for environmental monitoring.Keywords:Au/Cu/Ti3C2NS;Au–Hg alloy;oxidase-like activity;smartphone;colorimetric detection
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