ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xiang Cai,Tao Yuan,Xiangfu Liu,Guoli Tu
Solid alcohol 1-pyrenemethanol (PyM) was first introduced to modify the zinc oxide (ZnO) layer which is used in the inverted polymer solar cells (PSCs) as a cathode buffer layer (CBL). As a low-cost industrial product, the PyM can modify the surface defects and improve the electron mobility of ZnO CBL, which can be attributed to the self-assembly of PyM on the ZnO surface due to the hydrogen bonds and the conjugated structure in PyM. With a blend of PTB7:PC71BM as active layer, the device with ZnO/PyM CBL exhibited a notable power conversion efficiency (PCE) of 8.26%, which is better than that of control devices based on bare ZnO CBL (7.26%). With the addition of PyM, the device based on PTB7-Th:PC71BM showed a higher PCE of 9.10%, an obvious improvement from the 7.79% of control devices. There was no obvious change in device performance with the increase of PyM solution concentration, indicating that the device fabrications are thickness-insensitive. These results could be particularly useful in solution processing of buffer layer materials to high-efficiency organic solar cells.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2025
·
IF 4.7
Guosong Xin,Yanxiu Hou,Yuhan Liu,Hairu Li
Purpose This study examined the effects and underlying mechanisms of tetrandrine (TET) combined with adriamycin (ADR) in reversing multidrug resistance (MDR) in breast cancer cells. Methods Cell viability, proliferation, and drug resistance were assessed via the MTT assay. Small interfering RNA (siRNA) transfection was used to knock down GSDMD expression in MCF-7/ADR cells. Pyroptosis induction by the combined TET and ADR treatment was evaluated through morphological observations, cytotoxicity assays, and flow cytometry. The expression levels of mRNA and proteins were analyzed using qRT-PCR and western blotting, respectively. Results At non-cytotoxic concentrations, the combined treatment of TET and ADR significantly inhibited the growth of MCF-7/ADR cells, demonstrating a synergistic effect in reversing MDR. This combination effectively reduced MDR protein expression in MCF-7/ADR cells via GSDMD modulation, which diminished efflux activity and promoted ADR accumulation. The increased accumulation of ADR subsequently activated the NLRP3/Caspase-1/GSDMD signaling pathway, leading to elevated LDH release and enhanced pyroptosis rates. Conclusion The combined use of TET and ADR not only suppresses MCF-7/ADR cell growth but also reverses MDR by targeting the NLRP3/Caspase-1/GSDMD pyroptosis pathway. These findings propose a promising therapeutic strategy for combatting MDR in breast cancer and highlight the potential for further clinical application of this combination therapy.
研究领域:
肿瘤学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 17
·4810-4820
·
IF 6.183
Yuanyuan Zheng,Weihao Yuan,Huiling Liu,Shaoshan Huang,Liming Bian,Rui Guo
Prolonged inflammatory response and insufficient vascularization cause delayed and poor wound healing. In this study, we fabricated a supramolecular host–guest gelatin (HGM) hydrogel loaded with resveratrol (Res) and histatin-1 (His-1) to suppress inflammation and promote vascularization at skin burn wound sites. The HGM hydrogel showed good properties of shear-thinning and injectability, thereby allowing easy in situ injection and fast adaption to irregular wounds. Res and His-1 were demonstrated to enhance angiogenesis in vitro using cell migration and tube formation assays based on human umbilical vein endothelial cells (HUVECs). In an established rat burn wound model, HGM/Res/His-1 hydrogel treatment promoted wound healing by inhibiting expression of the pro-inflammatory factors of interleukin 6 (IL-6), interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) and increasing the expression of transforming growth factor β1 (TGF-β1) and platelet endothelial cell adhesion molecule-1 (CD31). HGM/Res/His-1 hydrogel treatment showed comparable efficacy with that of the commercial dressing, Tegaderm™, and therefore shows promising potential for clinical translation.
研究领域:
药剂学
·
伤口愈合
·
生物材料
·
炎症
·
血管生成
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2020
·
IF 8.247
Ning An,Zhuhang Shao,Zhen Guo,Jiao Xin,Yuanyuan He,Liwen Lv,Kefeng Xie,Xiuyan Dong,Yang Zhang,Zhongai Hu
In this work, we select a novel multi-redox poly (1, 5-diaminoanthraquinone) (PDAAQ) as electroactive material and Cetyltrimethylammonium bromide (CTAB) modified graphene oxide (CGO) as conductive substrate. Benefit from the excellent dispersion of CGO in organic polymerization medium and the abundant functional groups on the surface of CGO, 1, 5-diaminoanthraquinone (DAAQ) monomers may covalently graft on the conducting substrates and realize the directional growth of PDAAQ via the in-situ chemical oxidative polymerization. In three-electrode system, the optimization of PDAAQ/CGO electrode exhibits a high specific capacitance of 760 F g −1 at 1 A g −1 and superior electrochemical stability of 90.4% after 10 000 cycles. Most importantly, the electrochemical kinetic behavior of PDAAQ/CGO electrode is studied in detail. The result indicates that the energy storage process of PDAAQ/CGO is a synergistic result of diffusion-controlled process and capacitive effects, and the latter one is dominant. According to the simulation calculation of kinetic model , the capacitive contribution ratio of PDAAQ/CGO can be as high as 80.6% at a scan rate of 50 mV s −1 . Finally, the as-fabricated asymmetric supercapacitor (ASC) can deliver an energy density up to 41.1 W h kg −1 at a power density of 1000 W kg −1 , indicating a great potential application in high performance supercapacitors .
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Hong Qian Dai,Yuan Lu,Zhi Hin Ou,Min Xu
Fe3O4-APTES-CS2 was prepared by modification of Fe3O4 with 3-aminopropyltriethoxysilane (APTES) and carbon disulfide (CS2). Lipase was covalently bonded to Fe3O4-APTES-CS2 to obtain the immobilized lipase Fe3O4-APTES-CS2-lipase. The textural characteristic of Fe3O4-APTES-CS2-lipase was assessed by scanning electron microscopy. The optimal immobilization conditions were 2.5 mg/mL lipase, pH 7.0, 35 °C, 3 h. The loading amount of lipase was 119.0 mg/g carrier. The immobilization efficiency reached 57%. (R)-(+)-N-acetyl-1-methyl-3-amphetamine was synthesized by Fe3O4-APTES-CS2-Li- pase. The conversion, enantiomeric excess of (R)-(+)-N-acetyl-1-methyl-3-amphet-a- mine and E value reached 36.8%, 98.5% and 132, respectivel.
研究领域:
化学
·
生物化学
·
材料科学
·
催化
✓ 已验证
DOI
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Qianwen Cao,Luyao Liu,Xiaoge Ma,Chaomin Zhong,Mengqi Tang,Mengge Liu,Ling-Bo Qu,Bo Wei,Xia Xu
1, 8-Cineole (Cin), a cyclic monoterpenoid derived from tea trees and eucalyptus species, exhibits diverse pharmacological properties. Yet, its therapeutic impact and underlying mechanism against Staphylococcus aureus (S. aureus) pneumonia remain to be elucidated. In this study, metabolomics based on UPLC-MS/MS was integrated with network pharmacology, molecular biology, and molecular docking to investigate the effects of Cin. The findings demonstrated that Cin markedly reduced mortality and lung bacterial load, lessened pulmonary damage while suppressing the levels of proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF) of infected mice. Additionally, 19 metabolites, primarily involved in tryptophan metabolism and arginine biosynthesis, were notably modified by Cin via suppressing the enzymatic activity of indoleamine 2, 3-dioxygenase 1 (IDO1) and inducible nitric oxide synthase (iNOS), thereby attenuating the inflammatory response. Notably, knockdown of IDO1 or iNOS significantly diminished the anti-inflammation effect of Cin. In conclusion, our study validates the therapeutic potential of Cin against S. aureus pneumonia via anti-inflammation by downregulating IDO1 and iNOS. Our results provide a theoretical basis of natural substances applied in bacterial pneumonia treatment.
研究领域:
药理学
·
微生物学
·
免疫学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Microbiology
·
2025
·
IF 4.5
Jie Lu,Weifan He,Yuxing Liu,Shiqi Li,Xi Huang,Hongxing Wang,Xianmei Cao
Background: Areca palm velarivirus 1 (APV1), the causal agent of betel palm yellow leaf disease (YLD), has caused significant yield losses and decreased product quality of betel nuts, posing a serious economic threat to local farmers. There is an urgent need for a convenient and reliable method for the rapid detection and surveillance of APV1.Methods: The Capsid protein (CP) of APV1 was expressed in Escherichia coli and purified as antigen to immunize BALB/c mice. Two specific monoclonal antibodies (MAbs), APV1CP-1 and APV1CP-10, were generated through the hybridoma technique. APV1CP-1 was conjugated with colloidal gold served as detection reagent, while APV1CP-10 was coated onto a porous nitrocellulose membrane to act as the detection line. Goat anti-mouse IgG was used as the control line. These components were then assembled into a colloidal gold immunochromatographic strip (CGICS) for effective detection of APV1.Results: The MAbs APV1CP-1 and APV1CP-10 were successfully obtained with titers exceeding 1:102,400. Colloidal gold particles used in the assay had an approximate diameter of 30–40 nm, and exhibited a surface plasmon resonance peak around 530 nm. The CGICS allowed for the detection of APV1 by applying infected sap to the test strip, with results visible within 5–10 min. The test showed no cross-reactivity with other viruses tested, and the visual detection limit for APV1 was established at a 100-fold dilutions of APV1-infected leaf samples.Conclusion: The monoclonal antibody-based colloidal gold immunochromatographic strip developed in this study demonstrates significant convenience, rapidity, and reliability for APV1 detection. These advancements are anticipated to facilitate rapid diagnosis and surveillance of APV1 in field settings.
研究领域:
植物病理学
·
分子生物学
·
病毒学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2023
·Vol. 238
·期 6
·1069-1070
·
IF 0.3
Yan-Qing Wang,Wen-Qing Yan,Li-Xue Nie,Ping-Ping Luan,Chao-Qun Li
C 20 H 22 Cu 3 N 8 O 10 , monoclinic, C 2/ c (no. 15), a = 12.0766(11) Å, b = 16.2778(14) Å, c = 14.7605(13) Å, β = 97.8580(10) ∘ , V = 2874.4(4) Å 3 , Z = 4, R
gt ( F ) = 0.0420, wR
ref ( F
2 ) = 0.0988, T = 298.15 K.
研究领域:
无机化学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2022
·Vol. 52
·期 1
·91-104
·
IF 2
Yu Yingmin,Yi Lingxiao,Wei Jiajun,Guo Hongyue,Li Min
The liquid–liquid equilibrium (LLE) data for ethylene glycol + 2-ethyl-1-hexanol + { n -hexane, 1-hexene, 2-propyl-1-heptanol, and isopropyl ether} were measured at 298.2 K under 101.3 kPa. The distribution constant ( D ) and selectivity ( S ) of 2-ethyl-1-hexanol in the systems were calculated to analyze the extraction ability of the four extractants. The Bachman and Othmer–Tobias equations were chosen to examine the experimental LLE data. The linear correlation coefficient R 2 is greater than 0.98, indicating that the linear fitting of the experimental data is good. The data were regressed by thermodynamic models NRTL and UNIQUAC. The deviation between experimental data and simulated data was calculated by the root mean square deviation (RMSD) and the absolute average deviation (AAD). The RMSD is less than 0.79% and the AAD is less than 0.46%. It indicates that the two models are suitable for the regression of the system.
研究领域:
化学工程
·
热力学
✓ 已验证
DOI
高影响因子
FARADAY DISCUSSIONS
·
2016
·Vol. 190
·219-230
·
IF 3.544
Yong-Qi Li,Huan Liu,Peng Wang,Da Yang,Xiao-Li Zhao,Ye Liu
A highly efficient and stable Rh–P catalytic system in the RTIL of [PEmim]BF4 was developed for the biphasic hydroformylation of 1-octene by using the diphosphine-functionalized ionic liquid (FIL) of 2. While 2-Rh(acac)(CO)2 was immobilized in [PEmim]BF4 (solvent), a typical biphasic catalysis was fulfilled with advantages of facile separation and recycling ability – 9 runs without any loss of activity. It was found that not only the acquired π-acceptor character of 2, but also the synergetic role of the piperidyl group in [PEmim]BF4 as an N-containing donor, cooperatively contributed to the efficient hydroformylation due to the facilitated formation and stability of the Rh-H active species (ν 2045 cm−1). This was supported by the in situ high-pressure FT-IR spectral analysis.
研究领域:
化学工程
·
催化科学
✓ 已验证
DOI
PubMed
高影响因子
Materials Research Express
·
2020
·Vol. 6
·期 12
·125376
·
IF 1.929
Sainan Wu,Pan Zhang,Zhilong Xu,Zhang Chen,Yanfeng Gao
A series of microencapsulated phase change materials (microPCMs) are synthesized by encapsulating 1-dodecanol into cellulose nanofibers (CNFs) modified melamine-formaldehyde (MF) resin through in situ polymerization. The chemical structure and crystallography of the microcapsules are characterized by Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD). Scanning electronic microscopy (SEM) images show that the obtained microcapsules are regularly spherical with smooth surface and an average diameter about 1∼3 μm. The cracking ratio test indicates that the addition of CNFs largely enhances the mechanical strength of the microcapsules, and the CNFs/MF-microPCMs (with 3.4 wt% CNFs) have a phase change enthalpy of 100.4 J g−1. Furthermore, the simulation result demonstrates that the indoor temperature modulation ability of CNFs/MF-microPCMs model house is 4.2 °C, which is more than that of model house without microPCMs under room temperature. These results indicate that CNFs/MF-microPCMs are potential candidates for thermoregulating applications.
研究领域:
材料科学
·
能源工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2024
·Vol. 136
·期 3
·1-11
·
IF 1.7
Zhao Zhicai
A series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by recyclable10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost calcium carbide, an easy-to-handle acetylene source, and recyclable Pb/C catalysts. Graphic abstract The synthesis of a series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by 10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost feedstock, an easy-to-handle acetylene source, and recyclable Pb/C catalysts.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）