Small
·
2021
·Vol. 17
·期 38
·2102149
·
IF 13.281
Huaping Peng,Luyao Xu,Yilun Sheng,Weiming Sun,Yu Yang,Haohua Deng,Wei Chen,Juewen Liu
Design of high-performance all-inorganic halide perovskites, especially lead-free perovskites, is key to the broadening of its application prospects. Herein, the authors report the synthesis of ligand-free cesium platinum (IV) bromide nanocrystals (Cs 2 PtBr 6 NCs), a new kind of vacancy-ordered lead-free perovskite nanomaterial, by a facile one-pot method. The Cs 2 PtBr 6 NCs exhibits a narrow band gap of 1.32 eV covering the entire visible range, which is supported by density functional theory calculations. Together with their high conductivity, matching energy levels with the work function of carbon electrodes, and excellent environmental stability, this NC displays a cathodic photocurrent density as high as 335 µA cm -2 , two orders of magnitude higher than other perovskites in aqueous solutions without the need of other electron acceptors. These combined properties suggest that the Cs 2 PtBr 6 NCs have great potentials in a wide range of photoelectronic and photoelectrochemical sensing applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Frontiers
·
2021
·Vol. 2
·期 2
·208-217
·
IF 0
Huiting Lin,Jiawen Zhang,Shiyang Li,Baodong Zheng,Jiamiao Hu
The current study was aimed to explore the beneficial effects of p olysaccharides isolated from Laminaria japonica (LP) on gestational diabetes mellitus (GDM) mice. The obtained results demonstrated that the LP improved serum biochemical index, body weight index, and glucose tolerance. Furthermore, the evidence also suggested that the beneficial effects of LP might be attributed to the alternation in gut microbiota by LP supplementation. Particularly, the Turicibacter , a short-chain fatty acids-producing bacterium, was found to be up-regulated. In conclusion, the obtained results indicated that the LP might serve as prebiotic, and might have a great potential to be used as food supplementation for GDM patients.
✓ 已验证
产品关联
DOI
ISME Journal
·
2021
·Vol. 15
·期 11
·3239-3257
·
IF 10.302
Zhang Jiao,Wang Fei,Yuan Bo,Yang Lei,Yang Yi,Fang Qi,Kuhn Jens H.,Song Qisheng,Ye Gongyin
We identified a 9332-nucleotide-long novel picornaviral genome sequence in the transcriptome of an agriculturally important parasitoid wasp ( Pachycrepoideus vindemmiae (Rondani, 1875)). The genome of the novel virus, Rondani’s wasp virus 1 (RoWV-1), contains two long open reading frames encoding a nonstructural and a structural protein, respectively, and is 3’-polyadenylated. Phylogenetic analyses firmly place RoWV-1 into the dicistrovirid genus Cripavirus . We detected RoWV-1 in various tissues and life stages of the parasitoid wasp, with the highest virus load measured in the larval digestive tract. We demonstrate that RoWV-1 is transmitted horizontally from infected to uninfected wasps but not vertically to wasp offspring. Comparison of several important biological parameters between the infected and uninfected wasps indicates that RoWV-1 does not have obvious detrimental effects on wasps. We further demonstrate that RoWV-1 also infects Drosophila melanogaster (Meigen, 1830), the hosts of the pupal ectoparasitoid wasps, and thereby increases its pupal developmental duration and fecundity, but decreases the eclosion rate. Together, these results suggest that RoWV-1 may have a potential benefit to the wasp by increasing not only the number of potential wasp hosts but also the developmental time of the hosts to ensure proper development of wasp offspring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jingdong Li,Arthur Listwan,Jianxing Liang,Feng Shi,Kan Li,Jinping Jia
In this work, defect-rich 1 T-MoS 2 nanosheets are successfully synthesized by solvothermal method with acetic acid as the templating agent. It is found that changing the concentration of acetic acid can regulate the proportion of 1 T phase and affect the activity of hydrogen evolution. Under the optimum concentration of acetic acid, the overpotential is as low as 136 mV at the current density of 10 mA cm −2 with a Tafel slope at only 45 mV dec −1 , which shows an attractive potential for the development of electrocatalytic hydrogen evolution. In addition, the addition of acetic acid prevents the agglomeration of 1 T-MoS 2 and thus increases the stability of electrode materials, which is conducive to the long-term hydrogen evolution reaction and cost control. Most importantly, according to comparing several small molecular carboxylic acids, the probable formation mechanism of 1 T-MoS 2 nanosheets is proposed.
✓ 已验证
产品关联
DOI
高影响因子
Food & Function
·
2021
·Vol. 12
·期 12
·5524-5538
·
IF 5.396
Bo Li,Xinglishang He,Hai-Ying Jin,Hui-Ying Wang,Fu-Chen Zhou,Ning-Yu Zhang,Dong-Ying Jie,Lin-Zi Li,Jie Su,Xiang Zheng,Rong Luo,Gui-Yuan Lv,Ning-Hua Jiang,Qiao-Xian Yu,Su-Hong Chen
Given the increasing global trend toward unhealthy lifestyles and dietary decisions, such as “over-consumption of alcohol, and high sugar and fat diets” (ACHSFDs), it is not surprising that metabolic hypertension (MH) is now the most common type of hypertension. There is an urgent, global need for effective measures for the prevention and treatment of MH. Improper diet leads to decreased short-chain fatty acid (SCFA) production in the gut, leading to decreased gastrointestinal function, metabolism, and blood pressure as a result of signaling through G-protein-coupled receptors (GPCRs), ultimately causing MH. Previous studies have suggested that Dendrobium officinale (DO) may improve gastrointestinal function, lower blood pressure, and regulate metabolic abnormalities, but it is not clear whether it acts on MH by increasing SCFA and, if so, how. In this research, it was observed that Dendrobium officinale ultrafine powder (DOFP) could lower blood pressure and improve lipid abnormalities in ACHSFD-induced MH model rats. Moreover, DOFP was found to improve the intestinal flora and increased the SCFA level in feces and serum, as well as increased the expressions of GPCR43/41 and eNOS and the nitric oxide (NO) level. An experiment on isolated aorta rings revealed that DOFP improved the vascular endothelial relaxation function in MH rats, and this effect could be blocked by the eNOS inhibitor L-NAME. These experimental results suggest that DOFP improved the intestinal flora and increased the production, transportation, and utilization of SCFA, activated the intestinal-vascular axis SCFA-GPCR43/41 pathway, improved vascular endothelial function, and finally lowered blood pressure in MH model rats. This research provides a new focus for the mechanism of the effect of DOFP against MH by triggering the enteric-origin SCFA-GPCR43/41 pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Junjun Li,Han Jin,Ximei Yan,Dongyan Shao,Xinzhong Hu,Junling Shi
Artemisia sphaerocephala Krasch polysaccharide (ASKP) consists of two main fractions, 60P (molecular weight at 551 kDa) and 60S (molecular weight at 39 kDa). The anti-obesity effects of ASKP and its two fractions were investigated in high-fat-diet-fed mice and showed similar capability in efficiently preventing the development of obesity. The final body weight and body weight gain of obesity mice model were reduced by 12.44% and 35.33% by ASKP, 10.63% and 34.35% by 60P, and 7.82% and 20.04% by 60S. They also showed similar efficiency to ameliorate dyslipidemia, systematic inflammation, and gut dysbiosis. The colonic genes of barrier integrity were significantly upregulated and the genes of hepatic lipid metabolism and that of colonic inflammatory response were suppressed. They attenuated the gut dysbiosis in obese mice, such as the significant enrichment of beneficial genera ( Bifidobacterium and Olsenella ) and suppression of harmful ones ( Mucispirillum and Helicobacter ). Significant enrichment of carbohydrate metabolism associated with the promotion of short-chain fatty acid production and decrease of the metabolisms related to obesity and gut dysbiosis (valine, leucine, and isoleucine biosynthesis, and nitrogen metabolism) were also observed by the administration of ASKP, 60P, and 60S. Overall, these polysaccharides showed potential in acting as prebiotics in preventing high-fat-diet-induced obesity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Functional Foods
·
2021
·
IF 4.451
Guoliang Wang,Diying Zhong,Haohan Liu,Tao Yang,Qiqi Liang,Jing Wang,Runguang Zhang,Youlin Zhang
Dietary fiber intake is associated with a low incidence of suffering from metabolic syndrome. To explore the potential health benefits of walnut meal dietary fiber (WMDF) as a prebiotic, the functional role of WMDF on metabolic syndrome in mice induced by high fructose diet (20%, HF) was investigated. The animal experiment results showed that administration of WMDF to HF-fed mice alleviated abnormal body weight gain, insulin resistance, oxidative stress, lipid metabolism disorders and inflammation. Histopathological observation confirmed the preventative effects of WMDF on hepatic steatosis and vascular endothelial dysfunction. Also, WMDF intake increased the production of acetic acid, propionic acid and butyric acid. Moreover, WMDF ingestion effectively improved the disorder of gut microbiota caused by HF, increased the diversity of gut microbiota and the relative abundance of short-chain fatty acids-producing bacteria. These findings demonstrate WMDF can be used as a prebiotic to prevent HF-induced metabolic syndrome.
✓ 已验证
产品关联
DOI
高影响因子
Food & Function
·
2020
·Vol. 11
·期 9
·7681-7695
·
IF 4.171
Zhihong Zhang,Songtao Fan,Danfei Huang,Tao Xiong,Shaoping Nie,Mingyong Xie
Lactic acid bacteria strain (LAB) NCU116 fermented Asparagus officinalis polysaccharides (FAOP) have been proven to cause substantial changes in physicochemical properties such as monosaccharide composition and molecular weight, accounting for their enhanced immune activity than unprocessed Asparagus officinalis polysaccharides (AOP). In the current study, the hepatoprotective effects of FAOP in mice with cyclophosphamide (CTX)-induced hepatotoxicity were investigated. FAOP were more effective than AOP in alleviating CTX-induced hepatic damage, including inhibition of hepatic biochemical markers (ALT, AST, AKP and LDH) and pro-inflammatory cytokines (TNF-α and IL-1β) as well as reinforcement of antioxidant systems (T-AOC, SOD, CAT, and MDA). In particular, compared with AOP, FAOP showed superior performance by promoting GSH biosynthesis, and normalizing the expression level of bile acid receptors (FXR and SHP) and key enzymes in bile acid synthesis (CYP7A1, CYP8B1 and CYP27A1). Modulation of disordered homeostasis of bile acids by FAOP can be attributed to the upregulation of hepatic short chain fatty acid (SCFA) receptors GPR41 and GPR109A as well as intestinal SCFA production. Furthermore, serum metabolomics study validated the hepatoprotective superiority of FAOP than AOP with evidence from variations in bile acid compositions and the construction of related metabolic pathways. Therefore, LAB NCU116 fermentation of Asparagus officinalis was practical and effective to obtain promising hepatoprotective polysaccharides, which might arise from enhanced SCFA production than unprocessed AOP.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2020
·Vol. 151
·期 3
·720-733
·
IF 2.482
Zhu Anlian,Li Qixing,Feng Wanlu,Fan Dongshuang,Li Lingjun
Abstract The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract
Various aldehydes, malononitrile and activated phenols could be converted to the
corresponding 2-amino-4H-chromenes with good to excellent isolated yields under
the catalysis of choline acetate at room temperature.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Yanli Bao,Haiyang Yu,Yu Zhang,Li Chen
The photosensitizers (PS) play a vital role in photodynamic therapy (PDT), but the clinical therapeutic effect is limited by its low solubility, easy aggregation and lack of selective tumor uptake. Hence, some biocompatible materials such as poly(amino acid) have been chosen to deliver PS to solve these problems. In this study, we fabricated two kind of poly(amino acid)-based PS delivery systems by using poly ( L -glutamic acid) (PLG) as the backbone material to physically encapsulate (P(T)) and chemically conjugate PS (PT), respectively. Moreover, the anticancer effect of these two PS delivery systems had been comparatively investigated. In vitro experiments verified that the delivery system of PT exhibited more effective treatment effect than that of P(T) because PS was chemically conjugated with PLG in PT which could obviously avoid the π-π stacking effect of PS and induced the aggregation. The less aggregation avoiding the quenching effect could result in an enhanced generation ability of reactive oxygen species to improve PDT treatment effect. Contrarily, the treatment effect of P(T) was lower due to the rigid structure and hydrophobic π-π stacking effect, in which the physically encapsulated PS was easier to aggregate and quench. Hence, the way how to combine carrier with drug is significant for satisfied treatment effect.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2020
·
IF 3.69
Lujia Yang,Qian Zhang,Jieyao Huang,Danning Liu,Yunfei Lan,Lujiang Yuan,Qianfeng Chen
Ethnopharmacological relevance Xianglian Pill (XLP), a traditional Chinese pharmaceutical preparation for the treatment of gastrointestinal disease , possessing anti-inflammatory, anti-microbial and analgesic activities, may represent a promising candidate for the treatment of antibiotic-associated diarrhea (AAD). Aim of the study This study aimed to unravel the underlying mechanism of XLP on the amelioration of AAD. Materials and methods AAD was induced by intragastric administration of a mixture of cefuroxime and levofoxacin (300 mg/kg. bw + 200 mg/kg. bw) for five consecutive days. Then AAD mice were treated with XLP at the dose of 500, 1000 and 2000 mg/kg. bw, respectively for 5 days. The physical manifestations, diarrhea status were monitored during the drug delivery. Histopathology of colon, intestinal microbiota , inflammatory cytokines, tight junction protein and short chain fat acids (SCFAs) were determined. Results Mice received cefuroxime and levofoxacin for 5 days developed medium to severe diarrhea. XLP treatment, however, mitigated the diarrhea status. Further evaluation revealed that XLP promoted the recovery of mucosa, maintained the integrity of tight junction, attenuated the inflammatory disorders, restored intestinal microbiota and increased SCFAs level in feces. Conclusion XLP ameliorates AAD by restoring intestinal microbiota and attenuating mucosal damage.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Functional Foods
·
2020
·
IF 3.701
Xiaoguo Ji,Mai Chen,Mengyao Zhao,Yudong Song,Yong Lin,Hao Yin,Liming Zhao
Chitobiose (OC)and chitotriose (TOC)were used to simulate the in vitro fermentation of feces samples from nonalcoholic fatty liver disease (NAFLD) patients to evaluate their effects on gut microorganisms and metabolites. The results indicated that OC and TOC shifted the gut microbial community of NAFLD patients to that of healthy volunteers. Specifically, OC and TOC increased the relative abundance of Fusobacteria, while reducing Actinobacteria and the ratio of Firmicutes to Bacteroidetes. OC's targeted bacteria were Fusobacterium , Clostridium sensu stricto 13 and Parabacteroides , while TOC's targeted bacteria were Clostridium sensu stricto 1 , Enterococcus . The content of total short-chain fatty acids, propionic acid and butyric acid in the OC and TOC groups increased significantly, which was closely related to the increase in the abundance of the targeted flora. Although the non-targeted metabolites of OC and TOC had a high degree of similarity in the positive ion mode and a large difference in the negative ion mode. The up-regulated metabolites of the OC and TOC groups include bile acids (7-ketodeoxycholic acid, docosahexaenoic acid ethyl ester, deoxycholic acid, cholic acid), amino acids (succinyl proline, cys-tyr, L-β-leucine), antibiotics (fortimicin FU-10, kanoamine), and down-regulated metabolites include xanthine, hypoxanthine, L-glutamic acid, acetophenone, etc. The biomarker metabolites of OC and TOC may reveal the probiotic effect on gut microecological health on the biosynthesis of amino acids, butyric and bile acid metabolism pathways. The results can be helpful for the further development of COS as a functional food.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）