MOLECULES
·
2024
·Vol. 29
·期 9
·2027
·
IF 4.2
Huabin Jiang,Jiaqi Nie,Lei Zeng,Fei Zhu,Zhongwang Gao,Aiping Zhang,Jun Xie,Yong Chen
Hemicellulose can be selectively removed by acid pretreatment. In this study, selective removal of hemicellulose was achieved using dilute sulfuric acid assisted by aluminum sulfate pretreatment. The optimal pretreatment conditions were 160 °C, 1.5 wt% aluminum sulfate, 0.7 wt% dilute sulfuric acid, and 40 min. A component analysis showed that the removal rate of hemicellulose and lignin reached 98.05% and 9.01%, respectively, which indicated that hemicellulose was removed with high selectivity by dilute sulfuric acid assisted by aluminum sulfate pretreatment. Structural characterizations (SEM, FTIR, BET, TGA, and XRD) showed that pretreatment changed the roughness, crystallinity, pore size, and functional groups of corn straw, which was beneficial to improve the efficiency of enzymatic hydrolysis. This study provides a new approach for the high-selectivity separation of hemicellulose, thereby offering novel insights for its subsequent high-value utilization.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Lanlan Hu,Zhen Wang,Longfei Feng,Yangyang Jia,Yuanyang Nie,Ibrahim Khalifa,Hao Zhang,Xinhong Liang,Benguo Liu
BACKGROUND Diabetes mellitus presents a significant global health burden, highlighting the need for safe and cost-effective dietary interventions. Soluble dietary fiber (SDF) derived from sweet potato, rich in bioactive compounds, holds promise for improving glucose metabolism and gut microbiota, yet its effects on type 2 diabetes (T2D) remain underexplored. RESULTS The present study investigated the impact of different doses of sweet potato-derived SDF-high (SDF-H, 1000 mg kg −1 body weight), SDF-medium (SDF-M, 600 mg kg −1 body weight) and SDF-low (SDF-L, 200 mg kg −1 body weight) on T2D mice over 10 weeks. The results demonstrated that SDF supplementation significantly improved body weight, reduced excessive water intake and lowered postprandial blood glucose. Notably, high- and medium-dose SDF improved glucose tolerance, reducing postprandial blood glucose by 23.76% and 17.10%, respectively, and mitigated diabetes-induced damage to the liver, kidneys and pancreas. SDF also modulated lipid metabolism, decreasing serum total cholesterol and triglycerides at the same time as increasing high-density lipoprotein cholesterol. Importantly, SDF, particularly at high doses, enhanced gut microbiota diversity and abundance, suppressing harmful bacteria and promoting beneficial genera such as Alloprevotella and Lactobacillus , at the same time as decreasing the abundance of Helicobacter . These findings suggest that sweet potato-derived SDF exerts multi-targeted benefits in T2D through metabolic regulation and gut microbiota modulation. CONCLUSION Sweet potato-derived SDF is a promising natural agent for improving glycemic control, lipid profiles, and gut microbial balance in T2D, suggesting its potential as a dietary intervention for diabetes management, pending further validation in human studies. © 2025 Society of Chemical Industry.
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BIORESOURCE TECHNOLOGY
·
2025
·
IF 9
Xueyan Liang,Zhen Hao,Xiwen Jia,Kaili Ding,Hui Zhang,Aihua Deng,Haitao Yu,Lujia Han,Weihua Xiao
Peracetic acid (PAA) treatment is a promising delignification strategy for lignocellulose biorefinery; however, its cumbersome preparation has challenged industrial application. This work presents a facile approach for in situ PAA generation using phosphotungstic acid (PTA) as a catalyst in hydrogen peroxide-acetic acid (HPAC) system for one-pot global deconstruction and delignification of corn stover. With an HPAC concentration of 50% (v/v) and PTA loading of 1–1.5% (w/w), approximately 83.5% of lignin was removed. Meanwhile, 87.0–90.8% of glucan and 80.3–82.4% of xylan were retained. The streamlined process demonstrated exceptional enzymatic digestibility, reaching 92.9% and 82.4% glucose conversion under 5% and 15% solid loadings, respectively. Correlation analysis revealed that enzymatic hydrolysis efficiency primarily depended on the spatial structure of the pretreated substrate and its residual lignin content. This strategy successfully addresses the need for separate PAA synthesis through in situ generation and achieves efficient delignification in one step with remarkable carbohydrate retention. It provides an environmentally friendly and cost controllable pretreatment strategy, demonstrating significant potential for sustainable sugar production.
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APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Tinghao Han,Zhongdi Liu,Lincai Peng,Weipeng Song,Huai Liu,Wenlong Jia,Rui Zhang
The efficient production of γ-valerolactone (GVL) with high yield directly from xylose is of particular interest but remains a great challenge due to the long reaction path. We herein developed a facile catalytic system to directly convert xylose to GVL with a record-high yield of 54.3 %, employing β-zeolite supported Zr-based catalyst in 1,4-dioxane/isopropanol co-solvent. Using Zr(NO 3 ) 4 ·5 H 2 O as the Zr sources resulting in well-retained β-zeolite structure, larger surface area and pore volume and better dispersion of Zr species, as well as balanced acidic sites where higher amount of Brønsted acid sites promoted the ring-opening of furfural alcohol for this cascade reaction. Notably, the introduction of 1,4-dioxane facilitated the in situ formation of furfural (i.e. yield-determining step) by diluting the competitive adsorption behavior between isopropanol and xylose, allowing more xylose molecules to access the active center, thus promoting the sequential production of GVL with unexpectedly high yield. The present work provides a efficient and straightforward preparation of GVL from xylose, paving the pathway towards higher atom economy.
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ChemistrySelect
·
2025
·Vol. 10
·期 25
·e00963
·
IF 2
Lihan Yue,Ming Zhao,Qiang Zhou,Liqiu Sun,Dan Wang,Jun Li,Zhichun Shi
Graphical In this study, three water-soluble polysaccharides were isolated from Isatidis Radix , which had never been reported before. IRPS-1 and IRPS-2 possess starch branch chains, while IRPS-3 has a stable triple helix structure. Compared to IRPS-1 and IRPS-2, the structure of IRPS-3 has two additional branches, namely →4)Arap(1→ and Ribf(1→. All three polysaccharides exhibited significant antioxidant activities in vitro, with IRPS-3 demonstrating the best activity among them. This study was focused on the objective of investigating the composition, structure, and physicochemical attributes of Isatidis Radix polysaccharides (IRP). Three distinct polysaccharide fractions, IRPS-1, IRPS-2, and IRPS-3, were separated and purified from the crude polysaccharides of Isatidis Radix utilizing DEAE-52 cellulose and Sephadex G-100 columns. A series of technical methods were used to analyze the structure of the three polysaccharides. The analysis indicated that these compounds were heteropolysaccharides, with average molecular weights of 1.17 × 10 5 Da, 1.21 × 10 5 Da, and 1.06 × 10 5 Da. The primary compositional of IRPS-1 and IRPS-2 were glucose and galactose, while IRPS-3 consisted primarily of galactose, glucose, and arabinose. The methylation analysis elucidated that IRPS-1, IRPS-2, and IRPS-3 possessed similar linear backbones but differed in their branches. Distinguished from the other two polysaccharides, IRPS-3 has two additional branches, namely →4)Arap(1→ and Ribf(1→. I 2 -KI experiment showed that IRPS-1 and IRPS-2 had starch branch chains. In addition, IRPS-3 exhibited a stable triple-helix configuration in aqueous milieu and possessed longer side chains and more branches. In vitro antioxidant experiments demonstrated that IRP exhibited good concentration-dependent antioxidant activity. Based on these findings, IRP can be regarded as a potential natural antioxidant.
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ACS Nano
·
2025
·
IF 16
Yuchan Li,Baojun Long,Yanjia Cui,Wenqing Li,Dong He,Zunjian Ke,Xiangheng Xiao
Engineering anodic and cathodic half-reactions with more favorable thermodynamics and techno-economics in water-splitting cells for electrorefining offers a promising approach to producing green fuels and fine chemicals. Herein, we demonstrated a coelectrolysis system integrating nitrate reduction reaction (NO3RR) and biomass oxidation reaction (BOR), where a well-designed CuNi alloy acted as the catalyst at the cathode and anode. The CuNi delivered a yield rate of 2.87 mmol h–1 cm–2 (8.44 mmol h–1 mgcat–1) at 0 V vs RHE and a FE of 95.33% (a current density of −136 mA cm–2) at −0.2 V vs RHE for ammonia synthesis from nitrate reduction. Mechanistic studies revealed that Cu centers rapidly converted NO3– to NO2–, while Ni sites promoted water dissociation, generating *H species for intermediate deoxygenation and hydrogenation via stepwise proton transfer. At the anode, the CuNi efficiently catalyzed the oxidative upgradation of biomass derivatives, with a Faradaic efficiency of >90% and a long-term stability over 240 h for formate production. In situ experiments demonstrate that Cu substantially enhances the dynamic transformation efficiency of the NiIII–O active species on CuNi catalysts. The integrated NO3RR||BOR system demonstrated an efficient and stable electrosynthesis (>120 h) of ammonia (∼3.9 mmol h–1 cm–2 or 11.47 mmol h–1 mgcat–1) and formate (∼38.3 mmol h–1 cm–2 or 112.65 mmol h–1 mgcat–1). This study emphasizes the design of a hybrid system for electrocatalytic refining of waste feedstocks into commodity chemicals.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mengxiang Chen,Yi Peng,Rongtao Zhu,Xiaoting Luo,Xuemin Yang,Jiazhi Chen,Haiyan Chen,Wei Zhou,Zhiyun Du
Psoriasis is a chronic inflammatory skin disease with significant impacts on quality of life. Current treatments face challenges like high costs and side effects. This study explores the therapeutic potential of Rosa rugosa polysaccharide (RRPS) and its nanofiber membrane in psoriasis treatment. RRPS was extracted using a yeast fermentation enzyme-assisted method and characterized. In vitro studies on RAW264.7 macrophages showed that RRPS significantly reduced nitric oxide (NO) production, indicating anti-inflammatory effects. The nanofiber membrane, fabricated via electrospinning, has high porosity and sustained-release properties, enhancing drug delivery and skin barrier repair. In vivo studies using an imiquimod-induced psoriasis mouse model demonstrated that both RRPS and its nanofiber membrane improved psoriasis symptoms, reduced transepidermal water loss (TEWL), and inhibited pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-17A). Mechanistically, they suppressed the PI3K-AKT/mTOR pathway. The nanofiber membrane showed superior efficacy compared to RRPS alone, highlighting the benefits of electrospinning. This study suggests that Rosa rugosa polysaccharide and its nanofiber membrane could be a novel, effective, and safe alternative for psoriasis treatment by targeting the PI3K-AKT/mTOR pathway.
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RARE METALS
·
2025
·
IF 11
Luo Qi-Zhi,Huang Jin-Shu,Liu Teng-Yu,Yuan Ji-Li,Belousov Artem S.,Li Sheng-Kun,Yang Song,Li Hu
Photocatalytic selective synthesis of lactic acid (LA) from biomass sugars with a single heterogeneous catalyst is promising but challenging due to the multiple reaction steps involved. Herein, a K-doped C-rich red polymerized carbon nitride (RPCN) photocatalyst with uniform K/C dual sites was constructed by a molten salt template method, which was highly efficient for cascade isomerization dehydration of glucose to LA with > 90% selectivity under visible light and gentle conditions. Control experiments and theoretical calculations expounded that the introduced K/C dual sites could improve the light capture ability and photogenerated charge separation efficiency, while the K species provided sufficient Lewis acid sites (adsorption sites) for the isomerization of glucose to fructose. Meanwhile, the introduced C sites that substitute N atoms could promote electrons to be captured by adsorbed oxygen for selective generation of superoxide radicals, which was highly efficient for the scission of the C3–C4 bond in fructose, exclusively furnishing LA. Importantly, the RPCN photocatalyst was also suitable for the photocatalytic upgrading of various biomass saccharides into LA with high yields of 81.3%–95.3% and could be recycled for five consecutive cycles. The tailored construction of dual sites by localization of space charge lightens an avenue for multi-step conversion of biomass with pronounced selectivity. Graphical abstract
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Xiwen Jia,Jiajie Xu,Luoyang Liu,Xueyan Liang,Yinghui He,Lujia Han,Weihua Xiao
In this study, corn stover-based sugar served as the initial carbon source to investigate the impact of different co-culture strategies on the synthesis of short- and medium-chain fatty acids (SMCFAs) through carbon chain elongation (CCE). The results indicated that the sequential inoculation outperformed simultaneous inoculation in the M. elsdenii and Lactobacillus groups. The inclusion of Lactobacillus significantly enhanced substrate utilization, generating lactate that facilitated the integration of odd carbon carboxylates (such as propionate and valerate) into the CCE products. The caproate concentration in the M. elsdenii + L. pentosus group reached 3.4 g/L, which was 1.3 times that in the control group. Furthermore, the introduction of C. kluyveri effectively boosted the synthesis of butyrate and caproate through CCE using ethanol as an electron donor within the co-culture setup of the M. elsdenii+C. kluyveri group. Moreover, the carbon efficiency of the co-culture group increased by 10–21 % compared to the control group, and the cell protein titer was 1.5–2 times higher than that of the control group. This study has established a method for co-producing SMCFAs and cell proteins utilizing bio-sugars through a co-culture approach, offering implications for lignocellulose utilization and potential high-value applications of SMCFAs in the future.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Pengyue Li,Yongshuai Jing,Xiaoyue Qiu,Huina Xiao,Yuguang Zheng,Lanfang Wu
The purified polysaccharides fraction, DOP-2, was prepared from Dioscorea opposita Thunb ( D. opposita ). This study combined in vitro and in vivo experiments to comprehensively investigate the index changes in RAW264.7 cells and immunocompromised mice under DOP-2 intervention, aiming to elucidate the potential mechanisms of immunomodulatory effects of DOP-2. DOP-2 (10 ∼ 500 μg/mL) significantly elevated the levels of NO, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) factors secreted by RAW264.7 cells, and restored the body weight of immunosuppressed mice and improve the degree of injury to the immune organ index, resulting in significant immunomodulatory effects. Notably, DOP-2 promoted the production of short-chain fatty acids (SCFAs) in immunosuppressed mice and modulated the composition of their gut microflora. These findings highlight the potential benefits of DOP-2 therapy in improving immune function and gut health, and will provide a theoretical basis for the application of D. opposita polysaccharides as an immunomodulatory adjuvant.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Haizhao Song,Jing Lu,Qiang Chu,Rou Deng,Xinchun Shen
BACKGROUND Because of their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP-3a) derived from T. fuciformis and explore its interaction with gut microbiota in vitro . RESULTS The findings revealed that PTP-3a had a molecular weight of 1.22 × 10 3 kDa and consisted of fucose, glucose, xylose, mannose and glucuronic acid in a molar ratio of 0.271:0.016:0.275:0.400:0.038. The primary linkage types identified in PTP-3a were 1,3-linked-manp, 1,4-linked-xylp and 1,2,3-linked-fucp, with corresponding ratios of 0.215:0.161:0.15. In addition, PTP-3a demonstrated notable thermal stability and exhibited a triple-helical structure. Moreover, following in vitro fermentation for 48 h, PTP-3a was efficiently utilized, resulting in a reduction in carbohydrate levels, the production of short-chain fatty acids (SCFAs) and pH adjustment. Furthermore, during in vitro fecal microbial fermentation, PTP-3a decreased the relative abundance of Firmicutes while increasing the proportions of Bacteroidetes and Proteobacteria, resulting in a significantly reduced Firmicutes/Bacteroidete s ratio. Additionally, PTP-3a stimulated the growth of beneficial bacteria such as Parabacteroides merdae , Gordonibacter pamelaeae , Bifidobacterium pseudolongum and Parabacteroides distasonis . Importantly, a strong correlation was observed between the production of SCFAs and specific microorganisms. CONCLUSION These findings suggested that PTP-3a has potential as a prebiotic for modulating the gut microbiota. © 2024 Society of Chemical Industry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qian Yu,Xian Qiu,Jing Zhong,Chao Cao,Yuechan Liao,Zhiwei Zeng,Dawei Zhang,Chunyan Yan
Acorus tatarinowii , a famous traditional Chinese medicine, is used for the clinical treatment of memory impairment and dementia. In this research, AT50, the crude polysaccharide extracted from A. tatarinowii rhizome, significantly improved the memory and learning ability of mice with Alzheimer's disease (AD) and exerted excellent anti-neuroinflammatory effects. More importantly, AT50 returned the levels of NO, TNF- α , IL-1 β , PGE-2, and IL-6 in AD mouse brains to normal levels. To identify the active ingredients in AT50, a heteropolysaccharide ATP50–3 was obtained from AT50. Structural analysis indicated ATP50–3 consisted of α -L-Ara f -(1→, →2)- α -L-Ara f -(1→, →3)- α -L-Ara f -(1→, →5)- α -L-Ara f -(1→, α -D-Xyl p -(1→, →3,4)- β -D-Xyl p -(1→, →3)- α -D-Gal p -(1→, →3,6)- α -D-Gal p -(1→, →6)-4-OAc- α -D-Gal p -(1→, →3,4,6)- α -D-Gal p -(1→, →4)- α -D-Glc p -(1→, →2,3,6)- β -D-Glc p -(1→, →4,6)- α -D-Man p -(1→, →3,4)- α -L-Rha p -(1→, →4)- α -D-Gal p A-(1→, and →4)- α -D-Glc p A-(1 → residues and terminated with Xyl and Ara. Additionally, ATP50–3 significantly inhibited the release of proinflammatory factors in lipopolysaccharide-stimulated BV2 cells. ATP50–3 may be an active constituent of AT50, responsible for its anti-neuroinflammatory effects, with great potential to treat AD.
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