Materials Today Bio
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2026
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IF 11
Ye Fang,Xinyu Tao,Nengjie Yang,Jing Li,Jun Xiao,Liwei Qiu,Yujuan Zhu,Zhifeng Gu
Xerostomia is defined as the clinical syndrome characterized by reduced salivary secretion and/or abnormal composition of saliva, with the essential pathological basis being salivary gland dysfunction. These symptoms could not be effectively and persistently alleviated using current therapies. This study presents a microfluidics-based oral adhesive nanozyme microsphere system for the treatment of xerostomia. The adhesive hydrogel coating on the outer layer of the microspheres can rapidly establish robust adhesion to the moist oral mucosa. Furthermore, it contains cerium oxide nanoparticles (CeNP) which would be slowly released in presence of saliva collagenase enzyme. Of particular interest are the remarkable anti-inflammatory and antioxidant properties of CeNP, which have demonstrated significant efficacy in neutralizing reactive oxygen species (ROS) produced by macrophages and markedly suppressing proinflammatory responses. Animal experiments have revealed this microsphere system can effectively alleviate the infiltration of inflammatory cells into the salivary glands and maintain the integrity of the salivary gland duct and acinus. Based on the transcriptomic analysis, adCe-MS demonstrates a robust therapeutic effect on mice with xerostomia by significantly downregulating key inflammatory pathways and chemokines while upregulating salivary secretion-related genes. These results suggest that this drug delivery system not only presents a novel strategy for mucosal nanomedicine administration but also offers an effective solution for the treatment of xerostomia.
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高影响因子
MATERIALS & DESIGN
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2026
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IF 8.2
Yang Yang,Jingjian Liu,Jiye Zhang,Shuya Zhang,Jiazhen Wu,Qizhang Wang,Guangyi Yang,Qinhua Chen
Refractory diabetic wound is characterized by excessive oxidative stress and inadequate angiogenesis, both of which are primarily caused by mitochondrial dysfunction. Although nanozymes exhibit multiple enzyme-mimicking antioxidant activities, challenges such as immune rejection, limited catalytic activity, and poor biocompatibility remain. Here in, a novel therapeutic system based on plant exosome nanovesicle-incorporated nanozymes was designed to mitigate oxidative stress and promote healing in diabetic wounds by targeting and restoring mitochondrial function. Titanium-doped cerium vanadate (CeVO 4 -Ti) nanozymes with multiple enzyme catalytic activities had been rationally designed. The surface of CeVO 4 -Ti was modified with triphenylphosphine (TPP) to endow mitochondrial targeting. To enhance biosafety and delivery, the nanozymes were further encapsulated within dendrobium officinale-derived nanovesicles (DOEVs) and integrated into a dopamine-methacrylated hyaluronic acid (DHM) hydrogel, forming a composite system (DOEVs@CTT/DHM). DOEVs@CTT/DHM could effectively mimic the activity of natural enzymes, eliminate reactive oxygen species, reconstruct blood vessels, and promote re-epithelialization, thereby facilitating wound healing from multiple perspectives. Crucially, it activated the Nrf2/Parkin/Pink1 pathway to regulate mitophagy, thereby revitalizing mitochondrial function and then alleviating oxidative stress. This study presents a novel strategy for mitochondrial regulation, advancing the development of multifunctional nanozyme-based biomaterials for wound healing.
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POLYMER DEGRADATION AND STABILITY
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2026
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IF 8.1
Zhenyin Guo,Chen Peng,Kang Zhu,Hongtao Li,Xianru He
A single-molecule intumescent flame-retardant (ABDP) was designed and synthesized for the intrinsic flame-retardant modification of ethylene vinyl acetate rubber (EVM). Through peroxide-initiated radical reactions, ABDP was covalently grafted onto the EVM molecular chain, constructing a P–N flame-retardant network. The mechanical, thermal and fire performances of the resulting composites were systematically investigated. The composite containing 16wt % ABDP (ABDP16) facilitated the formation of a continuous and highly graphitized intumescent char layer in the condensed phase, reducing the peak heat release rate (PHRR) and peak smoke production rate (PSPR) by 52.1 % and 46.1 %, respectively, while markedly enhancing thermal stability and tensile strength. After magnesium hydroxide (MH) was introduced, the EVM16 composite achieved a limiting oxygen index (LOI) of 30.7 % and a V-0 rating in the UL-94 test, with the PHRR and PSPR reduced by 77.2 % and 70.6 %, respectively. Moreover, its fire-growth index (FGI) decreased from 13.1 to 1.53 kW/(m 2 ·s). The metal oxides generated from the decomposition of MH were anchored within the char layer, yielding a compact, continuous barrier that effectively suppressed gaseous-fuel transport and heat diffusion. This work provides a feasible flame-retardant molecular-design strategy for developing highly efficient, durable and eco-friendly intrinsically flame-retardant EVM composites.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Liu Yang,Tian-Bo Ma,Chen-Wan Guo,Run-Bo Yu,Ping Li,Hua Yang,Wen Gao
Background Thermal stability-based proteomic strategies, including thermal proteome profiling (TPP) and proteome integral solubility alteration (PISA), enable proteome-wide target identification but predominantly analyze soluble proteins, overlooking heat-induced aggregates that may contain informative targets. Conventional denaturants used for solubilization of these precipitates offer limited performance and compatibility. Here, we developed a deep eutectic solvent (DES)-assisted reverse PISA (DrPISA) strategy to enhance insoluble proteome accessibility and improve detection sensitivity for subtle thermal stability alterations. Results A systematic evaluation of 65 DES formulations identified DES-48 ( l -proline:glycerol:water, 1:1:4) as an optimal solubilization reagent for heat-aggregated proteomes, delivering up to 71.7% more identified proteins than GuHCl and 23.5% more than urea, together with 80.6% fully cleaved peptides and excellent quantitative reproducibility. Integrating DES-48 into a reverse PISA workflow enabled sensitive detection of early-stage aggregation events not captured in soluble-focused assays. Across five reference compounds, DrPISA reproducibly recovered known targets and increased kinase coverage, identifying 45 kinases among 1142 quantified proteins, including marginal kinase responses in staurosporine-treated samples undetectable by conventional PISA. A simplified six-temperature dimethyl labeling workflow was applied, pooling samples from six discrete heat treatments prior to isotopic labeling and quantitative mass spectrometry, reducing reagent consumption and MS acquisition time by more than 50%. Application to celastrol identified LULL1 as a previously under-recognized interacting protein, illustrating the biological insights gained by expanding target coverage into aggregated fractions. Significance DrPISA extends thermal profiling to insoluble fractions with improved performance over conventional workflows, offering a scalable approach for high-sensitivity target deconvolution. The introduction of DES-48 enables enhanced recovery and quantification of heat-aggregated proteins, broadening the analytical scope of chemical proteomics. These advances establish DrPISA as a practical and complementary strategy for expanding the discoverable drug-protein interaction landscape.
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Materials Today Bio
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2026
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IF 11
Rui Zhao,Shiwen Ni,Xinyu Tao,Yuxing Liu,Nengjie Yang,Chun Cheng,Yujuan Zhu,Mei Yang
Endometrial injury is a pathological damage caused by intrauterine infection, repeated miscarriage, or curettage, which can seriously impair fertility. Effective repair of damaged endometrium is crucial. Traditional interventions often only bring moderate improvements; therefore innovative repair strategies are needed. Herein, we propose a novel spatiotemporally responsive piezoelectric microsphere platform, which could be applied for ultrasound-guided endometrial regeneration and fertility recovery. These microspheres are manufactured by microfluidic technology, producing a core-shell structure: a Chinese herb-laden hydrogel embedded in piezoelectric nanoparticles, and wrapped by a viscous polydopamine (PDA) shell. The herbal hydrogel inhibits the release of inflammatory cytokines, and play the role of phytoestrogen to synergistically enhancing sexual function and tissue repair. The PDA shell scavenges reactive oxygen species (ROS), dampening oxidative stress and chronic inflammation. Meanwhile, the encapsulated gold-decorated tetragonal barium titanates (Au@BTO) nanoparticles generate bactericidal ROS upon ultrasonic activation, ensuring sterile local microenvironments. Vessel-on-a-chip and endometrium-injury rats model confirm the microspheres's outstanding compatibility, and their capacity to stimulate cell proliferation, migration and angiogenesis. Intrauterine delivery of the microspheres accelerates endometrial re-epithelialization, amplifies angiogenesis, restores myometrial integrity, and ultimately preserves fertility. With its precise spatiotemporal control and multimodal therapeutic functions, this microsphere system represents a transformative approach for localized treatment of gynecological diseases.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Tianle Zhou,Haoyang Du,Su Zhao,Gen Li,Siyu Wang,Sikai Wang,Jinfeng Ning,Manjie Zhang,Hang Yin
Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality worldwide, with therapeutic progress hindered by the immunosuppressive and heterogeneous tumor microenvironment (TME). Protein arginine methyltransferase 3 (PRMT3), a key regulator of post-translational modifications (PTMs), plays a pivotal role in immune evasion and therapeutic resistance by modulating key oncogenic and immune pathways. Despite the potential of PRMT3 inhibitors, such as SGC707, their clinical efficacy is limited by poor pharmacokinetics, inadequate therapeutic durability, and the complex interplay within the TME. To address these challenges, we developed a multifunctional nanoplatform, poly (acrylic acid)‑copper bismuth tellurium@SGC707 nanospheres (PAA-CuBiTe@SGC707 NSs), which integrates copper-induced cell death (cuproptosis), radiosensitization, and PRMT3 inhibition to achieve synergistic therapeutic outcomes. The nanoplatform induces mitochondrial DNA (mtDNA) release, thereby activating a cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-mediated immunogenic response, which is further amplified by SGC707 through the suppression of PRMT3-mediated arginine methylation of cGAS. Furthermore, the incorporation of Bi and Te nanoparticles endows the nanoplatform with effective radiosensitization capability, improving the precision and efficacy of radiotherapy. This study presents a novel nanotechnology-driven therapeutic strategy that simultaneously addresses immune resistance and radiotherapy limitations, providing a promising approach for improving NSCLC treatment outcomes.
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Journal of Materials Chemistry A
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2026
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IF 9.2
Fancang Meng,Huan Wu,Boyu Jia,Kexiang Li,Zhihua Wang,He Zhu,Chao Chen,Qingmin Ji
The development of Fe-N-C electrocatalysts for the oxygen reduction reaction (ORR) is crucial for sustainable energy technologies, yet achieving a high density of atomically dispersed Fe-Nx sites remains a challenge. Herein, we proposed a novel spatial confinement strategy based on the molecular-level infiltration of iron-coordinated, water-soluble fullerene (Fe/wsC60) into self-assembled fullerene microbelts (FMB). The -NH2/-OH functionalized C60s act as molecular metal chelator and nitrogen source, while the flexible FMB framework facilitates their effective permeation. This nanoscale confinement effectively mitigates Fe aggregation during pyrolysis, yielding a catalyst with abundant atomically dispersed curved Fe-N4 sites alongside fine Fe3C nanoparticles. The resultant (Fe/N@FMB) catalyst demonstrates an exceptional ORR activity and stability in alkaline media with a half-wave potential of 0.891 V, surpassing Pt/C and control samples derived solely from wsC60 or FMB. When integrated into a zinc-air battery, it also achieves a higher open-circuit voltage and power density than Pt/C. Theoretical calculations reveal that the curved carbon matrix and adjacent Fe3C synergistically modulate the electronic structure of the Fe-N4 moiety, thereby boosting the ORR kinetics. This work highlights the importance of nanoscale architectural design for precise precursor confinement in developing advanced electrocatalysts.
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CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Jian Liu,Jianyi Song,Na Liu,Qiao Lan
A pump-free, stable and efficient aerogel reactor with abundant pores is designed using Ag-loading cellulose Pickering emulsions as a template for the continuous flow catalytic reduction of 4-nitrophenol. The fabrication of the aerogel reactor entails the two-step oxidation synthesis of aldehyde-functionalized cellulose nanocrystals (ACNC), the in-situ reduction of Ag nanoparticles (NPs) on them to form Ag@ACNC, the utilization of this material to stabilize a Pickering emulsion for preparing the hydrogel, and finally the freeze-drying of the hydrogel laying on a fabric strip. The emulsion-templated aerogel features abundant pores with loading Ag NPs on inner walls, enabling reactant to flow through the pores rapidly under driving by its gravity and the capillary action of the supporting fabric strip and react on the walls. The aerogel reactor achieves efficient three-dimensional flow catalysis without an external power source and exhibits excellent conversion and stability. The conversion all remains above 91.8% during the continuous flow catalysis reaction of 6 cycles (totaling 72 h), and the conversion still reaches 94.4% at 12 h after storage in air for 60 days. This emulsion-templated aerogel reactor demonstrates great potential for advancing recyclable catalytic systems, thereby paving the way for its wide applications.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Senlin Deng,Wei Chang,Tingting Yan,Qi Li,Kai Zhao,Kaipeng Cao,Haifeng Dong,Jie Li,Gang Wang,Chunshan Li
Considered as the promising route to replace the petroleum-based propene selective oxidation process, direct vaporous aldol condensation of methyl acetate with formaldehyde to produce methyl acrylate has received broad attention. In this work, we found the synergistic effects between the mesoporous structure and acid-base properties on this transformative process over Cs/Zr-SiO 2 catalyst through systematic comprehensive characterizations and structure-activity analysis. The pore structure of SiO 2 support, as well as the acid-base properties of catalyst, can be regulated by the dosed Zr content during the kinetic control of tetraethoxysilane hydrolysis and consequential condensation. The weak acid and base sites derived from the generation of Si-O-Zr and Si-O-Cs structures in the Cs/Zr-SiO 2 -SG catalyst are linearly correlated to the methyl acetate conversion and methyl acrylate selectivity. The diffusion behavior of methyl acetate and formaldehyde confirmed by in situ DRIFTS measurements significantly is closely related to the conversion and selectivity. As a result, the 9.4Cs/2.2Zr-SiO 2 sample prepared with a modified sol-gel method has appropriate pore structure and balanced acid-base properties, which cooperatively improve the catalytic performance to 27.6% conversion and 78.2% selectivity. While the kinetic studies reveal that the reaction order of methyl acetate and formaldehyde on this optimal catalyst is respective to 1.1 and 0.9, with their activation barrier of 81.2 kJ/mol. Although the catalyst will become deactivated resulting from the deposition of amorphous aromatic and aliphatic species, it can be easily regenerated to the fresh sample after simple thermal treatment.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xinglong Liang,Yutong Nong,Weigang Wang,Cheng Peng,Yi Tian,Jingyi Zhang,Xiaowei Wang,Jiuqing Liu,Xi Li,Jiafeng Zhang,Ji Liang
P2-type layered transition metal oxides (TMOs) are among the most promising cathode materials for sodium-ion batteries due to their high capacity and energy density. However, their practical application is hindered by irreversible phase transitions and lattice oxygen loss at high voltages, while Mn 3+ -induced Jahn–Teller distortion and P2–P′2 phase transitions at low voltages accelerate structural degradation and capacity fading. Here, we present a Mg/Cu co-doping strategy to systematically regulate structural evolution and redox chemistry, addressing these key degradation mechanisms. Mg 2+ , with strong electrostatic interactions and a small ionic radius, acts as an “anchoring” agent during deep sodiation (low potential), stabilizing the transition-metal layers, suppressing Mn disproportionation and Jahn–Teller distortion, and mitigating the P2–P′2 phase transition. Cu 2+ , in contrast, functions during deep desodiation (high potential) by enhancing Ni O bond ionicity and lowering the charge-transfer barrier between O 2p and transition-metal 3d orbitals, thereby reducing lattice oxygen participation, transition-metal dissolution, and interlayer gliding, and delaying the P2–O2 phase transition. Benefiting from this synergistic effect, Na 0.67 Ni 0.2 Mn 0.65 Mg 0.1 Cu 0.05 O 2 exhibits excellent electrochemical performance, retaining 80% of its capacity after 300 cycles at 1C in the 2.0–4.5 V window and maintaining a high reversible capacity of 78.5 mAh g −1 at 20C. This work not only provides a solution to the dual high-/low-voltage degradation challenge in P2-type TMOs but also elucidates the underlying mechanism of multi-element co-doping, offering a strategy for designing high-energy-density, long-life sodium-ion battery cathodes.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Shoufeng Xue,Huixiang Wang,Yingfen Wang,Hengliang Liang,Wanxi Li,Baoliang lv
With the increasing demands for high-temperature resistance and superior electromagnetic wave absorption in complex environments, developing effective low-frequency (2–8 GHz) absorbers remains challenging, especially for magnetic composites with high magnetic content and dispersibility. This study proposes a hummingbird acoustic resonance mixing (HAM) strategy to fabricate FeSi@SiC composites. Compositing soft magnetic FeSi with high-surface-area nano-SiC enhances electromagnetic loss and improves the high-temperature stability of the composite material due to the partial protection of FeSi by SiC. The optimized composite achieves a minimum reflection loss of −35.9 dB and a qualified absorption efficiency of 3.9 GHz at only 3 mm thickness, along with maintained structural integrity at 800 °C. Enhanced low-frequency absorption is revealed to stem from a large-small size magnetic-dielectric structure, a high density of confined magnetic units and strong magnetic coupling, which collectively promote magnetic loss. This work introduces a new approach to designing low-frequency electromagnetic wave absorbers with high-temperature oxidation resistance by precisely tuning their dielectric and magnetic constituents, and elucidates the underlying low-frequency magnetic attenuation mechanism along with its potential applications.
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Food Bioscience
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2026
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IF 6.2
Linyu Mei,Zicheng Zhang,Yue Niu,Wenlong Deng,Jiwei Song,Yuan Yao,Ruien Yu,Yunpeng Shao,Xiujian Chou
In this study, a capillary coated with silver nanoparticles-modified zinc oxide nanorods (Ag/ZnO NRs) was developed as an ultrasensitive SERS substrate. The aggregation of Ag nanoparticles (Ag NPs) at the tips and sides of ZnO NRs generates high-density three-dimensional “hot spots”, which, together with the photocatalytic activity of Ag/ZnO and the extended light–analyte interaction time afforded by the capillary structure, enables efficient adsorption and in situ detection of trace pollutants. This substrate exhibits excellent SERS performance, achieving a detection limit of 10 -14 M for Rhodamine 6G (R6G), with a relative standard deviation of less than 12%, With in-situ and rapid detection of microplastics in different liquid environments such as seawater and various beverages, the detection limit of polystyrene microspheres is as low as 50 μg/mL. Therefore, our prepared substrate offers a highly sensitive and reusable solution for in-situ, real-time, and rapid monitoring of trace contaminants in liquid environments.
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