International Journal of Nanomedicine
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2024
·
IF 6.6
Jing Wang,Yanxiang Sang,Weijian Chen,Liang Cheng,Wenxiang Du,Hongjie Zhang,Benyan Zheng,Lei Song,Yuan Hu,Xiaopeng Ma
Introduction As an effective alternative choice to traditional mono-therapy, multifunctional nanoplatforms hold great promise for cancer therapy. Based on the strategies of Fenton-like reactions and reactive oxygen species (ROS)-mediated therapy, black phosphorus (BP) nanoplatform BP@Cu2O@L-Arg (BCL) co-assembly of cuprous oxide (Cu2O) and L-Arginine (L-Arg) nanoparticles was developed and evaluated for synergistic cascade breast cancer therapy.Methods Cu2O particles were generated in situ on the surface of the BP nanosheets, followed by L-Arg incorporation through electrostatic interactions. In vitro ROS/nitric oxide (NO) generation and glutathione (GSH) depletion were evaluated. In vitro and in vivo anti-cancer activity were also assessed. Finally, immune response of BCL under ultrasound was investigated.Results Cu2O was incorporated into BP to exhaust the overexpressed intracellular GSH in cancer cells via the Fenton reaction, thereby decreasing ROS consumption. Apart from being used as biocompatible carriers, BP nanoparticles served as sonosensitizers to produce excessive ROS under ultrasound irradiation. The enhanced ROS accumulation accelerated the oxidation of L-Arg, which further promoted NO generation for gas therapy. In vitro experiments revealed the outstanding therapeutic killing effects of BCL under ultrasound via mechanisms involving GSH deletion and excessive ROS and NO generation. In vivo studies have illustrated that the nanocomplex modified the immune response by promoting macrophage and CD8+ cell infiltration and inhibiting MDSC infiltration.Discussion BCL nanoparticles exhibited multifunctional characteristics for GSH depletion-induced ROS/NO generation, making a new multitherapy strategy for cascade breast cancer therapy.
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PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
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IF 7.7
Zhaocheng Zhang,Dongyang He,Yangjian Zhou,Edith Bai,Jiao Qu,Ya-nan Zhang
Black phosphorus nanosheets (BPNs)/CdS heterostructure was successfully synthesized via hydrothermal method . The experimental results indicated that BPNs modified the surface of CdS nanoparticles uniformly. Meanwhile, the BPNs/CdS heterostructure exhibited a distinguished high rate of photocatalytic activity for Tetrabromobisphenol A (TBBPA) degradation under visible light irradiation ( λ > 420 nm), the kinetic constant of TBBPA degradation reached 0.0261 min −1 was approximately 5.68 and 9.67 times higher than that of CdS and P25, respectively. Moreover, superoxide radical (•O 2 − ) is the main active component in the degradation process of TBBPA (the relative contribution is 91.57%). The photocatalytic mechanism and intermediates of the TBBPA was clarified, and a suitable model and pathway for the degradation of TBBPA were proposed. The results indicated that the toxicities of some intermediates were higher than the parent pollutant. This research provided an efficient approach by a novel photocatalyst for the removal of TBBPA from wastewater, and the appraisal methods for the latent risks from the intermediates were reported in this paper.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Chao-Jie Wang,Chen-Chen Guo,Le-Xi Zhang,Qi-Da Qiu,Quan-Wei Song,Yan-Yan Yin,Li-Jian Bie
Recently, lead-free halide perovskites have made outstanding achievements in gas/humidity sensors, yet their comprehensive performance still needs to be further optimized. Herein, CsCl@Cs 2 SnCl 6 composites with various CsCl contents were synthesized by in-situ pyrolysis of lead-free halide perovskite Cs 2 SnCl 6 micro-octahedra at different temperatures. After structural, morphological and optical characterization, CsCl@Cs 2 SnCl 6 composites were explored as humidity sensing materials for the first time. Compared with pristine and pyrolytic samples, Cs 2 SnCl 6 calcined at 300 °C (CSC-3) exhibited the best humidity sensing performance. The CSC-3 sensor has the characteristics of high response (1.6 × 10 5 ), small hysteresis (1.1 %), fast response speed (14 s) and good stability (30 d), enabling robust real-time touchless physiological humidity monitoring of human respiration and finger perspiration. In addition, the humidity sensing mechanism was discussed by complex impedance analysis, confirming the sensitization effect of CsCl on Cs 2 SnCl 6 perovskites. This study provides efficient CsCl@Cs 2 SnCl 6 composites for human body related humidity detection, moreover, gives new insights into electrolyte-sensitization strategy of lead-free halide perovskites for high-performance sensory devices.
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高影响因子
MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Xie Tianyu,Hu Wenbo,You Lin,Wang Xin
With cabozantinib as the precursor, a novel small molecule inhibitors of c-Met kinase with thieno [2,3- b ] pyridine as the scaffold were designed, synthesized and evaluated for their biological activity against A549, Hela and MCF-7 cell lines. The in vitro activities of 16 compounds were tested by MTT method with cabozantinib as control drug. Most compounds had moderate to strong inhibitory activities on cells. Among them, compound 10 had the strongest inhibitory activity, which was superior to the lead compound cabozantinib. Its IC 50 values for A549, Hela and MCF-7 cells were 0.005, 2.833 and 13.581 μM, respectively. The colony formation assay demonstrated that compound 10 significantly inhibited the colony formation of A549 cells and suppressed their growth in a concentration-dependent manner. The wound healing assay showed that compound 10 could effectively inhibit the migration of cancer cells compared to a blank control group. The AO/EB assay demonstrated that compound 10 possesses the capability to effectively trigger apoptosis in a concentration-dependent manner. The elementary structure–activity relationship, molecular docking and pharmacokinetics studies revealed the significance of thieno [2,3- b ] pyridine derivatives in anti-tumor activity. Graphical abstract
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高影响因子
SOLID STATE SCIENCES
·
2025
·
IF 3.3
Zhiwei Jiao,Aolong Sun,Xufang Zhang,Mulan Mu,Haoran Dong
Black phosphorus (BP) has attracted much attention for its excellent electrical and optical properties and its potential in field-effect transistors (FETs). In this work, BP doped with oxygen group elements (sulfur, selenium, and tellurium) was successfully synthesized using the chemical vapor transport method (CVT), and their optoelectronic properties were studied systematically. It is confirmed by X-ray diffraction (XRD) that BP crystals doped with the oxygen group elements exhibited high crystalline quality and yield. Changes in the absorption spectra and surface morphology indicated that doped BP demonstrated significantly enhanced environmental stability compared to undoped BP under prolonged air exposure. Among the doped samples, tellurium (Te)-doped BP showed the highest stability, with a degradation rate of only 9.91 % after 10 days. FETs based on doped BP were successfully fabricated, and their electrical performances were thoroughly evaluated. We found that the hole mobility of BP was dramatically improved by doping, and the selenium (Se)-doped BP possessed the highest hole mobility of 1684.24 cm 2 /V·s.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2025
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IF 6.2
Zhuoming Xu,Mohammad Nisar,Junze Zhang,Fu Li,Shuo Chen,Guangxing Liang,Jingting Luo,Zhuanghao Zheng,Yue-Xing Chen
SnSe, known for its low thermal conductivity and eco-friendly nature, is a potential medium-temperature thermoelectric (TE) material. However, its low carrier concentration has hindered achieving a high ZT value in n-type SnSe. This study reports the successful preparation of n-type polycrystalline SnSe 0.95-x (CuI) x samples via mechanical alloying and spark plasma sintering, which significantly increased carrier concentration and introduced point defects, enhancing phonon scattering and reducing lattice thermal conductivity. Density functional theory (DFT) calculations reveals that CuI doping altered the bandgap and band degeneracy, enhancing the density-of-states effective mass and benefiting the Seebeck coefficient. The ZT value for the x = 0.03 sample reached a peak of 0.74 at 773 K, marking a significant improvement over the undoped sample. This study presents an effective approach to optimize TE properties through CuI doping, offering a stable and effective method to enhance the thermoelectric performance of n-type polycrystalline SnSe.
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高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Liangyuan Qi,Wei Cai,Jiajun Li,Tianyang Cui,Liang Chen,Jing Gao,Bin Fei,Yuan Hu,Lei Song,Zhou Gui,Weiyi Xing
In the context of low-carbon and energy conservation initiatives, smart thermal management textiles for the human body, which operate without energy consumption and pollution, are gaining increased attention. However, conformal to human skin, ensuring the fire safety of these textiles remains a critical challenge for their practical application. Meanwhile, complicated and changed environments demand a high self-adaptation for designed textiles. This study introduces a dual-mode textile designed for freely switching radiative cooling (RC) and solar heating (SH). The textile is created by applying a high-white flame retardant and black phosphorus to both sides using a convenient scrape coating method. The combination of the cooling layer (90.0% solar reflectance and 95.9% infrared emissivity) and the heating layer (80% solar absorptivity) provides a comfortable thermal environment for the human body. Furthermore, the Janus coating, consisting of advanced flame retardants, synergistically enhances the textile's fire safety, confirmed by a limiting oxygen index of 28.0%, a reduction of 40.1% in peak value of heat release, and self-extinguishing properties. This research presents a simple and available approach to creating dual-mode smart textiles for maintaining a comfortable micro-environment towards changed seasons and weather, significantly contributing to the development of fire-safe personal thermal management technology.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Meiyang Hu,Jiyuan Yu,Wenhao Li,Yong Shuai,Liqiang Ai,Zhaolong Wang
Soft, flexible electronics is boosting the monitoring physiological data and assessing health conditions. However, their further practical utilization is limited due to the lack of intrinsic adhesion interfaces for mechanical deformation, self-healing capability against mechanical damages, and degradable properties for the waste electronic products treatment. Herein, we report the design concepts, materials, fabrication methods, and multifunctional applications of a new type of self-healing and degradable flexible health-detection electronics based on three-dimensional (3D) printable polymers and liquid metals. The 3D printable elastomer processes amazing self-healing efficiency (99.5 %), excellent mechanical properties (tensile strength: 3104 kPa), degradable, intrinsic adhesion, and so on. Polymer elastomers combined with the fluidity of Galinstan (GaInSn) allow the electronic devices to heal from fracture and restore electrical performance. Our polymer elastomers effectively solve the coordination problems between solid-state electronic devices and substrates, greatly improving the integration and functional complexity of the functional devices. The reliable connection between the GaInSn circuit, commercial components and elastomers can easily measure various physiological signals such as electrophysiology, temperature, and body motions. In addition, the commercial components and GaInSn circuits can be well recycled through ethanol to reduce pollution to the environment. The present 3D printed self-healing multifunctional electronics enables new opportunities for promising applications of flexible electronic devices.
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Nano Energy
·
2024
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IF 16.8
Jiangtao Guo,Liangfei Duan,Wen Yang,Qin Wang,Yunbo Zhang,Yong Zhang,Zhong Lin Wang,Peizhi Yang
Highly efficient and flexible power sources have always been the focus and goal in the field of wearable electronics. However, the existing wearable power sources are limited by their large size, high weight, electrolyte leakage, and poor mechanical compliance, which seriously hinders their practical applications. Herein, we propose a novel strategy to achieve and demonstrate a fabric-based high-performance wearable triboelectric nanogenerator (TENG) structure. The metals of gallium (Ga), bismuth (Bi), indium (In), and tin (Sn) are mixed according to specific mass ratios, and then they are transformed in liquid phase to form room-temperature multiphase soft metals of GaBiInSn. The material exhibits both metallic and fluidic properties, and possesses a characteristic of multiphase structure. The GaBiInSn material is directly deposited between polytetrafluoroethylene (PTFE) layers and nonwoven fabrics to establish multi-level conductive and frictional interfaces, creating charge transfer and solid-liquid hybrid dielectric layers. Therefore, the thin film-type triboelectric nanogenerators with a structure of PTFE/GaBiInSn/nonwoven fabric (LM-P-TENGs) is manufactured. The LM-P-TENGs can be integrated onto fabrics without compromising their breathability, comfortableness, and flexibility. Particularly, LM-P-TENGs efficiently convert the mechanical energy of human limb movements into sustainable electrical energy output. Under the human limb mechanical triggering conditions, LM-P-TENG achieves a champion specific open-circuit voltage up to 900 V, peak short-circuit current density of 43.3 mA/m 2 , and high power density of 12.56 W/m 2 . This work demonstrates the application potential of room-temperature multiphase soft materials in flexible wearable power sources, while introducing a novel power supply mode for wearable electronics. Additionally, the LM-P-TENGs also present applications in self-powered wearables, medical biosensing systems, human-machine interaction systems, near-eye display systems, etc. for the flexible electronics.
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高影响因子
ACS Applied Nano Materials
·
2024
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IF 5.3
Jiahui Wang,Shuai Zhang,Shufang Ma,Xiaodong Hao,Xiang Li,Bingshe Xu
Single-element phosphorus is an emerging class of two-dimensional (2D) semiconductor materials that has attracted extensive attention, particularly as a photocatalyst material. However, the inherent instability of elemental phosphorus causes insufficient surface activity for photocatalytic performance. In this study, the self-adsorption and clustering of metal ions on the surface of 2D materials were exploited to form Ag nanoparticle (NP)-modified black phosphorus (BP-Ag) heterostructures, which passivated the lone-pair electrons of phosphorus, promoted charge separation, and enhanced the photocatalytic activity. Consequently, the photocatalytic decomposition of methyl orange with BP-Ag was 99.05%, which was 1.87 times higher than that of pure black phosphorus. Within 3 h, the photocatalytic hydrogen evolution efficiency of BP modified by Ag NPs was about 20 times that of BP. In addition, the decomposition of dye molecules was investigated using active substances, such as hydroxyl radicals, superoxide radicals, and holes. In conclusion, the modification of metal NPs can greatly improve the stability and photocatalytic performance of single-element phosphorus materials, which has good application prospects for purifying dye wastewater and hydrogen evolution.
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Journal of Energy Storage
·
2024
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IF 8.9
Fangzhao Pang,Yongxin Wu,Xiaowei Liu,Xiang Chen,Lei Guo,Shuaibo Gao,Kaifa Du,Dihua Wang,Huayi Yin
The corrosion of positive grid alloys is important for determining the service life of lead-acid batteries (LABs). Herein, we prepared a series of PbCaSnAl-M (M = Mg, Sr, Ba) alloys by an induction melter and systematically investigated the effect of Mg, Sr and Ba on their microstructures and corrosion resistance. The results show that the average grain size of PbCaSnAl-Mg reduces from 14.56 μm to 11.96 μm, and the average grain size of PbCaSnAl-Sr and PbCaSnAl-Ba increases to 25.95 μm and 39.17 μm, respectively. The addition of Sr and Ba reduces the corrosion rate of PbCaSnAl alloys from 0.366 mg h −1 cm −2 to 0.258 and 0.289 mg h −1 cm −2 , respectively. The increase corrosion resistance is due to the Sr and Ba change the microstructures of the corrosion layer and improve the densification of the corrosion layer.
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高影响因子
CRYSTENGCOMM
·
2024
·Vol. 26
·期 10
·1418-1429
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IF 2.6
Jun Liao,Sihao Ye,Xupeng Zhu,Wenfeng Fu,Shuwen Xue,Jing Qi,Jun Zhang
Kesterite Cu2ZnSnS4 (CZTS) is considered as one of the most promising thin-film solar cell and photocatalytic materials; however, its efficiency in practical photoelectric applications is often seriously limited by the presence of large numbers of Cu–Zn antisite defects. Alloying with Ag to fabricate Ag-alloyed CZTS ((AgxCu1−x)2ZnSnS4, ACZTS) can reduce the Cu–Zn antisite defects in CZTS, but few research studies have been able to separately clarify the effect of Ag content and growth temperature on large-sized (AgxCu1−x)2ZnSnS4 single crystals. In this study, centimeter-scale high-quality ACZTS single crystals were synthesized via an Ag-alloying strategy by a molten salt method for the first time. The results showed that the synthesized ACZTS have a high-quality single-crystal structure. A series of experiments was performed using various characterization techniques and it was found that Ag content and growth temperature were crucial in determining the size of ACZTS single crystals obtained through a molten salt method and that the associated CZTS base generated at high temperature was beneficial for further ACZTS single-crystal growth in this high-temperature environment. The experimental results showed that the growth mechanism of ACZTS crystals prepared using a molten salt method could be attributed to a type of epitaxial growth process. Our study provides a promising approach for growing large-sized ACZTS single crystals with high quality that can provide a potential single-crystal platform for the study of light-emitting diodes, photocatalytic hydrogen production, etc.
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