MOLECULES
·
2024
·Vol. 29
·期 10
·2306
·
IF 4.2
Danyang Zhang,Xiaoshi He,Ting Wang,Yan Xing,Zhilong Xiu,Yongming Bao,Yuesheng Dong
Methylglyoxal-induced ROS elevation is the primary cause of neuronal damage. Metformin is a traditional hypoglycemic drug that has been reported to be beneficial to the nervous system. In this study, flavonoids were found to enhance the protective effect of metformin when added at a molar concentration of 0.5%. The structure–activity relationship (SAR) analysis indicated that ortho- substitution in the B ring, and the absence of double bonds between the 2 and 3 position combined with the gallate substitution with R configuration at the 3 position in the C ring played crucial roles in the synergistic effects, which could be beneficial for designing a combination of the compounds. Additionally, the mechanism study revealed that a typical flavonoid, EGCG, enhanced ROS scavenging and anti-apoptotic ability via the BCL2/Bax/Cyto C/Caspase-3 pathway, and synergistically inhibited the expression of GSK-3β, BACE-1, and APP in PC-12 cells when used in combination with metformin. The dose of metformin used in the combination was only 1/4 of the conventional dose when used alone. These results suggested that ROS-mediated apoptosis and the pathways related to amyloid plaques (Aβ) formation can be the targets for the synergistic neuroprotective effects of flavonoids and metformin.
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Wenyan Zhou,Jianbo Gan,Haiwen Li,Cunde Wang
A three-component reaction of 2-amino-4H-chromen-4-ones, aromatic aldehydes, and 4,4-dialkoxycyclohexa-2,5-dien-1-ones for the concise synthesis of chromeno[2,3-c]dihydroisoquinoline derivatives has been investigated. This reaction involved consecutive ZnCl2-promoted Micheal addition and intramolecular Friedel–Crafts alkylation. This synthetic protocol offered several advantages, including the readily accessible starting materials, good functional group tolerance, and simplicity of operation. Additionally, the structures of products obtained were determined based on X-ray diffraction studies.
研究领域:
有机化学
·
合成化学
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Journal of Materials Chemistry A
·
2026
·
IF 9.5
Ziyao Wang,Sijia Huo,Meichen Pan,Yihan Qiu,Ying Tian,Ying Zhou,Wei Yan,Wen Wang,Yu Zhou,Xiaoming Duan
Lithium metal is considered an ideal anode material owing to its high specific capacity, low density, and low redox potential, but its practical use in liquid systems is hindered by dendrite growth and interfacial instability. Solid-state electrolytes (SSEs) offer high thermal stability and mechanical strength, with Li 7 La 3 Zr 2 O 12 (LLZO) particularly attractive for its high ionic conductivity and wide electrochemical window. Semi-solid-state electrolytes (SSSEs), integrating the advantages of SSEs and liquid electrolytes (LEs), can be further enhanced by introducing porous solid frameworks. Such structures improve wettability and transport while providing mechanical support that suppresses dendrites, thereby achieving both high conductivity and structural safety. In this work, a two-dimensional porous solid-state skeleton model was established to investigate the influence of porosity on lithium-ion transport. The percolation threshold was determined to be 47.91% porosity, indicating the minimum connectivity required for efficient ion migration. Based on these insights, a graphite-template sacrificial method was employed to fabricate a highly interconnected porous Li 6.25 Ga 0.25 La 3 Zr 2 O 12 (LGLZO) framework (P G LF). The ionic conductivity of the P G LF-LiPF 6 SSSE reached 3.02×10 -3 S cm -1 at room temperature. The constructed Li/Li cell can be stably cycled for more than 1600 h at 0.5 mA cm -2 , and the capacity retention rate of the LFP/Li cell was 91.62% after 2000 cycles at 2 C. In addition, similar properties can be achieved by replacing the formwork material (charcoal powder). This work established a correlation between porosity and ion transport performance, providing a promising preparation method for high-performance lithium metal batteries (LMBs).
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BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Jin-Yu Liu,Xu-Ying Liu,Rui Liu,Fang Tang,Jing-Bo Yang,Quan Tang,Zhong-Lin Lu,Hai-Jun Qiao,Lan He
Two-photon fluorescent Acenaphtho[1,2- b ]quinoxaline (ANQ) and the hydrophilic di-(triazole-[12]aneN 3 ) moieties were combined through an alkyl chain ( ANQ-A-M ) or a β -hairpin motif with two aromatic γ -amino acid residues ( ANQ-H-M ) to explore their capabilities for in vitro and in vivo gene delivery and tracing. ANQ-A-M and ANQ-H-M showed the same maximum absorption at 420 nm, and their fluorescent intensities around 650 nm were varied in different solvents and became poor in the protic solvents. Gel electrophoresis assays indicated that both compounds completely retarded the migration of pDNA at 20 μM in the presence of DOPE . However, the DNA condensation with ANQ-H-M was not reversible, and the particle size of the corresponding complexes were larger indicated from the SEM and DLS measurements. In vitro transfections indicated ANQ-A-M /DOPE achieved Luciferase and GFP expressions were to be 7.9- and 5.7-fold of those by Lipo2000 in A549 cells respectively. However, ANQ-H-M showed very poor transfection efficiency in Luciferase expression. With the help of single/two-photon fluorescence imaging it clearly demonstrated that the successful transfection of ANQ-A-M was attributed to its cellular uptake, apparent lysosomal escape, and reversible release of DNA; and the poor transfection of ANQ-H-M was resulted from the aggregation of the DNA complexes which prevented them from the cellular uptake, and also the strong binding ability which is not easy to release DNA. ANQ-A-M /DOPE also exhibited robust gene silencing (83% knockdown of Luciferase) and GFP expression (2.47-fold higher) efficiency compared with Lipo2000 in A549 and zebrafish, respectively. The work demonstrated that the linkage structure between fluorescent and di(triazole-[12]aneN 3 ) played the important role for their gene delivery performance, and that ANQ-A-M represents a vector with the strong transfection efficiency in vitro and in vivo as well as the efficient real time bioimaging properties, which is potential for the development in biomedical research.
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MEDIATORS OF INFLAMMATION
·
2016
·
IF 3.418
Xin Liu,Ning Wang,Yuanfeng Zhu,Yongjun Yang,Xiaoli Chen,Shijun Fan,Qian Chen,Hong Zhou,Jiang Zheng
Activated macrophages are the primary sources of IL-12, a key cytokine bridging innate and adaptive immunity. However, macrophages produce low amounts of IL-12 upon stimulation and the underlying regulatory mechanism remains unclear. In this study, we found a new calcium-dependent mechanism that controlled IL-12 production in LPS-treated murine macrophages. First, LPS was demonstrated to induce extracellular calcium entry in murine peritoneal macrophages and inhibition of calcium influx resulted in marked enhancement in IL-12 production. Then, withdrawal of extracellular calcium was found to suppress CaMKK and AMPK activation triggered by LPS while chemical inhibition or genetic knockdown of these two kinases augmented LPS induced IL-12 production. AMPK activation increased the NAD+/NADH ratio and activated Sirtuin 1 (SIRT1), a NAD+-dependent deacetylating enzyme and negative regulator of inflammation. Chemical inhibitor or siRNA of SIRT1 enhanced IL-12 release while its agonist suppressed IL-12 production. Finally, it was found that SIRT1 selectively affected the transcriptional activity of NF-κB which thereby inhibited IL-12 production. Overall, our study demonstrates a new role of transmembrane calcium mobilization in immunity modulation such that inhibition of calcium influx leads to impaired activation of CaMKKβ-AMPK-SIRT1 signaling pathway which lifts restriction on NF-κB activation and results in enhanced IL-12 production.
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INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Nan Yu,Yingqiu Zhu,Tingting Wang,Ruihan Lin,Longhua Li,Guowei Yang,Xianglong Liu,Jianghua Li,Junli Wang
Currently, there is not much success in solving the molecular and crystal structures of long-chain metal alkanethiolate complexes [M(SCnH2n+1)m] at the atomic level. Taking Sb(SC16H33)3 (1) as an example, we herein disclose the structural characteristics of long-chain trivalent antimony(III) alkanethiolates Sb(SCnH2n+1)3 (n ≥ 12) by single-crystal X-ray crystallography. Specifically, the Sb atom is three-coordinated by alkanethiolate ligands and a slightly distorted triangular pyramid SbS3 core is formed owing to the unique intramolecular stereochemistry of three alkyl chains, namely, two of them almost parallel aligning and the third chain extending alone around the SbS3 core. We further determine the conformation, spatial orientation and packing density of alkyl chains in 1 along with a comparison to those in other long-chain crystalline systems, and reveal the roles of intermolecular van der Waals and Sb···S secondary interactions in molecular self-assembly, which enables 1 to be a layer-structured molecular crystal with a monoclinic P21/c unit cell. The band structures and the atomic orbital contributions to the valence band maximum and conduction band minimum for 1 have also been evaluated by DFT calculations and rationally correlated with its optical absorption property. This study will help understand and discover new structures and structure−property relations of long-chain chemical systems.
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CRYSTAL GROWTH & DESIGN
·
2019
·
IF 4.153
Xin-Rui Yang,He-Jie Lu,Si-Meng Zhang,Jing-Yi Yang,Xi Tang,Chun-Ya Pan,Ling Chen
Monofluorophosphate, being an important industry chemical, such as an additive in toothpaste, has been recently recognized as a new source of excellent deep-ultraviolet nonlinear optical materials with a desired large band gap and birefringence. To move this new material toward real application, an urgent demand is establishing an effective synthetic method owing to the easy loss of fluorine and serious corrosion of fluoride in the conventional methods. In this work, we establish a facile and green aqueous synthesis method overcoming the above-mentioned issues that can be generally applied to a wide range of monofluorophosphates by rational design either through acid–base neutralization or a metathesis reaction. To demonstrate such a method, we synthesized three types of representative monofluorophosphates that are crystallized with alkali metal cations (Na+, K+, Rb+, Cs+; 1–4), mixed cations (Li+NH4+, Na+NH4+, Li+K+, Na+K+; 5–8), and alkaline-earth metal cations (Mg2+, Ca2+, Sr2+, Ba2+; 9–12). Other than low cost and simple manipulation, the yield is pretty high (>80%). Thermal stabilities are also studied, nine of which are for the first time, revealing that [PO3F]2– usually stabilizes to 240–350 °C, whereas [PO3F]2– can stabilize to 650 °C in compounds without NH4+ or crystalline water.
研究领域:
材料科学
·
化学
·
光学材料
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Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 26
·20610-20619
·
IF 9.5
Yutong Xia,Gege Wang,Jing Wu,Xiaowei Chi,Yu Liu
Aqueous zinc metal batteries (AZMBs) have garnered significant attention owing to the inherent safety of aqueous electrolytes and the zinc anode's high theoretical specific capacity (820 mA h g−1). However, interfacial instability arising from rampant zinc dendrite growth and parasitic side reactions at the electrolyte/anode interface critically hinders practical implementation. Herein, we report an in situ solid electrolyte interphase (SEI) engineering strategy via frustrated Lewis pair (FLP)-mediated polymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS), where FLP catalysis is achieved through synergistic interactions between metallic zinc and Zn2+ cations at the electrolyte/anode interface. In contrast to conventional electrolyte additives that rely on physical adsorption or chemical passivation, the polymerized AMPS (PAMPS) establishes a dual-functional interface: (i) rapid Zn2+ ion transport channels through sulfonic acid groups, and (ii) robust chemical bonding with zinc via acrylamide moieties. This unique architecture enables simultaneous regulation of Zn2+ flux homogeneity and interfacial stabilization. Accordingly, Zn‖Zn symmetric cells with the AMPS-containing electrolyte show stable cycling for 6500 h at 1 mA cm−2. Notably, under extreme conditions (10 mA cm−2, 10 mA h cm−2), the PAMPS-enabled anode achieves a coulombic efficiency of 99.7% and an unprecedented cumulative areal capacity of 12 A h cm−2—a fourfold improvement over state-of-the-art benchmarks. Additionally, the MnO2‖Zn full cells with the AMPS-containing electrolyte exhibit a high specific capacity of 300 mA h g−1 at 500 mA g−1 and long cycling stability of 10 000 cycles at 1.58 A g−1. This work offers a facile, economical and effective approach for designing a high-performance aqueous zinc metal battery for practical applications.
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Microfluidics and Nanofluidics
·
2016
·Vol. 20
·期 7
·1-11
·
IF 2.537
Bridle H.,Morton J.,Cameron P.,Desmulliez M. P. Y.,Kersaudy-Kerhoas M.
Public engagement activities based on microfluidics are being increasingly delivered and reported on in the literature. Here, we evaluate the success of a novel approach to microfluidics outreach recently undertaken with schoolchildren aged 12–13. Unlike previous work, a problem-based learning approach was adopted whereby participants were asked to design and test a microfluidic system to solve a research challenge. Our aim was to develop understanding of microfluidics design, manufacture and operation via involvement in the full engineering cycle of a product, from ideas to design, and from fabrication to test. This article demonstrates that problem-based learning is a successful method of public engagement with microfluidics, and we share our best practice, including activity design, supporting material produced for the project and an example case study detailing the types of chips produced by the participants. Furthermore, following an evaluation of the activity by all participants recommendations for delivery of this, or similar, activities are provided.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yan Qiao,Menglin Wang,Erling Guo,Ke Wang,Ling Ma,Kaoqi Lian
This study aimed to design and synthesize a novel adsorbent Fe 3 O 4 @SiO 2 @MPA-TAPA-COF material for the first time and used as an adsorbent of MSPE. It had significant potential for the pretreatment of trace analytes. The MSPE was coupled with ultra performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) for the rapid extraction and detection of 12 sulfonamides (SAs) from water and milk samples for the first time. Several experimental parameters were optimized, including adsorbent dosage and the effects of pH, ionic strength, adsorption time, and desorption conditions. Under the optimized pretreatment and instrumental conditions, good linearity of 0.1–100 μg·L −1 with a correlation coefficient 0.9994–0.9999, low limits of detection (0.004–0.044 μg·L −1 ) and limits of quantitation (0.013–0.136 μg·L −1 ) were obtained. Moreover, the recoveries of sulfonamides in water and milk samples were in the range of 60.88 %-102.94 %, and the relative standard deviations not exceeding 9.62 %. Finally, the magnetic Fe 3 O 4 @SiO 2 @MPA-TAPA-COF material possessed the magnetic separation and high adsorption affinity for extracting SAs from real samples. This study holds great significance in enhancing the monitoring of SAs drug residues in water and milk.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Wan Wang,Hang Shang,Jinzhe Li,Yue Ma,Cong Xu,Jiage Ma,Juncai Hou,Zhanmei Jiang
Polyphenols have received attention as dietary supplements for the relief of alcoholic liver disease (ALD) due to various bioactivities. Ethanol-induced rat small intestinal epithelial cell 6 (IEC-6) and alpha mouse liver 12 (AML-12) cell models were pretreated with four dietary polyphenols with different structures to explore their effects on cytotoxicity and potential protective mechanisms. The results showed that polyphenols had potential functions to inhibit ethanol-induced AML-12 and IEC-6 cell damage and oxidative stress, and restore ethanol-induced IEC-6 permeability and tight junction gene expression. Especially, dihydromyricetin (DMY) had the best protective effect on ethanol-induced cytotoxicity, followed by apigenin (API). Western blot results showed that DMY and API had the best ability to inhibit CYP2E1 and Keap1, and promote nuclear translocation of Nrf2, which might be the potential mechanism by which DMY and API attenuate ethanol-induced cytotoxicity. Moreover, the molecular docking results predicted that DMY and API could bind more tightly to the amino acid residues of CYP2E1 and Keap1, which might be one of the inhibitory modes of dietary polyphenols on CYP2E1 and Keap1. This study provided a rationale for the subsequent protective effect of dietary polyphenols on alcohol-induced liver injury in animal models and provided new clues on bioactive components for ALD-protection based on the gut-liver axis.
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DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 24
·8122-8135
·
IF 4.174
Jialin Yu,Qi Gao,Lijuan Zhang,Yunshan Zhou,Yuxu Zhong,Jianbo Yin,Yuanyuan Zhou,Fangsheng Tao,Yong'an Wang
ε-[Al13O4(OH)24(H2O)12]7+, which shares similarity with the phosphotriesterase active site ZnII–OH–ZnII, was specially chosen to interact with the cluster α-PMo10V2O405− to form a new three-dimensional intercluster, which crystallized in the monoclinic space group P21/m with Z = 2, for the decontamination of chemical warfare agents. The experimental results showed that 50 mg of the compound decontaminated 96.4% (within 120 min) and 99.5% (within 40 min) of sulfur mustard (HD) (4 μL) and soman (GD) (4 μL), respectively, in ambient conditions. The decontamination processes followed first-order reaction kinetics with a rate constant and half-life of 0.01234 min−1 and 56.15 min for HD and 0.1198 min−1 and 5.78 min for GD, respectively. It was concluded that the α-PMo10V2O405− moiety was responsible for the catalytic oxidation of HD into non-toxic sulfoxide, while the ε-[Al13O4(OH)24(H2O)12]7+ moiety was responsible for the catalytic hydrolysis of HD and GD into nontoxic hydrolysates. Besides, the compound showed notable efficacy for the decontamination of HD on guinea pig skin and of GD on Kunming mouse skin, indicating high potential for use in human skin protection and treatment.
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