FASEB JOURNAL
·
2025
·Vol. 39
·期 11
·e70691
·
IF 4.2
Jianfeng Dong,Wen Chen,Shujuan Chang,Nana Liu,Wei Zhu,Li Ma,Jing Qiao,Yuhang Wang,Zhiyong Mao,Jiuhong Kang
Infants born with fetal growth restriction (FGR) are at increased risk of cognitive impairment in later life, yet the underlying mechanisms remain poorly understood, hampering clinical treatment development. Utilizing a FGR mouse model induced by prenatal dexamethasone overexposure, we observed impaired hippocampal dendritic maturation, synaptic plasticity, and hippocampal‐dependent learning and memory in FGR mice. FGR induces DNA hypomethylation in the hippocampal H19/Igf2 imprinted control region, resulting in reduced expression of Igf2, a key metabolic modulator previously implicated in FGR‐related placental and fetal growth. Using a neuron‐specific knockout mouse model, we validated the necessity of Igf2 for dendritic maturation and synaptic plasticity. Importantly, overexpression of Igf2 in the hippocampus of FGR mice improved synaptic plasticity and enhanced learning and memory abilities. Furthermore, running exercise ameliorated DNA hypomethylation driving Igf2 expression levels and counteracted synaptic and cognitive deficits in FGR mice through hippocampal Igf2. These findings unveil a molecular mechanism linking exercise‐induced epigenetic changes in the imprinting gene Igf2 to enhanced synaptic plasticity, ultimately leading to improved cognition in FGR offspring. Our results identify Igf2 as a potential mediator bridging metabolic dysfunction and cognitive impairments in FGR offspring and also propose that exercise represents a promising nondrug intervention for FGR‐related cognitive disorders. Fetal growth restriction (FGR) induces hippocampal DNA hypomethylation and loss of Igf2, contributing to impaired synaptic plasticity and cognitive deficits in offspring. Exercise restores Igf2 levels and rescues these impairments, suggesting a potential therapeutic strategy for FGR‐related cognitive dysfunction.
研究领域:
神经科学
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分子生物学
·
医学
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DOI
PubMed
高影响因子
RESPIRATORY RESEARCH
·
2023
·Vol. 24
·期 1
·1-19
·
IF 5.8
Liu Lin,Fan Haiyang,Li Liang,Fan Yunping
Background Type 2 diabetes mellitus (T2DM) is widely prevalent worldwide, and respiratory tract infections (RTIs) have become the primary cause of death for T2DM patients who develop concurrent infections. Among these, Pseudomonas aeruginosa infection has been found to exhibit a high mortality rate and poor prognosis and is frequently observed in bacterial infections that are concurrent with COVID-19. Studies have suggested that acarbose can be used to treat T2DM and reduce inflammation. Our objective was to explore the effect of acarbose on P. aeruginosa RTI in T2DM individuals and elucidate its underlying mechanism. Methods High-fat diet (HFD) induction and P. aeruginosa inhalation were used to establish a RTI model in T2DM mice. The effect and mechanism of acarbose administered by gavage on P. aeruginosa RTI were investigated in T2DM and nondiabetic mice using survival curves, pathological examination, and transcriptomics. Results We found that P. aeruginosa RTI was more severe in T2DM mice than in nondiabetic individuals, which could be attributed to the activation of the NF-κB and TREM-1 signaling pathways. When acarbose alleviated P. aeruginosa RTI in T2DM mice, both HIF-1α and NF-κB signaling pathways were inhibited. Furthermore, inhibition of the calcium ion signaling pathway and NF-κB signaling pathway contributed to the attenuation of P. aeruginosa RTI by acarbose in nondiabetic mice. Conclusions This study confirmed the attenuating effect of acarbose on P. aeruginosa RTIs in T2DM and nondiabetic mice and investigated its mechanism, providing novel support for its clinical application in related diseases.
研究领域:
药理学
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微生物学
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传染病学
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糖尿病学
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DOI
PubMed
高影响因子
ChemSusChem
·
2022
·Vol. 15
·期 13
·e202200092
·
IF 9.14
Xiaohong Hu,Zhijian Li,Haiyong Wang,Haosheng Xin,Song Li,Chenguang Wang,Longlong Ma,Qiying Liu
Graphical Ring-opening : Au/ZrO 2 catalysts with excellent ring-opening hydrogenolysis ability are developed for the selective hydrogenolysis of 5-hydroxymethylfurfural and furfural to produce 2-hexanol and pentanol (1-pentanol and 2-pentanol). The Au-O−Zr interfaces with Lewis acid and metal functionalities play key roles for obtaining the target products with high yield. 2-Hexanol (2-HOL) is a versatile biomass-derived platform molecule for synthesis of liquid transportation fuels, lubricants, or detergents. Herein, a one-step preparation of 2-HOL using 5-hydroxymethylfurfural (HMF) as a substrate was reported for the first time. Several Au-based catalysts supported on different metal oxides were prepared to explore the relationship between carrier and catalytic activity. The results showed that the highest 2-HOL yield of 65.8 % was obtained at complete HMF conversion over the 5 %Au/ZrO 2 catalyst. The 5 %Au/ZrO 2 catalyst exhibited excellent durability after five consecutive recycling runs, while confirming its remarkable ring-opening hydrogenolysis on other biomass-derived furanics, furfural, with a total yield of 1-pentanol and 2-pentanol of 67.4 %. The distinguished ring-opening hydrogenolysis performance of the Au/ZrO 2 catalyst originated from a synergistic effect between the interfacial Au-O-Zr oxygen vacancies-induced Lewis acidic sites (activating C−OH/C=O bonds) and metallic Au (activating H 2 ). This work provides a possibility for producing 2-HOL from HMF with high yield, expanding the sustainable application of lignocellulosic biomass.
研究领域:
催化
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化学工程
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可再生能源
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绿色化学
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DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2019
·Vol. 150
·期 1
·178-184
·
IF 2.372
Li Zhi-Xin,Wei Xian-Yong,Yang Zheng,Zhang Min,Meng Xing-Long,Niu Shuo,Zhang Di,Zong Zhi-Min
Abstract Highly selective hydrogenation of furfural to furan-2-ylmethanol (FM) in isopropanol was achieved over a novel magnetic Cu–Co/C derived from zeolitic imidazolate frameworks prepared by galvanic replacement reaction. Furfural conversion and FM selectivity (FMS) are 100% and 97.2%, respectively, at 200 °C. FMS was held around 95% after 5-times recycle of the Cu–Co/C. In addition, cinnamaldehyde was completely converted with 96.8% of phenylpropanol selectivity over the Cu–Co/C at 150 °C. Graphic Abstract
研究领域:
化学工程
·
催化材料科学
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DOI
高影响因子
Food Analytical Methods
·
2022
·Vol. 15
·期 9
·2479-2486
·
IF 3.498
Zhang Shengnan,Li Zhibo,Qi Yanxia,Yu Pei,Zhao Qiancheng
The determination of 2-acetyl-1-pyrroline (2-AP), which is an important flavour compound of crustaceans and has a low odour threshold of 0.05 μg/L in water, is still a challenge due to the instability and trace levels of 2-AP in food samples. In this study, 2-AP was trapped by o-phenylenediamine and subsequently purified by the dispersive solid-phase extraction and dispersive liquid–liquid microextraction (DSPE-DLLME) methods for HPLC–UV analysis. The developed method was simple, fast and sensitive for the determination of 2-AP in shrimp. Under the optimized DSPE-DLLME conditions, the developed method exhibited excellent linearity ( R 2 = 0.996) and a low limit of detection (LOD, 1.77 μg/kg) and limit of quantitation (LOQ, 5.33 μg/kg). The recoveries of 2-AP in shrimp ranged from 86.3 to 101.6%. In addition, the developed method was applied to detect 2-AP levels in baked shrimp (ranging from 5.6 to 12.6 μg/kg), indicating that the formation of 2-AP could be observed in thermally treated shrimp depending on heating temperature and time. In summary, the developed method has potential application for the trace determination of 2-AP in shrimp due to its convenience and high sensitivity.
研究领域:
食品科学
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分析化学
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DOI
高影响因子
ACS Applied Energy Materials
·
2025
·
IF 5.5
Huanjun Su,Weili Shi,Yumeng Zhang,Ying Lin,Yani Liu
Mg3Sb2 Zintl compounds have emerged as promising thermoelectric materials due to their favorable electronic structures and low lattice thermal conductivity. However, strong carrier scattering, including ionized impurity and grain boundary scattering, suppresses mobility and limits the power factor. This study reveals that Zn doping plays a crucial role in tuning carrier scattering mechanisms in n-type Mg3(Sb,Bi)2. The substitution of Mg with Zn weakens ionized impurity scattering, facilitating charge transport and increasing carrier mobility from ∼72 to ∼135 cm2 V–1 s–1. As a result, a high power factor of ∼2089 μW m–1 K–2 is achieved at 573 K in Mg3.155Zn0.045Sb1.5Bi0.49Te0.01. Furthermore, Zn incorporation introduces localized lattice distortions and promotes the formation of high-density dislocations, which intensify phonon scattering and significantly suppress lattice thermal conductivity to ∼0.54 W m–1 K–1 at 773 K. These synergistic enhancements contribute to an optimized thermoelectric performance, yielding a peak ZT of 1.71 at 773 K and an average ZT of 1.21. The estimated conversion efficiency reaches 13% under a 470 K temperature gradient, highlighting Zn doping as an effective strategy for advancing Mg3(Sb,Bi)2-based thermoelectric materials toward high-temperature energy harvesting applications.
研究领域:
材料科学
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能源材料
·
物理化学
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Jing Tang,Guangrong Zou,Chen Chen,Jing Ren,Fang Wang,Zilin Chen
The identification of formylpyrimidines in DNA is crucial for a better understanding of epigenetics. Although many techniques have been explored to detect their content, more accurate methods of formylpyrimidine determination are still required due to the relatively lower sensitivity or lack of selectivity in current methods. Herein, an electrochemical method based on the covalent bonding of the azido derivative of (2-benzimidazolyl) acetonitrile (azi-BIAN) and the aldehyde group of 5-formyluracil (5fU) was proposed for the selective detection of 5fU in the presence of 5-formylcytosine (5fC) and apyrimidinic (AP) sites. Target DNA containing 5fU was first treated with azi-BIAN and then incubated with DBCO-PEG4-Biotin to introduce a biotin group by copper-free click chemistry. Next, the sulfhydryl group was attached to the 5′ end of above DNA through T4 polynucleotide kinase-catalyzed reaction. Subsequently, the labeled DNA was assembled onto the AuNPs-modified glassy carbon electrode (AuNPs/GCE) through Au–S bonds, and the streptavidin–horseradish peroxidase conjugate (SA-HRP) was further immobilized onto the surface of the above electrode by specific recognition between biotin and streptavidin. Finally, HRP catalyzed hydroquinone oxidation to benzoquinone to enhance the current signal, which was related to the amount of 5fU in nucleic acids. This method demonstrated a good linear relationship with 5fU concentrations ranging from 0.1 to 10 nM. Moreover, the level of 5fU in γ-irradiated nucleic acids was also successfully detected, indicating that the combination of molecule-depended chemical recognition and electrochemical sensing is a promising method for the selective and sensitive detection of 5fU.
研究领域:
生物化学
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分析化学
·
分子生物学
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DOI
PubMed
高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2025
·Vol. 41
·期 11
·451
·
IF 4.2
Zhong Chenggang,Ding Weijian,Lin Haoran,Huang Jin
Cellobiose-2-epimerase is considered an ideal biocatalyst for the strictly thermodynamic synthesis of lactulose. However, its poor thermolability limits its industrial application. Herein, we successfully developed a novel thermostable cellobiose-2-epimerase for improving lactulose biosynthesis from lactose. The A242L mutant, derived from Dictyoglomus thermophilum (DiCE), was generated using semi-rational mutagenesis after computer-aided design via the FireProt web server. After systematic enzymatic characterization and optimization, A242L mutant exhibited a 123.5% T 1/2 in thermostability at 80 °C relative to the wild-type enzyme, and the E. coli BL21/pET28a(+)-A242L mutant harvested a maximal lactulose yield of 64.52%, representing a 51.38% improvement at a substrate concentration of 200 g/L for the whole-cell biotransformation reaction conducted at pH 7.0 and 80 °C for 4 h. Molecular docking and molecular dynamics (MD) simulation results indicated that the enhanced thermostability of the enzyme was closely related to the structure and rigidity of its flexible loops. The enhanced thermostability allows A242L to tolerate higher temperatures for extended periods, driving the reaction towards lactulose production, which is suitable for industrial lactulose production under harsh conditions.
研究领域:
酶工程
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工业生物技术
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生物化学
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分子生物学
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生物催化
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2019
·Vol. 26
·期 12
·1-12
·
IF 1.53
Jiao Yang,Chen Guofei,Zhou Haijun,Zhang Feng,Chen Xiaoqi,Li Yantao,Xiao Xueshan,Fang Xingzhong
A series of poly(benzimidazole-imide)s (PBIPIs) derived from different dianhydrides and 2-(3-aminophenyl)-5-aminobenzimidazole ( m -BIA) were synthesized via thermal imidization to form flexible films. This series of PBIPIs showed great T g s ranging from 296 to 484 °C, excellent thermal stability performed in 5% weight loss temperatures ( T d5% s) of 502–529 °C in N 2 and good mechanical properties (tensile strengths of 89–127 MPa, tensile moduli of 2.9–4.1 GPa and elongations at break of 3.9–6.9%). Compared with PIs derived from 6-amino-2-(4-(4-aminophenoxy)phenyl)-1H-benzimidazole ( p -BIODA), m -BIA based PBIPI films exhibited higher T g , and better solubility. Besides, the thermoplastic PBIPI resin (PI-6-PA) derived from 2,2-bis[4-(3,4-dicarboxyphenoxy)phenyl]propane dianhydride (BPADA) and m -BIA exhibited good melt processability with high T g of 273 °C, melt flow index (MFI) of 7.76 g/10 min, minimum complex viscosity of 11.9 × 10 3 Pa·s at 402 °C and low melt viscosity ratio of 2.46 at 400 °C.
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DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2018
·Vol. 124
·期 7
·1-11
·
IF 1.604
Yao Hanyu,Shen Honglie,Tang Quntao,Yang Nannan,Zhai Zihao,Li Yufang
NaY(WO 4 ) 2 : Er 3+ phosphors with various doping concentrations of [Er 3+ ]/([Er 3+ ]+[Y 3+ ]) (0, 5, 7, 10, 12, 15%) were successfully synthesized by high-temperature solid-state reaction. X-ray diffraction (XRD) measurement demonstrated the presence of tetragonal-phase NaY(WO 4 ) 2 phosphors and Fourier transform infrared (FT-IR) spectra showed a strong υ 3 stretching vibration mode of WO 4 2− , indicating the good crystallization of the phosphors. Well-crystallized phosphors showed a fine morphology with particle sizes of 0.8–10 µm by scanning electron microscope (SEM). Under excitation of 980 nm laser, Er 3+ -doped phosphors exhibited strong green emissions centered at 527 and 549 nm in addition to a 665 nm emission band in the red region, which were assigned to the 2 H 11/2 , 4 S 3/2 → 4 I 15/2 and 4 F 9/2 → 4 I 15/2 transitions, respectively. When the doping concentration was 10%, the intensities of green and red emissions reached their maximum values, stronger than that in 5% Er 3+ doped one by 13 times. The double-logarithm plot of the upconversion (UC) emission intensity to the excitation power for different Er 3+ doping concentrations depicted that at least two infrared photons were involved for every emitted green and red photon. UC emission intensity changing with temperature displayed different trends for the phosphors with different Er 3+ concentrations. The enhancement for green emission band centered on 549 nm could reach 50 times at 30 K in sample with 5% Er 3+ concentration. Under excitation by 355 nm laser, all the phosphors showed a strong PL emission band at 430 nm, while green luminescence band locating from 540 to 570 nm was only observed in 7, 10, and 12% Er 3+ -doped phosphors, which was ascribed to 4 S 3/2 → 4 I 15/2 transition.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 10
·1-12
·
IF 2.02
Tian Fei,Niu Libo,Chen Bo,Gao Xuejia,Lan Xingwang,Huo Li,Bai Guoyi
A novel magnetic core-shell nanocomposite Fe 3 O 4 @Chitosan@ZnO was successfully prepared by in situ chemical precipitation method. It has a clear core-shell structure with magnetic Fe 3 O 4 (about 160 nm in diameter) as core, chitosan as the inner shell, and ZnO as the outer shell, as demonstrated by the transmission electron microscopy and the related elemental mapping. Moreover, this nanocomposite has high magnetization (43.6 emu g −1 ) so that it can be easily separated from the reaction mixture within 4 s by an external magnetic field. The introduction of the natural chitosan shell, instead of the conventional SiO 2 shell, and its combination with the active ZnO ensures this novel nanocomposite green character and good catalytic performance in the synthesis of 2-benzimidazoles with moderate to excellent isolated yields at room temperature. Notably, it can be recycled seven times without appreciable loss of its initial catalytic activity, demonstrating its good stability and making it an attractive candidate for the green synthesis of 2-benzimidazoles.
A novel magnetic core-shell nanocomposite exhibited high activity and good stability in the green synthesis of 2-benzimidazoles under mild reaction conditions.
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Tong Zhou,Qingqing Chai,Man Zhang,Heping Cui,Ahmad Mohammad,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
Exogenous xylose (Xyl) could promote 2-furfural formation but inhibit pyrazines generation during its co-heating with alanine (Ala)-Xyl Amadori rearrangement product (AX-ARP). The activation energy of AX-ARP formation from Ala and Xyl was considerably lower than that of pyrazine formation from Ala and glyoxal (GO). Accordingly, the preferential interaction of exogenous Xyl with regenerated Ala triggered a continuous cycle of consumption and regeneration of Ala in AX-ARP-Xyl model. In this way, functioning as a catalyst, regenerated Ala facilitated the continuous conversion of AX-ARP into deoxyxylosones (DXs). However, exogenous Xyl accelerated the pH drop during the thermal treatment of AX-ARP, which favored the conversion of DXs into 2-furfural while limiting the transformation of their α-dicarbonyl fragments into pyrazines. Model reactions of AX-ARP-[ 13 C 5 -Xyl] further confirmed that exogenous Xyl was progressively converted into 2-furfural, while its downstream products, such as GO and methylglyoxal (MGO), did not exhibit an enhanced tendency to form pyrazines.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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