JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 9
·e70449
·
IF 2.8
Dai Lizhi,Yu Tong,Wang Jingxuan,Li Youchong,Cao Zheyuan,Xiao Jianhua
2-ethylhexyl diphenyl phosphate (EHDPHP), a ubiquitous organic phosphorus flame retardant, is extensively employed in food packaging, flame retardancy applications, and other industrial processes as a crucial chemical. However, recent discoveries have underscored its diverse toxic effects, posing a severe potential threat to biological health. Skeletal muscle, vital for locomotion, relies heavily on proper differentiation during development and maintenance for strength and functionality. This study investigated the impact of EHDPHP on skeletal muscle differentiation by culturing C2C12 cells with varying concentrations of EHDPHP during induction of differentiation, as well as constructing a mouse muscle injury repair model through oral administration of 30 μg/kg EHDPHP for 7 weeks. Exposure to EHDPHP was found to impede skeletal muscle differentiation in mice. Utilizing techniques such as western blot analysis, RNA-seq, and qRT-PCR, our preliminary analysis revealed that low concentrations of EHDPHP inhibited the expression of ACTC1, subsequently suppressing MyoG and MYH2 expression levels, thereby hindering C2C12 myoblast differentiation. Furthermore, EHDPHP exposure disrupted the repair process of muscle injury in mice and compromised the integrity of the repaired tissue. In conclusion, these findings elucidate the detrimental effects of EHDPHP exposure on muscle differentiation, uncovering its muscle toxicity.
研究领域:
毒理学
·
分子生物学
·
细胞生物学
·
药理学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Imran Mahmood Khan,Sen Zhao,Sobia Niazi,Ali Mohsin,Muhammad Shoaib,Nuo Duan,Shijia Wu,Zhouping Wang
T-2 is a trichthecenes mycotoxin responsible for severe food poisoning and toxic influences in humans and animals. Therefore, a rapid and sensitive detection of T-2 is an urgent need to protect the public health mainly caused by the consumption of contaminated agricultural products. Herein, we have prepared one pot synthesis of aptamer functionalized silver nanoclusters (apt-AgNCs) for fluorescent detection of T-2 that relies on novel fluorescence resonance energy transfer (FRET). Apt-AgNCs, act as energy donor, were applied as fluorescent sensing probe whose fluorescence was quenched by MoS 2 employed as fluorescent acceptor. Introduction of target in proposed bioassay leads to desorption of Apt-AgNCs from MoS 2 , and recovery of fluorescence in a toxin concentration dependent-manner. A dynamic quantification range was 0.005–500 ng mL −1 while the LOD was 0.93 pg mL −1 . Spiking analysis reveals the efficiency and robustness of the developed assembly, with recovery percentages ranged from 89.46% to 102.08% and 90.41% to 107.75% in maize and wheat samples, respectively. The results were cross-verified using standard commercial T-2 EISA kit. In conclusion, developed bioassay may find good utility in testing for risk assessment of T-2 toxin.
研究领域:
食品安全
·
生物传感
·
毒理学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2020
·Vol. 22
·期 2
·1-12
·
IF 2.132
Sun Xueying,Li Siqi,Liu Rongmei,Sun Xiulun,Liu Xinjie,Li Anran,Li Wen
In this work, we designed a simple hydrothermal synthetic method for a ZnCo-PBA@α-Co(OH) 2 nanosphere@nanosheet material with good electrochemical properties. The obtained material had a specific capacitance of 423.92 F g −1 at 1 A g −1 and a cycling retention ratio of 78.48% after 1000 cycles at 5 A g −1 . A hybrid supercapacitor device (ZnCo-PBA@α-Co(OH) 2 //AC) assembled with activated carbon as the negative electrode had a specific capacitance of 122.4 F g −1 at 1 A g −1 , a cycling retention rate of 73.53% after 5000 cycles at 5 A g −1 , and a very high energy density of 49.13 Wh kg −1 at power density of 1734.0 W kg −1 . The significantly improved electrochemical performance of the ZnCo-PBA@α-Co(OH) 2 nanocomposites can be attributed to the positive synergistic effects of the porous structure of the PBA material and the large specific surface area of the α-Co(OH) 2 nanosheets, on the ion permeability and number of active sites in the reinforcing material; thus, this composite is a potential material for use in future energy storage systems.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
PLASMA SCIENCE & TECHNOLOGY
·
2025
·
IF 1.8
Ruiting Jian,Qirui Zou,Jianjun Yan,Bowen Liu,Lijun Sang,Zhongwei Liu
Cr(VI), a hazardous heavy metal pollutant found in wastewater, exerts detrimental effects on biological system and the human body. Efficient photocatalytic reduction of Cr(VI) to Cr(III) using high-performance materials offers a viable approach for chromium decontamination. In the current work, the defective UiO-66-(OH)2 with enhanced photocatalytic activity was developed by the plasma treatment. These defects not only triggered an expansion in mesoporous domains and increased the BET surface area of the UiO-66-(OH)2 system, thereby exposing more adsorption and photocatalytically active sites, but also created additional electron migration pathways, enhancing the separation of photogenerated e-/h+ pairs. When subjected to an operating power of 15 W, chamber pressure at 20 Pa, and a 300-second treatment period, UiO-66-(OH)2 exhibited a removal efficiency of 83 %. This work explored a novel way for the construction of the defective MOFs and broadened the utilizationation of MOFs in the fields of photoreduction of heavy metal ions in water.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Yaoguo Shen,Longjie Huang,Zhifeng Wang,Yingwu Zhou,XiaoLing Xue,Hong Lin,Renwen Yan,Sangen Zhao,Junhua Luo
SO4 tetrahedral groups have weak polarization anisotropy, which thus results in the small birefringence of sulfates. Here, we report new sulfate CsY(SO4)2·4H2O with unprecedented birefringence among deep-ultraviolet (deep-UV) sulfates. Its single crystal (10 mm × 3.5 mm × 1.5 mm) was simply grown by an aqueous solution evaporation technique, and it features a rare layered structure composed of YO9 polyhedra, SO4 tetrahedra, and H2O molecules. Interestingly, each SO4 group donates two oxygen atoms to edge-share with one adjacent YO9 polyhedron and thus causes severe distortion of these groups. The characteristic edge-sharing mode gives CsY(SO4)2·4H2O a large birefringence of ∼0.045@546 nm, which is the maximum among deep-UV sulfates and phosphates with similar non-π-conjugated anionic groups. The ultraviolet–visible-near-infrared diffuse reflection and transmission spectra, infrared spectrum, thermal stability, and theoretical calculations are also presented. The fascinating results will improve our understanding of sulfates and may provide useful insights into the exploration of deep-UV sulfates with large birefringence.
研究领域:
材料科学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Yu-Jie Shen,Li-Feng Fang,Yan Yan,Jia-Jia Yuan,Zhi-Qiang Gan,Xiu-Zhen Wei,Bao-Ku Zhu
A metal-organic composite membrane with sub-2 nm pores was developed via interfacial coordination reaction in biphasic systems for the first time. Herein, tannic acid (TA) was dissolved in water, as aqueous phase; iron(III) acetylacetonate (Fe(acac) 3 ), used as Fe(III) source, was dissolved in n -hexane as organic phase. A detailed study was conducted to obtain the defect-free TA-Fe(III) separation layer, including the salt concentration in aqueous solution, pH of the aqueous solution and the ratio of TA to Fe(acac) 3 . The results indicated that the defect-free TA-Fe(III) composite membrane formed when the tris-complex (TA 3 -Fe(III)) was achieved. The optimal condition for preparing TA-Fe(III) composite membrane was using aqueous solution containing 0.4 M NaCl at pH = 6 with the ratio of TA to Fe(acac) 3 of 10. Different from the typical separation layer formed on the membrane surface by interfacial polymerization, the TA-Fe(III) separation layer was formed in the pores of the substrate, which is attributed to the higher diffusion coefficient of Fe(acac) 3 from organic phase to aqueous phase. This work provided a novel strategy to fabricate metal-organic composite membrane with sub-2 nm pores; meanwhile, the new-prepared membrane shows a high Na 2 SO 4 rejection of 97.3% with the water permeance of 8.6 L m −2 h −1 bar −1 , and a high VB 12 rejection of 97.6%, indicating an excellent ion/molecule separation performance.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2015
·
IF 2.912
Jun Huang,Haihua Xie,Sheng Hu,Tian Xie,Jinyan Gong,Chengjun Jiang,Qing Ge,Yuanfeng Wu,Shiwang Liu,Yanli Cui,Jianwei Mao,Lehe Mei
Chitosan was prepared by alkaline N-deacetylation of β-chitin from squid pens, and N-carboxyethylated derivatives (N-CECS) with different degrees of substitution (DS) were synthesized. The carboxyethylation of the polysaccharide was identified by Fourier transform infrared, 1H and 13C nuclear magnetic resonance (NMR), and X-ray diffraction analyses. The DS of the derivatives was calculated by 1H NMR and elemental analysis. All three N-CECS samples showed good water solubility at pH > 6.5. The antioxidant properties and bile acid binding capacity of the derivatives were studied in vitro. The highest bile acid binding capacity of all N-CECS reached 36.9 mg/g, which was 2.6-fold higher than that of chitosan. N-CECS showed a stronger scavenging effect on 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical ability, and EC50 values were below 2 mg/mL. The scavenging ability of N-CECS against superoxide radicals correlated well with the DS and concentration of N-CECS. These results indicated that N-carboxyethylation is a possible approach to prepare chitosan derivatives with desirable in vitro biochemical properties.
研究领域:
生物化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Bei-Bei Zhang,Ping Liu,Hao-Ran Wang,Yan-Yang Li,Lin Zhang,Qing-Chao Liu,Zhong-Jun Li,Hong-Chang Yao
Developing efficient photocatalysts for solar-driven overall water vapor splitting is crucial for sustainable hydrogen production. However, current photocatalytic efficiencies are limited by inadequate hygroscopicity, sluggish proton transport, and rapid recombination of photogenerated electron-hole pairs. Here, we report the successful synthesis of an amorphous Ni(OH) 2 /Ni 2 B heterojunction material with a core–shell structure by regulating the reducing environment during the formation of nickel boride. This material exhibits highly efficient overall water vapor splitting performance without any cocatalysts. Under simulated solar irradiation, the optimized sample achieves a hydrogen production rate of 976 μmol·g −1 ·h −1 , with near-stoichiometric evolution of hydrogen and oxygen, an apparent quantum yield of 5.4 %, and a solar-to-hydrogen conversion efficiency of 3.8 %. The enhanced performance is attributed to the unique amorphous/amorphous heterojunction structure that promotes effective charge separation, the abundant surface hydroxyl groups that improve proton transport and hygroscopicity, and the formation of photo-induced frustrated Lewis pairs (FLPs). Our findings shed light on the critical role of amorphous structures and surface chemistry in boosting photocatalytic activity, paving the way for the rational design of advanced photocatalysts for overall water vapor splitting.
研究领域:
材料科学
·
可再生能源
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 21
·3771
·
IF 5.719
Shizhuo Wang,Jikang Jiang,Minyan Gu,Yuanbo Song,Jiang Zhao,Zheng Shen,Xuefei Zhou,Yalei Zhang
To substitute fossil resources, it is necessary to investigate the conversion of biomass into 1,2-propanediol (1,2-PDO) as a high-value-added chemical. The Pt/deAl-Beta@Mg(OH)2catalytic system is designed to obtain a higher 1,2-PDO production yield. The optimal yield of 1,2-PDO is 34.1%. The unique shell-core structure of the catalyst demonstrates stability, with a catalytic yield of over 30% after three times of use. The primary process path from glucose to 1,2-PDO, glucose-hexitol-1,2-PDO, is speculated by the experiments of intermediate product selectivity. The alkaline catalytic mechanism of the reaction process is elucidated by studying catalyst characterization and analyzing different time courses of products. The introduction of Mg(OH)2improves the target yield by promoting the isomerization from glucose to fructose and retro-aldol condensation (RAC) conversion, with pseudo-yield increases of 76.1% and 42.1%, respectively. By studying the processes of producing lactic acid and 1,2-PDO from glucose, the glucose hydrogenolysis flow chart is improved, which is of great significance for accurately controlling 1,2-PDO production in industrial applications. The metal, acid, and alkali synergistic catalytic system constructed in this paper can provide a theoretical basis and route reference for applying biomass conversion technology in practice.Keywords:1,2-propanediol;alkaline modification;core–shell catalyst
研究领域:
生物化学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2018
·
IF 0.668
Da-Hua Shi,Xiao-Dong Ma,Yu-Wei Liu,Wei Min,Fu-Jun Yin,Zong-Ming Tang,Meng-Qiu Song,Chen Lu,Xiao-Kai Song,Wei-Wei Liu,Tong Dong
To find novel butyrylcholinesterase inhibitors, three novel 2-phenylthiazole derivatives were synthesised. The synthesised compounds were characterised by NMR and single-crystal X-ray diffraction analysis. Hirshfeld surface analysis and two-dimensional fingerprint plots of the compounds were used as a theoretical approach to assess the driving force for crystal structure formation via the intermolecular interactions in the crystal lattices of the synthesised compounds. Among the three compounds, N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro- 1H-pyrazol-4-yl)-2-(4-methoxyphenyl)thiazole-4-carboxamide showed the best butyrylcholinesterase-inhibition activity with an IC50 value of 75.12 μM. A docking study demonstrated that this compound interacts with the peripheral anionic site of butyrylcholinesterase.
研究领域:
有机化学
·
药物化学
·
结构生物学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 37
·15908-15918
·
IF 3.288
Xiuna Yu,Zhixiang Liu,Yemei Wang,Hongyu Luo,Xu Tang
Insights into active sites and charge transport behavior are challenging topics for fabricating composite photocatalysts and investigating their photocatalytic degradation reaction mechanisms. Herein, novel composites comprising biomass charcoal and graphitic carbon nitride (CN) were fabricated via facial alkali catalysis and thermal condensation of corncob and melamine precursors. By fine-tuning the calcination temperature, the carbonization temperature of corncob-derived biomass charcoal was controlled, which had a great influence on the optimal photocatalytic activity of C–CN-600, which was 90% of the degradation activity of 2-mercaptobenzothiazole (MBT), and about 2-fold higher than that of pure CN. The corncob not only acts as a precursor for biomass charcoal, but can also prevent the agglomeration of CN at high temperature. Moreover, the charge carrier lifetime, visible light absorption and surface area are also revealed in detail by systematic characterization. In addition, the intermediate products of MBT, the degradation reaction pathway, and the mechanism over C–CN are revealed in depth.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2020
·
IF 8.247
Zhenhua Ge,Bin Fu,Xing Li,Jinping Zhao,Bo Ma,Zhiqiang Luo,Yantao Chen
Electrochemical water splitting is a very prospective technique to obtain the green hydrogen fuel . The oxygen evolution reaction becomes a limitation owing to the multiple electron transfer process. Thereby, a lot of attention is paid on the development of noble-metal free electrocatalysts for boosting the water oxidation process . The heterostructure of Mn 3 O 4 nanoparticles on Cu(OH) 2 nanowire arrays is fabricated, which exhibits an electrocatalytic activity close to RuO 2 . Compared with the single (hydro)oxides, the largely improved performance of the heterostructure towards water oxidation can be attributed to the enhanced charge transfer by the electronic interaction across the interface and the increased active sites for the rational combination of different active species . This work can be valuable for highlighting the role of heterostructure in the design and development of novel transition metal-based electrocatalysts for water oxidation.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）