ACS Chemical Biology
·
2025
·
IF 3.8
Jinying Gu,Chenxi He,Zeyu Han,Qifei Huang,Yanyi He,Yun Lu,Qidong You,Qiuyue Zhang,Lei Wang
Hyperphosphorylation of proteins is implicated in various diseases, such as phosphorylated Tau (p-Tau), which is the main cause of Alzheimer’s disease (AD). Dephosphorylation strategies have still been limited. Currently, phosphatase recruitment chimeras (PHORCs) have become a potential strategy for accelerating the dephosphorylation of proteins. However, PHORCs are still in the proof-of-concept stage. The paucity of available phosphatase effectors and the lack of effective methods to identify the appropriate length of the linker impede the development of PHORCs. Protein phosphatase 5 (PP5) is responsible for dephosphorylation of p-Tau in the brain. PP5 is distinct from other phosphatases, with a unique activation mechanism. We demonstrated that PP5 can be simultaneously recruited and activated for the design of PHORCs, exhibiting a synergistic advantage for accelerating dephosphorylation of p-Tau. Moreover, we attempted computation-aided prediction methods to obtain the potential length of the linker, promoting the rational design of PHORCs. Therefore, our study provides critical insights into the development of PHORCs and proposes new ideas for accelerating the design of heterotrimeric chimeras.
研究领域:
生物化学
·
神经科学
·
药物开发
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yibo Tang,Jiayin Liang,Jiabing Chen,Mengheng Wang,Xinying Liu,Xiaojun Lu
Na- and Mn-promoted Co 2 C-based catalysts have demonstrated promise for the one-step conversion of syngas to olefins via Fischer-Tropsch synthesis to olefins (FTO). However, their consistently low activity limits their industrial applications. Here, we designed a compound catalyst comprising a CoMn composite catalyst and ZSM-5 zeolite, achieving 4.9 times the activity compared to the sole Co 2 C catalyst without compromising olefin selectivity. CO– and H 2 -TPD studies, in-situ DRIFT experiment, and DFT calculation revealed that the surface acidity of ZSM-5 modulated the strong electron effect of Na, subsequently strengthening H 2 adsorption on the Co 2 C catalyst surface. The H-assisted CO dissociation was therefore promoted and the catalyst activity was boosted. Meanwhile, Co 2 C as active site was unaffected, maintaining high selectivity to olefins. Constructing an interface between Co 2 C and ZSM-5 in the compound catalyst is proven to be a successful strategy for enhancing the activity of Co 2 C-based catalysts for FTO.
研究领域:
催化化学
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材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Linlin Yu,Ruoyu Chen,Qian Jia
Oily wastewater, especially oil-water emulsions, has caused severe environmental damage. It is urgent to develop a simple, efficient superhydrophobic and superoleophilic material to address this issue. In this work, a multifunctional sponge based on MOF was proposed. The hydroxy-assisted method was employed to prepare MOF-5 with metal coordination centers. Subsequently, octadecylphosphonic acid (OPA) was used to hydrophobically modify MOF-5 to prepare stable and hydrophobic OPA-MOF-5. Polydimethylsiloxane (PDMS) with low surface energy was employed as the adhesive, and the hydrophobic OPA-MOF-5 was loaded onto the polyurethane (PU) sponge to obtain the stable superhydrophobic OPA-MOF-5@PDMS@PU with a WCA of 155.9°. The produced modified sponge exhibited high sorption capacity and oil-water separation efficiency, with a sorption capacity of 26.7 (petroleum ether)-85.6 (chloroform) g/g and a separation efficiency of over 99 %. It has also shown satisfactory emulsion purification and flame retardancy capacities.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NANO
·
2024
·
IF 1
Xuecong Ma,Linlin Geng,Yu Li,Jianwen Wei,Lei Liao,Dunqiu Wang
Micro/mesoporous materials are low-cost functional materials with the potential for CO 2 adsorption. Modifying micro/mesoporous materials is significant for enhancing CO 2 adsorption and their high-value utilization. Herein, the micro/mesoporous material of composite molecular sieve ZSM-5/MCM-48 (ZM) was synthesized by a two-step crystallization method using cetyltrimethylammonium bromide as a template, tetraethyl orthosilicate as a silicon source and ZSM-5 seed as part of silicon aluminum source. Tetraethylenepentamine (TEPA) and polyethyleneimine (PEI) were used as impregnation modifiers to modify ZM with amine groups. The results showed that with the increase of amine loadings, both ZM-T60 (Impregnated with TEPA) and ZM-P60 (Impregnated with PEI) functionalized adsorbents exhibited the best adsorption capacities of 4 . 9 7 mmol ⋅ g − 1 and 3 . 2 8 mmol ⋅ g − 1 at 60, respectively, when the loading of ZM sample was 60%. The adsorption kinetic analysis showed that the adsorption of CO 2 by ZM-T60 and ZM-P60 was a chemisorption-dominated process accompanied by physical adsorption. After 10 adsorption/desorption cycles, the CO 2 adsorption capacity of ZM-T60 and ZM-P60 decreased by 8.7% and 2.6%, respectively. This work demonstrates that impregnation modification of the composite molecular sieve to achieve efficient CO 2 adsorption has practical application significance.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 89
·86034-86042
·
IF 3.289
Lujiang Xu,Qian Yao,Ying Zhang,Yao Fu
In this study, nano-sized HZSM-5 catalysts with different Si/Al ratios were synthesized and employed for producing pyridines from glycerol via a thermo-catalytic conversion and ammonization (TCC-A) process. The catalytic performance of micro-sized HZSM-5 and nano-sized HZSM-5 was studied firstly. The nano-sized HZSM-5 showed better catalytic performance in pyridine production in the TCC-A process due to its smaller particle size. When the nano-sized HZSM-5 (Si/Al = 25) served as the catalyst, and the reaction temperature was about 550 °C with the weight hourly space velocity of glycerol to catalyst at 1 h−1 and the ammonia to glycerol ratio at 12 : 1, the highest yield of pyridines was up to 42.1%, which was much higher than that when using micro-sized HZSM-5 (35.6%) reported before. In addition, nano-sized HZSM-5 also showed a better catalytic performance than micro-sized HZSM-5 in the catalytic conversion of bio-derived furans to produce indoles. After five reaction/regeneration cycles, the catalytic performance of nano-sized HZSM-5 slightly decreased compared with the first run, but was still higher than that of micro-sized HZSM-5.
研究领域:
化学工程
·
催化材料
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 4
·1083-1088
·
IF 2.726
Xiao Peiwen,Li Hui,Wang Pingmei,Liu Bolun,Jing Wendan,He Lipeng,Wang Runwei,Han Xue,Zhang Zongtao,Qiu Shilun,Luo Jianhui
Herein, we propose a novel approach to reduce the viscosity of heavy oil by functional hierarchical CTMS-ZSM-5-PTMS zeolites. CTMS-ZSM-5-PTMS zeolites synthesized by asymmetric modification and selective alkali etching can reduce the viscosity of heavy oil through adsorbing asphaltenes. This method can reduce the viscosity of heavy oil from hundreds of thousands mPa·s to about ten thousand mPa·s. The work provides an economical and environmentally friendly candidate for heavy oil viscosity reduction under low-temperature conditions.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
AICHE JOURNAL
·
2024
·
IF 3.5
Yanru Zhu,Zhen Zhang,Yunfei Zou,Jian Zhang,Zhe An,Xin Shu,Hongyan Song,Jing He
Catalytic conversion of biomass-derived 5-(hydroxymethyl)furfural (5-HMF) into carbon-increased hydrocarbons as drop-in energy-rich biofuels has received a great deal of concern for the development of sustainable chemical industry. Here, we demonstrate a one-pot conversion of 5-HMF into C 9 -alkanes on one single catalyst, acidic–basic layered double oxides (Mg(Al)(Zr)O) supported CuCo alloy. The well-defined multifunctional catalytic sites with harmonious combination carry out cascade catalysis, affording C 9 -alkanes (including 30% of more value-added branched-cycloalkanes) in 83% yield. The basic–acidic sites on Mg(Al)(Zr)O show high activity for aldol condensation of 5-HMF and acetone, producing 4-[5-(hydroxymethyl)-2-furanyl]-3-buten-2-one (HAc) in a yield of >99%. The engineered Co–Cu–Co linkages on supported CuCo perform efficient hydrodeoxygenation, affording C 9 -alkanes in a selectivity of 96% from HAc. C 9 -cycloalkanes are generated from the cyclization of the corresponding monohydric alcohol intermediates by the synergy of acidic and CuCo sites in the hydrodeoxygenation reaction.
研究领域:
化学工程
·
催化
·
可再生能源
·
生物质转化
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 5
·1-10
·
IF 20.1
Guo Sijia,Ma Min,Ge Ruixiang,Algadi Hassan,Shao Qian
Developing efficient electrocatalysts for biomass electro-oxidation in alkaline seawater is of great significance but remains less explored. Herein, we reported a hierarchical structure consisting of nickel-cobalt layered double hydroxide nanosheets and copper oxide nanowires (CuO@NiCo-LDH), which was favorable for increasing active sites and facilitating electron transfer during 5-hydroxymethylfurfural oxidation (HMFOR). As-designed CuO@NiCo-LDH catalyst achieved a high yield of 2,5-furandicarboxylic acid (FDCA, 89%) and 82% faradaic efficiency (F.E.). It also showed a large current density of 133.4 mA cm −2 at 1.4 V vs. RHE, outperforming most of the previously reported Ni/Co-based HMFOR electrocatalysts. More importantly, it also showed an outstanding HMFOR performance in alkaline seawater, suggesting great promise in practical electrolysis.
研究领域:
材料科学
·
电化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2019
·Vol. 42
·期 15
·2482-2490
·
IF 2.516
Lingping Cheng,Jianfeng Cai,Qing Fu,Yanxiong Ke
6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone is a key synthetic intermediate for cardiotonic agent levosimendan. Very few studies address the use of chiral stationary phases in chromatography for the enantioseparation of this intermediate. This study presents two efficient preparative methods for the isolation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in polar organic solvent chromatography and supercritical fluid chromatography using polysaccharide-based chiral stationary phases and volatile organic mobile phases without additives in isocratic mode. Under optimum conditions, Chiralcel OJ column showed the best performance ( α = 1.71, Rs = 5.47) in polar organic solvent chromatography, while Chiralpak AS column exhibited remarkable separations ( α = 1.81 and Rs = 6.51) in supercritical fluid chromatography with an opposite enantiomer elution order. Considering the sample solubility, runtime and solvent cost, the preparations were carried out on Chiralcel OJ column and Chiralpak AS column (250 × 20 mm i.d.; 10 µm) in polar organic mode and supercritical fluid chromatography mode with methanol and CO 2 /methanol as mobile phases, respectively. By utilizing the advantages of chromatographic techniques and polysaccharide-based chiral stationary phases, this work provides two methods for the fast and economic preparation of ( R )(−)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, which are suitable for the pharmaceutical industry.
研究领域:
药物化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Crystals
·
2021
·Vol. 11
·期 10
·1247
·
IF 2.589
Changsheng Zhang,Kai Fan,Ge Ma,Chi Lei,Wei Xu,Jie Jiang,Bing Sun,Hongxing Zhang,Yunfeng Zhu,Song Wen
Hierarchical zeolites attract people’s attention due to their enhanced mass transfer properties in catalytic reactions. The research over obtaining these zeolites in green and efficient methods is of great significance for the current post-treatments and templating strategies tend to be costly for hierarchical zeolite synthesis. In this research, nanosized mesoporous ZSM-5 (SN-ZSM-5) zeolites have been synthesized without the addition of mesoscale templates under highly concentrated conditions. The physicochemical characteristics were systematically investigated by XRD, SEM, N2 sorption, TEM, and NMR. The SEM images showed ZSM-5 crystals with sizes between 50–110 nm were obtained. N2sorption and high-resolution TEM images gave direct evidence for the hierarchical structure of SN-ZSM-5. The forming mechanism for the hierarchical structure was proposed that the etching effect of the highly alkaline environment for the starting gels played a critical role in the formation of hierarchical structure. Catalytic tests in methanol-to-olefins (MTO) showed the SN-ZSM-5 performed a longer catalyst lifetime and higher propylene selectivity than the conventional ZSM-5 zeolites (C-ZSM-5) obtained from a traditional hydrothermal method. The features of hierarchical structure in the SN-ZSM-5 crystals and the sustainability for synthesis method could show a promising choice for wide applications of these SN-ZSM-5 zeolites in the future.Keywords:ZSM-5 zeolite;efficient synthesis;hierarchical;nano crystals
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2013
·
IF 3.41
Bing Liu,Zehui Zhang,Kangle Lv,Kejian Deng,Hongmin Duan
Magnetic Fe 3 O 4 supported Mn 3 O 4 nanoparticles (Fe 3 O 4 /Mn 3 O 4 ) were prepared by the solvent thermal method, and its structure was characterized by XRD, XPS, TEM, and FT-IR technologies. The resulting Fe 3 O 4 /Mn 3 O 4 nanoparticles could be used as an excellent heterogeneous catalyst for the aerobic oxidation of the biomass-derived model molecule 5-hydroxymethylfurfural into 2,5-diformylfuran (DFF) under benign reaction conditions. Some important reaction parameters such as reaction temperature, catalyst amount, solvent, oxidant, and oxygen pressure were explored and high DFF yield of 82.1% with HMF conversion of 100% were obtained in DMF under optimal reaction conditions. More importantly, the catalyst could be readily separated from the reaction mixture by a permanent magnet, and recycled up to 6 times without the significant loss of its catalytic activity.
研究领域:
化学工程
·
材料科学
·
可再生能源
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Duoduo Zhang,Kunying Chen,Yongkang Yu,Ruting Feng,Steve W. Cui,Xingtao Zhou,Shaoping Nie
Metabolites of dietary fibers which consist of non-digestible carbohydrates (usually as plant-based polysaccharides) exert many benefits on gastrointestinal health. Previous studies proved that polysaccharides can change intestinal metabolic pathways, increase metabolite levels and alleviate intestinal inflammation. Our previous studies have shown that polysaccharide from Aloe vera gel (AGP) alleviated intestinal barrier dysfunction. However, whether intestinal protective function of AGP was related to metabolites need further exploration. Therefore, the effects of AGP on intestinal metabolites and the relevant mechanisms for subsequent mitigation of intestinal damage was investigated in this work. Metabolomics analysis results showed that AGP promoted tryptophan metabolism to 5-hydroxytryptamine (5-HT). Intriguingly, antibiotics treatment decreased the expression of tryptophan hydroxylase 1 (TPH1) in the intestinal epithelium of mice, and TPH1 inhibitor (PCPA) down-regulated 5-HT level in colonic contents, proving that AGP up-regulated TPH1 expression in the intestinal epithelium by restoring intestinal microbiota homeostasis, thus promoted the intestinal tryptophan metabolism to 5-HT. Combination of bioinformatics analysis of RNA-sequencing (RNA-Seq) in mice colon and the reported relationship among “5-HT, Htr4 (one of the 5-HT receptors), Kit + goblet cells, canonical Wnt pathway and intestinal stem cells (ISCs)” guided the confirmation of related mechanism in intestinal organoids (IOs) that 5-HT regulated ISCs function and intestinal barrier via Htr4-Kit-Wnt3 axis. Overall, AGP promoted 5-HT production to alleviate intestinal injury. This study revealed the effects of polysaccharides on intestinal health, which was critical and may provide new insights for the reasonable selection of dietary fiber to prevent intestinal inflammation and maintain intestinal function.
研究领域:
胃肠病学
·
营养学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）