DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2019
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IF 2.367
Xin-Cheng Zhong,Wen-Hong Xu,Zi-Ting Wang,Wang-Wei Guo,Jie-Jian Chen,Ning-Ning Guo,Tian-Tian Wang,Meng-Ting Lin,Zhen-Tao Zhang,Yi-Ying Lu,Qi-Yao Yang,Min Han,Dong-Hang Xu,Jian-Qing Gao
Objective: This study was aimed to develop DOX-TPP loaded acetal-PEG-PCCL micelles to improve the clinical efficacy of drug resistance tumor.Significance: Chemotherapy is one of the main treatments for breast cancer but is plagued by multidrug resistance (MDR). DOX-TPP-loaded micelles can enhance the specific concentration of drugs in the tumor and improve the efficacy and overcome MDR.Methods: In this study, DOX-TPP-loaded micelles based on acetal-PEG-PCCL were prepared and their physicochemical properties were characterized. The cellular uptake and ability to induce apoptosis of the micelles was confirmed by flow cytometry in MCF-7/ADR cells. In addition, cytotoxicity of the micelles was studied in MCF-7 cells and MCF-7/ADR cells. Confocal is used to study the subcellular distribution of DOX. Free DOX-TPP or DOX-TPP-loaded acetal-PEG-PCCL micelles were administered via intravenous injection in the tail vain for the biodistribution study in vivo.Results: The diameter of micelles was about 102.4 nm and their drug-loading efficiency is 61.8%. The structural characterization was confirmed by 1H NMR. The micelles exhibited better antitumor efficacy compared to free doxorubicin in MCF-7/ADR cells by MTT assay. The apoptotic rate and the cellular uptake of micelles were significantly higher than free DOX and DOX-TPP. Micelles can efficiently deliver mitochondria-targeting DOX-TPP to tumor cells. The result of bio-distribution showed that the micelles had stronger tumor infiltration ability than free drugs.Conclusions: In this study, mitochondriotropic DOX-TPP was conjugated to the nanocarrier acetal-PEG-PCCL via ionic interaction to form a polymer, which spontaneously formed spherical micelles. The cytotoxicity and cellular uptake of the micelles are superior to free DOX and exhibit mitochondrial targeting and passive tumor targeting, indicating that they have potential prospects.
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CHEMOSPHERE
·
2017
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IF 4.208
Jing Li,Heng Lin,Kangmeng Zhu,Hui Zhang
Electrochemistry coupled with granulated activated carbon catalysis of peroxymonosulfate (electro/GAC/PMS) as a novel wastewater treatment process was performed for the degradation of Acid Orange 7 (AO7) in aqueous solution. The decolorization of AO7 was compared under different permutations and combinations of electro-oxidation, GAC and PMS. It showed that the electro/GAC/PMS process was the most effective and the decolorization of AO7 followed pseudo-first order kinetics. The surface chemistry of GAC samples was analyzed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Compared with the fresh samples, π-electron density and hydroxyl group content decreased under the GAC/PMS system, but kept the similar values under the electro/GAC/PMS system. Electron paramagnetic resonance and radical scavenger studies were used to verify the formation of sulfate radicals (SO 4 − ) and hydroxyl radicals ( OH). The optimized conditions were found to be: current density 8 mA cm −2 ; PMS concentration 5 mM; GAC dosage 0.5 g L −1 ; and initial pH value 5.0. GAC recycling experiments over 4 runs showed some decrease in reactivity. Overall, the results indicate that 100% color removal was readily achieved and 50.4% of TOC was removed which shows high efficiency of the electro/GAC/PMS process.
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Journal of Water Process Engineering
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2022
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IF 7.34
Chen Fang,Yingping Huang,Yanlan Wang,Xu Meng,Xiaopei Wang,Xiang Liu
Although multifarious strategies, including oxygen vacancies or surface defects improvement, morphology modification, crystal phase transition and ion doping, have been developed for improving the catalytic performance of MnO 2 in the removal of pollutant substances. As far as we know, there is the first report providing enhanced performance of MnO 2 in the removal of pollutant substances by its electronic interaction effect. Herein, this study proposes a facile and high-efficiency method to achieve Ce-doping manganese oxide (CeMO) nanorods for the enhanced tetracycline removal via electronic interaction effect at 30 °C for the first time. The detailed characterizations and anions effect experiment have confirmed that CeMO-7 % nanorods possessed abundant surface reactive oxygen species , which is in favor of PMS activation . Compared to manganese oxide (MO), CeMO-5 % and CeMO-9 %, an obvious left shift has been observed in the Mn 2p of CeMO-7 %, suggesting that some electrons are transferred from Mn atoms to Ce atoms in CeMO-7 %, and implying that the highest degradation efficiency of CeMO-7 % in TC degradation may be due to the strong electronic interaction between Ce and Mn in CeMO-7 %. This study not only offers a facile and high-efficiency methodology for the synthesis of two-dimensional nanomaterial , but also proposes a new idea for enhancing the removal of TC.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2022
·Vol. 29
·期 33
·50135-50146
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IF 5.19
Qin Qingdong,Yan Lu,Liu Zheming,Liu Yahong,Gu Jia,Xu Yan
Morphology optimization of catalysts has been considered as a viable strategy to improve the catalytic efficiency for peroxymonosulfate (PMS) activation by providing high surface area and abundant active sites. In this study, nanotubular Co 3 O 4 (NT-Co 3 O 4 ) was successfully synthesized as a PMS activator for the rapid removal of acid orange 7 (AO7) in aqueous solutions. Characterization results showed that NT-Co 3 O 4 presented as aggregated nanotubes, with an average pore diameter of 10 nm. The specific surface area of NT-Co 3 O 4 was as high as 41.8 m 2 g −1 . Catalytic experiments demonstrated that the degradation rate of AO7 in the NT-Co 3 O 4 /PMS system was 15 times greater than that in commercially available Co 3 O 4 /PMS system. The effects of various experimental parameters, including catalyst dose, PMS dose, pH, and temperature, were comprehensively investigated. The reactive species in the NT-Co 3 O 4 /PMS system were identified as sulfate radical (SO 4 •− ) through both quenching tests and electron paramagnetic resonance (EPR) technology, and ≡CoOH + played an important role in PMS activation. N atoms in the AO7 molecule were found to be preferentially attacked by SO 4 •− . Moreover, the good stability and reusability of NT-Co 3 O 4 were confirmed by a five-cycle AO7 removal experiment. This study provides a broader view of the potential applications of nanotubular materials to achieve highly efficient PMS activation in treating dyes in wastewater.
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INTERNATIONAL JOURNAL OF PHOTOENERGY
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2022
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IF 2.535
Yaohui Xu,Chi Deng,Changxue Dong,Qin Wang,Nunan Gao
Acid Orange 7 (AO7) is one of the most common azo dyes; however, its strong azo bond makes them difficult to biologically degrade. We sought to degrade AO7 dye using CeO2 as a promising alternative photocatalyst. CeO2 powders were synthesized with alternative monoethanolamine (MEA), diethanolamine (DEA), and triethanolamine (TEA) as a precipitant by solvothermal process combined calcination in air. Compared to the oxygen storage capability of Blank-CeO2 (0.186 mmol O2/g), that of MEA-CeO2 synthesized in the presence of MEA as a precipitant increased by 21.0%, while that of DEA-CeO2 and TEA-CeO2 synthesized in the presence of DEA and TEA as precipitants were decreased. Importantly, such MEA-CeO2 exhibited the highest photocatalytic activity than Blank-, DEA-, and TEA-CeO2 in degradation of AO7 under simulated sunlight illumination, and the removal rate of AO7 by MEA-CeO2 could reach 98.3% within 100 min.
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JOURNAL OF MEMBRANE SCIENCE
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2022
·
IF 10.53
Jinyin Lv,Xuerong Zhou,Jianhua Yang,Lei Wang,Jinming Lu,Gaohong He,Yingchao Dong
A well-intergrown and defect-free tubular KAUST-7 membrane was fabricated via in-situ synthesis assisted by fluorinated molecular building block using green solvent of water on coarse asymmetric α-Al 2 O 3 tubes. The strategy averted the serious corrosion of high-concentration hydrofluoric acid (HF) to α-Al 2 O 3 supports due to the substitution of HF with the pre-synthesized NiNbOF 5 , overcoming the difficulty of serious corrosion to supports compared to traditional one-pot synthesis. The pH manipulation of synthesis solution is proved crucial to the fabrication of defect-free KAUST-7 membranes. In addition, effects of reactant concentration, crystallization temperature and reaction solvents on the morphology and separation performance of KAUST-7 membrane were investigated. The optimized KAUST-7 membrane M4 exhibited a H 2 perm-selectivity of 17.7 over CO 2 for H 2 /CO 2 binary mixture with a H 2 permeance of 2.2 × 10 −7 mol m −2 s −1 Pa −1 at 25 °C and 1 bar, while the H 2 /CO 2 separation factor just had a slight decrease when test temperature increased to 120 °C. The formation mechanism of KAUST-7 membranes via in-situ method in this work was investigated by exposing a bare α-Al 2 O 3 tube into NiNbOF 5 aqueous solution at the pH of 4.0 at 130 °C for 12 h. XPS and FT-IR observations revealed the formation of AlF x O y or AlF x species, which were deduced to be acted as linkers to connect with 2D Ni (II)-pyrazine layers, promoting the heterogeneous nucleation of KAUST-7 crystals on the surface of Al 2 O 3 support.
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Frontiers in Nutrition
·
2021
·
IF 6.576
Wei Wei,Fan Xiao-Man,Jia Shao-Hui,Zhang Xi-Ping,Zhang Zhao,Zhang Xue-Jun,Zhang Jiu-Xun,Zhang Ye-Wang
Sea cucumbers are one of many marine echinoderm animals that contain valuable nutrients and medicinal compounds. The bioactive substances in sea cucumbers make them have promising biological and pharmacological properties, including antioxidant, anti-bacterial, and anti-tumor effects. In this study, sea cucumber intestinal peptide (SCIP) is a small molecular oligopeptide (<1,000 Da) extracted from sea cucumber intestines hydrolyzed by alkaline protease. The analysis of amino acid composition showed that hydrophobic amino acids and branched-chain amino acids were rich in SCIP. Nowadays, although increasing studies have revealed the biological functions of the sea cucumber active substances, there are few studies on the function of SCIP. Furthermore, due to the anti-cancer activity being an essential characteristic of sea cucumber active substances, we also investigated the anti-cancer potential and the underlying mechanism of SCIP in vivo and in vitro. The results indicate that SCIP inhibits the growth of MCF-7 tumor cells in zebrafish and increases the apoptosis of human breast cancer MCF-7 cells. Further mechanism studies confirm that SCIP promotes the expression of apoptosis-related proteins and thus promotes the breast cancer cells (MCF-7) apoptosis via inhibition of PI3K/AKT signal transduction pathway.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Qin Wang,Li-Bing Lü,Zhu Tao,Tao Sun,Qing Tang,Ying Huang
In the present work, we have investigated the effect of pH and mercury ions on the host–guest complex formed between cucurbit[7]uril (Q[7]) and Hoechst 33342 (H33342). 1 H NMR, UV–vis and fluorescence spectroscopy revealed that acid/base stimulation could change the binding stoichiometry between Q[7] and H33342. The results suggest that two complexation equilibria (1:1 and 2:1) may exist between H33342 and Q[7] at pH 2.0 and 4.5, respectively. However, a 1:1 host–guest complex was formed between H33342 and Q[7] at pH 7.0 and 10.0. Q[7] shows differential affinities for the protonated and neutral forms of H33342 dye. Moreover, the switching between H33342∙2H + @2Q[7](1:2) at pH 4.5 and H33342∙H + @Q[7](1:1) at pH 7.0 was reversible. Furthermore, as a metal stimulus, Hg 2+ ions could push (i) Q[7] from the piperazine ring to the benzimidazole position with a 1:1 guest–host ratio and (ii) a second Q[7] onto the ethyl position with a 1:2 guest–host stoichiometry. This stimulus response system will have potential applications in the field of molecular switch design.
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高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 10
·3804-3813
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IF 6.843
Yuan-Fu Ding,Cheryl H. T. Kwong,Shengke Li,Ya-Ting Pan,Jianwen Wei,Lian-Hui Wang,Greta S. P. Mok,Ruibing Wang
Nano-graphene oxide (NGO) has attracted increasing attention as an advanced drug delivery system. However, the current surface functionalization and drug-loading of NGO either rely on π–π stacking that is limited to aromatic molecules, or covalent conjugation that requires tedious synthesis. Herein, we developed the first cucurbit[7]uril (CB[7])-conjugated NGO (NGO-CB[7]) that allows non-covalent, modular surface functionalization and drug loading via not only traditional π–π stacking interactions between the NGO surface and functional molecules, but also strong host–guest interactions between CB[7] and guest payloads or adamantane (ADA)-tagged functional molecules, for more versatile biomedical applications. To this end, chlorin e6 (Ce6, a photosensitizer), banoxantrone dihydrochloride (AQ4N, a hypoxia-responsive prodrug) and oxaliplatin (OX, a guest of CB[7]) were co-loaded onto NGO-CB[7] via π–π stacking and host–guest interactions, respectively. Subsequently, ADA-tagged hyaluronic acid (ADA-HA) wrapped NGO-CB[7] non-covalently via CB[7]-ADA host–guest interactions to improve the physiological stability and overall biocompatibility of this supramolecular nanosystem, and to enable targeted delivery into cancer cells with CD44 receptors overexpressed. Remarkably, this supramolecular nanomedicine exhibited significant antitumor efficacy via combined photothermal/photodynamic therapy (PTT/PDT) from NGO/Ce6, as well as dual chemotherapy from OX and AQ4N (activated by PDT-enhanced hypoxia), in vitro and in vivo. This study not only offers a new supramolecular inorganic/organic hybrid nanosystem for multi-modality cancer therapy, but may also provide important new insights into noncovalent functionalization of other carbon nanomaterials and inorganic nanomaterials leading to multifunctional drug delivery systems.
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JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Cheng Zhang,Xihao Pan,Hanyu Deng,Siyao Cheng,Aming Xie,Wei Dong
The frequent use of explosives puts enormous pressure on the environment and poses a potential threat to human health. Fluorescent probes , which can detect explosives quickly and accurately, have attracted increasing attention of researchers, but there are few reports about the detection of various novel explosives. In this work, a novel probe CST was synthesized through Cholesterol succinate and tetraphenylethylene derivative. Fluorescence spectra showed that CST had a typical aggregation-induced emission (AIE) effect in THF/H 2 O solution, and explosive FOX-7 could effectively quench this fluorescence without being affected by other explosives or ions, with the quenching constant of 0.799 × 10 5 M −1 . The filter paper and cotton rods prepared with the probe could detect FOX-7 specifically, which also provided the possibility for practical application on the battlefield.
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Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Chengcheng Yin,Xiaoshi Jia,Qin Zhao,Zifan Zhao,Jinyang Wang,Yufeng Zhang,Zhi Li,Hongchen Sun,Zubing Li
Boron-containing mesoporous bioactive glass (B-MBG) scaffolds could be capable of promoting osteogenesis by activating Wnt/β-catenin signaling pathway during the process of bone defect repair. Despite this, more involving molecular controls are still largely unclear. In the present study, we identified that the downstream of Wnt/β-catenin signaling pathway named transcription factor 7-like 2 (TCF7L2) served as a key effector to promote boron-induced bone regeneration and osteogenesis through lipocalin 2 (LCN2). TCF7L2 was highly expressed in osteoblasts when treated with B-MBG scaffold extraction than MBG. LCN2, as a secreted bone factor, positively affected osteogenic differentiation of MC3T3-E1 and osteogenesis in vivo , which could be induced by TCF7L2. In addition, interference of TCF7L2 decreased the osteogenic differentiation of osteoblasts. Finally, we identified that rLCN2 could rescue the poor ability of osteogenic differentiation of MC3T3-E1 whose Tcf7l2 gene was knocked down by lentiviral transfection of shRNA. Our findings provide some new insights into the molecular controls of boron-associated bone regeneration and potential therapeutic targets for the treatment of bone defects.
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ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Chenkai Zhou,Daohui Lin,Kun Yang
Nonlinear sorption and isotherm nonlinearity of organic compounds by widely used porous resins such as XAD-7 are commonly interpreted as adsorption due to their large surface area. However, through displacement experiments using saturated 4-nitrophenol as the displacer, we observed that the nonlinear sorption and isotherm nonlinearity of selected organic compounds (i.e., naphthalene , nitrobenzenes , phenols and anilines) by XAD-7 was captured by a nonlinear partition mechanism rather than the adsorption mechanism. Nonlinear sorption of organic compounds by XAD-7 includes a nonlinear/displaced fraction and a linear/non-displaced fraction. A dual-mode (DM) model, including a nonlinear Dubinin-Ashtakhov (DA) model component and a linear model component, was developed to describe the nonlinear/displaced fraction and the linear/non-displaced fraction, respectively. The capacity of these two fractions are dependent on their solubility in water or octanol with positively linear relationships but not their molecular size, supporting the nonlinear partitioning mechanism. Besides van-der-waals force, hydrogen-bonding is primarily responsible for the nonlinear partitioning of phenols and anilines into XAD-7, while π-π interaction is responsible for the nonlinear partitioning of naphthalene and nitrobenzenes. The explored nonlinear partitioning mechanism for XAD-7 implies that the nonlinear sorption of organic compounds by porous resins should be recognized for their recovery and applications as sorbents .
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