Science Advances
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2026
·Vol. 12
·期 18
·
IF 13.9
Erlong Wang,Mingyuan Sun,Du-An Ge,Shuai Dong,Gang Ma,Xiao Pan,Hongtai Ren,Yuewei Zhu,Hu Jin,Shi-Yang Tang,Xiangpeng Li,Weihua Li,Shiwu Zhang
Multimodal tactile sensing is crucial for next-generation robotics and human-machine interaction, but conventional solutions based on discrete sensor arrays suffer from complexity, limited flexibility, and high fabrication costs. Here, we introduce a continuum sensing paradigm based on a continuous liquid metal enabled flexible tactile sensing (CLiMETS) platform. This approach eliminates the need for sensor arrays by decoding tactile information from a single, unstructured liquid metal (LM) surface. We reveal a key mechanism where the deformation-induced voltage of the LM’s electric double layer (EDL) is synergistically amplified by over two orders of magnitude upon contact with a conductive rod. Our geometrically encoded, dual-channel scheme enables precise 5 by 5 localization and eight-directional sliding recognition. We further demonstrate the platform’s feasibility by realizing postprocessing visual feedback of an LED array, effectively translating complex tactile inputs into corresponding optical outputs. The CLiMETS platform offers a minimalist yet highly versatile proof-of-concept sensing modality, laying a strong foundation for more adaptive and interactive tactile technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Yingying Zhou,Yanjie Gao,Zijian Tan,Na Shang,Junyue Li,Liang Yin,Lili Duan,Haifeng Liu,Jine Li,Jinshan Li,Leilei Zhu
Identified Ha AST, a new aryl sulfotransferase for PAPS regeneration • Ha AST M13 shows 9-fold higher activity and 58-fold longer half-life at 50 °C. • Ha AST M13 enables efficient PAPS regeneration with significantly reduced PAPS usage. 3′-Phosphoadenosine-5′-phosphosulfate (PAPS) is an essential and expensive sulfonic acid donor, playing a central role in sulfonation modification for glycosaminoglycan biosynthesis. The aryl sulfotransferase (AST) is the primary enzyme responsible for catalyzing the regeneration of PAPS from 3′-phosphoadenosine-5′-phosphate (PAP). However, the application of AST in PAPS regeneration systems has been limited by its poor activity and stability. In this study, we identified a new AST from Hipposideros armiger, named as Ha AST. Subsequent protein engineering of Ha AST yielded variants exhibiting significantly enhanced catalytic activity and thermal stability. The variant Ha AST M13 (D247G/V243E/Y186H/M24I/R187P/R285K/K122N/V25A) exhibiting a 9-fold enhancement in activity and showed 58-fold longer half-life than the reported AST IV at 50 °C. The Ha AST M13-catalyzed PAPS regeneration system was successfully employed for the sulfation of glycosaminoglycans, including N- and 2-O-sulfated (NS2S) heparin and chondroitin sulfate (CS), with sulfation degree of 75.31% and 68.68%, respectively. Molecular dynamics (MD) simulations suggested that an enlarged entrance of the substrate pocket, together with increased rigidity in key regions including the substrate channel and binding sites, may contribute to the improvement of both catalytic activity and stability. This study offers an efficient PAPS regeneration system, providing a promising foundation for the enzymatic production of glycosaminoglycans. Download: Download high-res image (164KB) Download: Download full-size image
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Nature Communications
·
2026
·
IF 18.1
Huang Shuangyan,Yue Qilin,Lv Jiahao,Wang Yanan,Yang Hailei,He Qisheng,Zhang Jianwen,Wei Yong,Wang Shanlin
Extensive efforts have been made to enhance the durability of superhydrophobic coatings by adhesives, yet it raises a challenge to nondestructively remove the failed coatings. Here, we propose a nondestructively removable superhydrophobic (NRS) coating by an electrical switch, inspired by the nondestructive ecdysis of snakes. To achieve this, we sequentially spray i-layer and e-layer using electro-responsively epoxy-based ionic adhesive and superhydrophobic CNT coating, respectively. Its adhesion energy to stainless steel sheets significantly declines from 2.46 kJ m −2 to 0.01 kJ m −2 (about 99.6% of removal efficiency), through the disordered-ordered switching of free ions, only applying 90 V DC voltage for 3 min. This enables it to be nondestructively removed from the substrates even after 10 recoating cycles. This work offers a common strategy to sustainably protect the metal substrates and facilitates their recycling, showing great potential in green manufacturing and surface protection for large-scale equipment.
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Frontiers in Chemistry
·
2026
·
IF 4.2
Xinhua Zhu,Yanyu Wang,He Huang,Yuqiang Zhang,Xuhong Jia,Maoyong Zhi
In order to explore alternative substances for traditional fluorocarbon surfactants while maintaining high surface activity, this study successfully designed and synthesized an organosilicon surfactant (SiCH) containing a hydroxyl quaternary ammonium salt. Its molecular structure was confirmed by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). This surfactant exhibits excellent thermal stability, with an initial decomposition temperature of 167 °C and minimal residue at high temperatures. The critical micelle concentration (CMC) and the surface tension ( γ CMC ) at the CMC of SiCH are 9.10 mmol/L and 22.81 mN/m, respectively. The organosilicon surfactant–sodium hexanesulfonate (SiCH-SHS) exhibits significant synergistic effect, reducing the CMC and γ CMC to 6.88 mmol/L and 21.03 mN/m respectively. The area occupied by a single surfactant molecule at the air/water interface ( A S ) of the SiCH-SHS is 1.24 nm 2 , and the pC 20 is 2.91. The size distribution of SiCH is unimodal, and they can self-assemble into non-uniform sized spheroidal aggregates (122–295 nm). Moreover, the thermodynamic process of micelle formation of the surfactant was studied through conductivity tests conducted at different temperatures (298.15 − 303.15 K). Thermodynamic analysis indicates that micellization is a spontaneous ( Δ G m 0 <0), entropy-driven process.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2025
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IF 3.9
Ze Yu Lian,Fu Zhen Gao,Run Xiang Qin,Jing Qiang Ma,Xue Zhong Wang
Baicalin as a flavonoid compound exhibits diverse and significant pharmacological activities. Nevertheless, its intrinsically poor aqueous solubility has been an obstacle to its clinical application. To overcome this limitation, this study devised an innovative crystallization strategy, thereby enabling the controllable synthesis of baicalin nanocrystals. Initially, the crystallization process of baicalin microcrystals in a stirred tank crystallizer was optimized, and the effects of parameters such as additive types, equivalents, stirring rates, and crystallization temperatures on the particle size and morphology of crystals were explored. Subsequently, technologies including X-ray diffraction (XRD), proton nuclear magnetic resonance spectroscopy (¹H NMR), online microscopy imaging, and pH monitoring were utilized to elucidate the crystallization mechanism of baicalin, thereby laying the theoretical foundation for the preparation of baicalin nanocrystals. Finally, this study innovatively introduced an impinging jet crystallizer, based on the foregoing research findings. In contrast to the traditional reactors, this device integrates the advantages of both impinging jet reactor and batch crystallizer, which can simultaneously strengthen the micro- and macro-mixing processes. This dual-scale modulation strategy achieves precise kinetic control by synchronizing nucleation enhancement with growth suppression and regulation. To identify the optimal process parameters of the impinging jet crystallizer, a computational fluid dynamics (CFD) simulation and experimental research were combined. Eventually, the baicalin nanocrystals featuring an average particle size of less than 300 nm and spherical morphology were successfully prepared.
研究领域:
药剂学
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制药工程
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材料科学
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ADVANCED FUNCTIONAL MATERIALS
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2025
·
IF 19
Rui Zhou,Huasheng Tian,Hongyang Zhao,Li Ke,Haoyu Wu,Yaqing Liu,Jingcheng Hao
The increasing significance of data security promotes the development of multilevel information encryption and decryption techniques. However, the realization of logical outputs modulated by multiple stimuli is challenging in the design of advanced functional materials. Herein, a multilevel information decryption system with a combination of visual and digital outputs that responds to dual-optical inputs is developed based on a hydrogel-based synaptic device. ammonium molybdate nanoparticles and calcium alginate supramolecular networks is incorporated into a polyacrylamide hydrogel to enable optically regulated color change and ionic conductivity. Under UV irradiation, the reduction of the nanoparticles allows the hydrogel to change color as visual outputs. Meanwhile, the ionic conductivity of the hydrogel can be modulated by near-infrared (NIR) optical pulses to emulate the synaptic plasticity of biological synapses, producing NIR-mediated digital outputs. As a demonstration, a multilevel decryption strategy is provided using a hydrogel array that combines digital information decoding with visual information camouflage. Moreover, the short-term plasticity of the hydrogel synapse endows the system with time-dependent decryption, which improves information security and reduces the risk of data leakage. This study contributes to advancing multilevel decryption systems by providing an effective technique for integrating digital and visual decryption in hydrogel materials.
研究领域:
材料科学
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神经科学
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信息安全
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Cell Reports Medicine
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2025
·
IF 10.6
Chen Xu,Liting Chen,Guangna Liu,Jiaqi Xu,Wei Lv,Xiaoyu Gao,Peijun Xu,Ming Tang,Yaohe Wang,Xiao Zhao,Guangjun Nie,Keman Cheng,Funan Liu
Oncolytic viruses (OVs) combined with radiotherapy (RT) show promise but are limited by challenges such as poor intravenous delivery and insufficient RT-induced DNA damage. In this study, an oncolytic adenovirus (AD) formulation, RadioOnco (AD@PSSP), is developed to improve delivery, infectivity, immune response, and RT efficacy. The multifunctional polyethylenimine (PEI)-selenium-polyethylene glycol (PEG) (PSSP) enhances intravenous delivery, shields the virus from rapid clearance, and enables targeted delivery to tumor sites after RT. The exposed PEI enhances the infectivity of AD through electrostatic interactions, thereby increasing DNA damage after RT by inhibiting the expression of DNA repair proteins, such as CHEK1 and CDK1. Furthermore, AD-PEI captures and delivers RT-induced tumor-released antigens to lymph nodes, activating robust anti-tumor immune responses. Animal model data demonstrate that RadioOnco overcomes RT resistance, targets distant metastases, and promotes long-term immunity, addressing metastasis and recurrence. In summary, this intravenously injectable OV enhances RT synergy through surface modification with multifunctional materials.
研究领域:
肿瘤学
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病毒学
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辐射生物学
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免疫治疗
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CHEMBIOCHEM
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2024
·
IF 2.6
Xiang Zhu,Weizhe Luo,Donghui Zhang,Runhui Liu
With the increasing use of polyethylene glycol (PEG) based proteins and drug delivery systems, anti-PEG antibodies have commonly been detected among the population, causing the accelerated blood clearance and hypersensitivity reactions, poses potential risks to the clinical efficacy and safety of PEGylated drugs. Therefore, vigilant monitoring of anti-PEG antibodies is crucial for both research and clinical guidance regarding PEGylated drugs. The enzyme-linked immunosorbent assay (ELISA) is a common method for detecting anti-PEG antibodies. However, diverse coating methods, blocking solutions and washing solutions have been employed across different studies, and unsuitable use of Tween 20 as the surfactant even caused biased results. In this study, we established the optimal substrate coating conditions, and investigated the influence of various surfactants and blocking solutions on the detection accuracy. The findings revealed that incorporating 1% bovine serum albumin into the serum dilution in the absence of surfactants will result the credible outcomes of anti-PEG antibody detection.
研究领域:
药学
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免疫学
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药物递送系统
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ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Guorui Zhang,Yuanchang Li,Haoran Pang,Qin Tu,Jinyi Wang
Semiconductor refrigeration plates (also known as thermoelectric coolers, TECs) are increasingly recognized as one of the most promising refrigeration technologies due to their compact size and rapid cooling capabilities. However, the full utilization of the temperature difference on both sides of the TEC to maximize performance has been limited. This study developed a novel semiconductor refrigeration device integrated with microchannels. This design achieves synergistic thermal management, enabling precise and independent temperature control on both the cold (4 °C) and hot (42 °C) sides. Further optimization of the device enhanced the effective utilization of the temperature gradient between the two sides. Using this device, the transformation of Escherichia coli was completed in just 2 min, achieving a transformation efficiency of 11.9 × 108 CFU/μg DNA, which was 1.5 times higher than that of traditional heat shock methods. The study also revealed that the device could facilitate the intracellular delivery of small molecules like trehalose, achieving 84% cell viability in cryopreservation, compared to approximately 4% for the untreated control, and comparable to that of conventional DMSO-based methods (90%). Notably, this approach eliminates complex washing steps for organic solvent removal. With its simple structure, stability and portability, this dual-temperature platform holds considerable potential for effective temperature control and intracellular delivery in biotechnological applications.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2016
·Vol. 18
·期 3
·1-10
·
IF 2.101
Guo Leilei,Huang Kaixun,Liu Hongmei
Selenium nanoparticles (SeNPs) are considered to be the new selenium supplement forms with high biological activity and low toxicity; however, the molecular mechanism by which SeNPs exert the biological function is unclear. Here, we reported that biocompatibility SeNPs possessed intrinsic oxidase-like activity. Using Na 2 SeO 3 as a precursor and glutathione as a reductant, biocompatibility SeNPs were synthesized by the wet chemical reduction method in the presence of bovine serum albumin (BSA). The results of structure characterization revealed that synthesized SeNPs were amorphous red elementary selenium with spherical morphology, and ranged in size from 25 to 70 nm size with a narrow distribution (41.4 ± 6.7 nm). The oxidase-like activity of the as-synthesized SeNPs was tested with 3,3′,5,5′-tetramethylbenzidine (TMB) as a substrate. The results indicated that SeNPs could catalyze the oxidization of TMB by dissolved oxygen. These SeNPs showed an optimum catalytic activity at pH 4 and 30 °C, and the oxidase-like activity was higher as the concentration of SeNPs increased and the size of SeNPs decreased. The Michaelis constant ( K
m ) values and maximal reaction velocity ( V
max ) of the SeNPs for TMB oxidation were 0.0083 mol/L and 3.042 μmol/L min, respectively.
研究领域:
纳米生物学
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生物化学
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医学
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CHINESE JOURNAL OF CHEMICAL PHYSICS
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2023
·Vol. 36
·期 3
·249-258
·
IF 1
Zhang Wen,Zhou Yong,Chen Wei,Wang Tianjun,Qin Zhaoxian,Li Gao,Ren Zefeng,Yang Xueming,Zhou Chuanyao
Plasmonic catalysis, which is driven by the localized surface plasmon resonance of metal nanoparticles, has become an emerging field in heterogeneous catalysis. The microscopic mechanism of this kind of reaction, however, remains controversial partly because of the inaccuracy of temperature measurement and the ambiguity of reagent adsorption state. In order to investigate the kinetics of plasmonic catalysis, an online mass spectrometer-based apparatus has been built in our laboratory, with emphases on dealing with temperature measurement and adsorption state identification issues. Given the temperature inhomogeneity in the catalyst bed, three thermocouples are installed compared with the conventional design with only one. Such a multiple-point temperature measuring technique enables the quantitative calculation of equivalent temperature and thermal reaction contribution of the catalysts. Temperature-programmed desorption is incorporated into the apparatus, which
helps to identify the adsorption state of reagents. The capabilities of the improved apparatus have been demonstrated by studying the kinetics of a model plasmon-induced catalytic reaction, i.e. , H 2 +D 2 →HD over Au/TiO 2 . Dissociative adsorption of molecular hydrogen at Au/TiO 2 interface and non-thermal contribution to HD production have been confirmed.
研究领域:
化学
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催化科学
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材料科学
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CHEMISTRY-A EUROPEAN JOURNAL
·
2023
·Vol. 30
·期 10
·e202302936
·
IF 4.3
Feiyan Yuan,Jing Ding,Yiyang Sun,Jianhua Liang,Yunzi Luo,Yang Yu
Graphical The carbene transfer reaction was realized in the biosynthetic pathway. Using L-limonene as the precursor, L-carveol was biotransformed by P411-PFA to generate unnatural terpenoid derivatives with trifluoromethyl group. Protein engineering of cytochrome P450s has enabled these biocatalysts to promote a variety of abiotic reactions beyond nature‘s repertoire. Integrating such non-natural transformations with microbial biosynthetic pathways could allow sustainable enzymatic production of modified natural product derivatives. In particular, trifluoromethylation is a highly desirable modification in pharmaceutical research due to the positive effects of the trifluoromethyl group on drug potency, bioavailability, and metabolic stability. This study demonstrates the biosynthesis of non-natural trifluoromethyl-substituted cyclopropane derivatives of natural monoterpene scaffolds using an engineered cytochrome P450 variant, P411-PFA. P411-PFA successfully catalyzed the transfer of a trifluoromethyl carbene from 2-diazo-1,1,1-trifluoroethane to the terminal alkenes of several monoterpenes, including L-carveol, carvone, perilla alcohol, and perillartine, to generate the corresponding trifluoromethylated cyclopropane products. Furthermore, integration of this abiotic cyclopropanation reaction with a reconstructed metabolic pathway for L-carveol production in Escherichia coli enabled one-step biosynthesis of a trifluoromethylated L-carveol derivative from limonene precursor. Overall, amalgamating synthetic enzymatic chemistry with established metabolic pathways represents a promising approach to sustainably produce bioactive natural product analogs.
研究领域:
生物化学
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合成生物学
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药物化学
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