Biomaterials Science
·
2017
·Vol. 5
·期 3
·475-484
·
IF 4.21
Shuwen Peng,Yuanyuan He,Murat Er,Yuanzhi Sheng,Yueqing Gu,Haiyan Chen
Near-infrared (NIR) photothermal therapy (PTT) is a new approach to ablate cancer without affecting normal tissues. A pivotal concern of PPT is to develop photo-responsive agents with high biocompatibility as well as effective photothermal conversion efficiency. Copper sulfide (CuS) nanoparticles prepared are characterized by their low synthesis cost, wide NIR absorption range, good biocompatibility and favorable NIR photothermal conversion efficiency. CuS nanoparticles were then coated with mesoporous silicon dioxide (SiO2) by the Stober method, and further loaded with anticancer drug doxorubicin (DOX). The nanocomposites obtained were named CuS@MSN-DOX. The infrared thermal imaging of CuS@MSN-DOX demonstrated its favorable photothermal efficacy. The potential of CuS@MSN-DOX utilized as a multifunctional platform for combined PPT and chemotherapy was exploited both at the cell level and in a mice model. The result demonstrated that CuS@MSN-DOX was endowed with the synergistic effect of chemo-photothermal therapy, which confirmed that it is a promising candidate for combined therapy of cancer.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2012
·
IF 2.159
Kaisheng Yao,Weiwei Lu,Xinying Li,Jianji Wang
A novel method was proposed for successful fabrication of CuS nanostructures with various morphologies. At the ionic liquids (ILs)-modulated CHCl 3 –H 2 O interface, copper cupferronate [Cu(cup) 2 ] in CHCl 3 reacted with thiourea in water to generate CuS nanostructures via a solvothermal reaction process. The effects of alkyl chain length of imidazolium cations and nature of anions of the ILs, molar ratio of Cu(cup) 2 to thiourea, the reaction temperature and time on the morphology of the products were studied systematically. It was shown that by changing alkyl chain length of imidazolium cations and nature of anions of the ILs, CuS nanostructures with various morphologies, including flowers, urchins, large nanodisks and nanoparticles , could be obtained at the liquid–liquid interface, and the ILs played important template roles in directing the formation of CuS nanostructures. Furthermore, the as-prepared CuS samples exhibited high catalytic activity for photodegradation of methyl orange and thermal decomposition of ammonium perchlorate .
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Wei Jiang,Huiyuan Zhang,Jilian Wu,Guangxi Zhai,Zhonghao Li,Yuxia Luan,Sanjay Garg
Quercetin (QT) is one promising candidate for the treatment of various cancers with virtually no toxic side effects. However, its anticancer effect is severely restricted by its poor bioavailability, low water solubility, and chemical instability in the neutral and alkaline medium. Herein, zeolitic imidazolate framework-8 (ZIF-8) is first reported as the multifunctional nanoplatform to the codelivery of quercetin as an anticancer agent and CuS nanoparticles as a photothermal therapy (PTT) agent for synergistic combination of chemotherapy and PTT as well as overcoming the drawbacks of quercetin. Moreover, folic acid–bovine serum albumin (FA–BSA) conjugates are applied to stabilize the CuS@ZIF-8-QT to promote the bioavailability of quercetin and realize active-targeting drug delivery. Near-infrared (NIR) fluorescent imaging demonstrated the highly increased drug accumulations of FA–BSA/CuS@ZIF-8-QT in tumors, resulting from efficient internalization via FA-receptors-mediated endocytosis. The results of in vivo and in vitro anticancer experiments demonstrate that quercetin and PTT agent can work together efficiently under NIR irradiation, thus remarkably improving the anticancer effect. Therefore, our newly designed FA–BSA/CuS@ZIF-8-QT multifunctional drug delivery system might be a promising nanoplatform for cancer treatment.
研究领域:
癌症治疗
·
纳米技术
·
药物递送系统
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
2D Materials
·
2022
·Vol. 9
·期 2
·025024
·
IF 6.861
Xiangang Zhai,Zicheng Zuo,Zecheng Xiong,Houhe Pan,Xiaoya Gao,Yuliang Li
Copper sulfide (CuS) is emerged as a promising electrode material for Na-ion batteries due to its high theoretical specific capacity, environmental friendliness and abundant resource. However, the conversion type mechanism for storing the Na+ causes huge volume variations, irreversible phase changes and disintegration of the structure during charge and discharge processes. These intractable issues lead to the fast capacity degradation, and sluggish reaction kinetics, and performances are hard to fulfill the criteria in practical applications. Herein, the large-scale free-standing CuS nanotube arrays sandwiched by successive graphdiyne (GDY) nanofilm are readily prepared using a simple and efficient strategy. The in-situ protection of GDY nanofilm successfully enhances the structural stability and the network conductivity of the free-standing electrode. The as-obtained CuS electrode protected by GDY exhibits excellent electrochemical sodium storage capability, in the term of long-term reversibility (After 1000 cycles at 2 C, the capacity retention is 78.7%.) and rate performance.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
Journal of Extracellular Vesicles
·
2022
·Vol. 11
·期 1
·e12185
·
IF 17.337
Xiaoyu Yu,Ying Bai,Bing Han,Minzi Ju,Tianci Tang,Ling Shen,Mingyue Li,Li Yang,Zhao Zhang,Guoku Hu,Jie Chao,Yuan Zhang,Honghong Yao
Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and severely limits psychosocial function and quality of life, but no effective medication is currently available. Circular RNAs (circRNAs) have been revealed to participate in the MDD pathological process. Targeted delivery of circRNAs without blood-brain barrier (BBB) restriction for remission of MDD represents a promising approach for antidepressant therapy. In this study, RVG-circDYM-extracellular vesicles (RVG-circDYM-EVs) were engineered to target and preferentially transfer circDYM to the brain, and the effect on the pathological process in a chronic unpredictable stress (CUS) mouse model of depression was investigated. The results showed that RVG-circDYM-EVs were successfully purified by ultracentrifugation from overexpressed circDYM HEK 293T cells, and the characterization of RVG-circDYM-EVs was successfully demonstrated in terms of size, morphology and specific markers. Beyond demonstrating proof-of-concept for an RNA drug delivery technology, we observed that systemic administration of RVG-circDYM-EVs efficiently delivered circDYM to the brain, and alleviated CUS-induced depressive-like behaviours, and we discovered that RVG-circDYM-EVs notably inhibited microglial activation, BBB leakiness and peripheral immune cells infiltration, and attenuated astrocyte disfunction induced by CUS. CircDYM can bind mechanistically to the transcription factor TAF1 (TATA-box binding protein associated factor 1), resulting in the decreased expression of its downstream target genes with consequently suppressed neuroinflammation. Taken together, our findings suggest that extracellular vesicle-mediated delivery of circDYM is effective for MDD treatment and promising for clinical applications.
研究领域:
神经科学
·
药理学
·
分子生物学
·
精神病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yujie Sun,Qi Dong,Huan Yang,Weiling Song,Hong Zhou
Telomerase activity detection has attracted much attention concerning its importance for early cancer diagnosis. Here, we established a ratiometric electrochemical biosensor for telomerase detection based on CuS quantum dots (CuS QDs) dependent DNAzyme-regulated dual signals. The telomerase substrate probe was used as the linker to combine the DNA fabricated magnetic beads and CuS QDs. In this way, telomerase extended the substrate probe with repeated sequence to from hairpin structure, releasing CuS QDs as an input to DNAzyme modified electrode . DNAzyme was cleaved with high current of ferrocene (Fc) and low current of methylene blue (MB). On the basis of the obtained ratiometric signals, telomerase activity detection was achieved in the range of 1.0 × 10 −12 -1.0 × 10 −6 IU/L, with the limit of detection down to 2.75 × 10 −14 IU/L. Moreover, telomerase activity from HeLa extracts was also tested to verify the clinical application.
研究领域:
生物化学
·
分析化学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
COMPOSITES COMMUNICATIONS
·
2020
·
IF 4.915
Hao Yuan,Ting Li,Yang Wang,Piming Ma,Mingliang Du,Tianxi Liu,Yangyang Yan,Huiyu Bai,Mingqing Chen,Weifu Dong
Polymeric optical composites have played an important role in selectively shielding solar light to satisfy the increasing requirements of photoprotection and environmental comfort as well as improving the energy saving efficiency of buildings and cars. In the present work, a smart polymer film with high near-infrared (NIR) and ultraviolet (UV) light shielding, acceptable visible light transmittance was developed on basis of CuS nanoplate. The influences of the CuS nanoplate size and the thickness of polymer composite films on the optical and shielding properties were studied. In particular, the composite film can shield 86.5% of the near-infrared light from 800 to 1800 nm and at the same time permitting acceptable visible light (63.4%) with the film thickness of 30 μm. In order to improved UV-shielding performance, CuS nanoplate coated by polydopamine (PDA) was used for preparation of polymer composite film. It was found that UV-shielding performance was further promoted in the entire UV region and exhibited a synergistic relationship between PDA and CuS, which certificating the outstanding contribution of PDA layer on the surface of CuS nanoplate. In a word, the comprehensive research on nanocomposite fabrication, surface modification, and integration techniques enable us to fabricate highly flexible, transparent and reliable composite films with outstanding UV and NIR shielding performance. This novel film is potential to be used as smart windows of buildings and cars for the application of cooling energy saving and UV protection.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Junli Guo,Lingling Yang,Huijie Xu,Chenxi Zhao,Zhenqing Dai,Zhida Gao,Yanyan Song
The level of hydrogen sulfide in the brain and vasculature has long been associated with human health and diseases. Hence, simple and robust analytical tools allowing determination of hydrogen sulfide levels are highly desirable. In this work, a biomineralization-driven ion gate in TiO2 nanochannel arrays for H2S sensing was designed and developed. The formed CuS precipitation decreased the transmembrane current in the presence of bovine serum albumin used as biological mineralizer. Label-free assay for sensing of intracellular S2– was achieved based on changes in ionic current with a detection limit of 56 MCF-7 cells. More importantly, the proposed sensing strategy was promising for reusable application through dissolution of CuS in an acidic media (pH = 1).
研究领域:
生物传感
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Juan Ding,Ligang Cheng,Na Zhang,Jiale Sun,Jin Gao,Mengkang Bi
The development of electromagnetic microwave (EMW) absorbers featuring broad bandwidth, low cost, and engineering feasibility is considered strategically important to address the application demands of 5G/6G communications and stealth technologies. In this study, the CuS/Fe3O4/C nanocomposites with enhanced absorption properties were synthesized through the incorporation of CuS into a polyacrylonitrile (PAN) precursor using electrospinning technology. The obtained composites demonstrate an ultrawide effective absorption bandwidth (EAB) in the X and Ku bands, achieving a minimum reflection loss (RLmin) of −50.37 dB at 15.44 GHz with a thickness of 1.9 mm, along with an EAB of 4.8 GHz (RL ≤ −10 dB, 13.2–18 GHz). For the CuS/Fe3O4/C nanocomposites with 10% CuS loading, optimal EMW absorption performance was observed at 3.5 mm, exhibiting an RLmin of −40.09 dB at 6.96 GHz and an ultrawide EAB covering 9.6 GHz (RL ≤ −10 dB, 8.4–18 GHz). Based on Cole–Cole curve analysis, the nanocomposite with 20% CuS loading is characterized by five distinct and well-defined relaxation arcs, confirming its remarkable dielectric loss capability. Furthermore, CST simulation results indicate that the radar cross-section (RCS) values of compressed samples were significantly reduced, which is attributed to improved magnetic absorption. These findings substantiate that the superior EMW absorption performance of the nanocomposites stems from a strong polarization loss mechanism and considerable eddy current loss. This study underscores the significant potential of the CuS/Fe3O4/C nanocomposites in ultrabroadband EMW absorption research and offers valuable guidance for further in this area.
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2013
·Vol. 38
·期 25
·10739-10745
·
IF 3.548
Qizhao Wang,Ning An,Yan Bai,Haohao Hang,Jiajia Li,Xiaolin Lu,Yinghua Liu,Fangping Wang,Zhimin Li,Ziqiang Lei
Photocatalysts CuS/TiO 2 for hydrogen production were synthesized by hydrothermal method at high temperature and characterized by XRD , UV–visible DRS , XPS, EDX , SEM and TEM . When TiO 2 was loaded with CuS, it showed photocatalytic activities for water decomposition to hydrogen in methanol aqueous solution under 500 W Xe lamp. Among the photocatalysts with various compositions , the one with 1 wt% CuS-loaded TiO 2 showed the maximum photocatalytic activity for water splitting, which indicated CuS could improve the separation ratio of photoexcited electrons and holes. What's more, the amounts of the produced hydrogen was about 570 μmol h −1 , which had exceeded pure titania (P25) 32 times. In the present paper, it is proven that CuS can act as an effective co-catalyst to enhance the photocatalytic H 2 production activity of TiO 2 .
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Lvlv Ji,Lei Zhu,Jianying Wang,Zuofeng Chen
A self-supported copper sulfide (CuS) nanowire array (NWA) of hierarchical and porous structure has been developed on Cu foil via two consecutive liquid-solid reactions at room temperature. The composition, structure and morphology of the as-prepared CuS NWA samples have been systematically investigated by a series of techniques. When applied as cathode for the hydrogen evolution reaction (HER) in neutral solution, the optimized CuS NWA electrode exhibits excellent HER performance with high long-term stability. To achieve current densities of 10 and 100 mA cm −2 , it requires overpotentials of only ∼97 and ∼226 mV, respectively. The excellent catalytic performance of CuS NWA toward HER is attributable to the binder-free electrode construction strategy, the unique porous nanowire array structure, and the small solubility product ( K sp ) value of CuS that guarantees the high catalyst stability.
研究领域:
材料科学
·
电化学
·
纳米科技
·
能源化学
·
催化化学
✓ 已验证
DOI
高影响因子
NANO
·
2023
·
IF 1.2
Xueqi Wang,Jinkun Cheng,Xudong Xiong,Chao Xu,Zhao Fan,Yongqian Wang
Photothermal-assisted photocatalysis is a novel catalytic technology that can not only utilize both light energy and light heat, but also simultaneously incorporate superhydrophobicity and self-healing ability into photocatalysts. It represents a significant advancement in efficient photocatalytic degradation of water pollution. Here, by incorporating the semiconductor photothermal agent CuS on the outer layer of ZnO nanoflowers, the deposited CuS layer exhibits an outstanding photothermal effect under near-infrared light irradiation, which can absorb infrared light and convert it into heat energy, enhancing the performance of the ZnO nanoflowers in situ . Meanwhile, a photothermal conversion surface material with self-healing superhydrophobicity is prepared by using a mixture of beeswax and polydimethylsiloxane. The broad light absorption ability and enhanced charge transfer accelerate the photocatalytic efficiency, in addition, the incorporation of superhydrophobicity enables resistance to corrosive liquid pollution and repairs its superhydrophobicity damage by beeswax migration to provide lasting protection. The degradation rate of MB is as high as 98% within 80 min. Finally, the mechanism of photothermal effect in photocatalysis and the mechanism of self-healing superhydrophobicity are proposed. This work innovatively integrates photothermal effect and self-healing superhydrophobic function into photocatalytic degradation of water pollution technology, which broadens the scope of improving photocatalytic performance and extends the photocatalyst operation life to a certain extent.
研究领域:
材料科学
·
环境催化
·
纳米技术
·
光催化
·
表面化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）