JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Junping Lv,Yaqiong Zhang,Jie An,Min Li,Haitao Zhou,Zhifang Wu,Sijin Li
Two novel metal complexes, Zn(CAPHPD) 3 (C 5 H 10 NH + ) and Cd(CAPHPD) 2 ·2H 2 O were prepared by simple solvent evaporation method, named as complexes 1 and 2 respectively. The physicochemical properties were systematically characterized. Single crystal X-ray diffraction patterns show that the two complexes crystallize in Monoclinic and Triclinic systems with trigonal bipyramidal and octahedral configurations, respectively. Activity experiments demonstrated that the complex exhibited lower cytotoxicity to normal NIH/3T3 cells and enhanced toxicity to 4T1 breast cancer cells compared to the ligand. IC 50 showed that coordination of Zn 2+ or Cd 2+ significantly reduced the toxic effect of the ligand on non-cancerous cells, while substantially enhancing its anticancer activity. The results of FITC/PI double staining showed that the ligand and complex 2 could induce cell death in both 4T1 and A549 cells, while complex 1 could specifically promote late apoptosis. The ROS level was further detected by DCFH-DA fluorescence probe method, and it was found that the ROS content in 4T1 cells treated with ligand was significantly lower than complex 1 and complex 2. This result is consistent with the data from the double-staining experiment, indicating that the ROS-dependent apoptosis pathway plays a key role in the anticancer mechanism of the complex.
研究领域:
无机化学
·
生物无机化学
·
晶体学
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药物化学
·
癌症研究
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Dongfang Wang,Guilong Zhang,Zhangyu Dai,Linglin Zhou,Po Bian,Kang Zheng,Zhengyan Wu,Dongqing Cai
In this work, a novel nanosystem with a sandwich-like structure was synthesized via face-to-face combination of two pieces of waste cotton fabrics (CFs) carrying ferrous sulfide (FeS) and carboxyl-functionalized ferroferric oxide microsphere (CFFM), respectively, and the obtained nanosystem was named as FeS/CFFM/CF. Therein, FeS has high reduction and adsorption capabilities for hexavalent chromium (Cr(VI)), CFFM possesses a high adsorption ability on cadmium ion (Cd(II)) through electrostatic attraction and chelation, and CF displays high immobilization ability for FeS and CFFM and adsorption performance on Cd(II). FeS/CFFM/CF could simultaneously remove Cr(VI) and Cd(II) from water and inhibit the uptake of Cr and Cd by fish and water spinach, ensuring the food safety. Besides, this technology could efficiently control the migration of Cr(VI) and Cd(II) in the sand–soil mixture, which was favorable to prevent their wide diffusion. Importantly, FeS/CFFM/CF possessed a high flexibility and could be conveniently produced with needed scale and shape and easily separated from water and soil, displaying a promising approach to remediate Cr(VI)-/Cd(II)-contaminated water and soil and a huge application potential.
研究领域:
环境科学
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材料科学
·
生态学
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DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Tengpeng Liu,Xudong Huang,Chunhui Wang,Jixin Liu,Xuefei Mao
Direct analysis of solid samples is always challenging for ionic sensors due to solidified elemental presence and matrix interference. In this work, a “three-phase transforming” technique was first established to make solid sampling elemental sensors and visual detection possible in the future. For Cd transforming from soil samples, a metal ceramic heater (MCH) electrothermal vaporizer (ETV) coupled with a dielectric barrier discharge quartz trap (DBD-QT) was first utilized to fulfill the solid sampling and preconcentration of Cd in soil; for on-site analysis, a colorimetric sensor based on the trithiocyanuric acid (TMT) functionalized gold nanoparticles (AuNPs) was chosen as a chromogenic analysis model. The portable and miniature ETV-DBD apparatus directly introduced Cd from soil and then captured Cd, consuming only <130 W and 4.5 kg weight; finally, only 200 μL water was injected as eluent to dissolve Cd for the following colorimetric detection . Herein, the Cd analyte underwent a “three-phase transforming” from solid (Cd compounds in soil), to aerosol (vaporization and transportation), to solid (Cd oxides trapped on quartz surface) and to liquid (Cd 2+ in eluate). Under optimized conditions, the method limit of detection (LOD) reached 0.04 mg/kg Cd (50 mg sample), fulfilling fast monitoring of Cd contamination in soil, with <20 % relative standard deviations (RSDs). The analysis time was <10 min excluding sample digestion and acid application, as well as the interference of Pb 2+ on the AuNPs sensor can be eliminated via the “three-phase transforming” process, proving an excellent anti-interference for solid analysis. This “three-phase transforming” processing technique coupled with colorimetric sensor holds a great potential for direct and on-site analysis in solid samples without complicated handling, providing a fantastic methodology for the application of ionic sensors and making solid sampling elemental sensor and visual detection possible.
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DOI
PubMed
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 11
·862
·
IF 4.3
Na Xia,Qian Zhou,Yanquan Liu,Dan Gao,Siming Zhu,Zuoshan Feng
Neohesperidin (NH), a bioactive flavanone glycoside, exhibits multifaceted pharmacological properties including antioxidant and anti-inflammatory activities. However, its clinical application is severely constrained by inherent physicochemical limitations such as poor aqueous solubility and instability under physiological conditions. To address these challenges, this study developed a dual-carrier nano-liposomal system through the synergistic integration of phospholipid complexation and hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion technologies. Two formulations—NH-PC (phospholipid complex) and NH-PC-CD (phospholipid/HP-β-CD hybrid)—were fabricated via ultrasonication-assisted ethanol precipitation. Comprehensive characterization using FTIR and PXRD confirmed the amorphous dispersion of NH within lipid bilayers, with complete elimination of crystalline diffraction peaks, indicative of molecular-level interactions between NH’s hydroxyl groups and phospholipid polar moieties. The engineered nanosystems demonstrated remarkable solubility enhancement, achieving 321.77 μg/mL (NH-PC) and 318.75 μg/mL (NH-PC-CD), representing 2.01- and 1.99-fold increases over free NH. Encapsulation efficiencies exceeded 95% for both formulations, with sustained release profiles revealing 60.81% (NH-PC) and 80.78% (NH-PC-CD) cumulative release over 72 h, governed predominantly by non-Fickian diffusion kinetics. In vitro gastrointestinal simulations highlighted superior bioaccessibility for NH-PC-CD (66.35%) compared to NH-PC (58.52%) and free NH (20.85%), attributed to enhanced stability against enzymatic degradation. Storage stability assessments further validated the robustness of HP-β-CD-modified liposomes, with NH-PC-CD maintaining consistent particle size (<3% variation) and encapsulation efficiency (>92%) over 30 days. Antioxidant evaluations demonstrated concentration-dependent DPPH radical scavenging, wherein nanoencapsulation significantly amplified NH’s activity compared to its free form. This study establishes a paradigm for dual-functional nanocarriers, offering a scalable strategy to optimize the delivery of hydrophobic nutraceuticals while addressing critical challenges in bioavailability and physiological stability.
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PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 6
·6258-6264
·
IF 1.338
Lian Ting,Peng Mingli,Vermorken Alphons J. M,Jin Yanyan,Luo Zhiyi,Van de Ven Wim J. M,Wan Yinsheng,Hou Peng,Cui Yali
Curcumin, a polyphenol extracted from turmeric (Curcuma longa), has emerged as a potent multimodal cancer-preventing agent. It may attenuate the spread of cancer and render chemotherapy more effective. However, curcumin is neither well absorbed nor well retained in the blood,
resulting in low efficacy. In an attempt to enhance the potency and to improve the bioavailability of curcumin, new delivery agents, hydroxypropyl-beta-cyclodextrin (HP-β-CD)-modified GoldMag nanoparticles (CD-GMNs) were designed and synthesized to incorporate curcumin. The CD-GMNs
were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), Thermo-gravimetric Analysis (TGA), X-ray Diffraction (XRD), Dynamic Light Scattering measurements (DLS), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometer (VSM) analyses. For the magnetic carrier
of CD-GMNs, the content of HP-β-CD was 26.9 wt%. CD-GMNs have a saturation magnetization of 22.7 emu/g with an average hydrodynamic diameter of 80 nm. The curcumin loading, encapsulation efficiency and releasing properties in vitro were also investigated. The results showed
that the drug encapsulation ratio was 88% and the maximum curcumin loading capacity of CD-GMNs was 660 μg/5 mg. in vitro drug release studies showed a controlled and pH-sensitive curcumin release over a period of one week. Collectively, our data suggest that HP-β-CD-modified
GoldMag nanoparticles can be considered to form a promising delivery system for curcumin to tumor sites. Targeting can be achieved by the combined effects of the application of an external magnetic field and the effect on drug release of lower pH values often found in the tumor microenvironment.
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Xueni Lin,Zhiwei Lu,Wanlin Dai,Baichen Liu,Yuxin Zhang,Junye Li,Jianshan Ye
Recently, graphene-based nanomaterials have attracted widespread attention as new electrode-modified materials for different electrochemical sensing platforms. However, graphene-based nanomaterials modified heavy metal sensors often have the disadvantages in that their detection ranges are not wide enough. To solve this problem, an easy and feasible approach derived from laser engraving technique to fabricate a high-quality 3D porous graphene-based heavy metal sensor with a quite wide detection range was established. The nitrogen-doped laser engraved graphene (N@LEG) was synthesized via introducing polyaniline (PANI) and polyvinylpyrrolidone (PVP) as N-dopant. Herein, by coupling the unique electrochemical properties and the 3D porous structure framework with large electrochemical active surface areas of LEG with the strong metal ions affinity of N atoms, N@LEG modified glassy carbon electrode (N@LEG/GCE) with in-situ bismuth film modification has been successfully utilized for the simultaneous determination of Cd(II) and Pb(II) using square wave anodic stripping voltammetry (SWASV). After optimizing conditions, the proposed sensor exhibits quite wide linear ranges varying from 5 to 10 g L −1 and 10 to 380 g L −1 for Cd(II), and 0.5 to 10 μg L −1 and 10 μg L −1 to 380 μg L −1 for Pb(II), respectively. In addition, the detection limits are calculated to be 1.08 g L −1 (S/N = 3) for Cd(II) and 0.16 g L −1 (S/N = 3) for Pb(II), which are nearly 3 times and 60 times less than the guideline values of the drinking water presented by the World Health Organization (WHO), for Cd(II) and Pb(II), respectively. Furthermore, the results describe satisfactory advantages of remarkable sensitivity, selectivity, anti-interference, repeatability, reproducibility and stability. Besides, the fabricated sensor is proved to be a potential perspective to detect Cd(II) and Pb(II) in actual water samples.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2022
·
IF 10.508
Mao-Yin Ran,Sheng-Hua Zhou,Bingxuan Li,Wenbo Wei,Xin-Tao Wu,Hua Lin,Qi-Long Zhu
Simultaneous regulation and control of non-linear second-harmonic-generation (SHG) coefficients (deff) and linear birefringence (Δn) of non-centrosymmetric (NCS) crystals is a crucial aspect of improving the non-linear optical (NLO) performance, yet it remains a huge challenge in modern laser techniques and science. Herein, a series of melilite-type oxide-derived NCS oxychalcogenides, Sr2MGe2OS6 (M = Mn, Zn, and Cd), are successfully designed and synthesized through a facile partial isovalent chemical substitution strategy. These isostructural compounds crystallize in the tetragonal NCS space group P4̅21m (no. 113) and feature unique two-dimensional Cairo pentagonal tiling layers composed of heteroligand [GeOS3] and tetrahedral [MS4] asymmetric building units (ABUs). Compared to the parent melilite-type oxides, the derived title compounds not only successfully realize the phase matchability transformation [i.e., from non-phase-matching (NPM) to phase-matching (PM)] but also greatly improve the IR-NLO performance (especially, simultaneously boosting deff and Δn). Sr2CdGe2OS6 exhibits the best comprehensive performance among oxychalcogenides, including a wide PM cutoff edge (>525 nm), a strong deff (0.8 × AgGaS2), a giant laser-induced damage threshold (19.2 × AgGaS2), a large band gap (3.62 eV), as well as a broad transmission cutoff region (0.28–12.0 μm). Furthermore, highly distorted [GeOS3] ABU in this melilite-type structure is proved to be the profitable bifunctional NLO-active unit, which can contribute to the search and design of novel IR-NLO crystals with a large Δn and a strong deff based on the experimental results and theoretical calculations. This work demonstrates the first examples of PM melilite-type oxychalcogenides and offers new perspectives on the phase matchability transformation through the partial isovalent chemical substitution approach, which will play a constructive role in the future design of high-performance IR-NLO heteroanionic materials.
研究领域:
材料科学
·
光学
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DOI
高影响因子
IEEE TRANSACTIONS ON ELECTRON DEVICES
·
2023
·Vol. 70
·期 11
·5751-5756
·
IF 3.1
Yibo Ma,Xiaodong Zhang,Haiyu Qiu,Jing Guo,Chuan Tian,Liqiang Zheng,Chong Shen
At present, great success has been achieved in the development of perovskite light-emitting devices (LEDs) with red, green, blue, and near-infrared emission. However, red perovskite LEDs, as a key optoelectronic device, are still challenging, principally because under high bias voltage, halide separation will inevitably occur in mixed halide perovskite, resulting in unwanted color changes of the device. In addition, the poor stability and inherent toxicity of traditional lead halide perovskite limit its practical application. Here, the manufacturing of stable red LEDs based on ternary manganese halide CsMnBr3 is reported, which solves the problems of color instability and lead toxicity faced by perovskite red LEDs. The quantum efficiency is effectively improved by Cd $^{{2}+}$ ion doping. Photoluminescence (PL) quantum yield (PLQY) reaches 73.1% and has long-term stability. It can be stored at room temperature in air for more than 300 days. In addition, the red electroluminescent LEDs prepared with Cd:CsMnBr3 nanocrystals (NCs) has the broadband emission of self-trapping excitons centered at 660 nm and a comparable and reasonable low carrier valid mass conducive to charge transmission. The maximum brightness of the prepared red LEDs is 46.2 cd/ $\text{m}^{{2}}$ , showing a long half-life of 90 min at 25 °C, which is due to the excellent heat resistance, moisture resistance and high temperature resistance of Cd:CsMnBr3, as well as oxidation under environmental conditions. The results show that the broadband and stable emission of Cd:CsMnBr3 is compatible with the practical application of LEDs.
研究领域:
光电子学
·
材料科学
·
钙钛矿发光二极管（PeLED）
·
纳米材料
·
固态照明
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanfei Liu,Juan Li,Shaowen Huang,Dingbo Shu,Yanru Shan,Zhuohao Qiao,Xiaogang Yin
To address the heavy metal water pollution caused by industrial wastewater discharge, a novel hydrogel adsorbent was prepared using organic matter derived from distiller's grains (DGS), a by-product of the brewing industry, as the main raw material and carboxymethyl chitosan (CMCS) as the modifier. Characterization results revealed that CMCS converted the adsorbent into a three-dimensional macroporous structure while enhancing its highly selective adsorption performance for Pb(II) and Cd(II), with adsorption capacities reaching as high as 825.3 mg·g −1 and 644.3 mg·g −1 , respectively, and removal efficiencies up to 99.4% and 95.2% within 10 min. The adsorption process fitted well with the pseudo-second-order adsorption kinetic model (R 2 > 0.996) and the Langmuir isotherm model, indicating that the adsorption was dominated by chemical adsorption. Mechanistic analysis revealed that the hydrogel formed complexation and coordination with Pb(II) and Cd(II) via the lone pair electrons of O and N atoms, and combined with hydrogen bonding and electrostatic attraction to achieve synergistic adsorption. Furthermore, adsorption experiments on industrial wastewater using this adsorbent demonstrated that it maintained excellent adsorption performance even after six adsorption-desorption cycles, and achieved a degradation rate of 51.3% after 28 days. The synthesis of this highly efficient adsorbent not only realizes the functional modification and high-value utilization of DGS but also provides a green solution for wastewater remediation, exhibiting great application potential.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yidong Xu,Wenzhuo Dong,Mengqian Jia,Jiwei Shen,Chaozhan Wang,Yinmao Wei
This work explores an enrichment integrated derivatization strategy for diols-containing short-chain aliphatic compounds (DSCAs) by using cyclodextrin (CD)-metal–organic frameworks (MOFs) as adsorbents. For this purpose, α-, β-, γ-CD-MOFs with different sizes of hydrophobic cavities were prepared and their encapsulation ability towards polycyclic aromatic hydrocarbons, especially phenylboronic acid (PBA), was investigated. It is found that the formed supramolecular adsorbents PBA@CD-MOFs can simultaneously perform the enrichment and derivatization of DSCAs in organic solution, simplifying the sample pre-treatment procedure of the DSCAs. Finally, an analytical method based on solid-phase extraction combined with high-performance liquid chromatography (HPLC) was established for the detection of 3-monochloropropane-1,2-diol (3-MCPD) in canned samples. The relative recoveries of three analytes are 82.4 to 87.5 %, the intra- and inter-day relative standard deviations (RSDs) are less than 10.9 %, and the limits of detection (LODs) are 0.934–2.77 ng∙g −1 . In conclusion, the enrichment integrated derivatization strategy can be used as an alternative to the traditional sample pretreatment method, which usually requires enrichment, elution and derivatization for the detection of DSCAs in various food samples.
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高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2023
·Vol. 56
·期 49
·495103
·
IF 3.4
Yujiao Ma,Yuzhou Sun,Zihan Zhang,Haokai Zhao,Haifeng Gao,Qing Zhou,Wenbo Li,Xiaoyun Teng,Chao Gao,Wei Yu
In this paper, the open-circuit voltages (VOC) of Cu2ZnSn(S,Se)4 (CZTSSe) solar cells were improved by soaking the CZTSSe films in Cd/NH3 solutions before the deposition of buffer layers. The effects of Cd/NH3 soaking on the properties of CZTSSe films and solar cells were investigated in depth. We found Cd/NH3 soaking can promote downward band bending of the CZTSSe layer at the surface region. In addition, the Cd/NH3 soaking can eliminate the deep level acceptor in CZTSSe and decrease the density of the defects at the absorber/buffer interface. These effects can significantly reduce the carrier recombination in the depletion region of CZTSSe solar cells. As a result, the VOC of CZTSSe solar cells were increased from ∼460 mV to ∼480 mV, the efficiency of the best CZTSSe solar cell was increased from 10.2% to 11.6% by the Cd/NH3 soaking process.
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高影响因子
Journal of Water Process Engineering
·
2023
·
IF 7
Qingsheng Xu,Zhengbo Yue,Rui Deng,Xinquan Wang,Xiao He,Xin Chuai,Shaoping Wang,Jin Wang
The alkaline sludge produced by the neutralization treatment of acid mine drainage (AMD) is not only large and difficult to treat, but also prone to secondary pollution. The cost of conventional sludge treatment technology is high, so there is an urgent need to develop new methods. The process of neutralizing AMD is similar to the co-precipitation reaction of LDHs, so the cost of recovering LDHs from AMD is lower, but the application performance of LDHs is limited by the stacking of laminates. In this paper, the structure of LDHs was optimized by adding biochar (BC) during the neutralization process of AMD. After adding 40 % BC, the crystal planes of alkaline sludge based LDHs (AS-LDHs) became more parallel, and the adsorption properties of Cd and Cu were increased by 2.7 and 1.95 times, with the maximum adsorption amounts of 901.5 and 231.3 mg/g, respectively. The relevant removal mechanism was investigated in depth at the electronic scale by experiments combined with DFT calculations. Since AS-LDHs have the advantages of good acid stability, low zero-point charge and strong adsorption and regeneration capacity, this method has a broad application prospect.
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高影响因子
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