Food Packaging and Shelf Life
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2023
·
IF 8
Yitong Dong,Zhilu Rao,Yanchun Liu,Xuejing Zheng,Keyong Tang,Jie Liu
An edible film based on soluble soybean polysaccharide (SSPS) and gelatin incorporating curcumin was fabricated as active packaging material for soybean oil . The effect of curcumin (Cur) on structural and physical properties of SSPS/gelatin films were investigated. Scanning electron microscopy revealed that curcumin was evenly distributed in the SSPS/gelatin matrix. Hydrogen bonding interactions between SSPS/gelatin and curcumin were unveiled by Fourier-transform infrared spectroscopy. The addition of curcumin (0 −0.20 %) significantly increased the tensile strength , temperature of maximum mass loss rate, yellow index, transparency value and water contact angle from 2.3 to 5.5 MPa, 249–252 °C, 2.04–183.07, 0.51–1.63, and 70.7–98.6°, respectively. The DPPH and ABTS radical scavenging activities of the SSPS/gelatin film containing 0.20% curcumin were 42.6 % and 99.6 %, respectively, which were remarkably higher than those of neat SSPS/gelatin film. The SSPS/gelatin/Cur composite films showed antibacterial activity against Escherichia coli and Staphylococcus aureus . The heat-sealed SSPS/gelatin/Cur pouch of soybean oil showed quick-dissolving property upon contact with hot water. Moreover, peroxide value results indicated that the SSPS/gelatin/Cur pouch could effectively delay the soybean oil oxidation under accelerated storage conditions. Therefore, the SSPS/gelatin/Cur composite films may be served as active packaging materials for edible oils .
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Biomaterials Science
·
2022
·Vol. 10
·期 9
·2384-2393
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IF 7.59
Jingjin Liu,Suwan Liu,Yunchao Wu,Xiao Xu,Qianzhe Li,Mengyu Yang,Aihua Gong,Miaomiao Zhang,Rongzhu Lu,Fengyi Du
Curcumin as a hydrophobic polyphenol has great potential for tumor therapy, yet its rapid degradation and hydrophobicity severely impair its therapeutic effect in the clinic. Herein, we report a novel strategy for the formation of curcumin doped zeolitic imidazolate framework nanoparticles (Cur-ZIF NPs) by zinc ion driven simultaneous coordination of curcumin and 2-methylimidazole. The resultant Cur-ZIF NPs with a uniform nanosize exhibit favorable stability and dispersibility in water, as well as high drug-loading capacities. The pH and redox sensitivity of ZIF NPs enable the controlled release of curcumin in vivo. Moreover, Cur-ZIF NPs serve as nanocarriers that can load the toll-like-receptor-7 agonist (imiquimod, IQ) and be coated by homotypic cancer cell membranes to enhance tumor-targeted delivery. This study provides an attractive nanoplatform to effectively utilize curcumin and integrate multiple therapeutic modalities into a single system for tumor treatment.
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Drug Design Development and Therapy
·
2022
·
IF 4.319
Yali Zhang,Chengguang Zhao,Wenfei He,Zhe Wang,Qilu Fang,Bing Xiao,Zhiguo Liu,Guang Liang,Shulin Yang
Sepsis is a systemic inflammatory response syndrome and is mainly caused by lipopolysaccharides (LPS) – a component of the cell walls of gram-negative bacteria, via toll-like receptor 4–mitogen-activated protein kinases/nuclear factor-kappa B-dependent proinflammatory signaling pathway. Here, we synthesized 26 asymmetric monocarbonyl analogs of curcumin and evaluated their anti-inflammatory activity by inhibiting the LPS-induced secretion of tumor necrosis factor-α and interleukin-6 in mouse RAW264.7 macrophages. Five active compounds (3a, 3c, 3d, 3j, and 3l) exhibited dose-dependent inhibition against the release of tumor necrosis factor-α and interleukin-6, and they also showed much higher chemical stability than curcumin in vitro. The anti-inflammatory activity of analogs 3a and 3c may be associated with their inhibition of the phosphorylation of extracellular signal-regulated kinase and the activation of nuclear factor-kappa B. In addition, 3c exhibited significant protection against LPS-induced septic death in vivo. These results indicate that asymmetrical monocarbonyl curcumin analogs may be utilized as candidates for the treatment of acute inflammatory diseases.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2021
·
IF 3.133
Kang Sha,Qianfang Ma,Hanitrarimalala Veroniaina,Xiaole Qi,Jiayi Qin,Zhenghong Wu
Solidification of self-microemulsifying drug delivery systems (SMEDDS) is one of the major trends to promote the transformation of self-microemulsion technology into industrialization. Here, a preliminary curcumin SMEDDS formulation was constructed to improve the druggability of curcumin, through the determination of equilibrium solubility determination, self-emulsifying grading assessment, and pseudo-ternary phase diagrams drafting. Furthermore, the optimal curcumin SMEDDS formulation consisted of 10% Ethyl oleate, 57.82% Cremophor RH 40, and 32.18% Transcutol P was obtained by the simplex lattice design. Besides, curcumin solid self-microemulsifying drug delivery system (S-SMEDDS) was developed by the extrusion and spheronization process to achieve the solidification of SMEDDS. The formulation of curcumin S-SMEDDS pellets was screened by the single factor experiment and the process parameters were investigated using the orthogonal optimization method. Subsequently, curcumin S-SMEDDS pellets were evaluated by apparent morphology characterization, redispersibility study, drug release behavior, and pharmacokinetic evaluation. Results from the pharmacokinetic study in rabbits showed that the AUC0–τ of the curcumin S-SMEDDS pellets and curcumin suspension were 5.91 ± 0.28 µg/mL·h and 2.05 ± 0.04 µg/mL·h, while the relative bioavailability was 289.30%. These studies demonstrated that S-SMEDDS pellets can be a promising strategy for curcumin industrialized outputs.
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JOURNAL OF FOOD PROCESS ENGINEERING
·
2020
·Vol. 43
·期 12
·e13556
·
IF 1.703
Shenghua He,Sanjiu Zhou,Weiyun Guo,Yonghui Wang,Chunhong Liu,Rongchun Wang,Fugang Xiao
In this study, rapeseed oil bodies (RPOBs) were used to prepare curcumin emulsions (CEs) in order to investigate their stability and gastrointestinal. The results showed that particle size significantly reduced ( p < .05) with increasing RPOBs concentrations from 1.0 to 6.0 wt%. Additionally, CEs showed good stability at pH 2.0–10.0. However, CEs were instable at salt concentration ranging from 100 to 500 mM and at temperatures between 35 and 95°C. CE fat droplet size after 30 min of digestion time exhibited a remarkable increase ( p < .05) compared with other times. Upon exposure to simulated intestinal fluid (SIF) conditions, CEs particle sizes gradually decreased with increasing digestion time. Then, 56% curcumin and 40 μmol/ml free fatty acids were produced from CEs after 180 min digestion time under SIF conditions. Practical applications Our findings indicate that rapeseed oil bodies as a novel carrier can be applied for the delivery-controlled release of lipophilic bioactive compounds from emulsions during gastrointestinal digestion.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Jun Wang,Leyna G. Liu,Wen-Qiao Jiao,Hua Yang,Jing Liu,Dahai Liu
In order to achieve high loading and efficient delivery of curcumin, phenylboronic acid-conjugated chitosan nanoparticles were prepared by a simple desolvation method. These nanoparticles exhibited a regular spherical shape with the average size about 200−230 nm and narrow size distribution, which were kinetically stable under physiological condition. Due to boronate ester formation between curcumin and phenylboronic acid groups in the nanoparticles, and the hydrogen bonding interactions between curcumin and nanocarriers, curcumin was successfully loaded into the nanoparticles with high drug loading content. These curcumin-loaded nanoparticles showed pH and reactive oxygen species (ROS)-triggered drug release behavior. In vitro cell experiments revealed that the blank nanoparticles were completely nontoxic to cultured cells, and the curcumin-loaded nanoparticles exhibited efficient antitumor efficiency against cancer cells. Moreover, the drug-loaded nanoparticles performed an enhanced growth inhibition in three-dimensional multicellular tumor spheroids. Thus, these nanocarriers would be a promising candidate for curcumin delivery in tumor treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Lihong Fan,Yuqing Lu,Xiao-kun Ouyang,Junhong Ling
Curcumin (Cur) is a natural polyphenol with beneficial biological and pharmacological activities; however, it has limited applications owing to its low solubility and light sensitivity. The protein-polysaccharide complex can effectively embed lipid-soluble drugs to increase their stability and dispensability in aqueous solutions. Soybean protein isolate (Spi) and fucoidan (Fuc) were used as a polymer matrix, and core-shell nanoparticles were prepared to encapsulate Cur via electrostatic interaction under acidic and neutral conditions. The structure of the Spi-Fuc nanoparticles was studied via Fourier-transform infrared spectroscopy, transmission electron microscopy , and scanning electron microscopy. Concurrently, we evaluated the efficacy of the nanoparticles based on stability, drug loading rate, and simulated release. Our results showed that the Spi-Fuc nanoparticles (size, approximately 236.56 nm) had a spherical, core-shell structure and that they could effectively load Cur with an embedding efficiency of >95%; moreover, the system had long-term dispersion stability. Thus, we provide a simple method for Cur delivery, which can also be potentially used for delivering lipid-soluble active ingredients.
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TALANTA
·
2020
·
IF 5.339
Fangzheng Yuan,Xia Wu,Hui Zhang
An intrinsic Eu(III) luminescence phenomenon of Eu(III) complex was found under near-infrared light (NIRL) excitation of xenon lamp, and the maximum excitation wavelength is about twice the excitation wavelength of its Stokes fluorescence. The NIRL excitation fluorescence was mainly originated from second order diffracted light (SODL) excitation. The Eu(III) complex was consist of Eu(III), Gd(III), 2-trifluoroacetylacetone (TTA) and cetyltrimethylammonium bromide (CTAB). Curcumin (Cur) could notably quench the luminescence intensity of the Eu(III) complex. Based on this, a sensitive method for Cur detection was developed. Under optimum conditions, the decrease extent in the fluorescence intensity at 611 nm exhibited a good linear relationship with the Cur concentration in the range of 2.0 × 10 −9 mol/L - 6.0 × 10 −8 mol/L under 746 nm excitation, the limit of detection (LOD, S/N = 3) was 5.2 × 10 −10 mol/L. While, the linear relationship and the LOD of Stokes fluorescence method ( λ ex / λ em = 360/611 nm) were found to be 1.0 × 10 −8 mol/L - 6.0 × 10 −8 mol/L and 2.6 × 10 −9 mol/L, respectively. The former method is superior to the latter one in Cur detection. Both two methods were successfully applied to determine Cur in real samples. The luminescence mechanism of Eu(III) complex under the NIRL excitation and the quenching mechanism of Cur on the Eu(III) fluorescence was also investigated.
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Pharmaceutics
·
2019
·Vol. 11
·期 11
·584
·
IF 4.773
Xiaoxiao Sun,Dongyan Yu,Zhuoyang Ying,Chuqiao Pan,Nan Wang,Fangfang Huang,Junhong Ling,Xiao-kun Ouyang
Curcumin (Cur) has anticancer activities but has poor stability, which can be improved using carrier materials. In this study, chitosan was aminated to increase the number of amino groups on its surface, modified with folic acid (FA), and then made into nanoparticles by ionic crosslinking. Owing to ion interaction, the negatively charged, non-toxic tripolyphosphate (TPP) interacted with the positively charged amino group on the aminated chitosan (AmCS) surface, producing FA-AmCS-TPP nanoparticles, which were then characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectrophotometry (FT-IR), and thermogravimetric analysis (TGA). Their small particle size (175.2 ± 0.99 nm) and good surface positive potential (+42.4 mV) are beneficial for carrying antitumor drugs. We subsequently investigated whether coating of Cur by AmCS allows slow drug release by FA-AmCS-TPP nanoparticles in different pH environments, and estimated the Cur loading efficiency (EE-Cur). Our results showed that the cumulative release rate of Cur at 48 h was 56.2%, and that the EE-Cur reached 94.26 ± 0.91% with nanoparticles composed of 0.10 g AmCS, 10.0 mg FA, 10.0 mg TPP, and 15.0 mg Cur. Additionally, cytotoxicity experiments showed that the Cur/FA-AmCS-TPP nanoparticles had good targeting ability for tumor cells. Therefore, the non-toxic targeted composite nanoparticles had potential as a new antitumor agent that can overcome the limitations of Cur.Keywords:aminated chitosan;folic acid;nanoparticles;targeted delivery;curcumin
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JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Fangzhou Wen,Peiyuan Li,Ying Zhang,Haiyi Zhong,Hongjun Yan,Wei Su
Carbon quantum dots with good biocompatibility can be used as nanomaterial carriers to improve the bioavailability of curcumin. In this paper, green tea was used as raw material to provide a green synthesis method for preparing carbon dots nanoparticles, and Curcumin was loaded to prepare carbon quantum dots/Curcumin nanocomposites (CQDs/Cur). A series of characterization methods were used to study the morphology and chemical structure of composite nanoparticles. The tea carbon dots had the characteristics of excitation wavelength dependence, salt solution stability and light stability. Finally, the antioxidant activities of CQDs/Cur nanocomposites were investigated by DPPH, ABTS •+ , hydroxyl radical, metal ion chelating and reducing power assays. The compound system not only improved the antioxidant performance of curcumin, but also retained the antibacterial activity of curcumin. These results suggested that tea carbon quantum dots loaded with curcumin had the potential to be developed as natural antioxidants and antibacterial agents.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Ce Cheng,Zhihua Wu,David Julian McClements,Liqiang Zou,Shengfeng Peng,Wei Zhou,Wei Liu
A novel cholesterol-free curcumin delivery system was fabricated by rhamnolipids modified liposomes (RL-Lps). The incorporation of the rhamnolipids increased the sphericity, reduced the size, and decreased the polydispersity of the liposomes compared with pure liposomes (Lps). Analysis of the environmental stability of the RL-Lps showed they have good long-term stability over a wide range of pH (2–3 and 5–8), ionic strengths (0–200 mM), and accelerated centrifugal conditions. The curcumin-loaded rhamnolipids modified liposomes (Cur-RL-Lps) could be prepared with a relatively high loading efficiency (LE > 90%) and loading capacity (LC > 3.5%). The thermal and photochemical stability of the curcumin was improved after encapsulation in the Cur-RL-Lps. In vitro release studies indicated that the sustained release of the curcumin was prolonged when rhamnolipids were incorporated into the liposomes. This study shows that rhamnolipids have great potential for liposomal delivery system suitable for utilization in functional foods, dietary supplements, and pharmaceutical preparations.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ailong Hu,Zongwei Hao,Xinran Liu,Jinhua Song,Lihua Chu,Daxiang Li,Yiqun Du
Natural biopolymer-based nanoparticles are promising candidates for emulsion stabilization and delivery of hydrophobic compounds. In this study, tea protein (TP) and chitosan (CS) were employed to fabricate complex nanoparticles (NPs) using a pH-dependent method. At a mass ratio of 2:1 (TP:CS), the NPs exhibited favorable properties (206.62 nm, −30.86 mV, 85.41° contact angle) owing to electrostatic interactions, hydrogen bonding, and hydrophobic interactions (binding energy of the complex was −5.40 kcal/mol). At a particle concentration of 2 % and an oil-phase volume fraction of 60 %, the Pickering emulsion stabilized by TP-CS 2:1 NPs remained physically stable. Compared with TP alone, TP-CS 2:1 NPs significantly enhanced the encapsulation efficiency and antioxidant capacity (DPPH/ABTS) of curcumin (Cur). In vitro digestion confirmed that the emulsions reduced gastric degradation of Cur, increasing its bioaccessibility by 17.4 %. Accordingly, this study provides a strategy for designing natural protein-polysaccharide NPs for functional emulsions and sustained delivery systems.
研究领域:
食品科学与技术
·
纳米技术
·
药物递送
·
胶体与界面化学
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