BIOSENSORS & BIOELECTRONICS
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2025
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IF 10.5
An Tang,Jiachen Wang,Jia-Li Xu,Jun-Tao Liu,Tianpeng Xu,Qiang Zhang,Yu Tian
The integration of visualization and electrical feedback in biomimetic electronic skin (E-skin) for real-time motion tracking has attracted significant attention in wearable electronics. To facilitate human-readable interactive feedback and improve the overall performance of E-skin, particularly regarding mechanical compliance, sensitivity, and stability, we propose a novel high-performance photonic-ionic skin (PI-skin) based on mechanochromic photonic ionogel. The PI-skin, prepared by incorporating aligned magnetic colloids into an ionogel matrix, integrates interactive structural coloration and electrical responses to external stimuli, achieving dual-mode precise motion recognition. Due to the enhanced hydrogen bonding and electrostatic interactions within the ionogel matrix, the PI-skin exhibits excellent mechanical properties (tensile strain >1000%), remarkable adhesive strength (peeling force >7 kPa), high sensitivity (gauge factor = 1.42 at straining 0%–300% and 2.71 at straining 300%–500%), rapid response time (120 ms), and exceptional mechanical compliance (>500 continuous cycles). More importantly, such PI-skin demonstrates ultrafast and highly accurate optical/electrical dual-signal motion detection, thereby facilitating posture correction during sitting and encoding of vocal cord vibrations during speech. We anticipate that this versatile PI-skin will possess substantial potential in the field of wearable electronics, and may inspire the design of next-generation E-skin for human-computer interaction and personalized healthcare applications.
研究领域:
生物医学工程
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材料科学
·
可穿戴设备
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Journal of Materials Chemistry A
·
2024
·
IF 10.7
Zhihao Zhou,Siyuan Duan,Guangze Nie,Zhenkun Sun,Lunbo Duan
Reverse water-gas shift (RWGS) reaction offers a promising pathway for utilising green H2 to reduce CO2 into CO, a valuable precursor for e-fuel production. Conventional catalyst synthesis methods, however, often rely on costly and complex procedures using fine chemical precursors. In this study, we repurpose retired ternary lithium-ion battery cathodes (rTLIBCs), prevalent e-waste from the electric vehicle industry, as catalysts for the RWGS reaction. Using a straightforward method of mixing rTLIBC material with Al2O3 powder, we successfully synthesise xNCM/Al2O3 catalysts with high CO2 conversion and CO selectivity. Notably, the 10NCM/Al2O3 catalyst demonstrates the highest CO space-time yield at 450–600 °C, with stable performance across long-term tests, maintaining CO2 conversion, CO selectivity, and CO space-time yield. The performance of our prepared catalyst is comparable to that of the best catalysts synthesised using fine chemicals. The high catalytic performance is attributed to the synergistic effect of a Ni-Co bimetallic alloy formed during pretreatment, strong metal-support interaction, and alkali metal Li. Ni-Co alloy formation optimises the catalytic activity and selectivity, the metal-support interaction enhances CO2 activation, and Li boosts basicity and fine-tunes the reaction pathway. This study validates that rTLIBCs are a viable raw material for practical RWGS catalyst synthesis, providing a sustainable alternative for e-waste utilisation.
研究领域:
环境科学
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催化化学
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能源化学
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Jiahuan Ling,Rui Chen,Minghai Wang,Chun-Xiao Yan,Ruomu Xia,Lihui Zhang
Ergothioneine (EGT) is a powerful and natural antioxidant, which can protect cells in the human body from oxidative damage. Numerous studies have attempted to enhance the heterologous synthesis. However, research on EGT transport out of Escherichia coli cells and the wild-type enzyme from Trichoderma reesei is rare. Here, membrane permeability engineering and protein engineering are combined to improve EGT production in E. coli. After metabolic engineering to enhance precursor supply, we deleted the genes involved in lipopolysaccharide biosynthesis to increase the membrane permeability, which promoted EGT production. Further, a mutant of Tregt2E155C with improved catalytic capacity was created, and the expression level of enzymes involved in EGT synthesis was optimized. Finally, fermentation parameters were systematically tuned to maximize the EGT production. The engineered strain MT9-PET-T1/RSF-T2E155C produced 334.20 ± 6.33 mg/L EGT during 48 h of shake-flask fermentation, corresponding to an 8.4-fold increase compared with wild-type strain MT1. When scaled up to 5 L bioreactors, the strain achieved a final EGT titer of 4.06 g/L within 96 h (42.29 mg/L/h). Our work shows significant implications for EGT synthesis and is also a reference for manipulating E. coli to synthesize other biomolecules.
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MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 4
·2000375
·
IF 4.979
Wenjuan Wei,Nouredine Behloul,Weiqi Wang,Sarra Baha,Zhenzhen Liu,Ruihua Shi,Jihong Meng
In a continuous effort to develop effective vaccines against hepatitis E (HE), oral vaccine nanoparticles using the truncated capsid protein p146 (aa460–605) are formulated and characterized. To improve the immunogenicity of p146, chitosan nanoparticles (CSNPs) are used as a mucosal delivery system. Next, the physical-chemical properties, cytotoxic effects in vitro, and immunogenicity in mice of the produced NPs are analyzed. The results show that the produced CS/p146 NPs are stable and well dispersive and display a near-spherical shape with a mean size of 200–300 nm. The findings also demonstrate high encapsulation efficiency (65–73.9%) and loading capacity (27.7–67.5%) of the formulated nanoparticles. Further, the CS/p146 NPs exhibit low cytotoxicity and an obvious sustained-release effect in vitro. Immunogenicity experiments in mice indicate that CS/p146 NPs can induce antigen-specific systemic and mucosal immune responses higher than the purified p146 do. Besides, the expression levels and mRNA transcription of Interleukin (IL)-4 in spleen cells of CS/p146 NPs-immunized mice are higher than those of p146, indicating that a Th2-mediated cellular immune response is activated by the CS/p146 NPs. Overall, the synthesized CS/p146 NPs display promising properties as a potential HE oral vaccine candidate.
研究领域:
病毒学
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药学
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免疫学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
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IF 4.784
Jianying Huang,Yuhong Liu,Lijun Yang,Fengyan Zhou
A sulfonated chitosan (SCS) was prepared via nucleophilic substitution and characterized by Fourier transform infrared spectroscopy, 1 H and 13 C NMR spectra, gel permeation chromatography, elemental analysis, and thermo gravimetric analysis. The inhibition activities of bacterial adhesion and biofilm formation against E. coli and S. aureus of SCS were assessed in comparison with those of unmodified chitosan hydrochloride (WCS) which was commercially available. The metabolic activity and secretion of exopolysaccharide in biofilms of E. coli and S. aureus were significantly decreased after the treatment of SCS. Scanning electron microscopy and confocal laser scanning microscopy also demonstrated that SCS and WCS at 1MIC concentrations could obviously inhibit the formation of biofilm. Upon the experimental data obtained, it can be concluded that the alkylsulfonation of chitosan could significantly improve efficacy in killing biofilm-embedded bacteria, and the inhibition activities against biofilm formation of E. coli and S. aureus . The exploitation of SCS in this study is helpful to extend the understanding to an alternative to antibiotics and chemical preservatives in food and medicine fields.
研究领域:
材料科学
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微生物学
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生物技术
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RSC Advances
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2015
·Vol. 5
·期 37
·29185-29192
·
IF 3.84
He Li,Jun-Mian Tian,Hao-Yu Tang,Shi-Yin Pan,An-Ling Zhang,Jin-Ming Gao
Fifteen aromatic polyketide metabolites, including four new chromones, chaetosemins B–E (2–5), with compound 4 bearing a new skeleton, and two new natural products, chaetosemin A (1) and (+)-(S)-chaetoquadrin J (14), together with nine known ones (6–13, 15), were isolated from the organic extract of a solid fermented culture of an Ascomycete filamentous fungus, Chaetomium seminudum. The structures of 1–5 were determined by spectroscopic analysis, and the absolute configuration of chaetosemin A (1) was confirmed by X-ray crystallography, whereas the stereochemistry of 1–4 and 14 was assigned by comparison of their specific optical rotations with reported data for structurally related compounds. All compounds were isolated for the first time from Chaetomium seminudum. Compounds 1 and 2 consisted of L-cysteine and D-cysteine units, respectively. Most of them were evaluated for in vitro antifungal activities against some phytopathogenic fungi. Among them, chaetosemin B (2) was the most active against Magnaporthe oryzae and Gibberella saubinettii with MICs of 6.25 and 12.5 μM, respectively. In addition, chaetosemin C (3) showed antioxidant activity with 50.7% DPPH free radical scavenging activity at 50 μM, and chaetoquadrin J (14) displayed weak inhibition of soluble epoxide hydrolase (sEH).
研究领域:
天然产物化学
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真菌学
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药用微生物学
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生物有机化学
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抗真菌研究
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Nanomaterials
·
2023
·Vol. 13
·期 22
·2954
·
IF 5.3
Suyi Zhao,Zhenzeng Chong,Xiaogang Zuo,Wenjun Qi
For environmental remediation, it is significant to design membranes with good mechanical properties and excellent photocatalytic activity. In this work, RGO/TiO2membranes with heterogeneous structures and good photocatalytic efficiency were synthesized using the method of electrospinning combined with a thermal treatment process. In the binary nanocomposites, RGO was tightly adhered to TiO2fibers and by simply adjusting the loading of RGO, the strength and modulus of the fibrous membranes were improved. Notably, the RGO-permeated TiO2fibers exhibited 1.41 MPa in tensile strength and 140.02 MPa in Young’s modulus, which were 705% and 343% of the original TiO2fibers, respectively. Benefiting from the enhanced light response and the homogeneous and compact heterogeneous structure, the synthesized RGO/TiO2membranes displayed good antibacterial performance with a photocatalytic inactivation rate of 6 log againstE. coliwithin 60 min. This study offers a highly efficient alternative to inactivateE. colifor the synthesis of TiO2-based membranes.Keywords:RGO/TiO2;nanomembrane;photocatalytic;sterilization
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Advanced Science
·
2023
·Vol. 10
·期 31
·2304121
·
IF 15.1
Shengshun Duan,Xiao Wei,Fangzhi Zhao,Huiying Yang,Ye Wang,Pinzhen Chen,Jianlong Hong,Shengxin Xiang,Minzhou Luo,Qiongfeng Shi,Guozhen Shen,Jun Wu
As key interfaces for the disabled, optimal prosthetics should elicit natural sensations of skin touch or proprioception, by unambiguously delivering the multimodal signals acquired by the prosthetics to the nervous system, which still remains challenging. Here, a bioinspired temperature-pressure electronic skin with decoupling capability (TPD e-skin), inspired by the high-low modulus hierarchical structure of human skin, is developed to restore such functionality. Due to the bionic dual-state amplifying microstructure and contact resistance modulation, the MXene TPD e-skin exhibits high sensitivity over a wide pressure range and excellent temperature insensitivity (91.2% reduction). Additionally, the high-low modulus structural configuration enables the pressure insensitivity of the thermistor. Furthermore, a neural model is proposed to neutrally code the temperature-pressure signals into three types of nerve-acceptable frequency signals, corresponding to thermoreceptors, slow-adapting receptors, and fast-adapting receptors. Four operational states in the time domain are also distinguished after the neural coding in the frequency domain. Besides, a brain-like machine learning-based fusion process for frequency signals is also constructed to analyze the frequency pattern and achieve object recognition with a high accuracy of 98.7%. The TPD neural system offers promising potential to enable advanced prosthetic devices with the capability of multimodality-decoupling sensing and deep neural integration.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Xiaoxia Liu,Ronghao Liu,Yiming Lu,Qian Sun,Wenfeng Xue,Mengmeng Cheng,Yanzhao Yang
Recycling gold from e-waste is not only beneficial to environmental protection, but also to resource sustainability. However, it remains a great challenge due to the limitations of high cost, lengthy balance process and the interference of coexisting metals. Herein, a family of low-cost, nitrogen-rich content and acid-stable imidazolium-based poly(ionic liquid)s, designated as P(nDVB-mVBIMCl)s, were synthesized for recovery of gold from e-waste. The obtained P(2DVB-8VBIMCl)s achieves outstanding adsorption capacity (820.5 mg·g −1 ) and rapid equilibrium time (15 min) and satisfactory reusability (more than 8 cycles). XPS, EDS and ion chromatography revealed that the excellent adsorption performance was attributed to synergistic effect of ion exchange and chemical reduction. In addition, the P(2DVB-8VBIMCl)s showed excellent selectivity for gold in actual e-waste leaching solution, exhibited satisfactory selectivity coefficient for Fe 3+ (1.46 × 10 4 ) and Ni 2+ (1.12 × 10 4 ), obtaining 23.4 karat high-purity gold after calcination. In addition, the P(2DVB-8VBIMCl)s shows its good economic feasibility. Overall, this work provides a feasible adsorbent, which becomes a promising candidate for industrial gold recovery from e-waste.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Yunkai Sun,Xiaoxia Wu,Meng Cao,Xiaoqiang Xue,Dongfang Jiang,Zhao Liu
In the classical route of synthesizing of avanafil, the last step of the reaction uses EDCI and HOBT as an acid and amine binding agent. HOBT may contain residues of hydrazine, and potential mutagenic impurities containing acylhydrazide structures may be formed. The intermediate product (M6) of avanafil was synthesized by 6 steps using diethyl ethoxylmethylmalonate and S-methyl isothiourea semisulfide as starting materials. The potentially genotoxic impurity E (Imp-E) of avanafil was given by the reaction of M6 and hydrazine sulfate acid amine, yield of 20%. The single crystal of Imp-E was cultivated by solvent volatilization method, and its structure was analyzed by high resolution mass spectrometry (HRMS) and nuclear magnetic resonance spectroscopy (NMR). The Flack parameter of Imp-E was -0.03(3) by X-ray single crystal diffraction analysis, and the absolute configuration of Imp-E was determined as S configuration. The intramolecular / intermolecular hydrogen bonds of Imp-E make the molecules maintain a stable arrangement in space.
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CARBON
·
2023
·
IF 10.9
Xuewei Shi,Alamusi Lee,Bo Yang,Lingxiao Gao,Huiming Ning,Kaiyan Huang,Xiaolin Luo,Lidan Zhang,Jiaofei Zhang,Chao Yang,Bin Gu,Ning Hu
Artificial hydrogel electronic skin (E-skin) sensing systems have received considerable attention due to their ability in providing tactile perception. Recent advancements in hydrogel E-skin have allowed for simultaneous sensing of touch position and pressure through construction of sensor arrays. However, the fabrication process is complex, and the sensing resolution is limited by the size and number of array cells. Here, we report a multi-modal sensory E-skin based on a polyvinyl alcohol (PVA) hydrogel embedded with carbon nano-materials, which can recognize touch position and pressure simultaneously without constructing arrays. Combining the advantages of high electron transfer efficiency of 1D nanotube and 2D graphene nanosheet, the 3D hierarchical cross-linked polydopamine (PDA) modified reduced graphene oxide (rGO)/carboxylic multiwalled carbon nanotube (MWCNT-COOH) composites were proposed as a conductive filler, which was added by nano-doping to hydrogel substrate to gain an elastic modulus and stretchability of the hydrogel similar to that of human skin. Meanwhile, a surface-capacitive touch (SCT) system and piezoresistive technology were adopted to sense touch position and pressure due to the stability of conductive networks and the piezoresistive properties of carbon nanomaterials. Our E-skin device demonstrates superior sensing performance and provides a new direction for designing novel E-skin sensor devices.
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FOOD AND CHEMICAL TOXICOLOGY
·
2023
·
IF 4.3
Kaiyuan Chen,Yahui Tang,Linhua Lan,Mengxuan Li,Zhongqiu Lu
Acute kidney injury (AKI) induced by diquat (DQ) progresses rapidly, leading to high mortality, and there is no specific antidote for this chemical. Our limited knowledge of the pathogenic toxicological mechanisms of DQ has hindered the development of treatments against DQ poisoning. Pyroptosis is a form of programmed cell death and was recently identified as a novel molecular mechanism of drug-induced AKI. To explore the role of pyroptosis in HK-2 cells exposed to DQ, the plasma membrane damage of the cells was detected by LDH release assay. Western blot was performed to detect the cleavage of GSDME. Proteomics analysis was performed to explore the mechanism of DQ induced nephrotoxicity . FerroOrange probe was used to measure the intracellular Fe 2+ levels. Herein, we show that DQ induces pyroptosis in HK-2 cells. Mechanistically, DQ induces the accumulation of mitochondrial ROS and initiates the cleavage of gasdermin E (GSDME) in an intrinsic mitochondrial pathway. Knockout of GSDME attenuated DQ-induced cell death. Further analysis revealed that loss of FTH1 induces Fe 2+ accumulation, contributing to DQ-induced pyroptosis. Knockdown LC3B could help restore the expression of FTH1 and improve cell viability . Moreover, we found DFO , an iron chelator , could reduce cellular Fe 2+ levels and inhibit pyroptosis. Collectively, these findings suggest an unrecognized mechanism for GSDME-dependent pyroptosis in DQ-induced AKI.
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