COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
·
IF 5.2
Jiayu Zhao,Yutie Gong,Hairong Li,Aihua Xu,Zhenzhen Li,Jing Huang,Hao Xu,Leping Huang,Ming Jiang
Thermally-triggered electrical switching materials are of urgent demand for developing novel temperature sensors , overheat protection circuits, thermal controllers, battery management systems against overheating, etc. Here, we report a water-in-oil emulsion system with giant electrical switching ratios at room temperature prepared by a simple and efficient method. The temperature-sensitive phase transition process of alkanes as the oil phase causes the formation and collapse of conductive paths in the emulsion, resulting in electrical switching ratios of up to 6 orders of magnitude. The emulsions have good thermal cycle stability, and the switching ratio remains essentially unchanged after 100 cycles. The switching temperature can be easily adjusted by using alkanes of various chain lengths. In addition, the similar electrical switching effect is observed in four emulsions containing different neutral salts, ensuring the tunability and versatility of the system. The electrical switching emulsions offer a promising avenue to developing future high-performance, energy-saving, and low-cost electrical switching systems.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Jing Peng,Dongyan Tang,Shuyue Jia,Yue Zhang,Zhaojie Sun,Xu Yang,Hongyun Zou,Haitao Lv
In situ formation of nanocrystals within thermoresponsive microgels has become a significant technology in the fields of catalysis and biomedicine to fabricate multifunctional hybrid nanostructures . Usually, the room temperature or cooler was set to control the formation of nanocrystals using microgels as template in such process. Here, the relatively higher temperature was used to synthesize molybdenum oxide nanocrystals where the poly( N -vinyl caprolactam) microgels were found to work as both the stabilizer and the template. Specifically, ethanol was added in the solution of the microgels to raise their volume phase transition temperature (VPTT). Later, a modified hydrothermal process was performed at 70 °C with precursor molybdic acid concentrated in the microgels matrix through the hydrogen bond between molybdic acid and N -vinyl caprolactam units. 2D nanoflakes , nanorods and nanoplatelets of molybdenum oxide were successfully synthesized. Specially, the microgels with the crosslinked degree of 2% exhibited well hybrid with controlled sizes and ideal confine of the molybdenum oxide nanoplatelets within microgels, along with strong photoluminescence intensity. These results emphasized the feasibility of poly( N -vinyl caprolactam) microgels as template and stabilizer at high temperature and provided a novel synthesis strategies for hybrid microgels applicable in wide areas of nanotechnology from catalysis, sensing to therapy.
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ARCHIVES OF TOXICOLOGY
·
2017
·Vol. 92
·期 3
·1215-1223
·
IF 5.901
Zhang Jie,Li Tiezhu,Wang Tuoyi,Yuan Cuiping,Zhong Shuning,Guan Tianzhu,Li Zhuolin,Wang Yongzhi,Yu Hansong,Luo Quan,Wang Yongjun,Zhang Tiehua
The binding interactions of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to human estrogen receptor α ligand binding domain (hERα-LBD) was investigated using a combined in vitro and in silico approach. First, the recombinant hERα-LBD was prepared as a soluble protein in Escherichia coli BL21(DE3)pLysS. A native fluorescent phytoestrogen, coumestrol, was employed as tracer for the fluorescence polarization assay. The results of the in vitro binding assay showed that bisphenol compounds could bind to hERα-LBD as the affinity ligands. All the tested halogenated BPAs exhibited weaker receptor binding than BPA, which might be explained by the steric effect of substituents. Molecular docking studies elucidated that the halogenated BPAs adopted different conformations in the flexible hydrophobic ligand binding pocket (LBP), which is mainly dependent on their distinct halogenation patterns. The compounds with halogen substituents on the phenolic rings and on the bridging alkyl moiety acted as agonists and antagonists for hERα, respectively. Interestingly, all the compounds in the agonist conformation of hERα formed a hydrogen bond with His524, while the compounds in the antagonist conformation formed a hydrogen bond with Thr347. These docking results suggested a pivotal role of His524/Thr347 in maintaining the hERα structure in the biologically active agonist/antagonist conformation. Comparison of the calculated binding energies vs. experimental binding affinities yielded a good correlation, which might be applicable for the structure-based design of novel bisphenol compounds with reduced toxicities and for environmental risk assessment. In addition, based on hERα-LBD as a recognition element, the proposed fluorescence polarization assay may offer an alternative to chromatographic techniques for the multi-residue determination of bisphenol compounds.
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Nature Communications
·
2017
·Vol. 8
·期 1
·1-9
·
IF 12.124
Hu Chenji,Chen Hongwei,Shen Yanbin,Lu Di,Zhao Yanfei,Lu An-Hui,Wu Xiaodong,Lu Wei,Chen Liwei
While lithium–sulfur batteries are poised to be the next-generation high-density energy storage devices, the intrinsic polysulfide shuttle has limited their practical applications. Many recent investigations have focused on the development of methods to wrap the sulfur material with a diffusion barrier layer. However, there is a trade-off between a perfect preassembled wrapping layer and electrolyte infiltration into the wrapped sulfur cathode. Here, we demonstrate an in situ wrapping approach to construct a compact layer on carbon/sulfur composite particles with an imperfect wrapping layer. This special configuration suppresses the shuttle effect while allowing polysulfide diffusion within the interior of the wrapped composite particles. As a result, the wrapped cathode for lithium–sulfur batteries greatly improves the Coulombic efficiency and cycle life. Importantly, the capacity decay of the cell at 1000 cycles is as small as 0.03% per cycle at 1672 mA g –1 .
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PEST MANAGEMENT SCIENCE
·
2022
·Vol. 79
·期 2
·833-844
·
IF 4.462
Kaixin Li,Jiantao Liu,Ziqiong Geng,Wei Xu,Zhuang Zhang,Dong Chu,Lei Guo
BACKGROUND Bemisia tabaci (Gennadius) is a serious agricultural pest worldwide. Neonicotinoids are the most important new class of synthetic insecticides used in the management of B. tabaci . However, B. tabaci populations have developed resistance to various active ingredients in neonicotinoids following long-term and widespread application. RESULTS Dinotefuran exhibited high toxicity against most B. tabaci field populations. One population (Din-R) with a high level of resistance to dinotefuran (255.6-fold) was first identified in the field. The Din-R population exhibited medium to high levels of resistance to all the tested neonicotinoid insecticides and a high level of resistance to spinetoram. Genetic inheritance analysis revealed that resistance to dinotefuran was incompletely recessive and polygenic. The synergist piperonyl butoxide significantly increased the toxicity of dinotefuran to Din-R. P450 activity in the Din-R population was 2.19-fold higher than in the susceptible population. RNA-sequencing analysis showed that 12 P450 genes were significantly upregulated in the Din-R population, of which CYP6DW5 , CYP6JM1 and CYP306A1 were found to exhibit more than 3.00-fold higher expression in Din-R when using a reverse transcription quantitative real-time polymerase chain reaction. Expression of eight P450 genes was obviously induced by dinotefuran, and CYP6DW5 showed the highest expression level. After knockdown of CYP6DW5 in Din-R, the toxicity of dinotefuran increased significantly. CONCLUSION P450 had a crucial role in dinotefuran resistance in B. tabaci , and CYP6DW5 was involved in the resistance. These results provide important information for the management of resistance in B. tabaci and improve our understanding of the resistance mechanism of dinotefuran. © 2022 Society of Chemical Industry.
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Food Quality and Safety
·
2022
·
IF 3.949
Shen Changxin,Liu Lian,Yin Xiaoyao,Tu Fengqin,Wu Kejia,Wu Qian,Peng Lingfeng,Fang Min,Wu Yongning,Gong Zhiyong
Perchlorate concentrations in 387 unhusked rice samples from 15 main producing provinces/municipality in China were investigated by high-performance liquid chromatography–tanden mass spectrometry. The results indicated that perchlorate displays a mean level of 17.17 μg/kg in unhusked rice samples. Intriguingly, we also found that perchlorate is mainly observed in rice husk among these collected unhusked rice samples, while less observed in rice bran and milled rice. Specifically, the perchlorate levels in rice were found in the husks (73.61%), bran (10.09%), and milled rice (19.52%), respectively. Our results indicated that there is no significantly perchlorate exposure risk in edible milled rice.
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Crystals
·
2021
·Vol. 11
·期 9
·1132
·
IF 2.589
Lianxing Liao,Kunhua Quan,Xiangshi Bin,Ruosheng Zeng,Tao Lin
Bandgap tunability through ion substitution is a key feature of lead halide perovskite nanocrystals (LHP-NCs). However, the low stability and low luminescent performance of CsPbCl3hinder their full-color applications. In this work, quantum confinement effect (QCE) was utilized to control the bandgap of CsPbBr3NCs instead of using unstable CsPbCl3, which possess much higher emission efficiency in blue spectra region. Studies of microstructures, optical spectra and carrier dynamics revealed that tuning the reaction temperature was an effective way of controlling the NC sizes as well as QCE. Furthermore, the obtained CsPbBr3NCs were encapsulated in a PDMS matrix while maintaining their size distribution and quantum-confined optoelectronic properties. The encapsulated samples showed long-term air and water stability. These results provide valuable guidance for both applications of LHP-NCs and principal investigation related to the carrier transition in LHP-NCs.Keywords:lead halide perovskites;nanocrystals;quantum confinement effect;carrier lifetimes
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PLANT CELL TISSUE AND ORGAN CULTURE
·
2021
·Vol. 147
·期 2
·389-404
·
IF 2.711
Shi Min,Hua Qiang,Kai Guoyin
Phenolic acids and tanshinones are important bioactive components with multiple pharmacological properties accumulated in traditional Chinese medicinal plant Salvia miltiorrhiza . Abscisic acid (ABA) is effective to enhance the content of the two compounds in S. miltiorrhiza , while the regulation mechanism remains unknown. Deep transcriptome profile of S. miltiorrhiza hairy roots treated with ABA was conducted. Totally, 42,710 unigenes with the average length of 1,157 bp were obtained from de novo assembly from about 2.81 billion produced clean reads, of which 27,641 unigenes (64.72%) were successfully annotated. Unigenes encoding key enzymes such as PAL, TAT, C4H, RAS, CYP98A14, GGPPS expressed significantly higher than that in control. Candidate laccases showing similar expression with RAS and CYP98A14 in phenolic acid biosynthesis and potential P450 unigenes involved in tanshinone biosynthesis genes were screened out. Furthermore, transcription factor (TF) profiles revealed that 1,250 TFs representing 35 families were identified, of which MYB, AP2/ERF, bHLH and bZIP were most abundant. The present study provided a comprehensive transcriptional expression profile affected by ABA, which will help underly the biosynthesis and regulation mechanism.
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ENVIRONMENTAL POLLUTION
·
2021
·
IF 8.071
Jianfeng Tang,Jing Sun,Wendong Wang,Lei Yang,Yaoyang Xu
Pharmaceuticals are of increasing environmental concern due to their potential threat to aquatic ecosystems . Intensive human activities are a major factor influencing the level of pharmaceutical pollution in aquatic ecosystems. In this study, we investigated the occurrence, ecological risks of 31 pharmaceuticals and the possible influence of human activities on pharmaceutical distribution in two watersheds in the Yangtze River Delta, Eastern China. The target compounds were grouped into six categories: three non-steroidal anti-inflammatory drugs, ten antibiotics, six cardiovascular drugs, five hormones, six psychotropic drugs , and one antiparasitic. All target pharmaceuticals were detected in the surface water samples, with dexamethasone (100% of samples), tetracycline (100% of samples), and cefradine (100% of samples) being the dominant compounds (maximum concentrations of 686, 128, and 2280 ng/L, respectively). The total pharmaceutical concentrations were significantly higher in the urban watershed (711–2790 ng/L, mean = 1150 ng/L) than in the peri-urban watershed (467–1525 ng/L, mean = 863 ng/L) (p < 0.05). Distinct variation in the total pharmaceutical concentration also occurred between the dry season (507–2790 ng/L, mean = 1100 ng/L) and the wet season (467–1525 ng/L, mean = 943 ng/L). Ecological risk assessment showed that in the two watersheds, benzylpenicillin potassium, tetracycline hydrochloride, chlormadinone, ampicillin, cefotaxime acid, atorvastatin, sertraline hydrochloride, and oxazepam posed a medium potential risk (0.1 < risk quotient < 1), while norethisterone posed a high potential risk (risk quotient > 1). Redundancy analysis revealed that the concentrations of pharmaceuticals in various categories were positively correlated with land-use type (urban and agricultural land-use percentages), population density, and distance from town in both watersheds. Urban and agricultural activities were likely the main factors influencing the concentrations and composition of pharmaceuticals in these aquatic environments. Positive correlations were also found between total pharmaceutical concentrations and population density in both watersheds, suggesting a significant contribution of human disturbance to pharmaceutical pollution. The results provide useful information for pharmaceutical pollution control , ecological risk assessment, and sustainable water management at the watershed scale.
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JOURNAL OF FOOD PROTECTION
·
2020
·
IF 1.581
Mengmeng Jiang,Haicheng Gao,Xinxin Liu,Yu Wang,Jiaqi Lan,Yuanxiang Li,Shaowu Lv,Ketong Zhu,Pingsheng Gong
ABSTRACT We evaluated fresh vegetables for residues of 18 pesticides with different chemical structures, including organochlorine pesticides, organophosphorus pesticides, carbamate pesticides, and pyrethroid pesticides and estimated that the potential health risks for consumers. A total of 313 samples were collected from 12 kinds of vegetables in Changchun, the capital of Jilin Province, People's Republic of China. Pesticide residues were analyzed by gas chromatography and mass spectrometry, and the curves were highly linear at 0.01 to 1.00 μg/mL ( R 2 ≥ 0.99). The mean recovery rate of the pesticides was 62 to 110% (relative standard deviation of <5%). The limit of detection was 0.0001 to 0.0167 mg/kg, the limit of quantification was 0.0002 to 0.0556 mg/kg, and the overall detection rate was 28.43%. The prevalence of pesticides and of samples above the standard limit were highest in celery, the prevalence of pesticides was lowest in potatoes, and the prevalence of samples above the standard limit was lowest in cucumber. Three of the 18 pesticides were not detected: omethoate, chlorpyrifos, and fenvalerate. Among the 15 pesticides detected, the maximum risk factor of six (carbofuran, omethoate, phorate, dicofol, dimethoate, and dichlorvos) is >1, indicating possible harm to human health. Residues of a single pesticide may not adversely affect a person's health, but multiple pesticide residues could present a health risk.
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MOLECULAR MICROBIOLOGY
·
2016
·Vol. 103
·期 4
·713-728
·
IF 3.761
Tan-Jun Wang,Yi-Ming Shan,Han Li,Wei-Wang Dou,Xin-Hang Jiang,Xu-Ming Mao,Shui-Ping Liu,Wen-Jun Guan,Yong-Quan Li
Summary Antibiotic-producing microorganisms have evolved several self-resistance mechanisms to prevent auto-toxicity. Overexpression of specific transporters to improve the efflux of toxic antibiotics has been found one of the most important and intrinsic resistance strategies used by many Streptomyces strains. In this work, two ATP-binding cassette (ABC) transporter-encoding genes located in the natamycin biosynthetic gene cluster, scnA and scnB , were identified as the primary exporter genes for natamycin efflux in Streptomyces chattanoogensis L10. Two other transporters located outside the cluster, a major facilitator superfamily transporter Mfs1 and an ABC transporter NepI/II were found to play a complementary role in natamycin efflux. ScnA/ScnB and Mfs1 also participate in exporting the immediate precursor of natamycin, 4,5-de-epoxynatamycin, which is more toxic to S. chattanoogensis L10 than natamycin. As the major complementary exporter for natamycin efflux, Mfs1 is up-regulated in response to intracellular accumulation of natamycin and 4,5-de-epoxynatamycin, suggesting a key role in the stress response for self-resistance. This article discusses a novel antibiotic-related efflux and response system in Streptomyces , as well as a self-resistance mechanism in antibiotic-producing strains.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Xian-xian Chen,Chao Li,Krishna Kumar Selvaraj,Qing-song Ji,Zhi-hong Fang,Shao-gui Yang,Shi-yin Li,Li-min Zhang,Huan He
In this study, the relative bioavailability (RBA) of nitrated polycyclic aromatic hydrocarbons (NPAHs) in soil samples ( n = 30) was assessed using an in vivo mouse model. Based on the correlation between the bioaccessibility data obtained from the Tenax improved traditional Fed ORganic Estimation human Simulation Test (FOREhST) in vitro method (TITF) and the bioavailability data obtained from in vivo experiments, the TITF method was further optimized and simplified by referring to the “Pharmacopoeia of the People's Republic of China: Volume IV, 2020” to adjust the formulation and parameters of the gastrointestinal fluid (GIF) in order to establish a simpler and lower cost in vitro method for the determination of the bioaccessibilities of NPAHs. The dose-accumulation relationship of the in vivo experiment showed that the linear dose-response was better in adipose tissue (R 2 = 0.77–0.93), and the accumulation of NPAHs in adipose tissue was higher than that in kidney or liver tissue. Depending on the mouse adipose model, the NPAHs-RBA ranged from 1.88 % to 73.92 %, and a strongly significant negative relationship (R 2 = 0.94, p < 0.05) was found between the NPAHs-RBA and Log K ow . The simplified experiment of the TITF showed that the composition of the GIF medium had a significant effect on the bioaccessibilities of NPAHs. The NPAH bioaccessibilities measured by the Tenax improved simplified FOREhST method (TISF) (9.0–36.5 %) were higher than that of the traditional FOREhST method (6.8–22.8 %) but significantly lower than that of the TITF method (16.8–55.2 %). With an increase in the bile concentration in the GIF (from 6 to 10 g/L), the bioaccessibilities of NPAHs increased from 9.0 to 36.5 % to 12.9–42.4 %. The accuracies of the four in vitro methods for predicting the bioavailabilities of NPAHs was in the following order: Tenax improved simplified FOREhST method with increased bile concentration (TITF-IB) (R 2 = 0.54–0.87) ≈ TITF (R 2 = 0.55–0.85) > TISF (R 2 = 0.41–0.77) > FOREhST (R 2 = 0.02–0.68). These results indicated that the simple in vitro method could also effectively predict the bioavailabilities of NPAHs.
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危险品化学品经营许可证（带存储）