CARBOHYDRATE POLYMERS
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2011
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IF 3.463
Quan Li,Bing Xia,Mickey Branham,Wei Ha,Hao Wu,Shu-Lin Peng,Li-Sheng Ding,Bang-Jing Li,Sheng Zhang
The self-assembly of rod–coil carboxymethyl konjac glucomannan-graft-poly(ethylene glycol) (CKGM- g -PEG) and α-cyclodextrin (α-CD) complexes were investigated and used as encapsulating hollow nanospheres for the enzyme glucose oxidase (GOX) in aqueous solution. These hollow nanospheres exhibited “cell-like” semi-permeability allowing enzyme substrates to pass through the surface while restricting the encapsulated enzyme (i.e. GOX) to the interior. Encapsulated GOX exhibited higher thermostability , optimal enzymatic activity over a wider pH range and improved storage stability in comparison to free un-encapsulated GOX. In addition, these CKGM- g -PEG/α-CD hollow nanospheres showed in vitro biocompatibility when exposed to L929 cells when tested using MTT viability assay. These studies suggested that self-assembly of CKGM- g -PEG and α-CD to form stable nanospheres may be an effective method for enzyme encapsulation with numerous biomedical applications.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Mengying Li,Shuangshuang Xu,Yunying Li,Ying Xiong,Yi Liu,Guohua Zhao,Binjia Zhang,Jia Chen,Dongling Qiao,Fengwei Xie
In the food industry, synergistic interaction gels (SIGs) offer significant potential, due to their easy gelation, enhanced texture tailoring capabilities, and excellent processability. Konjac glucomannan (KGM) and xanthan gum constitute a common pairing of polysaccharides that form SIGs; however, their gel strength remains insufficient for practical applications. This study demonstrates that directional freeze-thaw (DFT) treatment reinforced KGM/xanthan SIGs by orienting molecular chains and promoting reassembly during the successive freeze-thaw cycles. In the cyclic DFT treatment, the type-A aggregates contents gradually increased revealed by the increased enthalpy change values (Δ H 1 ) and area of the peak-1 centered at q = 0.02 Å −1 ( A peak-1 ), along with reducing the average size of high-density domains (scatters) and compacting the arrangement of these scatters (signified by the decreased average size of scatterers ( d 1 ) and increased the fractal dimension ( n )). These thereby enhanced the gel integrity and almost double the strength across various deformations after three cycles of DFT. For sample with a component ratio 4:6 for KGM: xanthan, its average storage modulus at 25–30 °C ( G A ′ ) increased from about 100 Pa to 200 Pa, and the hardness increased from 0.19 N to 0.34 N. These insights will facilitate the design of structured gel foods and broaden their applications in anisotropic-textured application.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2023
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IF 10.7
Yuntao Wang,Hui Zhang,Qing Liang,Xiuqin Guo,Zijian Niu,Si Qiu,Wei Xu,Rui Li
In this study, the effect of konjac glucomannan (KGM) with different degrees of deacetylation (DD) on the gel properties of transglutaminase induced soybean protein isolate (SPI) emulsion gel was investigated. It was found that the three kinds of KGM increased the breaking force and water holding capacity , enhanced the freeze-thaw stability of the SPI emulsion gel, while KGM with DD of 59% (DKGM1) improved these properties to the largest extent. This was because SPI-DKGM1 had the lowest oil water interfacial tension, resulting in the formation of the most uniform and the smallest oil droplets, which then led to the formation of much denser gel network. Moreover, the hydrophobic interaction and hydrogen bonding between DKGM1 and SPI were the strongest compared with that of other KGM. Besides, FTIR results showed that SPI-DKGM1 emulsion gel had higher β-sheet content, which was conductive to the formation of a stable three-dimensional network structure. However, the combination of SPI and KGM with high DD (DKGM2, DD = 92%) destroyed the gel structure to some extent and resulted in emulsion gel with weakened gel properties compared with that of DKGM1. Therefore, KGM with proper DD was conducive to the formation of more ordered and much denser gel network structure, which then resulted in SPI emulsion gel with the best gel properties.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2020
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IF 2.734
Kai An,Huiting Kang,Lilei Zhang,Lianxiong Guan,Dating Tian
Biocompatible thermosensitive molecularly imprinted polymers (MIPs) based on konjac glucomannan was prepared by graft copolymerization of N -isopropyl acrylamide , a thermosensitive monomer , with konjac glucomannan, a natural polysaccharide . The products were characterized by various means. The MIPs possessed switchable thermal regulation on the recognition and delivery of 5-fluorouracil (5-Fu), an anticancer drug . The results of adsorption experiments showed that the MIPs had excellent adsorption capacity at a temperature below the lower critical solution temperature, and the MIPs could specifically recognize and adsorb 5-Fu with good selectivity, repeatability, and stability. The adsorption isotherms of MIPs were fitted by six isothermal models and the dual-site Langmuir- Freundlich model presented the best fit. In addition, the in vitro release properties of 5-Fu from the thermosensitive MIPs were evaluated in phosphate buffer solution and the cumulative release of 5-Fu at 25 °C was higher than that at 38 °C. The release curves were fitted by zero-order, first-order, and Higuchi kinetic equations, respectively, and the results showed that the release of 5-Fu complied with the Fick 's law. Compared with non-molecularly imprinted polymers, the MIPs could release 5-Fu continuously for a certain period with a good controlled release effect, indicating that they possess great prospects as drug delivery materials.
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FOOD CHEMISTRY
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2022
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IF 9.231
Li Wang,Yishu Zhang,Qinhui Xing,Jingge Xu,Li Li
The current study aimed to reveal the changes in quality and microbial diversity of bread at 25 °C, and to analyze the activity of antifungal bilayer film on maintaining the quality of bread during 10 days of storage. Antifungal bilayer film prepared with cinnamaldehyde loaded polylactic acid/konjac glucomannan/wheat gluten (PLA/KGM/WG-CIN) was used to preserve bread samples fermented at different times. The changes in the morphology, moisture state, texture properties and microbiological analysis of bread were investigated during the storage. Analysis of microbial diversity of bread samples showed a clear decrease in the abundance of the main spoilage fungi ( Aspergillus and Penicillium ) in samples packed with PLA/KGM/WG-CIN film. The PLA/KGM/WG-CIN film effectively prevented moisture from evaporation, maintained the texture properties, retarded the growth of fungi, and reduced the fungi diversity during the storage. Results suggest a large potential of PLA/KGM/WG-CIN film to ensure the quality and safety of bread products.
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PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Xiaoqing Ding,Yibin Xu,Yuanyuan Wang,Lingyu Xie,Shuang Liang,Danlei Li,Yongxia Wang,Jiangshui Wang,Xiuan Zhan
In this study, we developed (W 1 /O/W 2 ) double emulsions encapsulated by calcium-alginate hydrogel beads system (ACGs) for intestinal-targeted delivery of probiotics ( Lactobacillus reuteri ). Firstly, the carboxymethyl konjac glucomannan-chitosan (CMKGM-CS) nanogels were successfully fabricated by EDC/NHS initiated crosslinking, as concluded from the TEM images, FTIR spectra, XRD , etc. Then, double emulsions were prepared and encapsulated with various concentrations of alginate to form ACGs hydrogel beads. In vitro probiotic release experiments showed the lyophilized ACG-2 and ACG-3 hydrogel beads had a sustained release in simulated intestinal fluid (SIF), the viability of cells exceeded 10 7 CFU/mL at 6 h. The lyophilized ACG-3 hydrogel beads exhibited the viable release amount of 8.4 × 10 7 CFU/mL after storage for 90 d at 4 °C. Besides, the alginate concentration in the ACGs hydrogel beads influences the swelling behavior and structure of hydrogel beads by affecting the hydrogen bonds between alginate and CMKGM-CS, thereby mediating the release of probiotics.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xintong Hu,Jianhua Wang,Shiqiang Song,Wenjun Gan,Weizhen Li,Hechuang Qi,Yong Zhang
The ionic conductive hydrogel-based sensor exhibits wide applications in wearable electronic devices. However, the strength and ductility trade-off, multimodal requirements, and water-soluble polymer alternatives are significant challenges for the hydrogel-based sensor. Herein, a stretchable and conductive hydrogel is developed with a double network formed by incorporating polyacrylamide and ionic liquid into the konjac glucomannan network. The hydrogel displays significantly enhanced mechanical properties, and good tear/puncture resistance owing to the existence of covalent and non-covalent interactions. In addition, by the introduction of nematic liquid crystal hydroxypropyl cellulose , the hydrogel/cellulose-based strain sensor demonstrates excellent sensing performance in monitoring human motions and writing recognition ability with optical and electrical bimodal sensing response. This work provides new insights to further expand the options of hydrogel-based sensor matrix and to construct bimodal sensors.
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PubMed
高影响因子
FOOD CHEMISTRY
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2021
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IF 7.514
Nuo Duan,Qian Li,Xiangyi Meng,Zhouping Wang,Shijia Wu
A nano-composite film was prepared from k-carrageenan (KC), konjac glucomannan (KGM) and TiO 2 nanoparticles (NPs) by solvent casting method. The morphology and structure of the KC/KGM based nano-composite films prepared from different weight ratio of TiO 2 NPs were characterized by SEM, XRD and FT-IR techniques. The addition of TiO 2 NPs to KC/KGM films improved the mechanical, thermal, structural, and barrier properties of nano-composite films. In particular, the film containing 7 wt% of TiO 2 NPs exhibited effective photocatalytic anti-fungal activity (79%) for Penicillium viridicatum after irradiating 6 h through generating reactive oxygen species thus destroying the fungi. Benefitting from the improved characteristics investigated above, the nano-composite films showed a favorable effect on strawberry storage. Overall, the fabricated KC/KGM/TiO 2 nano-composite films have a broad application in the field of food preservation and packaging applications.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2024
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IF 7
Fen Zhao,Jinying Guo,Gege Zhang,Lantian Zhang
Konjac glucomannan (KGM), a water-soluble hydrocolloid, holds considerable potential in the food industry, especially for improving the quality and nutritional properties of frozen products. This study explored the alleviative effect of KGM on the quality characteristics, water status, multi-scale structure, and flavor compounds of steamed bread throughout frozen storage. KGM significantly improved the quality of steamed bread by slowing down the decrease in water content and the increase in water migration while maintaining softness and taste during frozen storage. Notably, KGM also delayed amylopectin retrogradation and starch recrystallization, thus preserving the texture and structure of the steamed bread. At week 3, the microstructure of the steamed bread with 1.0 % KGM remained intact, with the lowest free sulfhydryl content. Additionally, heat map analysis revealed that KGM contributed to flavor retention in steamed bread frozen for 3 weeks. These results indicate that KGM holds promise as an effective cryoprotectant for improving the quality of frozen steamed bread.
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高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
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2023
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IF 7
Peng Huang,Jie Ding,Chunyan Liu,Hongying Li,Chenlin Wang,Yezi Lin,Dur E. Sameen,Md Alomgir Hossen,Mingrui Chen,Jing Yan,Yaowen Liu,Wen Qin
Softening is one of the crucial factors causing the deterioration of postharvest fruit quality. In this study, the effects of konjac glucomannan/low-acyl gellan gum/microcapsule of thymol (TKL) coating on the storage characteristics, the ultrastructure of cell wall and transcription expression of pectin-related metabolism of blueberries fruits during low-temperature storage were investigated. TKL coating suppressed the expression of pectin-related enzymes disassembly ( VaPE 2 , VaPE 3 , VaPG 3 , VaPL 2 and Vaβ-Gal 2 ), reduced the activity of cell wall polysaccharide degrading enzymes (PG, PE , PL , β-Gal, α-Man, α-Af, Xth, β-Xyl, Cx, β-Glu), maintained the normal morphological structure and stability of cell wall, and prolonged the shelf life of blueberries fruits. Overall, TKL is a promising coating that can effectively maintain the firmness, inhibit the postharvest softening and prolong the shelf life of the blueberries during storage period.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Kexin Zhang,Hongting Lei,Tongfei Zhang,Jie Xu,Zhongyuan Liu,Fawen Yin,Dayong Zhou,Deyang Li
Antarctic krill ( Euphausia superba ) surimi faces commercialization challenges due to endogenous proteases causing poor gelation, exacerbated by sodium reduction strategies aimed at mitigating health risks from high salt consumption. This study innovatively utilized soy protein isolate-konjac glucomannan (SPI-KGM) sodium-loaded hydrogel as a functional sodium carrier to enhance the quality of low-salt (1.5 % NaCl) Antarctic krill surimi. The hydrogel's structural stability, sodium-loading capacity (1.47 g/100 g at 3 % KGM, pH 7), and heterogeneous sodium distribution were systematically characterized via confocal laser scanning microscopy (CLSM), Fourier-transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDX). Incorporation of 20 % hydrogel into low-salt surimi significantly improved water-holding capacity (WHC) by 54.07 % and gel strength by 2.35-fold compared to the low-salt control, while reducing cooking loss by 63.16 %. Cryo-SEM revealed a denser, more homogeneous gel microstructure. The hydrogel facilitated targeted sodium release during simulated oral mastication, enhancing saltiness perception by optimizing spatial sodium distribution within the gel matrix, as validated via electronic tongue and in vitro digestion studies. Rheological analysis confirmed enhanced viscoelasticity and structural recovery in hydrogel-modified surimi. These findings demonstrate that SPI-KGM hydrogel simultaneously mitigates texture deterioration and amplifies saltiness perception in low-salt surimi through microstructure engineering and controlled sodium delivery. This strategy offers a dual-functional solution for developing nutritious, sensorially acceptable reduced‑sodium surimi products.
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高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Wenxia Chen,Minghui Yu,Shuangyi Hu,Bingqian Zhou,Xianlong Lu,Rui Yuan,Yangyang Xue,Jue Wang,Rui Yang
In the field of biomedical detection, chemiluminescence (CL) immunosensors are valued for their high sensitivity, strong selectivity, and straightforward operation. Nonetheless, the majority of conventional CL immunosensors are flash-type, requiring large-scale instruments to capture CL signals, which restricts their use in point-of-care testing (POCT). In this work, konjac glucomannan (KGM) is firstly carboxymethylated to form CKGM, and chitosan (CS) is then connected through electrostatic interaction to obtain CKGM-CS hydrogel. Cu 2+ is subsequently loaded onto CKGM-CS hydrogel via coordination and electrostatic interactions. Luminol is finally encapsulated in CKGM-CS hydrogel by electrostatic interaction and adsorption. The obtained CKGM-CS@luminol/Cu 2+ exhibits a high density of “glow-type” CL emission. On this basis, an ultrasensitive label-free immunosensor was developed for the detection of neuron-specific enolase (NSE) by immobilizing specific antibodies, where the quantitation relies on the immunorecognition event directly modulating the CL signal. This dual-detection platform integrates a CL instrument with a smartphone. For the CL instrument, the linear range and limit of detection (LOD) of the established method are 0.1–1000 pg/mL and 0.027 pg/mL, respectively. For the smartphone, the linear range and LOD are 0.1–1000 pg/mL and 0.043 pg/mL, respectively. Ultimately, the technique can track NSE concentration in actual samples using two distinct capture approaches, offering a versatile method for developing sensitive, cost-effective, and simple dual detection platform label-free immunosensors for NSE detection. Moreover, employing a smartphone as a readout device simplifies the detection process, making it convenient for POCT and providing a novel approach for early small cell lung cancer (SCLC) diagnosis.
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高影响因子
危险品化学品经营许可证（带存储）