International Journal of Nanomedicine
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2026
·
IF 8.7
Saiting Xu,Nan Zhang,Tianyou Xu,Qiang Deng,Disha Dai,Xujun Li,Liping Zhou,Xiaoya Zhou
Background: Cardiac sympathetic hyperactivation of the left stellate ganglion (LSG) critically promotes ventricular arrhythmias (VAs) following myocardial infarction (MI). Although neuromodulatory strategies targeting sympathetic activity have shown therapeutic potential, current strategies are limited by invasiveness, incomplete targeting and transient efficacy. Therefore, safe and precise approaches for modulating LSG activity are needed. This study aimed to investigate the enhanced neuromodulatory effects of phospholipid-coated carbon nanotubes (PC-CNTs) combined with near-infrared (NIR) photothermal therapy on the LSG for preventing post-MI VAs.Methods: PC-CNTs were synthesized and characterized, followed by evaluation of their photothermal properties and in vitro/in vivo biocompatibility. In a canine MI model induced by left anterior descending artery occlusion (n = 18), animals were randomly assigned to PBS, PC-CNTs and PC-CNTs + NIR groups. PBS or PC-CNTs (30 μg mL− 1, 0.1 mL) were locally microinjected into the LSG, and animals in the PC-CNTs + NIR group subsequently received 808 nm NIR laser irradiation (1.0 W cm− 2 for 5 min). LSG neural activity, heart rate variability (HRV), ventricular effective refractory period (ERP) and VA incidence were assessed. Transcriptomic profiling of LSG tissue and molecular analysis of peri-ganglionic adipose tissue were performed to evaluate therapeutic effects and potential mechanisms.Results: PC-CNTs exhibited excellent photothermal conversion efficiency and favorable biocompatibility. In vivo, PC-CNTs treatment suppressed MI-induced LSG hyperactivity, improved cardiac autonomic balance, enhanced ventricular electrophysiological stability and reduced VA susceptibility compared with the PBS group. The addition of NIR photothermal therapy further enhanced these protective effects, resulting in further suppression of sympathetic activation and reduction of post-MI arrhythmias. Molecular analyses suggested that combined PC-CNTs and NIR treatment modulated the LSG microenvironment, as evidenced by reduced expression of inflammation-related genes (CXCL14, CSF3, TIMP1 and CRLF1), indicating attenuation of neuroinflammatory signaling. Additionally, NIR-induced local hyperthermia was associated with thermogenic browning of peri-ganglionic white adipose tissue, characterized by increased expression of thermogenic markers and reduced adipocyte size. These changes may contribute to reduced sympathetic hyperactivity and decreased arrhythmia susceptibility.Conclusion: The combination of PC-CNTs and NIR photothermal therapy provides enhanced anti-arrhythmic effects associated with suppression of LSG hyperactivity and modulation of neuroinflammatory signaling and peri-ganglionic adipose browning, representing a promising preclinical strategy for preventing VAs.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Xufeng Xiong,Jiayong Si,Songbo Li,Wencong Yi,Yuheng He,Gemei Cai
Phosphor-converted LEDs (pc-LEDs) operating in the near-infrared (NIR) region are gaining attention as promising next-generation light sources for spectroscopy, bioimaging, and smart agriculture. However, developing NIR phosphors with emission spectra that match the absorption of phytochrome far-red (P fr ), a key photosensitizing pigment regulating plant photomorphogenesis, remains a major challenge for indoor agriculture applications. This study successfully synthesized the near-infrared phosphor GaBO 3 :Cr 3+ . Upon excitation at 420 nm, GaBO 3 :Cr 3+ shows an emission maximum centered at 710 nm, and the full width at half maximum (FWHM) is 108 nm, demonstrating high spectral compatibility with P fr . Compared to room temperature intensity, the phosphor retains 85.6% of its emission intensity at 373 K. In conjunction with a 420 nm LED chip, GaBO 3 :Cr 3+ was employed to construct pc-LED devices for applications in night vision, non-destructive imaging, and plant growth experiments. Under near-infrared pc-LED illumination, Bidens pilosa exhibited a 133% increase in growth rate compared to natural sunlight conditions, confirming the efficacy of this NIR light source for plant growth promotion. This work demonstrates the potential applications of GaBO 3 :Cr 3+ phosphor for night vision, non-destructive imaging, and plant lighting.
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CARBON
·
2025
·
IF 11.6
Xin Qu,Jinqiu Ye,Yuzhe Huang,Ce Wang,Ping Hu,Rui Zhao,Yong Liu
With the growing threat of electromagnetic interference, developing lightweight and flexible multiband protection materials to shield humans from harmful electromagnetic interference is becoming particularly crucial. However, existing protection materials are bulky and designed primarily for single-band electromagnetic waves. This paper constructs bismuth/tungsten oxide/multi-walled carbon nanotube/polyacrylonitrile (Bi/WO 3 /MWCNTs/PAN) nanofiber composites with multilevel nanostructures through electrospinning and post-processing technology for effective NIR/UV/X-ray Multiband Electromagnetic Protection. The porous structure, combined with the strong absorption capabilities of MWCNTs for low-frequency electromagnetic waves and high photoelectric effects of high atomic number materials (Bi/WO 3 ), synergistically achieves remarkable electromagnetic protection performance. This includes 99.6 % near-infrared shielding and 99.95 % against ultraviolet (thickness: 0.12 mm), along with 55.2 % X-ray attenuation and a mass attenuation coefficient of 13.94 cm 2 g −1 at 33 keV (thickness: 1.92 mm). Light weight (0.3 g cm −3 ), fantastic flexibility, and moisture permeability (9.22 kg m −2 d −1 ) endow the material with outstanding wearable performance. In addition, Bi/WO 3 /MWCNTs/PAN also possesses excellent thermal insulation performance (36.96 mW m −1 K −1 ), temperature resistance (289.8 °C), and good electrical insulation. These exceptional performances demonstrate its enormous potential for application in electromagnetic shielding and provide new ideas for designing advanced multiband electromagnetic protection materials.
研究领域:
材料科学
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电磁防护技术
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Nanoscale Advances
·
2025
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IF 4.6
Bo Ling,Yaguang Wang,Huaze Dong,Hongqi Chen,Lun Wang
A core–shell–shell nanoplatform responsive to alkaline phosphatase (ALP) was developed for efficient tumor targeting and near-infrared (NIR)-activated photodynamic therapy (PDT). Specifically, UCNP@SiO2-Bodipy@FFYp was synthesized by encapsulating upconversion nanoparticles (UCNPs) within a silica shell, embedding bodipy derivatives as photosensitizers, and covalently attaching a phosphorylated peptide (FFYp). Förster resonance energy transfer (FRET) from the UCNP emission at 550 nm to bodipy facilitated reactive oxygen species (ROS) generation upon NIR excitation. In the tumor microenvironment, ALP-triggered dephosphorylation converted UCNP@SiO2-Bodipy@FFYp into the more hydrophobic UCNP@SiO2-Bodipy@FFY, thereby promoting tumor cell uptake and tumor-specific accumulation. By leveraging this ALP-responsive targeting strategy alongside the deep-tissue penetration of NIR light, significant tumor growth inhibition was achieved both in vitro and in vivo. Notably, after 15 days of treatment in Balb/c mice bearing HeLa tumors, the tumor volume was reduced by over 95%. Taken together, these results highlight the promise of UCNP@SiO2-Bodipy@FFYp as a tumor-responsive nanoplatform for highly effective, targeted PDT in cancer therapy.
研究领域:
生物医学工程
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癌症治疗
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纳米医学
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PubMed
高影响因子
Acta Pharmaceutica Sinica B
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2025
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IF 14.6
Pu Jiang,Ruihu Song,Yue Hu,Xin He,Zewei Zhang,Xuemei Wei,Zhiming Wang,De-an Guo,Hao Chen
The precise and rapid monitoring of multiple organ dysfunction is crucial in drug discovery. Traditional methods, such as pathological analysis, are often time-consuming and inefficient. Here, we developed a multiplexed near-infrared window two (NIR-II) fluorescent bioimaging method that allows for real-time, rapid, and quantitative assessment of multiple organ dysfunctions. Given that existing probes did not fully meet requirements, we synthesized a range of NIR-II hemicyanine dyes (HDs) with varying absorption and emission wavelengths. By modifying these dyes, we achieved high spatial and temporal resolution imaging of the liver, kidneys, stomach, and intestines. This method was further applied to investigate disorders induced by cisplatin, a drug known to cause gastric emptying issues along with liver and kidney injuries. By monitoring the metabolic rate of the dyes in these organs, we accurately quantified multi-organ dysfunction, which was also confirmed by gold-standard pathological analysis. Additionally, we evaluated the effects of five aristolochic acids (AAs) on multiple organ dysfunction. For the first time, we identified that AA-I and AA-II could cause gastric emptying disorders, which was further validated through transcriptomics analysis. Our study introduces a novel approach for the simultaneous monitoring of multi-organ dysfunction, which may significantly enhance the evaluation of drug side effects.
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PubMed
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ACS Nano
·
2025
·
IF 16
Xue Meng,Jianwen Song,Zekun Du,Yongyou Tao,Ji Qi
Pulmonary embolism (PE) is a life-threatening thrombotic condition, yet its precise diagnosis and effective treatment remain a major clinical challenge. In this study, we report the development of a microenvironment-activatable nanoplatform that enables hypoxia-triggered long-wavelength second near-infrared (NIR-II) fluorescence imaging for accurate thrombus visualization, combined with photothermal therapy (PTT) and controlled hydrogen sulfide (H2S) release for synergistic therapeutic intervention. We first synthesize an N-oxide-based molecular probe that undergoes hypoxia-induced structural transition, thereby activating both NIR-II fluorescence and photothermal properties. This probe, together with a thermosensitive H2S donor, is encapsulated into nanoparticles, which are further functionalized with bis-serotonin groups to achieve thrombus-specific targeting via the myeloperoxidase and hydrogen peroxide-mediated aggregation. In a PE mouse model, the nanoagent enables highly selective and sensitive visualization of thrombi via activatable NIR-II fluorescence imaging after intravenous injection, achieving a remarkable signal-to-noise ratio exceeding 120. The combined PTT and H2S therapy significantly enhance thrombolytic efficacy compared to conventional treatment (e.g., urokinase). Importantly, the nanoagent exhibits excellent biocompatibility in vivo, with minimal risk of hemorrhagic complications. This high-performance hypoxia-responsive platform offers a promising strategy for the precise diagnosis and effective treatment of PE and other cardiovascular diseases.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
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2013
·Vol. 2013
·期 16
·2963-2970
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IF 3.12
Yan-Jing Gu,Bing Yan
Graphical Ln 3+ (Eu 3+ , Nd 3+ , Yb 3+ ) organic–inorganic mesoporous hybrid materials are prepared. The hybrids contain lanthanide complexes covalently grafted to 2-methyl-9-hydroxyphenalenone (MHPO) functionalized ordered mesoporous SBA-15 and with 1,10-phenanthroline as a second ligand. The materials exhibit the characteristic visible (Eu 3+ ) and near-infrared (NIR) luminescence (Nd + and Yb 3+ ) of lanthanides. 9-Hydroxy-2-methyl-phenalenone (MHPO) was synthesized and modified with 3-(triethoxysilyl)propyl isocyanate (TEPIC) through a hydrogen atom addition reaction to achieve a new chemical linkage (named as MHPOSi). SBA-15 mesoporous silica organically functionalized with MHPOSi was synthesized. The MHPOSi was linked to tetraethoxysilane (TEOS) through a condensation process in the presence of Pluronic P123 surfactant as a template. New Ln 3+ (Eu 3+ , Nd 3+ , Yb 3+ ) organic–inorganic mesoporous hybrid materials were prepared, in which the Ln 3+ complexes are covalently attached to SBA-15 and have 1,10-phenanthroline (phen) as a second ligand. The resultant mesoporous hybrids were characterized by FTIR spectroscopy, small-angle X-ray diffraction, N 2 adsorption–desorption measurements, thermal analysis, and UV/Vis spectroscopy. They all have high surface areas, uniform mesostructures, and good crystallinity. The photophysical properties of the functionalized mesoporous SBA-15 networks are discussed in detail and they still present excitation capability in the visible region despite the modification of the organic silane. Subsequently, they exhibit characteristic visible (Eu 3+ ) and near-infrared (NIR) luminescence (Nd + and Yb 3+ ).
研究领域:
材料科学
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光学
·
化学
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DYES AND PIGMENTS
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2025
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IF 4.2
Ru Yan,Zhao-Cheng Liu,Hao-Xiang Jiang,Kai Wang
This study presents WK-NE, an innovative near-infrared (NIR) fluorescent probe engineered for highly sensitive and selective detection of neutrophil elastase (NE), a key inflammatory protease implicated in cardiovascular diseases. Distinguished by its unique structural design, WK-NE incorporates a sulfonic acid group into its hemicyanine scaffold, significantly enhancing water solubility and eliminating the need for post-synthetic modifications—a critical advancement over conventional hydrophobic probes. The probe operates through an intramolecular charge transfer (ICT) mechanism, exhibiting a 5-fold fluorescence enhancement at 735 nm upon NE activation with exceptional specificity (R 2 = 0.9949, linear range 0–2.5 U/L) and minimal interference from biological analytes (<5% signal variation). WK-NE demonstrates superior performance in physiological conditions (optimal pH 7.4, 37°C) and successfully tracks NE dynamics in living macrophages, mouse models, and clinical samples. Notably, it reveals progressive NE elevation in serum and cerebrospinal fluid of cardiovascular patients, correlating with disease severity, representing a transformative tool for cardiovascular research and clinical translation.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Chunhao Li,Aojue Ke,Huifang Shen,Xinya Zhang
Smart windows have attracted significant attention due to their potential for energy conservation. However, their practical applications are limited by the monotonous color variation and poor near-infrared (NIR) shielding performance. In this study, a novel smart window was constructed by integrating a crack-free photonic crystal array (100 mm×100 mm) with poly(N-isopropylacrylamide) (PNIPAm), sodium carboxymethyl cellulose (CMC), and antimony tin oxide (ATO) nanoparticles. The photonic band gap of the photonic crystal array endows the smart window with unique visible light modulation properties and temperature indication functionality, enabling dynamic color variation at various surrounding temperatures. The smart window exhibits excellent solar light modulation (ΔTsol=38%) and NIR transmittance (TIR=30%), which is attributed to the synergistic effect of ATO nanoparticles and PNIPAm hydrogel. The incorporation of CMC enhances the optical modulation capability and durability of the PNIPAm hydrogel. Due to the heat-absorbing and NIR absorption properties of ATO nanoparticles and the thermochromic and heat insulation characteristics of PNIPAm hydrogel, the smart window achieves a maximum temperature difference of 7.2 °C compared with normal glass. This work provides a novel strategy for constructing smart windows based on photonic crystals, demonstrating great potential in temperature monitoring, heat insulation, and other applications.
研究领域:
材料科学
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能源技术
·
光学工程
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Materials Advances
·
2025
·
IF 4.7
Li-Ping Wang,Lu-Lu Jiang,Zong-Ze Cui,Zheng-Hui Hu,Le-Ping Miao,Jian-Rong Li,Heng-Yun Ye,Chao Shi
Hybrid perovskites are highly desirable for potential applicationsin optoelectronics. Although luminescent hybrid perovskites have a variety of technically important applications, achieving dielectric transition and near-infrared (NIR) luminescence properties simultaneously is still challenging. Herein, utilizing the NIR-luminescent properties of rare-earth ions, an Nd3+-containing nitrate-bridged hybrid bimetal dielectric, (MQ)5[K2Nd2(NO3)13] (1; MQ = N-methylquinuclidinium cation), was successfully constructed. It exhibited a switchable dielectric constant (ε′) between low- and high-dielectric states along with NIR-luminescent property. The contrast was strikingly reached 1.88, and the was 1.18 times higher than that of silicon nitride. Furthermore, the reversibility of the switchable dielectric constant between the and at 1 MHz was observed after many ε′-switching cycles with no obvious weakening, which endowed this material with the desirable thermodynamic stability. Notably, 1 exhibited NIR photoluminescence at 1068 nm with a fluorescence lifetime of 1.920 μs, and the Nd3+ ion acted as an activator of the NIR luminescence. This finding represents a significant step toward advanced NIR-emissive responsive dielectrics for optoelectronic applications.
研究领域:
材料科学
·
光学
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Materials Today Bio
·
2026
·
IF 10.2
Yijun Liu,Peng Qiu,Huifang Hao,Ang’ang Ding,Zhaoyu Wu,Jiahao Lei,Zhaoxi Peng,Hongji Pu,Chenlin Zeng,Hongbin Guo,Xiaodong Wu,Huaxiang Lu,Jinbao Qin,Ruihua Wang,Haoqi Liu,Kaichuang Ye,Xinwu Lu
Abdominal aortic aneurysm (AAA) is a degenerative aortic disease with high rupture-associated mortality. There is no effective medical therapy for early intervention, inflammatory microenvironment remodeling is a crucial therapeutic strategy. Herein, we designed a multifunctional nanoplatform, Cu 9 S 8 @MCC950-Belnacasan-cRGDfK (CS@MBR) for AAA treatment. This platform employed a Cu 9 S 8 core for near-infrared-II (NIR-II) photothermal therapy (PTT), encapsulated NLRP3 inflammasome inhibitors (MCC950 and Belnacasan), and coated with a cRGDfK peptide for active targeting of the aneurysm. In vitro, CS@MBR with mild PTT inhibited NLRP3 inflammasome activation, decreased pro-inflammatory macrophage polarization, and prevented the phenotype switching of vascular smooth muscle cells. In vivo, CS@MBR demonstrated excellent accumulation at the aneurysm site in an angiotensin-II-induced murine AAA model. Upon NIR-II irradiation, the treatment effectively inhibited AAA development, damage of elastic fibers, and imbalance of the inflammatory microenvironment. This study presents a promising, targeted nanotherapeutic strategy for the treatment of AAA and other inflammatory vascular diseases.
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WATER AIR AND SOIL POLLUTION
·
2017
·Vol. 228
·期 5
·177
·
IF 1.702
Qu Jia-Huan,Sun Da-Wen,Pu Hongbin
This study aimed to develop a visible and near-infrared (Vis/NIR) chemical imaging (400–1000 nm) technique to provide rapid prediction of the contents of sodium humate dissolved in aquaculture environment. Gray reference image with 5% reflectance value was first used to correct the obtained raw images in order to promote the reflectance values as compared to that with 99% reflectance for further spectral analysis. Successive projection algorithm (SPA) was introduced to extract four optimal wavelengths, which were then used for the establishment of back-propagation artificial neural network (BP-ANN) models. The results revealed that the BP-ANN model based on the selected four optimal wavelengths better performed ( \( {R}_C^2 \) = 0.986, \( {R}_{CV}^2 \) = 0.985, \( {R}_P^2 \) = 0.993, RMSEC = 0.329 mg/L, RMSECV = 0.433, RMSEP = 0.734 mg/L) than that based on the whole 381 wavelengths ( \( {R}_C^2 \) = 0.978, \( {R}_{CV}^2 \) = 0.996, \( {R}_P^2 \) = 0.977, RMSEC = 0.388 mg/L, RMSECV = 0.625, RMSEP = 0.734 mg/L). Finally, a series of chemical images were developed to clearly display the concentration distribution of the sodium humate dissolved in water, demonstrating that Vis/NIR chemical imaging technique was feasible to quantify the contents of sodium humate in the aquatic environment and could be further used for real-time monitoring the quality of aquaculture water.
研究领域:
环境监测
·
水产养殖水质
·
化学成像
·
光谱学
·
分析化学
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高影响因子
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