Science China-Chemistry
·
2014
·Vol. 58
·期 3
·532-538
·
IF 1.516
Chai XiaoHui,Liu ZhiHong,Huang YingPing
Three different nanorod-like gallium oxides with mono/poly-crystalline nature (α, β, and α/β-Ga 2 O 3 ) were prepared by regulating the amount of polyethylene glycol (PEG) 6000 in the range of 0.2–0.8 g proportionally via a hydrothermal method combined with further calcination. The bandgap of the products, given by UV-Vis diffuse reflectance spectra (UV-Vis DRS), was in the order of α-Ga 2 O 3 > α/β-Ga 2 O 3 > β-Ga 2 O 3 . To further investigate the photocatalysis performance of the catalysts, the decomposition of rhodamine B (RhB) by Ga 2 O 3 under UV light illumination ( λ < 387 nm) was presented and complete degradation could be achieved within 30 min, a result that showed the highest efficiency. The photocatalytic oxidation mechanism is further discussed and prominently related to the active species: hydroxyl radical (·OH) and superoxide radical (O 2
· − ), which were confirmed by electron paramagnetic resonance (EPR).
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
NANOTECHNOLOGY
·
2015
·Vol. 26
·期 42
·425101
·
IF 3.821
Jun Zhou,Jinghua Li,Xingwei Ding,Junjie Liu,Zhong Luo,Yun Liu,Qichun Ran,Kaiyong Cai
In recent years, magnetic hyperthermia nanoparticles have drawn great attention for cancer therapy because they have no limitation of tissue penetration during the therapy process. In this study, cubic nanoporous Fe2O3 nanoparticles derived from cubic Prussian blue nanoparticles were used as magnetic cores to generate heat by alternating the current magnetic field (AMF) for killing cancer cells. In addition, polypyrrole (PPy) was coated on the surfaces of the cubic Fe2O3 nanoparticles to load doxorubicin hydrochloride (DOX). The PEG component was then physically adsorbed onto the surfaces of the nanoparticles, resulting in a Fe2O3@PPy-DOX-PEG nanocomposite. The nanocomposite was triggered by acid stimulus and AMF to release DOX, resulting in a remarkable combination therapeutic effect via chemotherapy and magnetic hyperthermia. Furthermore, the nanocomposite could realize magnetic resonance imaging (MRI) due to the magnetic core structure. The study provides an alternative for the development of new nanocomposites for combination cancer therapy with MR imaging in vivo.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
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DOI
PubMed
高影响因子
Science China-Chemistry
·
2016
·Vol. 59
·期 8
·1003-1009
·
IF 2.429
Chu Jun,Lv Qiulan,Guo Chunliang,Xu Dazhuang,Wang Ke,Liu Meiying,Huang Hongye,Zhang Xiaoyong,Wei Yen
The synthesis of amphiphilic aggregation-induced emission (AIE) dyes based organic nanoparticles has recently attracted increasing attention in the biomedical fields. These AIE dyes based nanoparticles could effectively overcome the aggregation caused quenching effect of conventional organic dyes, making them promising candidates for fabrication of ultrabright organic luminescent nanomaterials. In this work, AIE-active luminescent polymeric nanoparticles (4-NH 2 -PEG-TPE-E LPNs) were facilely fabricated through Michael addition reaction between tetraphenylethene acrylate (TPE-E) and 4-arm-poly(ethylene glycol)-amine (4-NH 2 -PEG) in rather mild ambient. The 4-NH 2 -PEG can not only endow these AIE-active LPNs good water dispersibility, but also provide functional groups for further conjugation reaction. The size, morphology and luminescent properties of 4-NH 2 -PEG-TPE-E LPNs were characterized by a series of techniques in detail. Results suggested that these AIE-active LPNs showed spherical morphology with diameter about 100–200 nm. The obtained 4-NH 2 -PEG-TPE-E LPNs display high water dispersibility and strong fluorescence intensity because of their self assembly and AIE properties of TPE-E. Biological evaluation results demonstrated that 4-NH 2 -PEG-TPE-E LPNs showed negative toxicity toward cancer cells and good fluorescent imaging performance. All of these features make 4-NH 2 -PEG-TPE-E LPNs promising candidates for biological imaging and therapeutic applications.
研究领域:
材料科学
·
生物医学工程
·
分子影像学
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DOI
高影响因子
Biomedical Materials
·
2016
·Vol. 11
·期 3
·035014
·
IF 3.361
Jingjing Zhang,Justin Wang,Hui Zhang,Jianhao Lin,Zigang Ge,Xuenong Zou
Poor mechanical properties hinder the application of hydrogels in cartilage tissue engineering. In this study, macroporous interpenetrating network (IPN) hydrogels of gelatin and polyethylene glycol (PEG) were fabricated for use as a functional biomaterial to support chondrocyte culture. The IPN structure enhanced mechanical properties, while the macroporous structure facilitated cell–cell interactions. The hydrogels had pore sizes around 80 μm with favorable interconnectivity, reduced volume swelling ratios, and nearly unchanged weight swelling ratios with increasing gelatin ratios. More significantly, the Young's modulus increased with increasing gelatin ratio, reaching a 5.3-fold increase (p < 0.01) in IPN-10% over that of the PEG group. Chondrocytes developed elongated and fibroblast morphologies with extensive cell–cell interaction throughout IPN hydrogels, compared with round, isolated aggregates in PEG hydrogels. The glycosaminoglycan (GAG) accumulation was significantly higher in IPN hydrogels than in PEG hydrogels at day 21 and day 28. Additionally, significantly higher gene expressions of collagen II (p < 0.01) and sox-9 (p < 0.01) were found in IPN-10% when compared with other groups. Overall, the macroporous IPN hydrogels showed strong tissue formation abilities and enhanced mechanical properties, demonstrating high potential as scaffolds for cartilage regeneration.
研究领域:
生物材料学
·
组织工程学
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DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Guifeng Miao,Yuejian He,Keren Lai,Yan Zhao,Peiyi He,Guozhu Tan,Xiaorui Wang
PEGylated nanomedicines have been extensively developed and applied to cancer therapy. However, the antitumor efficacy of these nanoparticles is hampered by the accelerated blood clearance (ABC) effect caused by anti-PEG antibodies in vivo . There is still limited understanding about the cause of pre-existing anti-PEG antibodies in the human body. Herein, we discovered that PEG-based pharmaceutical excipients, commonly used in clinical and daily settings, could induce anti-PEG antibodies in vivo and lead to considerable potential clinical impacts on pharmacokinetics and pharmacodynamics of PEGylated nanoparticles. Specifically, we investigated the ability of poloxamer 188 (F68) and poloxamer 407 (F127), the two most frequently used PEG-based pharmaceutical excipients, to elicit the production of anti-PEG antibodies and influence the pharmacokinetics of PEGylated nanoparticles, with PEGylated liposome nanoparticles (L-NPs) as a model. Anti-PEG IgG and IgM levels were significantly boosted 3.8- and 32.2-fold, respectively, after pre-injection with F68, leading to rapid clearance of subsequently injected L-NPs from circulation due to the capture by neutrophils and monocytes. However, pre-injection of F127 did not induce the production of anti-PEG IgG, although there was a 7.7-fold increase in IgM level, which resulted in minimal effect on circulation time of L-NPs. Furthermore, the potential clinical impacts of F68 and F127 were further inspected for PEGylated liposomal doxorubicin (PLD). It was found that administering F68 prior to treatment led to over a one-third decrease in the antitumor effectiveness of PLD, while F127 had a negligible impact. Our study elucidates the mechanism by which PEG-based pharmaceutical excipients influence the effectiveness of PEGylated nanomedicines. It also highlights the significance of considering the potential for an ABC effect induced by PEG-based pharmaceutical excipients in patients.
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PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2022
·
IF 7.305
Yan Zhou,Xiaojian Wang,Dekun Sheng,Xiangdong Liu,Yuming Yang
Light-driven PEG/Ti 3 C 2 T x form-stable phase change films for energy storage crosslinked by Co 2+ were prepared through facile solution mixing. It is the strong interactions among PEG , Ti 3 C 2 T x and Co 2+ that endowed the system with excellent form-stability with only 5.0 wt% supporting. And the latent heat of samples was 142.1 J/g with light-thermal conversion and storage efficiency higher than 86.9%. Meanwhile, the samples possessed improved thermal stability and favorable thermal reliability. The fabricated films with comprehensive properties shows great perspective to be used in energy storage devices.
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高影响因子
Journal of Materials Research and Technology-JMR&T
·
2021
·
IF 5.039
Yuzhe Chen,Wenxuan Zhao,Honglian Dai
Chitosan (CS) is a type of natural polysaccharide, widely used as a biomaterial on account of its great biocompatibility and the multitudes of functional groups on the long chitosan chain, making it easy for property augmentations. Nevertheless, the lack of workability and mechanical capacity limits the applications. Herein, electrospinning was chosen to fabricate oriented chitosan/polyethylene oxide (PEO) nanofibres decorated by integrin-targeting polypeptides (RGD, Arg-Gly-Asp), which is essential for cell adhesion. At the same time, porous PLGA-PEG membranes were taken as a shell of the composite film, which can provide mechanical support for the scaffold. Adequate topological anisotropic information from oriented nanofibres helps the scaffold simulate the natural axon structure, which can induce accelerated regeneration of neurotmesis. Moreover, β-Tricalcium Phosphate (β-TCP) nanoparticles were brought into nanofibers to neutralize the acidic environment produced by the degeneration of PLGA-PEG. Cell viability tests at the in vitro level and dorsal root ganglion (DRG, 1-day sucking SD rat) co-culture detection proved that the scaffold possesses excellent biocompatibility while guiding oriented regeneration of damaged nerves. In this study, a CS-RGD/PEO/β-TCP/PLGA-PEG porous composite scaffold with low cytotoxicity was fabricated. The scaffold can not only lead to the oriented growth of nerves but also has selectivity, which can help nutrient exchange while inhibiting the invasion of fibrous tissue.
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高影响因子
Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-18
·
IF 23.2
Yuan Chengke,Li Yingchun,Xue Jianyu,Mi Jia,Wang Yu,Toktarbay Zhexenbek
Thermoplastic polyamide elastomers (TPAEs) possess remarkable characteristics such as high-temperature tolerance, superior mechanical properties, and the shape memory effect (SME). The current study develops a type of TPAE with SME by fabricating the long carbon chain polyamide (PA512) and polyethylene glycol (PEG) through a two-step melt polycondensation process. The properties of TPAEs were investigated by varying the PA512 prepolymer’s molecular weight and the amount of PEG. During synthesizing TPAEs with SME, the crucial balance of COOH and OH groups was skillfully achieved by introducing biobased butanediol (BDO). The chemical structure of TPAEs is confirmed by FTIR and 1 H NMR tests. By meticulously engineering the PA512 molecular weight and refining the PEG domain content, TPAEs are fabricated to elongate at a break of 592.4% at room temperature while maintaining a tensile strength of 23.1 MPa. TPAEs, which have two distinct melting temperatures, exhibit microphase separation between the PEG and PA512 domains. This phenomenon is further corroborated by the scanning electron microscope (SEM) test. Additionally, TPAEs exhibit the SME, which can fix a temporary shape when heated, twisted, and cooled, and then recover to its original shape upon reheating, with TPAE230 demonstrating the most outstanding shape memory effect, achieving an average shape fixity ratio of 91.2% and a shape recovery ratio of 94.4%. This behavior is attributed to the fixing force provided by the PEG domains and the entropy elasticity of the physically cross-linked PA512 domains. The findings indicate that TPAEs exhibit enhanced SME in response to temperature changes. Leveraging this property, developing a temperature-sensitive device holds promise for breakthroughs in elastic temperature sensing applications.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
E-POLYMERS
·
2021
·Vol. 21
·期 1
·466-475
·
IF 2.025
Xiaoping Zhan,Xiaopeng Jian,Zhenmin Mao
Snus is one of the types of smokeless tobaccos, which is popular in many countries and regions. The nicotine level in the plasma samples obtained from snus users is similar to the nicotine level obtained from cigarette smokers; hence, the snus users find it difficult to quit. The aim of this study is to develop new semi-interpenetrating polymer (SIPN) membranes that control the stable release of nicotine from snus, achieving the purpose of quitting smoking. Here, the SIPN comprising a polyacrylate network and PEG chains was synthesized through in situ radical polymerization. The SIPN was characterized by Fourier transform infrared spectroscopy, contact angle, differential scanning calorimetry, scanning electron microscopy, cytotoxicity, and in vitro release experiments. Furthermore, this SIPN was used to evaluate the release properties of nicotine in different snus samples varying in moisture, pH, and the tobacco’s particle size. The results indicated that the new SIPN could control release of nicotine at a specific rate, and the release rate could be adjusted according to the customer requirements. Thus, the new SIPN was contributed to build a new nicotine replacement therapy that served the snus users.
研究领域:
生物医学工程
·
材料科学
·
毒理学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Man Wang,Zhipeng Zhang,Qingyi Xie,Jiansen Pan,Chunfeng Ma,Guangzhao Zhang
Polyurea has found applications in protective coatings. Yet, the too fast polymerization and lack of functions limit its application. Herein, we report a high-performance polyurea via the stepwise polymerization of an isocyanate (NCO)-terminated prepolymer consisting of poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) (PPG-b-PEG-b-PPG) with a nanocluster synthesized via the hydrolysis of N-phenylaminomethyltriethoxysilane. Such a nanocluster contains low-reactivity secondary amines, so the polymerization of polyurea can be slowed down (over 1 h), which improves its wetting and adhesion to a substrate. The residual silanol groups on the nanocluster further increase the adhesion. Such polyurea exhibits high adhesion on various substrates, including glass, ceramic, steel, copper, titanium, wood, and natural rubber (∼2.35–14.64 MPa). Besides, the nanoclusters can cross-link the prepolymer into a tough network, endowing the polyurea with a high mechanical strength of ∼25 MPa, much higher than the traditional polyaspartic ester polyurea. On the other hand, the PEG segments enable the polyurea to have good fouling resistance against proteins (fibrinogen absorption was reduced by over 90%), bacteria (RBA of S. aureusE. coli and Pseudomonas sp. was less than 10%), as well as diatom (diatom density was less than 100 cells/mm2). The polyurea is expected to find applications in biomedical engineering and marine antifouling.
研究领域:
材料科学
·
生物医学工程
·
海洋科学
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DOI
PubMed
高影响因子
Drug Research
·
2017
·Vol. 68
·期 05
·270-279
·
IF 0
Shuoye Yang
Long-circulating liposomal delivery systems of encapsulated Coenzyme Q10 (CoQ10), a ubiquinone anti-cataract agent, were developed with different molar ratios of PEGylated lipids and/or cholesterol. The resulting samples were contrasted through observation of morphology, analysis of particle size and Zeta potential, and in vivo pharmacokinetics. A protamine aggregation method with high selectivity was developed to determine the encapsulation efficiency (EE), after which the liposome formulation was further optimized by applying a Box Behnken design (BBD) using EE as the evaluation index. The results showed that liposomes had a large, unilamellar structure, and that particle sizes of cholesterol-containing liposomes increased along with the increase of cholesterol molar percentage, while the size of PEGylated vesicles decreased slightly as PEG-lipid contents increasing. The optimum formulation and optimal values of each influencing factor were quantitatively obtained, and the measured value was highly consistent with the predicted results. In vivo evaluation performed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) demonstrated that liposomal encapsulation largely prolonged half-lives and improved bioavailability for vectors prepared with either lipid component, and the liposomes composed of both cholesterol and PEG-lipid possessed the best pharmacokinetic properties. The results suggest that incorporating high contents of cholesterol and PEG modification could be a potentially useful method for enhancing the length of circulation and the sustained release effect for liposome-encapsulated chemicals.
研究领域:
药剂学
·
生物医学工程
·
药物代谢动力学
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DOI
PubMed
RSC Advances
·
2015
·Vol. 5
·期 84
·68998-69005
·
IF 3.84
Yongliang Chen,Xinzhen Zhao,Chunju He
Polydimethylsiloxane-graft-polyethylene glycol (PDMS-graft-PEG), an amphiphilic polymer with four hydrophilic arms, was prepared and used to improve the antifouling property of PVDF membranes by a dip-coating method. The interface properties of the modified PVDF membranes were investigated and it was found that the increased molecular weight of the PEG segment exhibited a negative effect on the anchoring ability of the PDMS-graft-PEG on the membrane surface. However, the antifouling properties of the modified membranes were significantly improved due to the dual-mode antifouling ability of fouling repulsion (PEG) and fouling release (PDMS). The adsorption mass of BSA on the modified membrane surface decreased to a low level, and an enhanced water flux recovery ratio after washing (FRR-W) of the modified membranes was obtained for two typical pollutants of bovine serum albumin and sodium alginate. It was demonstrated that surface anchoring is an effective way to improve the interface characteristics of membrane materials with functional polymers.
研究领域:
材料科学
·
环境工程
·
生物技术
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高影响因子
危险品化学品经营许可证（带存储）