JOURNAL OF MEMBRANE SCIENCE
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2019
·
IF 7.015
Yanqing Xu,Guibin Peng,Junbin Liao,Jiangnan Shen,Congjie Gao
The state-of-the-art graphene oxide (GO) has been wildly used in water purification due to its tunable nanoscale interlayer between the two-dimensional nanosheets . However, the structural instability and flux decline performances significantly limit the practical application of GO-based membranes. Herein, a novel GO/DTiO 2 -PDA-PEI (dopamine modified TiO 2 ) composite nanofiltration membrane has been prepared via a multi-coupled strategy, combining with the self-assembly, copolymerization and surface grafting. Tuning the nanoscale interspace between the GO nanosheets , and constructing the membrane with positively charged surface and negatively charged subsurface, the loose GO/DTiO 2 -PDA-PEI composite nanofiltration membrane (GDP 1 P 2 -0.6 membrane with a mean pore size = 0.87 nm) show the filtration performance with water permeance as high as 41.6 L m −2 h −1 bar −1 and dye rejection around 99.9%, and the molecular selective factor (Eriochrome black T/Na 2 SO 4 ) of α = 47.6. Long-term performance and stimulation have been investigated to further analyze the dye concentration and salt removing. The investigations demonstrate that the GO/DTiO 2 -PDA-PEI composite nanofiltration membrane enriches 14.9-fold Eriochrome black T (ET) and reduces Na 2 SO 4 to 0.36% in the term of the concentration factor 15 and batch diafiltration factor 5.
研究领域:
材料科学
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环境工程
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化学工程
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高影响因子
MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Zheng Chang,Qiqi Zhao
In this paper, using a strong coordination of the multi-amino groups of polyethylenimine (PEI)/SiO 2 nanoparticles with Cu 2+ and the weaker carboxyl-amine interactions with heme chloride (hemin), novel Cu 2+ -hemin dual-functionalized PEI/SiO 2 nanoparticles (abbreviated as Cu 2+ /hemin/PEI/SiO 2 NPs) were conveniently synthesized. The Cu 2+ /hemin/PEI/SiO 2 NPs exhibit both the peroxidase-like activity of hemin and the electrochemical signaling properties of Cu 2+ . Moreover, a large number of hemin molecules were successfully loaded onto Cu 2+ /PEI/SiO 2 NPs through electrostatic interactions. This not only prevented their self-aggregation-induced inactivation in aqueous solutions, but also catalytically amplified the electrooxidation signal of Cu 2+ /PEI/SiO 2 NPs by shortening the electron transfer distance. Subsequently, these nanoparticles spontaneously assembled on the overoxidized polypyrrole-modified reduced graphene oxide (abbreviated as OPPy/rGO) electrode surface through Cu N coordination between OPPy and Cu 2+ , and π-π stacking interactions between hemin and rGO. As a novel immunosensing platform, a label-free electrochemical immunosensor for carbohydrate antigen-125 (CA125), a specific biomarker for epithelial ovarian cancer was developed by covalently immobilizing CA125 capture antibodies onto the Cu 2+ /hemin/PEI/SiO 2 NPs@OPPy/rGO hybrid nanomaterials. Elevated serum CA125 levels correlate significantly with ovarian cancer progression. With the increasing concentration of CA125 antigen, the current responses of this immunosensor were decreased due to the formation of antigen-antibody insulating immune complexes. The proposed immunosensor exhibited excellent performances within a wide linear range from 5 × 10 −5 to 200 U·mL −1 for CA125 and a low detection limit of 1.2 × 10 −5 U·mL −1 (S/N = 3). Additionally, this immunosensor demonstrated good stability, reproducibility, and selectivity, making it a promising tool in clinical screening, early diagnosis, and prognostic monitoring of ovarian cancer.
研究领域:
分析化学
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生物传感器
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纳米技术
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生物电化学
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癌症诊断
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材料科学
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Yunping Wang,Chenlin Mu,Jingtao Bi,Mengmeng Sun,Yingying Zhao
The monovalent cation exchange membrane (MCEM) plays a crucial role in strategic resource recovery fields such as lithium/magnesium separation and seawater softening. This study proposes a two-stage modification strategy of “nanoparticle deposition – quaternization cross-linking”: first, deposit the Polypyrrole -Polyethyleneimine (PPY-PEI) composite nanoparticles in situ on the commercial Cation Exchange Membrane (CEM) surface, and then undergo quaternization cross-linking to prepare a high-performance monovalent cation exchange membrane (MCEM). The rigid structure of Polypyrrole -Polyethyleneimine (PPY-PEI) nanoparticles completely avoids the traditional problem of monomer penetration, and the rate of membrane pore blockage is significantly reduced. Electrified nanoparticles form gradient nanochannels to achieve dual mechanism synergy: The surface positive charge layer repels and blocks Mg 2+ through the Donnan effect; 2–5 nm mesoporous channels facilitate K + transport through size sieving. Subsequent quaternization crosslinking strengthened the modified layer and increased the positive membrane charge density, leading to further improvement in perm-selectivity. The results show that the modified membrane achieves a breakthrough performance in the separation of K + /Mg 2+ : the selectivity reaches 6.9; the K + flux remains at 0.14/(m 2 ·s). Molecular dynamic simulation of the ion diffusion behavior confirmed that the presence of Polypyrrole -Polyethyleneimine (PPY-PEI) can accelerate the diffusion rate of K + while limiting the transport of Mg 2+ , providing a theoretical basis for the performance prediction of selective ion exchange membranes.
研究领域:
膜科学与技术
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分离工程
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材料化学
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环境功能材料
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离子传输
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电化学
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资源回收
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DOI
高影响因子
MICROCHIMICA ACTA
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2026
·Vol. 193
·期 7
·492
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IF 5.4
Shen Fei,Wang Sen,Yang Qian,Li Guanglei,Lin Xianchang,Chen Guanyao,Wang Ji,Sheng Rizhi
Endotoxins, specifically lipopolysaccharides (LPS), are components of the outer membrane of Gram-negative bacteria. Due to the fact that even extremely low concentrations of endotoxins can trigger the human body’s inflammatory cascade, there is an urgent need to develop highly sensitive detection technologies for accurate identification and quantitative analysis of trace amounts of endotoxin. This study, based on an electrochemical sensing platform constructed using AuNPs/NH 2 –UiO-66/PEI/MCNs functionalized nanocomposite materials, has successfully achieved efficient detection of endotoxins in food. Given the complex food matrix and numerous interfering substances, this sensor enhances its anti-interference capability through a multi-level cooperative interface design. It uses polyethyleneimine-modified mesoporous carbon nanospheres (PEI/MCNs) as the substrate and integrates the directional loading capability of NH 2 -UIO-66 with the conductivity-enhancing effect of gold nanoparticles (AuNPs), thereby significantly improving signal stability. This biosensor achieves a remarkable detection limit as low as 40 fg/mL, enabling trace-level identification of LPS. Additionally, it exhibits excellent selectivity against common foodborne interferents, facilitating rapid and accurate LPS detection.This study presents a novel, portable detection solution for the rapid screening of microbial contamination in food. The nanocomposite interface construction strategy employed herein provides significant guidance for developing trace-level hazard detection technologies in complex matrices. Graphical
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Li Xu,Yike Qian,Tingting Xu,Xiaoqin Zhang,Ling Ling,Yuxiang Sun
The sustained free radicals derived from drug-resistant chronic myeloid leukemia (CML) cells can trigger oxidative stress, thereby reducing cell drug sensitivity and therapeutic efficacy. Our prior work demonstrated that dextran-modified ceria nanoparticles (CeO 2 NPs) exhibit the intrinsic antioxidant capability and are capable of enhancing anti-leukemia therapeutic responses. However, excessive intracellular free radicals trigger the interfacial electron transfer across nano-enzymatic surfaces, disrupting Ce 3+ /Ce 4+ valence equilibrium and compromising their long-term antioxidant performance. Here, we found that CeO 2 NPs modified by citric acid (CA) and polyethyleneimine (PEI) and dextran (CeO 2 @CA@PEI@Dextran) provided the long-lasting capacity to scavenge radicals by the aid of electronic buffer effect of CA@PEI, which can buffer the process of electronic gain and loss to maintain the stability of Ce 3+ /Ce 4+ ratio and a long-term performance to scavenge free radicals in vitro and in vivo. CeO 2 @CA@PEI@Dextran thus regulated intracellular oxidative stress persistently to improve the effects of doxorubicin in K562-ADR cells, one CML cell line resistant to doxorubicin. In contrast, the regulatory effect of small-molecule antioxidants such as N -acetylcysteine and glutathione in diminishing free radicals is unsustainable and undulant. Consequently, reshaping the redox homeostasis in CML patients by the continuous anti-oxidation mediated by CeO 2 @CA@PEI@Dextran may be a potential way to improve the treatment of drug-resistant patients, distinct from the unsustainable anti-oxidation strategies, which presents a novel perspective for clinical drug usage. Scheme 1 CeO 2 nanoparticles modified by citric acid (CA) and polyethyleneimine (PEI) and Dextran (CeO 2 @CA@PEI@Dextran) provided the long-lasting capacity to scavenge radicals by the aid of electronic buffer effect of CA@PEI, which can buffer the process of electronic gain and loss to maintain the stability of Ce 3+ /Ce 4+ ratio and a long-term performance to scavenge free radicals. CeO 2 @CA@PEI@Dextran thus regulated intracellular oxidative stress persistently to improve the drug sensitivity in drug-resistant CML cells. Download: Download high-res image (288KB) Download: Download full-size image
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Weiyi Kong,Min Li,Dingguang Wu,Kaizhou Zhang,Jinbo Jin
In this study, PVDF/SMA membranes were fabricated via non-solvent induced phase separation(NIPS), followed by grafting of polyethyleneimine (PEI) onto the membrane surface through reaction with the anhydride groups of SMA, yielding PVDF/SMA-PEI membranes. Owing to the considerable free volume of PEI chains, stacking tends to occur during cross-linking with SMA, resulting in a loose selective layer and poor retention of small- to medium-sized dye molecules. To address this, the small-molecule additive sodium dodecyl sulfate (SDS) was introduced into the PEI solution. The electrostatic interaction between the sulfate ions of SDS and PEI promotes a more uniform distribution of PEI on the membrane surface, reducing inter-chain aggregation and forming a denser selective layer. The resulting PEI-SDS membrane maintained a high pure-water flux of 220 L/m 2 ·h while achieving methyl blue, indigo carmine, and acid fuchsin rejection rates of 98.86%, 99.57%, and 86.77%, respectively. In conclusion, this work provides a simple method for preparing highly efficient positively charged membranes for dye removal.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yuxuan Zhang,Zaosheng Lv,Jiangqin Wu,Qianwen Xue,Yang Lei,Yanfen Huang
Polyacrylic acid has a wide range of applications in the field of superhydrophilicity, but due to its single composition, there are problems such as insufficient mechanical strength and functional limitations. In order to extend its application, we prepared a new IPN hydrogel PEI-PAA/PDMC. The results show that the new hydrogel loaded on different substrates (stainless steel mesh/filter cloth) possesses superhydrophilicity (WCA < 10°) and underwater superoleophobicity (OCA > 150°). The hydrogels not only separated oil–water mixtures with high throughput and efficiency (98%, 12,000 L m −2 h −1 ), but also separated oil-in-water emulsions by gravity alone (95%, 700 L m −2 h −1 ). Due to the large number of quaternary ammonium groups in the DMC, we have tested the antimicrobial properties of the DMC with excellent results (99.2% inhibition). Compared with previous studies, this paper introduces that PEI has the ability to adsorb heavy metals, and we tested Cu 2+ and found that the adsorption and separation efficiency reached 75%. This study provides new ideas for the direction of wastewater treatment.
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高影响因子
Materials Today Energy
·
2022
·
IF 9.257
Lulu Ren,Jingqi Qiao,Can Wang,Wenyue Zheng,He Li,Xuetong Zhao,Lijun Yang,Ruijin Liao
Since the promotion of the concept of nanodielectrics, the composite approach has long been considered as an effective way to improve the energy density of electrostatic capacitor films for energy storage applications. However, the selection criteria of nanofiller are blur in spite of multifarious attempts, such as Al 2 O 3 , HfO 2 , BaTiO 3 , TiO 2 , MnO 2 , MgO , etc. This paper is devoted to demonstrating the priority consideration of bandgap and permittivity in the filler selection of capacitive nanocomposite. The antagonistic effect between the bandgap and permittivity of fillers in the capacitive nanocomposite was revealed by the study of the physicochemical, dielectric , electric breakdown, and capacitive energy storage properties of polyetherimide (PEI) nanocomposites, i.e., PEI/ZrO 2 , PEI/SiO 2 , and PEI/TiO 2 nanocomposites with systematically varied bandgap and permittivity. It is found that the ZrO 2 nanofillers combine a wide bandgap and moderate permittivity; hence, the corresponding PEI/ZrO 2 nanocomposite shows the highest discharged energy density over PEI/SiO 2 and PEI/TiO 2 nanocomposite. Specifically, the PEI/ZrO 2 nanocomposite exhibits a maximum discharged energy density of 6.15 J/cm 3 at an optimal filler content of 3 vol%, which is 57.7% higher than that of neat PEI.
研究领域:
材料科学
·
能源存储
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DOI
高影响因子
JOURNAL OF RARE EARTHS
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2019
·
IF 2.846
Zaifa Pan,Yingting Wen,Tao Wang,Kai Wang,Yuanjie Teng,Kang Shao
Novel PEI-modified NaBiF 4 :Yb 3+ /Er 3+ upconversion nanoparticles (UCNPs) with hollow structure were prepared by a surface modification free one-step solvothermal method and applied as a luminescent probe to determinate water content in organic solvents . XRD , SEM and HRTEM results demonstrate that the obtained PEI-NaBiF 4 :Yb 3+ /Er 3+ UCNPs are pure hexagonal phase with uniform size. The successful modification of PEI on the UCNPs surface was evidenced by ζ-potential test, XPS and TG analysis . These synthesized UCNPs are disintegrated into smaller nanoparticles in the presence of water and thus result in a surface quenching effect, which show the features of 0–100% wide range water response in various organic solvents. The sensing performance towards real samples was validated by the water content determination in beer, rum and white spirit. Furthermore, the luminescence intensity variation of the PEI-modified NaBiF 4 :Yb 3+ /Er 3+ enable the test visualization and ease of portability.
研究领域:
材料科学
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分析化学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2016
·
IF 7.476
Yayun Yang,Huan Zhang,Chusen Huang,Dapeng Yang,Nengqing Jia
Clenbuterol (CLB), a kind of β 2 -adrenergic agonists, could disrupt cardiovascular and central nervous system. In this work, a new electrochemical non-enzyme sensor for detecting Clenbuterol (CLB) was fabricated based on MoS 2 -Au-PEI-hemin layered nanocomposites . The two-dimensional (2-D) MoS 2 nanosheets were first in-situ assembled with Au nanoparticles , and polyethylenimine (PEI), then hemin molecules were immobilized onto the MoS 2 -Au-PEI film-modified glassy carbon electrode (GCE) via amide bond. Scanning electron microscopy (SEM) and Zeta potential measurements were employed to characterize the MoS 2 -based nanomaterials . Cyclic voltammetry (CV) was used to investigate electrochemical activity of the immobilized hemin on the modified electrode . Upon the optimum conditions, the proposed electrochemical sensor showed an excellent response for CLB including a wide linear ranging from 10 ng/mL to 2 μg/mL and a detection limit (LOD) of 1.92 ng/mL CLB (S/N=3) with favorable reproducibility and stability. Furthermore, this presented method could be feasible for determining CLB in the real pork samples.
研究领域:
分析化学
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生物医学工程
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毒理学
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PubMed
高影响因子
BIOMATERIALS
·
2013
·
IF 7.604
Yiyan He,Yu Nie,Li Xie,Hongmei Song,Zhongwei Gu
Reduction-sensitive hyaluronic acid derivatives (HA–SS–COOH) were shielded on the DNA/polyethylenimine (PEI) to construct ternary complexes ( D NA/ P EI/HA– S S–COOH, DPS ternary complexes) with efficient gene transfection. Details studied were conducted to investigation of factors influencing transfection efficiency, including the gene compression by fluorescence resonance energy transfer (FRET) spectrum and the intracellular fate of fluorescent labeled complexes by the confocal laser scanning microscope (CLSM). In the FRET study, DPS complexes were found to enhance condensation of DNA in preparation, while timely loosen gene under exposure to reductive reagent. Similar cellular uptake levels were observed for the designed reduction sensitive complexes and the stable one ( D NA/ P EI/ H A, DPH ternary complexes), but the intracellular process was strikingly different for the two types of complexes. Only DPS showed obvious desired intracellular deshielding and endosomal escape, which contributed to highly efficient gene delivery. After loading with p53 plasmid, DPS complexes achieved significantly up-regulated p53 tumor suppressor gene expression at both mRNA and protein levels, as revealed by quantitative polymerase chain reaction (qPCR) and western blot investigations. Transgene induced apoptosis was evaluated by propidium iodide staining and flow cytometry analysis of cell cycle. Tumor cells transfected by DPS complexes containing p53 gene displayed almost 50% higher suppression in proliferation compared to those untreated cells, accompanied with a 46% elevation in the number of cells at sub-G1 phase and remarkable p53 dependent cell cycle perturbations prior to apoptosis. These results demonstrated that targeted delivery of p53 gene via reduction-sensitive DPS ternary complexes enabled up-regulated cellular p53 mRNA level through the exogenous p53 gene, inducing a significant p53-dependent anti-proliferative effect on tumor cells, which could be effective means of cancer treatment.
研究领域:
生物医学工程
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分子生物学
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癌症研究
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基因治疗
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 46
·18345-18354
·
IF 3.069
Gaozhi Bai,Yu Han,Panpeng Du,Zhaoyang Fei,Xian Chen,Zhuxiu Zhang,Jihai Tang,Mifen Cui,Qing Liu,Xu Qiao
A highly efficient solid-amine adsorbent with excellent CO2 capacity from flue gas was successfully prepared using polyethyleneimine (PEI)-impregnated resin HPD450 in this study. The adsorbents were characterized by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), N2 adsorption–desorption, thermogravimetric analysis (TGA) techniques and elemental analysis (EA). The CO2 adsorption behaviors of the adsorbent were studied for their adsorption capacity, kinetics, thermodynamics and stability. The optimal adsorbent (HPD450/PEI-50) exhibited an excellent adsorption capacity of 4.44 mmol g−1 for pure CO2 and 3.62 mmol g−1 for 15 vol% CO2. Moreover, HPD450/PEI-50 retained an average capacity of 3.58 mmol g−1 under flue gas for 90 consecutive adsorption cycles. The adsorption/desorption process of CO2 on HPD450/PEI-50 was investigated using in situ FTIR. The capture of carbon dioxide in the simulated flue gas stream also demonstrated that moisture had a promoting effect on CO2 adsorption. This design of the high-performance HPD450/PEI-50 with a fantastic CO2 capacity could provide an up-and-coming candidate for CO2 capture from flue gas.
研究领域:
环境科学
·
材料科学
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高影响因子
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