EUROPEAN POLYMER JOURNAL
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2024
·
IF 5.8
Weiwei Liu,Tengfei Liu,Xiaofei Wang,Yuan Gao,Pingye Deng,Tao Zou,Zhi Luo,Shuangkun Zhang
Development of high-performance fluorescent materials is crucial for fluorescence imaging technology. Herein, well-defined fluorescent star poly-N-isopropylacrylamide (Flu-PNIPAM) was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization in a continuous-flow microreactor. A tetrafunctional RAFT agent and the functional monomer fluorescein undecylenoyl (Flu-UE) were synthesized, and then pumped into a microreactor with NIPAM monomer together for RAFT polymerization. The microreactor process parameters for the RAFT polymerization were optimized to obtain well-defined Flu-PNIPAM. The NIPAM and Flu-UE units endow Flu-PNIPAM with temperature and pH responsiveness, respectively. Transmission electron microscopy and dynamic light scattering analyses revealed that Flu-PNIPAM self-assembled into nanoparticles with uniform size in an aqueous solution at 37 °C. Moreover, Flu-PNIPAM exhibited good fluorescence and biocompatibility, rendering it highly promising for cell imaging.
研究领域:
高分子化学
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生物医学工程
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材料科学
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2016
·Vol. 54
·期 15
·2413-2420
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IF 3.114
Ye Sha,Qing Zhu,Yuanxin Wan,Linling Li,Xiaoliang Wang,Gi Xue,Dongshan Zhou
A new type of chain transfer agent used in reversible addition fragmentation chain transfer (RAFT) polymerization named 9-anthracenylmethyl (4-cyano-4-( N -carbazylcarbodithioate) pentanoate) (ACCP) was synthesized with a total yield over 75% by the incorporation of both fluorescent donor and acceptor chromophores. Polymerization of heterotelechelic α,ω end-labeled dye-functionalized polystyrene (PS), poly(methyl methacrylate) (PMMA), and poly( n -butyl methacrylate) (PBMA) with adjustable molecular weights and narrow polydispersity could be conducted by a one-pot procedure through RAFT polymerization with this bischromophore chain transfer agent. The polymerizations demonstrated “living” controlled characteristics. By taking advantage of the characteristic fluorescence resonance energy transfer (FRET) response between the polymer chain terminals, the variation of chain dimensions in solution from the dilute region to the semidilute region can be monitored by changes in the ratio of the fluorescence intensities of the carbazolyl group to the anthryl group, which lends itself to potential applications in characterizing chain dimensions in solutions for thermodynamic or dynamic studies. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 2413–2420
研究领域:
高分子化学
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物理化学
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
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2019
·Vol. 297
·期 10
·1287-1299
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IF 1.906
Zheng Zhenan,Gao Xiang,Luo Yingwu
Electrode binders have significant influences on lithium-ion battery performance. Good binders should be able to absorb electrolyte to accelerate lithium-ion transport while simultaneously maintaining adequate adhesion and mechanical strength after swelling. Currently, most polymer binders are based on homo or random copolymers so they may only meet one of these requirements, as an improvement in electrolyte swelling ability is detrimental to mechanical strength, and vice versa. This work investigates whether the design of chain sequence can resolve this contradiction. Reversible addition-fragmentation chain transfer (RAFT) emulsion polymerization is employed to synthesize copolymer latex with different chain sequences as electrode binders, which are examined in both LiFePO 4 cathode and silicon anodes. The results show a triblock copolymer chain sequence gives the best performance. The microphase separation in triblock copolymer distributes functionalities of electrolyte affinity and strength maintenance into disparate blocks and therefore satisfies both requirements simultaneously. The advantages of triblock chain sequence are demonstrated by superior ionic conductivity, mechanical strength after electrolyte absorption, and lithium-ion diffusion coefficient and then lead to better battery performance compared with random counterpart and commercial aqueous binders.
研究领域:
材料科学
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能源存储技术
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DOI
高影响因子
CHROMATOGRAPHIA
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2024
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IF 1.2
Wang Yongjian,Muntiza Nurimangul,Zhang Wenbin,Zhang Hongfeng,Li Qinran,Deng Qiliang
Phosphorylation is one of the most common post-translational modifications of proteins. Recognition of phosphorylated peptides with high selectivity is an important prerequisite for the structural identification of protein phosphorylation. By the application of molecular imprinting technology, a kind of tyrosine-phosphorylated peptide imprinted particles was prepared by the combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and “epitope” strategy that applied in tyrosine-phosphorylated peptides recognition. Phenylphosphonic acid was used as the dummy template of the phosphorylated angiotensin II, which was one of the natural tyrosine-phosphorylated peptides. After the template modified by hydrogen bond with ureidopropyl group on the surface of silica, the surface imprinted particles with controlled and imprinted shell were synthesized by radical polymerization with RAFT strategy. The imprinted particles were obtained after the peptide removed and dithioester group destructed under alkaline condition. The binding capacity of phenylphosphonic acid reached 0.198 mg g −1 with imprinting factor (IF) as 2.70, while the binding capacity of phosphorylated angiotensin II reached 0.792 mg g −1 with IF as 1.96, which were obviously higher than with IF of that without RAFT strategy. Furthermore, phosphorylated angiotensin II could be selectively recognized by the imprinted particles even in presence of angiotensin II without phosphorylated. The performance of the phosphopeptide recognition remained 92% after five cycles of adsorption and desorption. All these results demonstrated that the tyrosine-phosphorylated imprinted particles prepared by combing RAFT polymerization and “epitope” strategy are promising to achieve the phosphopeptide recognition with higher recognition ability, selectivity and reusability.
研究领域:
生物化学
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分析化学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2015
·
IF 4.169
Xiaoyu Xie,Liang Chen,Xiaoyan Pan,Sicen Wang
Magnetic molecularly imprinted polymers (MMIPs) have become a hotspot owing to the dual functions of target recognition and magnetic separation. In this study, the MMIPs were obtained by the surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization using Sudan I as the template. The resultant MMIPs were characterized by transmission electron microscope, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, vibrating sample magnetometer, and X-ray diffraction. Benefiting from the controlled/living property of the RAFT strategy, the uniform MIP layer was successfully grafted on the surface of RAFT agent-modified Fe 3 O 4 @SiO 2 nanoparticles, favoring the fast mass transfer and rapid binding kinetics. The developed MMIPs were used as the solid-phase extraction sorbents to selectively extract four Sudan dyes (Sudan I, II, III, and IV) from chili powder samples. The recoveries of the spiked samples in chili powder samples ranged from 74.1 to 93.3% with RSD lower than 6.4% and the relative standard uncertainty lower than 0.029. This work provided a good platform for the extraction and removal of Sudan dyes in complicated matrixes and demonstrated a bright future for the application of the well-constructed MMIPs in the field of solid-phase extraction.
研究领域:
分析化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULES
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2016
·
IF 5.554
Zhenghe Zhang,Yudong Xue,Pengcheng Zhang,Axel H. E. Müller,Weian Zhang
A novel amphiphilic diblock copolymer, PHEMAPOSS-b-P(DMAEMA-co-CMA), was prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization, where PHEMAPOSS block was first synthesized using a methacrylate monomer based on polyhedral oligomeric silsesquioxane (HEMAPOSS), and PHEMAPOSS was further utilized to prepare the block copolymer via RAFT copolymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and reduction-cleavable coumarin methacrylate (CMA) monomer. PHEMAPOSS-b-P(DMAEMA-co-CMA) could self-assemble in water to form spherical micelles with POSS core and stimuli-responsive shell. The micelles were cross-linked by photodimerization of coumarin, and then hollow polymeric capsules could be finally obtained via etching the POSS core in the solution of hydrofluoric acid (HF). The morphologies of the micelles and hollow polymeric capsules were well characterized by TEM, SEM, and DLS. The hollow polymeric capsules are responsive to typical physiological stimuli such as pH, and redox potential, and could be further utilized in the encapsulation and release of tetraphenylporphyrin tetrasulfonic acid hydrate (TPPS) for photodynamic therapy (PDT). The in vitro release of TPPS-loaded polymeric capsules allowed a relatively low TPPS release at pH = 7.4. However, a burst release of TPPS was observed in the presence of 10 mM glutathione (GSH) at pH = 5.5. Confocal laser scanning microscopy (CLSM) confirmed that TPPS-loaded polymeric capsules could well improve the internalization rate in MCF-7 cells. According to the result of MTT assay, TPPS-loaded polymeric capsules demonstrated efficient PDT efficacy and low dark toxicity toward MCF-7 cells. Thus, TPPS-loaded polymeric capsules have presented potential application in PDT.
研究领域:
材料科学
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生物医学工程
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药剂学
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DOI
高影响因子
POWDER TECHNOLOGY
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2022
·
IF 5.64
Jiaojiao Zhao,Jianhua Zhou,Hong Li,Xiang Li
Phase change materials (PCMs) have great promise in many fields related to energy utilization and thermal management. However, PCMs face great challenges in large-scale applications due to the intrinsic melting leakage, low thermal conductivity and poor photothermal conversion. Herein, nanoencapsulated phase change materials (NanoPCMs) were fabricated by RAFT miniemulsion polymerization using quaternized poly(2-(dimethylamino)ethyl methacrylate)- b -poly(methyl methacrylate) (QPDMAEMA- b -PMMA) as emulsifier . N-octadecane and n-butyl stearate were used as binary cores, and Cu 2 O nanoparticles were doped into PMMA as hybrid shell. The resulting Cu 2 O/PMMA-NanoPCMs had an encapsulation efficiency of 86.68%, excellent thermal stability and thermal cycle durability. The thermal conductivity was enhanced by 67.25% compared with the original nanocapsules . Furthermore, the cotton fabrics finished with Cu 2 O/PMMA-NanoPCMs showed fast thermal response and superior photothermal conversion. Therefore, the synthesized nanocapsules are considered as potential candidates in the field of solar energy utilization and smart thermo-regulated textiles.
研究领域:
材料科学
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能源工程
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2011
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IF 2.925
Jiucun Chen,Mingzhu Liu,Chen Chen,Honghong Gong,Chunmei Gao
Covalent functionalization of azide-modified SiO2 with well-defined, alkyne-terminated poly(N-isopropylacrylamide) was accomplished by the Cu(I)-catalyzed [3 + 2] Huisgen cycloaddition. The alkyne-terminated RAFT chain transfer agent was first synthesized, and then the alkyne-terminated thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) with different molecular weights were synthesized by the RAFT of NIPAM monomer. The polymerization kinetics and the evolution of number-average molecular weights (Mn), and polydispersities (Mw/Mn), with monomer conversions were investigated. A copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “grafting to” method was used to attach thermoresponsive polymers onto the exterior surface of SiO2 nanoparticles which produced relatively high grafting density. The as-synthesized hybrid nanoparticles showed thermoresponsive behavior and were characterized by FTIR, XPS, TGA, DLS, and TEM, etc.
研究领域:
高分子化学
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纳米材料
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表面改性
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智能材料
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胶体与界面科学
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DOI
高影响因子
DYES AND PIGMENTS
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2020
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IF 4.613
Zengfang Huang,Yali Chen,Chaoyue Zhou,Ke Wang,Xiaobo Liu,Liucheng Mao,Jinying Yuan,Lei Tao,Yen Wei
Recently, various AIE-based materials with new characteristics and functions have been developing for different fields. Many chiral polymers are attracting the research interests for the new multifunctional materials in biomedicine, chiral recognition, etc. In this work, novel AIE copolymers with chirality activity were successfully fabricated for the first time. Firstly, a new fluorescent monomer (R)-THM with AIE effect and chirality activity was firstly synthesized by Suzuki reaction and enzymatic transesterification reaction. The quantum yield of (R)-THM increased to 0.643 from 0.100 of its substrate TBP with remarkable red-shift of emission spectra , which was consistent with their quantum chemical calculations of HOMO and LUMO situations, and its specific optical rotation [ α ] D 25 °C was about −9.67°. Subsequently, a series of chiral AIE copolymers of PEG-(R)-THM1 and PEG-(R)-THM2 were prepared via RAFT polymerization of (R)-THM and PEGMA with different feeding ratios. Their molecular weights were about 2.0 × 10 4 g/mol with narrow polydispersity index (PDI), and the kinetics analysis presented a pseudo-first-order linear procedure. For the molar 24.2%–32.3% feeding ratio of (R)-THM, the actual fraction of (R)-THM in the copolymers PEG-(R)-THM1 and PEG-(R)-THM2 was respectively about 22.3% and 30.2%, and the [ α ] D 25 °C value of copolymers PEG-(R)-THM1 and PEG-(R)-THM2 was about −2.51° and −3.74°. The amphiphilic structure of the obtained PEG-(R)-THM make them be easily dispersed in water solution and tend to self-assemble into fluorescent organic nanoparticles (FONs) with 100–150 nm diameter by TEM , and their maximum emission wavelength presented at 495 nm with obvious AIE effect. Moreover, the PEG-(R)-THM FONs had good biological compatibility, desirable low cytotoxicity and good cells absorption effect, which showed the great potential in bioimaging application.
研究领域:
高分子化学
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材料科学
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生物医学工程
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荧光材料
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纳米技术
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手性识别
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生物成像
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DOI
高影响因子
Polymers
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2021
·Vol. 13
·期 6
·968
·
IF 4.329
Yuzhi Xu,Ning Li,Guangbin Wang,Chunpeng Wang,Fuxiang Chu
The conversion of cornstalk lignin derived from the co-product of bio-refinery into value-added products such as polymeric material has remarkable environmental and economic potential. A novel bio-based methyl methacrylate copolymerized with butyl acrylate (MMA-co-BA) hybrid resin in our research was prepared by the reversible addition–fragmentation chain transfer method using lignin-graft-polyacrylamide (lignin-g-PAM) as a bio-derived macromolecular chain transfer agent. The molecular architecture of lignin-g-PAM and the lignin-based MMA-co-BA hybrid resin was elucidated using1H nuclear magnetic resonance and attenuated total reflectance–Fourier transform infrared. The thermal behavior and mechanical performance of the resultant lignin-based MMA-co-BA hybrid resins were also investigated through thermogravimetric analysis, differential scanning calorimetry, and a stress–strain test, respectively. The lignin-based acrylate resins system exhibited structure-related thermal and mechanical properties. Compared with pure MMA-co-BA resin, the incorporation of lignin into various lignin-based MMA-co-BA graft copolymers resulted in an improved tensile strength and a higher Young’s modulus. This research could provide not only a new avenue to utilize waste biomass for high-value applications, but also a reference for designing new materials for coatings or adhesives.Keywords:lignin;macromolecular chain transfer agent;RAFT miniemulsion polymerization;thermal behavior;mechanical performance
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2019
·
IF 3.375
Jie Jiang,Wen-Jun Wang,Bo-Geng Li,Shiping Zhu
The tactics of targeting copolymer composition (CC) and molecular weight (MW) via semibatch controlled radical polymerization (CRP) have been extensively studied. However, little effort is made to target copolymer sequence length (CSL) and its triad sequence, which are among the key microstructures determining material properties of the copolymers. This work presents a method to design and synthesize targeted CSL and copolymer triads in a reversible addition–fragmentation chain transfer radical mini-emulsion copolymerization system (RAFT) through a semibatch chain and sequence model coupled with Alfrey Mayo model. The kinetic model was first derived and correlated with experimental results of the batch St/BA copolymerizations. The semibatch RAFT model was then employed to calculate the feed-rate to target CSL and their triads. St/BA copolymers with different uniform CSLs and their triads are synthesized through the programmed semibatch RAFT mini-emulsion copolymerization processes.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Mohammad Hegazy,Pei Zhou,Nahla Rahoui,Guangyu Wu,Nadia Taloub,Youping Lin,Xin Huang,Yudong Huang
The rational design of hybrid nanostructures with an active core and a modified shell can promote several biological applications. Herein, a coating platform has been developed to obtain monodispersed core-shell magnetic mesoporous silica nanocarriers. The surface of silica shells has been successfully modified by disulfide bonds and the photoresponsive polymer, poly(2-nitrobenzyl acrylate) (PNBA), via RAFT polymerization using azobisisobutyronitrile (AIBN) as a thermal initiator. The results showed that these nanocarriers have nanospherical morphologies with high porosity, large surface areas, and suitable pore volumes. Furthermore, ibuprofen (IBU) as a model drug has been loaded easily into the polymeric nanocontainers with a high loading content, followed by coating with β-Cyclodextrin (β-CD) as effective gatekeeper molecules. Treating these nanocarriers with ultraviolet light causes the photocleavage of o-nitrobenzyl ester moieties contained in the growing polymer chains. The controlled release of the loaded IBU cargo can be achieved by ultraviolet light, or reduction cleavable of the disulfide bond, or both together. Interestingly, the magnetic core can enhance the release process through magnetic guiding and pushing the nanocarriers to the targeted sites by using an external magnet or a directed magnetic field. The prepared photodegradable polymer nanocarriers can be widely applied in the fields of controlled drug delivery systems (DDS) and pharmacologically active polymers.
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产品关联
DOI
高影响因子
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