Molecular Catalysis
·
2023
·
IF 4.6
Xuan Gao,Zhihui Li,Dongsheng Zhang,Baoquan Zhang,Yanji Wang
Efficient and safe conversion of 5-hydroxymethylfurfural (HMF) to 5-hydroxymethyl-2-furancarbonitrile (HMFC) with hydroxylamine zinc chloride salt (ZnCl 2 ·2NH 2 OH) obtained from a novel method was developed. Without a catalyst, free NH 2 OH could react with HMF to produce HMFC with a yield of 41% at 55 °C. ZnCl 2 was an appropriate catalyst that increased HMFC yield to 64%. However, the reaction has a potential explosion safety hazard and a low effective utilization rate of NH 2 OH due to the easy decomposition property of free NH 2 OH. To address these issues, ZnCl 2 ·2NH 2 OH was prepared to serve as a hydroxylamine stabilizer, catalyst, and nitrogen source in the synthesis of HMFC. Therefore, NH 2 OH could be slowly released to participate in the reaction, slowing the invalid decomposition and increasing the utilization rate of elemental N. Under optimal conditions of n(HMF): n(NH 2 OH) = 1:1.5, 100 °C for 20 min with acetonitrile as solvent, the yield of HMFC was 100%. A plausible reaction mechanism for HMFC synthesis was also proposed.
研究领域:
化学
·
有机化学
·
催化
·
安全工程
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高影响因子
Molecular Therapy-Nucleic Acids
·
2023
·
IF 8.8
Xin Chang,Chang Liu,Yu-Mo Han,Qiu-Ling Li,Bin Guo,Hu-Lin Jiang
Pulmonary fibrosis (PF) is an interstitial lung disease with complex pathological mechanism, and there is currently a lack of therapeutics that can heal it completely. Using gene therapy with drugs provides promising therapeutic strategies for synergistically reversing PF. However, improving the intracellular accumulation and transfection efficiency of therapeutic nucleic acids is still a critical issue that urgently needs to be addressed. Herein, we developed lipid nanoparticles (PEDPs) with high transfection efficiency coloaded with pDNA of nuclear factor erythroid 2-related factor 2 (pNrf2) and pirfenidone (PFD) for PF therapy. PEDPs can penetrate biological barriers, accumulate at the target, and exert therapeutic effects, eventually alleviating the oxidative stress imbalance in type II alveolar epithelial cells (AECs II) and inhibiting myofibroblast overactivation through the synergistic effects of Nrf2 combined with PFD, thus reversing PF. In addition, we systematically engineered various liposomes (LNPs), demonstrated that reducing the polyethylene glycol (PEG) proportion could significantly improve the uptake and transfection efficiency of the LNPs, and proposed a possible mechanism for this influence. This study clearly reveals that controlling the composition ratio of PEG in PEDPs can efficiently deliver therapeutics into AECs II, improve pNrf2 transfection, and synergize with PFD in a prospective strategy to reverse PF.
研究领域:
药理学
·
分子生物学
·
基因治疗
·
肺科学
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Advanced Healthcare Materials
·
2023
·
IF 10
Huimin Zhu,Jinfa Ye,Yiming Wu,Yuhang Cheng,Min Su,Qixuan Dai,Yun Han,Jintao Pan,Zhenyu Wu,Chuan Chen,Chenyue Qiu,Wei Li,Gang Liu,Chengchao Chu
Corneal neovascularization (CNV) is one of the leading causes of blindness in the world. In clinical practice, however, it remains a challenge to achieve a noninvasive and safe treatment. Herein, a biocompatible shell with excellent antioxidant and antivascular is prepared by co-assemly of epigallocatechin gallate (EGCG)/gallic acid (GC) and Copper (Cu II). Afther loading gluocose oxidase (GOx) inside, the shell is modified with dimeric DPA-Zn for codelivering vascular endothelial growth factor (VEGF) small interfering RNA (VEGF-siRNA. Meanwhile, the Arg-Gly-Asp peptide (RGD) peptide-engineered cell membranes coating improves angiogenesis-targeting and biocompatible for the multifunctional nanomedicine (CEGs/RGD). After eye drops administration, CEGs/RGD targets enrichment in neovascularization and CEGs NPs enter cells. Then, the inner GOx consumes glucose with a decrease in local pH, which in turn leads to the release of EGCE and VEGF-siRNA. As a result, the nanomedicines significantly reduce angiogenesis and inhibit CNV formation through synergistic effect of antioxidant and antivascular via down-regulation of cluster of differentiation 31(CD31) and VEGF. The nanomedicine represents a safe and efficient CNV treatment through the combined effect of antioxidant/gene, which provides important theoretical and clinical significance. This article is protected by copyright. All rights reserved
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Jiangai Long,Sheng Ma,Renming Wan,Aolin Sun,Zhenyi Zhu,Ruoyi Wang,Zhaopei Guo,Wantong Song
Cationic polymers have garnered considerable attention as mRNA carriers due to their structural tunability and chemical diversity. Nevertheless, their broader application remains limited by poor stability under physiological conditions and cytotoxicity associated with excessive charge density. Here, we report thiourea-modified poly( l -lysine) (PLL-T) carriers constructed by combinatorial side-chain modification with ionizable and hydrophobic isothiocyanates. The resulting thiourea linkage introduced two hydrogen bonding donor sites, enabling stronger hydrogen bonding with mRNA. These hydrogen bonding could synergize with electrostatic and hydrophobic interactions, forming multiple cooperative interactions with mRNA. This design enhanced mRNA encapsulation, colloidal stability, and high transfection efficiency without increasing cytotoxicity. The optimized PLL-1A1B(T) variant achieved over 10,000-fold higher transfection efficiency than the parent polymer PLL, and outperformed the commercial gold-standard Lipofectamine MessengerMAX in both HEK293T and RAW264.7 cells. Compared with its amide-linked analogue PLL-1A1B(A), in which the amide linkage provided only a single hydrogen bonding donor site, PLL-1A1B(T) exhibited superior mRNA encapsulation (91 % vs. 42 %), higher storage stability, and over 50-fold increase in intramuscular transfection. Unlike PLL-1A1B(A), which induced high levels of inflammation, PLL-1A1B(T) exhibited minimal inflammation in vivo. Importantly, PLL-1A1B(T) enabled efficient delivery of mRNA cancer vaccines and elicited potent CD8 + T cell mediated antitumor immunity. A single administration of PLL-1A1B(T)@E6/E7 mRNA vaccine achieved 77 % tumor suppression rate (TSR) in the TC-1 tumor model. Moreover, in combination with anti PD-1, PLL-1A1B(T)@OVA mRNA vaccine achieved 90 % TSR in the B16-OVA tumor model. This study demonstrates hydrogen bonding-driven carriers engineering as a versatile strategy to tune nucleic acid-carrier interactions, offering a potent and safe platform for mRNA therapeutics.
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JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Haibo Wang,Yongbing Gu,Huifen Zhu,Xianlang Chen,Yanling He,Rongrong Li,Ansheng Yu,Chenli Xu,Xiaohe Zheng,Lei Shi
Inspired by the structural motifs of Selinexor, a series of novel pyrazole-hydrazine hybrids were rationally designed and synthesized as potential reversible Exportin-1 (XPO1) inhibitors for the treatment of leukemia. The design strategy deliberately excluded the covalent warhead of Selinexor, aiming to achieve potent anti-leukemic activity through high-affinity, non-covalent interactions. Among the synthesized compounds, 5–33 was identified as the most potent candidate, demonstrating superior in vitro anti-leukemic activity against Jurkat, K562, and CMK cell lines (IC₅₀ values of 0.41, 1.01, and 0.88 μM, respectively), outperforming the positive controls Selinexor and cisplatin. Crucially, all hybrids exhibited significantly lower hepatotoxicity than cisplatin. Structure-activity relationship (SAR) studies revealed that strong electron-withdrawing trifluoromethyl groups on the pyridine ring and an electron-donating para -methoxyl group on the benzene ring were critical for potency. This was further rationalized by conceptual DFT calculations, where 5–33 displayed the most reactive electronic profile, characterized by the narrowest HOMO-LUMO gap and highest electrophilicity index. Molecular docking confirmed that 5–33 binds strongly to the XPO1 active site (-4.61 kcal/mol) via superior shape complementarity and an extensive non-covalent interaction network, aligning with the design of a reversible inhibitor. Molecular dynamics simulations further substantiated the stability of this non-covalent complex, demonstrating sustained key interactions and a high binding free energy (-33.90 kcal/mol). This study identifies 5–33 as a promising, safe, and potent lead compound for developing next-generation anti-leukemia therapeutics.
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ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Xiaolin Li,Jieqi Chen,Zijin Chen,Yashan Hu,Fengqiang Xie,Jiakun Li,Haiyan Zhang,Zhenghui Li
Sulfur (S)-doped carbon materials have attracted growing interest as promising anode candidates for sodium-ion batteries (SIBs) due to their abundant active sites, large capacity, and fast electrochemical kinetics. However, the current S doping strategies frequently employ elemental S, thiourea, (NH4)2SO4, H2S, etc. as dopants, which have low boiling or decomposition temperatures, bringing along environmental concerns, safety hazards, and fire risks. This study provides an innovative molten-salt-assisted sulfate doping strategy to design S-rich carbon materials. Different from conventional molten-salt systems, it is found that the KCl molten salt and dopant ZnSO4 in this work undergo complicated ion exchange, eutecticum and carbothermal reduction processes, and then release SOx or S to dope the carbon framework. It is demonstrated that the participation of KCl molten salt significantly facilitates the incorporation of S atoms, and the S-doped carbon material retains a S content of 7.3% even at 900 °C, much higher than the blank sample (<3.0%). When employed as an anode for SIBs, this S-doped carbon delivers a reversible capacity of >400 mAh g–1 and demonstrates negligible capacity degradation over 1000 cycles. Notably, highly doped carbon at 900 °C has been rarely achieved, and the employment of highly stable inorganic sulfates as dopants provides many advances such as enhanced safety, low toxicity, and minimal environmental contamination.
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JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Tianjiao Zhu,Xiaoqian Hao,Yongan Cao,Tianle Li,Yuqian Li,Wenju Wang
Lithium-ion (Li-ion) batteries assembled with gel polymer electrolytes (GPEs) are predicted to increase battery energy density while maintaining battery safety. In this work, poly (vinylidene fluoride- co -hexafluoropropylene) (PVDF-HFP) is successfully used as a polymer matrix to prepare a new kind of GPE (PHHNT) by ultraviolet (UV) curing technology. The polymer network structure formed by photopolymerization technology significantly enhances the tensile properties of the electrolyte. Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) improves the concentration and transport efficiency of lithium ions in the electrolyte as well as the ionic conductivity (1.22 × 10 −3 S cm −1 ) of the GPEs. In addition, the unique tubular structure of the halloysite nanotube (HNT) and the opposite charges carried by the inner and outer surfaces provide additional channels for the lithium salt and facilitate its dissociation. This enhances the expedited movement of Li + inside the electrolyte, while simultaneously improving the electrochemical and thermal durability of the electrolyte. The assembled LiFePO 4 (LFP)/PHHNT/Li battery has an initial discharge-specific capacity of 140.5 mAhg −1 at a current density of 0.5C, showing a high capacity retention rate of 89 % after 120 cycles. The design of this composite material significantly improves the overall performance of the electrolyte and is more suitable for flexible and safe solid-state Li-ion batteries.
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RARE METALS
·
2024
·Vol. 43
·期 6
·2597-2612
·
IF 9.6
Wang Chun-Fang,Zhang Shi-Wei,Huang Lan,Zhu Yuan-Min,Liu Feng,Wang Jian-Chuan,Tan Li-Ming,Zhi Chun-Yi,Han Cui-Ping
Calcium-ion batteries (CIBs) have generated intense interest due to the growing demand for safer, cheaper, and large-scale energy storage systems. However, their development is still in its infancy, owing to the lack of suitable cathodes for sustaining reversible Ca 2+ intercalation/deintercalation. Herein, layered H 2 V 3 O 8 (HVO) with Zn 2+ pre-insertion (ZHVO) is reported as a high-rate and highly durable cathode material for CIBs. The existence of Zn 2+ and H 2 O pillars could expand the interlayer spacing up to 1.8 nm, which is favorable for the diffusion of bulky Ca 2+ . The formation of Zn–O bonds facilitates electron transfer and enhances electrical conduction. Consequently, the ZHVO cathode achieves superior capacity performance (213.9 mAh·g −1 at 0.2 A·g −1 ) and long lifespan (78.3% for 1,000 cycles at 5 A·g −1 ) compared to pristine HVO. Density functional theory (DFT) calculations revealed that Zn 2+ moved during Ca 2+ intercalation, thereby reducing the diffusion energy barrier and facilitating Ca 2+ diffusion. Finally, a safe aqueous calcium ion cell was successfully assembled. Graphical abstract
研究领域:
材料科学
·
电化学
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 20
·50444
·
IF 3.125
Xinxing Zhang,Qingyin Wang,Shaoying Liu,Lilei Zhang,Gongying Wang
To get better processability and preparing process of Poly (ethylene terephthalate) polymer, -NO 2 was used to modify Schiff Base to synthesize a novel flame retardant monomer of 5-([3-nitrobenzylidene] amino) isophthalic acid (BNA) to prepare flame retardant and anti-dripping PET copolyester (BNA n PETs), where the electron effect of -NO 2 passivate the cross-linking reactivity of BNA in BNA n PETs to enhance its cross-linking temperature to improve its processing zone with better processability. The results demonstrated that the cross-linking temperature of BNA n PETs was improved from the range of (250–348°C) to (355–385°C), and BNA accelerated the reaction of the polycondensation of PET for saving time of 42%. -NO 2 enhanced the residue char of BNA n PETs in high temperature and further improved its flame retardancy. BNA 10 PET with 7.2 mol% of BNA had LOI of 31.8% and V-0 of UL-94 without drip, and the introduction of –NO 2 did not change the flame retardant mechanism in BNA n PETs.
研究领域:
材料科学
·
高分子化学
·
消防安全工程
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高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 35
·期 1
·e6238
·
IF 3.4
Ben Hu,Jun Wang,Xi Chen,Jingsheng Wang,Shuang Yang,Lu Zhu,Lanian Zou,Siqi Huo
This work reported a flame-retardant, single-component epoxy resin (EP) via introducing diphenylphosphine (DPP) and benzimidazolyl-substituted cyclotriphosphazene (BICP) into EP. The differential scanning calorimetry (DSC) test showed that the onset curing temperature of DPP/BICP-15/10 was 50°C lower than that of BICP-12 due to the catalytic decomposition effect of DPP toward BICP under heating. Besides, the shelf life of DPP/BICP-15/10 at room temperature reached ~14 days, demonstrating good storage stability. EP/DPP/BICP maintained satisfactory thermal properties and showed excellent flame retardancy with a UL-94V-0 classification. Compared with the unmodified EP sample, the peak heat release rate (PHRR) and total heat release (THR) of DPP/BICP-15/13 were decreased by ~68.1% and ~55.1%, respectively. Hence, this flame-retardant, single-component epoxy resin with satisfactory comprehensive properties exhibited great potential for versatile industrial applications.
研究领域:
材料科学
·
化学工程
·
高分子科学
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2026
·
IF 10.6
Zhuo Huang,Jiawei Ying,Long Liu,Jiantao Zheng,Youming Yu,Wenhui Bao,Wenbo Che
The widespread contamination of micro/nano-plastics (MNPs) has become a major environmental concern, highlighting the need for efficient treatment technologies and sustainable disposal methods. Herein, a hydrophobized magnetic lignocellulosic fiber (HLF) adsorbent derived from wood waste was engineered to realize a circular “capture-and-upcycle” strategy. HLF with excellent adsorption capacity can be prepared by modifying lignocellulosic fibers from wood waste through in situ synthesis of nanoscale Fe 3 O 4 particles and silanization. It has achieved equilibrium adsorption capacities of 2544.7 mg g −1 for micro-sized PS and 2571.1 mg g −1 for PMMA. The adsorption mechanism is a synergistic physicochemical interaction dominated by van der Waals forces and hydrophobic effects. Notably, the challenge of adsorbent disposal is addressed by directly transforming the MNPs-saturated HLF into robust functional composites via hot-pressing. The resulting HLF/MNPs composites exhibit ideal mechanical properties with a flexural strength of 151.1 MPa and a tensile strength of 37.6 MPa, far surpassing commercial wood-plastic composites. Furthermore, it exhibits self-extinguishing behavior and improves fire safety due to the action of magnetic particles, and their peak smoke release rate was reduced by 79.3% compared to non-magnetic LF/MNPs composites. This work establishes a scalable, circular approach for remediating aquatic plastic pollution while simultaneously valorizing waste into high-performance engineering materials.
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PubMed
高影响因子
Gels
·
2026
·Vol. 12
·期 8
·732
·
IF 6.4
Erdong Yao,Kun Zhang
As critical infrastructure for carbon capture, utilization, and storage (CCUS) and large-scale energy storage, subsurface salt caverns are seriously challenged by fluid-induced sediment mobilization during the supplementary debrining. Conventional bulk resin consolidation often causes severe viscous fingering, uneven consolidation, and pore clogging under hypersaline conditions. Here, we develop a foam-templated hybrid polymer gel co-stabilized by silica nanoparticles, polyvinyl alcohol, and the zwitterionic surfactant. The key novelty is the use of foam as a transient transport template that redistributes the resin phase and promotes selective cementation at grain-contact points instead of indiscriminate pore filling. This nano-reinforced gel system remained stable under hypersaline conditions (24% NaCl), and temperatures ranging from 20–80 °C. Micro-CT analysis showed that this selective templating preserved an interconnected pore network with a porosity above 45% and a CT-derived permeability of approximately 1.18 D, while reducing binder consumption by 55.6% relative to bulk resin injection. Crucially, a 1:200 geometrically scaled, velocity-matched pilot model demonstrated that this gel strategy limited sediment entrainment below 0.5% and reduced fluid discharge by 45.9%. These results establish a material-efficient consolidation strategy that combines sediment stabilization with permeability preservation, providing a promising solution for safer supplementary debrining in salt-cavern CCUS and energy-storage operations.
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