Journal of Neuroimmune Pharmacology
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2025
·Vol. 20
·期 1
·1-23
·
IF 3.5
Liu Jiawei,Shi Yusheng,Jin Lingling,Sun Baixue,Wang Ruonan,Ge Guangbo,Zhu Guanghao,Cui Xiaolin,Zhao Jie,Zhang Yan,Li Sheng
Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, remains without a curative pharmacological intervention. Sea Cucumber Peptides (SCP) are recognized for their antioxidant properties and neuroprotective potential, while no specific SCP have been documented for PD treatment. Moreover, sea cucumbers have long been consumed as a traditional food; viewed through the lens of “food-medicine homology”, their peptides possess clear pharmaceutical potential. This study sets out to pinpoint particular peptide sequences from sea cucumbers could combat PD, exploring their therapeutic efficacy and the underlying mechanisms. We treated Rotenone (Rot)-induced C57BL/6 J mice and SH-SY5Y cells with the SCP which were extracted from the sea cucumbers, to assess the impact on behavioral metrics in mice, histopathological outcomes, cellular viability, and in vitro bioactivity. Employing a combination of peptide profiling and silico analysis, we established a SCP spectrum to identify novel SCP with potential anti-PD activity. The therapeutic effects and mechanisms of the peptides were further investigated in 7-day-old zebrafish larvae and SH-SY5Y cells exposed in Rot, respectively. Our findings indicate that the SCP significantly improved behavioral deficits in mice, reduced the degeneration of dopaminergic neurons in the substantia nigra, and increased the survival of Rot-exposed SH-SY5Y cells. Notably, a novel peptide, Gln-Trp-Phe-Asp-Trp (QWFDW), emerged from our peptide profiling and in silico analysis, showing significant anti-PD activity. QWFDW was demonstrated to enhance the behavioral performance of Rot-induced zebrafish larvae, and ameliorate the pathological features of PD by attenuating endogenous reactive oxygen species (ROS) and maintaining mitochondrial membrane potential in SH-SY5Y cells. At the cellular level, QWFDW activates the Nrf2/HO-1/GPX4 pathway to alleviate ferroptosis and exert therapeutic effects on PD. Collectively, our results point out that SCP, particularly QWFDW, was a prospective therapeutic agent for PD. Graphical
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Journal of the Taiwan Institute of Chemical Engineers
·
2025
·
IF 6.3
Huage Lin,Mingyang Wei,Haitong Li,Teng Liu,Weinan Xing
Background Transition metal phosphonates have demonstrated significant potential in catalysis due to their versatile coordination configurations and tunable structural frameworks. However, their direct application in photo-self-Fenton and peroxymonosulfate activation systems for organic pollutant degradation has rarely been explored. Methods In this study, a novel three-dimensional (3D) sea-urchin-like iron-doped nickel phosphonate (NiFeP2) was synthesized and employed as a catalyst in a photo-self-Fenton system for the efficient degradation of tetracycline (TC). Characterization revealed that the hierarchical architecture of NiFeP2 not only enhances light absorption and exposes abundant active sites but also facilitates synergistic peroxymonosulfate activation and photo-self-Fenton reactions, thereby improving catalytic performance. Significant findings Under optimized conditions, NiFeP2 achieved an apparent reaction rate constant (k obs ) of 0.0589 min⁻¹ for TC degradation, demonstrating superior pollutant removal efficiency. The synthesized NiFeP2 photocatalyst exhibited excellent recyclability and maintained stable photocatalytic performance over multiple cycles, demonstrating its promising suitability for real-world wastewater purification applications. This work presents an effective photo-self-Fenton system based on NiFeP2, offering a promising strategy for the remediation of refractory organic pollutants in wastewater treatment.
研究领域:
环境科学
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催化
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材料科学
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化学工程
·
水处理
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Guanting Li,Xianze Meng,Yangmin Wu,Wenjie Zhao
Ti 3 C 2 T x nanosheets, which can act as effective physical barrier against corrosion species, have emerged as promising corrosion-resistant reinforcements in organic coatings due to abundant surface functional groups. However, relying solely on Ti 3 C 2 T x for passive protection does not adequately meet higher corrosion protection requirements, especially under high hydrostatic pressure environment in the deep sea. Herein, we synthesized Ti 3 C 2 T x @PPy-MoO 4 (MPMo) hybrid through in-situ oxidative polymerization strategy, which endowed epoxy coating with collaborative protection of passive physical barrier and active corrosion-inhibition. MPMo enhanced epoxy coating (MPMo/EP) exhibited superior anti-corrosion durability in simulated 60 MPa deep sea environment, maintaining a |Z| f=0.01 Hz value above 10 8 Ω·cm 2 and outperforming Ti 3 C 2 T x -based coatings by three orders of magnitude even after six cycles of AHP test. Moreover, polypyrrole (PPy) significantly improved the structural stability of Ti 3 C 2 T x , and successfully loaded with MoO 4 2− through anion doping. Meanwhile, Raman mapping analysis also revealed that MoO 4 2− anions adsorbed onto the Q235 steel surface and formed Fe 2 (MoO 4 ) 3 protective layers, which significantly hindered the generation of corrosion products. This work achieves active-passive synergistic protection of coatings through in-situ oxidation polymerization, providing a new approach for constructing robust anti-corrosion coatings suitable for higher protection demand in deep sea environment.
研究领域:
材料科学
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腐蚀工程
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纳米技术
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聚合物涂层
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海洋工程
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Lanlan Yu,Ningning Liu,Baojun Liu,Fei Yu,Jie Ma
Cathode materials with high capacity and cyclic durability are urgently needed for capacitive deionization . Na 3 V 2 (PO 4 ) 3 is an emerging pseudocapacitive candidate for this process on account of its high capacity and Na + reversible insertion, while it suffers from the intrinsic low electrical conductivity and small electrolyte-accessible surface area. Herein, a sea urchin-like Na 3 V 2 (PO 4 ) 3 @carbon (NVP@C) compound material was synthesized from MXene-V 2 C via hydrothermal method followed by annealing treatment, and then assembled as capacitive deionization (CDI) electrode material . Benefiting from three-dimensional sea urchin-like structure, where the nanoneedles of NVP@C serve as fast transport channel for Na + , NVP@C performed high specific capacity (437 F g −1 at 5 mV s −1 ) and fast ionic diffusion kinetics. Moreover, the NVP@C showed attractive desalination performance as cathode material for CDI, achieving a remarkable adsorption capacity of 74.0 mg g −1 in a NaCl salt solution (1000 mg L −1 ) and long life cycle stability. The present work provides a novel perspective to construct practical redox-active and stable CDI electrode with 3D structure from MXene for highly capacitive and durable desalination application .
研究领域:
材料科学
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电化学
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环境工程
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能源存储
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纳米材料
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水处理技术
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Yujia Song,Li Tian,Ruidan Li,Yanjia Guo,Pengfei Han,Guangping Ma,Hanyue Jiang,Wenzhuo Wang,Tengying Ma
A highly sensitive molecular imprinting electrochemiluminescence (MIP-ECL) sensor was developed for Sudan III detection in food. The sensor utilized nitrogen-vacancy carbon nitride (CNNV) as an efficient ECL emitter in the S 2 O 8 2− system, with sea-urchin-like Pt Au nanoparticles (Pt Au NPs) and Ti 3 CN MXene serving as co-reaction accelerators and support material respectively to enhance signal intensity. Molecular imprinting was achieved using O -phenylenediamine (O-PD) as functional monomer, creating specific recognition sites for Sudan III. The detection mechanism was based on target-induced ECL quenching through electron transfer inhibition. The sensor showed excellent analytical performance with a wide linear range from 1 × 10 −12 to 1 × 10 −6 mol L −1 and an ultralow detection limit of 3.3 × 10 −13 mol L −1 (S/N = 3). Real sample analysis demonstrated good accuracy and precision. The sensor maintained 87.5% of initial response after 20-day storage, indicating good stability. This method provides a reliable approach for monitoring Sudan III in food.
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Food Bioscience
·
2024
·
IF 4.8
Xuening Chen,Weiqing Lan,Zhenfei Xu,Huanyu Li,Jing Xie
There has been a growing interest in employing active films for fish preservation due to the environmental concern of plastic packaging and the high perishability of fish. This work aimed to develop active films (CPB 0.8 ) based on chitosan/polyvinyl alcohol integrated with ginger essential oil (GEO) -loaded bacterial cellulose, and to evaluate the preservation effect of the films on refrigerated sea bass fillets. Different active films were obtained by the solution blending method. It was evaluated by measuring microbiological indicators, physicochemical indexes, and water loss of sea bass fillets. The sample wrapped by CPB 0.8 film had a lower microbial load after 12 days of storage. The results showed that the sample wrapped by CPB 0.8 film had a lower microbial load after 12 days of storage compared to the active film sample without GEO and the control sample. Besides, the reduction of hardness and springiness of fillets packaged with CPB 0.8 film was markedly inhibited. Additionally, the fillets wrapped by CPB 0.8 film indicated a lower K-value (56.54%) under the rejection limit (60%) on the 10th day, which confirmed that CPB 0.8 films extended the shelf-life of fillets to 10 days. Also, the active packaging could preserve fish quality by controlling water migration and lipid oxidation. Overall, these findings indicate that CPB 0.8 films can be useful for the preservation of fish and effectively reduce petroleum-based plastics.
研究领域:
食品科学
·
海洋生物学
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Journal of Oceanology and Limnology
·
2021
·Vol. 39
·期 5
·1622-1633
·
IF 1.265
Qu Yang,Xu Kuidong,Li Tao,Wang Maoyu,Zhong Huan,Chen Tianyu
The ocean is an important inventory of anthropogenic mercury (Hg), yet the history of anthropogenic Hg accumulation in the ocean remains largely unexplored. Deep-sea corals are an emerging archive of past ocean chemistry, which take in sinking or suspended particulate organic matter as their food sources. Such organic matter would exchange Hg with the local seawater before being consumed by the deep, sea corals. As such, the organics preserved in the coral skeleton may record the Hg evolution of the ambient seawater during the time of coral growth. Here, we report the first data on Hg concentrations variability of a deep-sea proteinaceous coral in the oligotrophic North Pacific at the water depth of 1 249 m, in attempt to understand the transfer of anthropogenic Hg into the deep Pacific ocean over the last seven centuries. We find that the Hg concentrations of different coral growth layers have remained relatively constant albeit with considerable short-term variability through time. The overall stable Hg concentration of the last seven centuries recorded in our sample suggests that anthropogenic pollution is not yet a clearly resolvable component in the deep oligotrophic North Pacific waters, in agreement with recent estimation from modelling works and observational studies of modern seawater profiles. As there is hardly an unambiguous way to separate anthropogenic Hg from the natural background based on recent seawater profiles, our historical data provide valuable information helping to understand the oceanic cycle of Hg through time.
研究领域:
海洋地球化学
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环境科学
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古气候学
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生物地球化学循环
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深海生态学
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Journal of Environmental Chemical Engineering
·
2021
·Vol. 9
·期 4
·105785
·
IF 5.909
Jinjia Guo,Yongmei Wang,Zhao Luo,Feng Zhang,Dewang Yang
Carbon cycle in coastal water is a significant dynamic component of global carbon budget , however, the diverse sources, carbon sinks and their complex interactions remained poorly understood. In order to detect the dissolved inorganic carbon (DIC) and their interactions, gas-liquid Raman spectroscopy was built and applied to simultaneously detect the constituents of air, dissolved CO 2 , HCO 3 - and chlorophyll in coastal water. The linear fitting curve between peak intensity and concentration was built for the quantitative analysis of HCO 3 - and CO 2 , meanwhile, the fluorescence peaks of chlorophyll at 679 nm were detected for the qualitative analysis. For the multi-components analysis, typical Raman spectra of the constituents of air, dissolved CO 2 , HCO 3 - in seawater, and the fluorescence spectra of chlorophyll in seawater were detected. Results showed that the time dependent change of CO 2 and O 2 in the air exhibited a contrary tendency, while that of dissolved CO 2 and O 2 was curved like a cosine. The changing tendency of relative concentrations of dissolved CO 2 was about 2 h earlier than CO 2 in air, due to the life activity of microorganisms driving the gas exchange at the air-sea interface. Furthermore, the study makes a study on the relationship between DIC and chlorophyll based on the detection of HCO 3 - and chlorophyll in coastal water, indicating that this gas-liquid Raman spectroscopy could successfully provide real-time analysis of multicomponent DIC in the air-sea exchanging process.
研究领域:
海洋化学
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环境光谱学
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碳循环
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分析化学
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生物地球化学
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MICROCHEMICAL JOURNAL
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2023
·
IF 4.8
Wenqian Yan,Jiayi Yao,Zilin Yue,Hong Lin,Lei Wang,Kaiqiang Wang,Jinjie Li
TVB-N is a commonly used chemical indicator for assessing the freshness of aquatic products during storage. In this study, the combination of Raman spectroscopy with multivariate analysis for monitoring the freshness of sea bass ( Lateolabrax japonicus ) fillets was investigated. Orthogonal signal correction (OSC) method was applied to pre-process the Raman spectra of sea bass fillets with different freshness levels. Results suggested that PLSR models outperformed PCR and SVMR models in monitoring TVB-N values of sea bass fillets. In comparison, the OSC-PLSR model with full-band Raman spectra showed the best performance for predicting TVB-N contents, with R 2 C of 0.981, RMSEC of 1.162 mgN/100 g, R 2 CV of 0.804, RMSECV of 3.756 mgN/100 g, R 2 P of 0.898, RMSEP of 2.199 mgN/100 g, and RPD of 3.824. In addition, sea bass fillets with three different freshness grades (first-grade, second-grade, and spoilage) could be distinguished from the PCA score plot. The PLS-DA model showed an average classification accuracy of 91.11% for different freshness grades. The combination of Raman spectroscopy and chemometrics provided a new tool for the non-destructive evaluation of fish quality.
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Food Packaging and Shelf Life
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2022
·
IF 8.749
Jingwen Chen,Yinxuan Li,Yifen Wang,Salimata Yakubu,Haibing Tang,Li Li
Most edible films/coatings including those made of gelatin cannot be used independently as packaging films. In this study, active fish gelatin-based bilayer packaging films were developed and applied to preserve Japanese sea bass. The coating method was applied to produce polylactic acid/tilapia fish gelatin-sodium alginate bilayer film (PLA/FGSA). β -cyclodextrin inclusion complexes of cinnamaldehyde ( β -CD-CI) and thymol ( β -CD-Ty) were added into the gelatin-based layer of the PLA/FGSA to obtain active bilayer films (PLA/FGSA-CI and PLA/FGSA-Ty). This combination improved the oxygen and water vapor barrier abilities of the films, compared with PLA and edible gelatin-based monolayer films. Both active bilayer films possessed strong antibacterial and antioxidant activities . PLA/FGSA-Ty film showed the most effective inhibition against the growth of Pseudomonas .spp and H 2 S-producing Shewanella , generation of total volatile basic nitrogen (TVB-N) and thiobarbituric acid reactive substances (TBARS) of fish meat. These results indicate the active bilayer films are promising in the preservation of seafood.
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Food & Function
·
2022
·Vol. 13
·期 11
·6008-6021
·
IF 6.317
Rui Ma,Qiqi Chen,Yanping Dai,Yan Huang,Qing Hou,Yuting Huang,Kai Zhong,Yina Huang,Hong Gao,Qian Bu
Ocean life contains a wealth of bioactive peptides that could be utilized in nutraceuticals and pharmaceuticals. This study aimed to obtain neuroprotective antioxidant peptides in sea squirt (Halocynthia roretzi) through protamex enzymolysis. Fraction F4 (ultrafiltration generated four fractions) had a lower molecular weight (<500 Dalton (Da)) with greater 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical scavenging activities (94.24 ± 2.50% and 91.80 ± 1.19%). After gel filtration, six peptides, including Phe-Gly-Phe (FGF), Leu-Gly-Phe (LGF), Leu-Phe-VAL (LFV), Val-Phe-Leu (VFL), Trp-Leu-Pro (WLP), and Ile-Ser-Trp (ISW), were identified and sequenced by liquid chromatography-mass spectrometry (LC-MS/MS). Peptides WLP and ISW showed higher oxygen radical absorbance capacity (ORAC) values (2.72 ± 0.47 and 1.93 ± 0.01 μmol L−1 of Trolox equivalent (TE) per μmol L−1 of peptide) than glutathione (GSH). Additionally, WLP effectively increased cell viability, dramatically attenuated 6-Hydroxydopamine (6-OHDA)-induced cell apoptosis and decreased reactive oxygen species (ROS) levels to nearly two-fold, and significantly boosted glutathione peroxidase (GSH-Px) activity in PC12 cells. Transcriptome sequencing revealed differential expression of genes associated with various oxidative stress pathways after WLP treatment, such as glutathione metabolism. These results suggest that the Halocynthia roretzi-derived tripeptide WLP could alleviate neurodegenerative diseases associated with oxidative stress.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Xing Xing,Yurong Zhao,Congbin Xu,Yali He,Chen Yang,Kang Xiao,Jianzhong Zheng,Baolin Deng
Membrane distillation, an emerging desalination technology, shows much promise for treating industrial wastewater with high salinity. One major challenge that impedes its implementation for industrial applications is the wetting of hydrophobic membranes such as polyvinylidene fluoride (PVDF), resulting in a sharp decline in salt rejection. Wetting occurs when the feed solution contains surfactants, such as sodium dodecyl sulfate (SDS). It has been demonstrated that growing rough structures on the membrane surface followed by fluorination helps the membrane maintain its hydrophobicity. In this study, an omniphobic membrane was successfully prepared by first growing a layer of dense nano-ZnO needles on the surface of a pristine PVDF membrane, followed by a typical fluorination treatment. The modified membrane, with its surface similar to a nano sea urchin in appearance, exhibited a superior antiwetting property, having a high contact angle about 160° against a 50 g/L NaCl solution containing 0.3 mM SDS. The modified membrane showed a fairly good wetting resistance against 0.3 mM SDS, having a nearly 100% salt rejection in treating 50 g/L NaCl, whereas the pristine PVDF membrane could be easily wetted. The modified PVDF membrane shows promise in treating high-salinity wastewaters containing surface-active substances.
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危险品化学品经营许可证（带存储）