COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Weibing Wu,Sijie Li,Wen Deng,Shanshan Zhai,Youlu Chu,Xingyue Liu,Peng Li,Lei Zhang
Surface enhanced Raman scattering spectroscopy (SERS) technology has received increasing attention in the bioimaging field. Herein, based on the support of cellulose nanocrystal (CNC) with thiol groups, one-dimensional (1D) "hot spot" structure was constructed by the self-assembly of gold nanoparticles (AuNPs) via Au-S bonding. Silica shell was subsequently coated on the CNC loaded with AuNPs to fabricate core-shell SERS nanoprobe, which was further successfully applied for the SERS imaging of Hela cells. Owing to the presence of silica shell, the nanoprobe exhibited excellent water-dispersible stability in phosphate buffer salt solution (PBS). Moreover, the silica shell effectively protected both the "hot spot" structure and the adsorbed Raman reporter of 4-mercaptobenzoic acid from external interference, thereby improving the signal stability of SERS nanoprobe. In addition, the plasma coupling of electromagnetic field between AuNPs and silica significantly enhanced the Raman signal of "hot spots". The SERS nanoprobe possessed good biocompatibility even at relatively high concentrations, and successfully achieved bioimaging of Hela cell using the Raman signal at 1580 cm -1 channel.
研究领域:
纳米技术
·
生物医学工程
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材料科学
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分析化学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Kuo Yang,Shenfei Zong,Yizhi Zhang,Ziting Qian,Yun Liu,Kai Zhu,Lang Li,Na Li,Zhuyuan Wang,Yiping Cui
A novel kind of array-assisted surface-enhanced Raman spectroscopy (SERS) microfluidic chip (ArraySERS chip) is demonstrated for gas sensing, which has the advantages of both ultrahigh sensitivity and multiplex sensing ability. On the one hand, the introduction of a microstructured triangular array can greatly increase the multiple collision probability between gas molecules and sensing interfaces in the channel. Compared with traditional gas sensors using sealed boxes, where gaseous molecules move only by diffusion, the ArraySERS chip exhibits significantly improved sensitivity. On the other hand, a composite nanoparticle is fabricated as a SERS probe for reading out the fingerprint spectral data, which consists of metal–organic framework (MOF) materials [Zeolitic Imidazolate framework-8 (ZIF-8)] and Au@Ag nanocubes, as well as cysteamine (CA) that serves as the gas-capturing agent. The experimental results show that such a structure of the SERS probe can further increase the sensing ability because of better adsorption of ZIF-8 for gas and the lower SERS background of CA itself. In addition, the simultaneous detection of multiplex gases was easily performed according to their own intrinsic SERS signals. Taking aldehyde gas as a model of a typical air pollutant, trace and multicomponent detection was realized using the ArraySERS chip. The limit of detection value was as low as 1 ppb, which is 2 magnitudes lower than that obtained by traditional methods. This strategy can be well extended for the detection of universal gases and help unleash the potential of existing gas sensors, especially for samples at low concentrations in air.
研究领域:
化学传感器
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纳米技术
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分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Rong Wang,Yi Xu,Chunyan Wang,Huazhou Zhao,Renjie Wang,Xin Liao,Li Chen,Gang Chen
A novel composite structure of reduced graphene oxide (rGO)–Ag nanoparticles (Ag NPs) nanocomposite, which was integrated on the indium tin oxide (ITO) glass by a facile and rapid two-step chronoamperometry electrodeposition route, was proposed and developed in this paper. SERS-activity of the rGO/Ag NPs nanocomposite was mainly affected by the structure and size of the fabricated rGO/Ag NPs nanocomposite. In the experiments, the operational conditions of electrodeposition process were studied in details. The electrodeposited time was the important controllable factor, which decided the particle size and surface coverage of the deposited Ag NPs on ITO glass. Under the optimized conditions, the detection limit for rhodamine6G (R6G) was as low as 10 −11 M and the Raman enhancement factor was as large as 5.9 × 10 8 , which was 24 times higher than that for the ITO–Ag NPs substrate. Apart from this higher enhancement effect, it was also illustrated that extremely good uniformity and reproducibility with low standard deviation could be obtained by the prepared ITO-rGO/Ag NPs nanocomposite for SRES detection.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 187
·期 1
·1-10
·
IF 5.479
Li Yue,Wang Yan,Wang Mingchao,Zhang Jinyue,Wang Qingwei,Li Hongji
In a new method for the determination of trace levels of chlorophenols in river waters, detection via surface-enhanced Raman scattering (SERS) is combined with recognition by a molecularly imprinted polymer (MIP). Nanoparticles of type Cu 2 O@Ag were synthesized by attaching silver particles to the surface of Cu 2 O nanoparticles. The Cu 2 O@Ag were then coated with a layer of a MIP that was obtained by atom transfer radical polymerization using from methacrylic acid as monomers and 2,6-dichlorophenol as the template. The morphology of Cu 2 O is found to be flower-like. The Cu 2 O@Ag-MIPs displays a strong SERS effect. Following removal of the template by rinsing with the mixture solution of methanol/acetic acid (9/1, v /v), the material was used to selectively bind 2,6-dichlorophenol, 2,4-dichlorophenol and 2,4-dichlorophenol. The SERS peak intensity at 1580 cm −1 increases linearly with the concentration of the various chlorophenols in the range from 10 nM to 1 mM, and the detection limit is 5.8 nM. The imprinting factor is 4.62. The method was applied to the analysis of (spiked) river water, with recoveries ranging from 91.8 to 115.4% and relative standard deviations of <4.5%.
Graphical abstract
研究领域:
环境科学
·
分析化学
·
纳米技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zizhen Yu,Li Jiang,Rongyang Liu,Weidan Zhao,Ziheng Yang,Jinyao Zhang,Shangzhong Jin
The emergence of antibiotic-resistant bacterial strains has caused bacterial infections to become a more serious worldwide health problem. The development of multi-functional platform that can quickly and sensitively detect bacteria and effectively inhibit or kill bacterial is important and urgent. Herein, a novel versatile MXene-Au nanocomposite was successfully synthesized by self-assembly method for rapid detection of bacteria and photothermal sterilization. The typical gram-negative Escherichia coli (E. coli) and the gram-positive Bacillus subtilis (B. subtilis) were used as models to perform label-free, rapid and sensitive detection of bacteria based on SERS method. The antibacterial performance of the material was proved by the colony counting method, and the survival rates of E. coli and B. subtilis were as low as 8.05% and 0.06%, respectively. The Ti 3 C 2 T x -Au nanoparticles (NPs) irradiated with 808 nm light showed significant antibacterial effect within only 6 min, and the germicidal rates for E. coli and B. subtilis were 99.25% and 100%, respectively. The photothermal conversion efficiency reached as high as 43.40%. Accordingly, this multi-functional nanocomposite material can not only detect bacteria sensitively, but also has antibacterial and photothermal sterilization effects, which provides a greatly promising countermeasure for clinical treatment of diseases caused by multi-drug resistant bacteria.
研究领域:
材料科学
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纳米技术
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生物医学工程
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微生物学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Wei Fang,Zhuyuan Wang,Shenfei Zong,Hui Chen,Dan Zhu,Yuan Zhong,Yiping Cui
A type of pH-controllable drug carrier is demonstrated based on mesoporous silica nanoparticles and chitosan/poly (methacrylic acid), which can simultaneously serve as the surface enhanced Raman scattering (SERS) traceable drug carriers for targeting cancer cells. The pH-sensitive releasing characteristics can be achieved by coating the nanoparticles with a layer of chitosan/poly (methacrylic acid) (CS-PMAA), while strong SERS signals can be obtained from the SERS reporter tagged Ag nanoparticles in the core. Our experimental results show that doxorubicin (DOX) was effectively encapsulated into the nanocarriers and can be released in response to the ambient pH value. Specifically, an increased amount of DOX release was observed at lower pH value. In addition, the composite nanoparticles were conjugated with transferrin (Tf) to target transferrin receptor (TfR)-overexpressed cancer cells. The targeting ability as well as the intracellular location of the drug carrier was investigated through SERS mapping while the distribution of DOX was monitored by fluorescence images. The results show that the demonstrated drug carrier can simultaneously fulfill the functionalities of pH-responsive drug release, SERS-traceable characteristics and cancer cells targeting, which has a unique potential for the pH-controllable drug delivery nanosystems .
研究领域:
纳米技术
·
药学
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癌症研究
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 38
·17469-17476
·
IF 2.562
Li-Jun You,Qiao An,Jia Guo,Jack J. Hu,Chang-Chun Wang
Uniform MF/Ag-NPs core–shell composite microspheres were fabricated as isolated SERS (surface-enhanced Raman scattering)-active substrates through coating of Ag nanoparticles (Ag-NPs) onto MF (melamine formaldehyde resin) microspheres. These composite microspheres can be imaged and individually manipulated under an optical microscope. Their SERS spectra can be taken at the focal point to ensure the best analysis result or to recognize the identity of the microsphere for flow cytometry. In this paper, the SERS activity of the composite microspheres was evaluated using 4-ABT, 4-CBT, and 4-DTNB as the Raman reporting molecules; the SERS data of tetramethylthiuram disulfide were also acquired on the isolated MF/Ag-NPs core–shell composite microsphere. Due to the significant electromagnetic coupling effect created by the Ag-NPs on the MF microsphere, the SERS detection limits for 4-ABT, 4-CBT, and 4-DTNB were as low as 10−9 mol L−1, 10−10 mol L−1, and 10−8 mol L−1, respectively. For the insecticide tetramethylthiuram disulfide, the detection limit was 10−9 mol L−1 using the isolated MF/Ag-NPs microsphere as the SERS substrate. The SERS signal intensity linearly depended upon the concentration of tetramethylthiuram disulfide, indicating that the MF/Ag-NPs core–shell composite microsphere can be used for quantitative analysis of this insecticide.
研究领域:
材料科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Shuang Xiong,Tao He,Tao Zhou,Dalei Wang,Yueyue Wang,Chaoqing Dai,Wei Liu
Pesticides are often overused in production and life, which harms the environment and human health. However, the current tools for detecting pesticides are not effective enough due to lower flexibility and stability. With regards to this, we synthesized a flexible substrate of PDMS modified by MXene (Ti 3 C 2 Tx)/Ag. The MXene-noble metal composite substrate can detect 4-mercaptobenzoic acid (4MBA) at a low concentration of 1.0 × 10 −11 M. Furthermore, MXene can inhibit the oxidation of Ag nanoparticles (NPs) and efficiently localize the molecules to be tested within the hot spots. In particular, the flexibility of the substrate enables the detection of trace amounts of thiabendazole (TBZ) by collecting samples directly from uneven surfaces such as fruits and vegetables. The substrate is also capable of detecting a mixture of TBZ and 4MBA simultaneously. Using intrinsic Raman peak of PDMS as the internal standard can eliminate the influence of environmental factors on the detection results, which makes the detection results more quantitative. The resultant noble metal-semiconductor substrates show great potential applications in food safety and environmental monitoring fields.
研究领域:
材料科学
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分析化学
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环境科学
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食品安全
✓ 已验证
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2017
·Vol. 19
·期 33
·22302-22308
·
IF 4.123
Libin Yang,Di Yin,Yu Shen,Ming Yang,Xiuling Li,Xiaoxia Han,Xin Jiang,Bing Zhao
In this study, highly-dispersed TiO2 nanoparticles (NPs) with abundant active sites were synthesized by a simple sol-hydrothermal method with the assistance of surfactant polyethylene glycol (PEG) which served as an effective SERS-active substrate for the first time. The observed considerable SERS enhancement of 4-mercaptobenzoic acid (4-MBA) probe molecules on TiO2 NPs is attributed to the contribution of the charge transfer mechanism from the substrate to the probe molecule. It is suggested that PEG can act as a protective agent in the reductive calcination of the surfactant-coated nanocrystallite and consequently brings about abundant surface oxygen vacancies for TiO2 NPs, which provide more effective sites for the adsorption of probe molecules and promote the charge transfer effect and its consequent SERS enhancement. Moreover, the prepared TiO2 NPs can serve as an effective substrate for highly sensitive detection of p-aminobenzoic acid (PABA). The detection limit of PABA is as low as 1 × 10−8 M, which is the highest sensitivity among the reported determination methods. And, it proves that the prepared TiO2 substrate with abundant active sites is characterized by high stability, which offers a unique long service lifetime for SERS detection without losing its activity.
研究领域:
材料科学
·
光谱学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Wei Li,Shijie Dai,Xiang Li,Qianjin Li,Jianlin Li
The stability, reproducibility and engineering of SERS substrate faces a great challenge in melamine SERS assay. In this work, a simple, highly sensitive, stable and cost-efficient SERS detection platform for melamine was established based on its Raman fingerprints spectrum. The Ag@ porous silicon photonic crystal (Ag@PPC) was prepared as the 3D SERS substrate by electrochemical etching and magnetron sputter technology. The main influence factors for the preparation of SERS substrate were investigated in detail. The analytical enhancement factor of the 3D SERS substrate can reach to 2.6 × 10 8 . The 3D SERS detection platform showed a wide linear detection range of 10 −4 ∼10 mg L −1 and a low limit of detection of 0.1 μg L −1 for melamine. Moreover, such detection platform showed good stability, high reproducibility and high recovery rates for melamine. The 3D Ag@PPC SERS substrate can be easily prepared and engineered, displaying a great potential application in food safety field.
研究领域:
分析化学
·
材料科学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yi He,Xiaoyu Yang,Shunbi Xie,Runzi Zhang,Yao Liu,Mengjun Wang
Roxithromycin (ROX) is an effective antibiotic, but its prolonged administration may lead to hepatotoxicity and other side effects. To address this concern, the present study introduced a novel strategy that integrated a CHA-mediated dual-end DNA walker with hydrogen-bonded organic frameworks (HOFs) combined with Au nanoparticles (NPs) as efficient SERS substrates, enabling highly sensitive detection of ROX in food. Notably, HOF possessed a large specific surface area and strong adsorption properties that making it excellent platforms for the in-situ synthesis of abundant Au NPs and contributed to robust and uniform SERS signals. When ROX was present, it can trigger the activation of CHA and resulting the formation of a dual-end DNAzyme structure. Meanwhile, under the catalytic action of Mg 2+ , DNAzyme initiated the DNA walker mechanism and generated a substantial amount of Output DNA. Moreover, the Au@4-NTP@Ag core-shell structure generated numerous SERS “hot spots” and combined with the signal-amplifying capability of HOF@Au, leading to a remarkable improvement in SERS sensitivity. Based on this mechanism, the developed sensor employs a “signal-on” strategy for ultra-sensitive detection of ROX, achieving a detection range from 1.0 × 10 −6 to 1.0 × 10 −13 mol/L with a detection limit of 3.72 × 10 −14 mol/L. Furthermore, the method had been successfully applied to the detection of ROX in real food samples, including milk and honey, offering a promising and innovative framework for the development of next-generation SERS biosensors. This approach demonstrated significant potential for highly selective and sensitive antibiotic monitoring in food safety applications.
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
食品安全
·
抗生素检测
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Yansheng Liu,Zhenle Qin,Xiaobo Jia,Jin Zhou,Hongli Li,Xiaohong Wang,Guofu Wang
Plastics as very important materials have been extensively utilized, and they make people’s lives comparative and economic. However, recent studies find that the micro/nano-plastic particles degenerating from plastic materials especially for food containers may lead to some unknown diseases when they enter into the human lung or stomach. The methods of detecting micro/nano-plastic particles are urgently required, and conventional methods necessitate intricate pre-processing steps and specialized equipment. Hence, this paper introduces a highly sensitive and direct detection method based on Surface-Enhanced Raman Spectroscopy (SERS) in quantitatively and qualitatively analyzing polystyrene (PS) nanoplastics that are drop cast on substrate. The mechanism of SERS performance of the proposed Ag core embedded Au film (Ag@AuFilm) SERS substrate is studied by using the finite-different time-domain (FDTD) method. By optimizing the gap distance between the Ag core and the Au film, PS nanoplastics with three diameters were used to validate the effectiveness of the SERS substrate. The limits of detection (LOD) for PS nanoparticles with diameters of 50 nm, 70 nm, and 310 nm in DI water and real-river water were the same and the corresponding LODs were 50, 50, and 25 μg/mL, respectively. Thus, this study proposes an easily fabricated SERS substrate and provides a rapid, quantitative, and qualitative method for detecting PS nanoplastics. This new way of addressing the pervasive issue of nanoplastics pollution provided an accurate, efficient, and rapid detection of the nanoplastics.
研究领域:
环境科学
·
分析化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）