MATERIALS & DESIGN
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2025
·
IF 7.9
Yu Ma,Bin Zhao,Guozhen Yan,Ting Zhou,Zhihua Xu,Zhihan Niu,Zhenghong Xu,Tongtong Zhang,Feng Shi
Nucleic acid dyes play important roles in the quantification and detection of nucleic acids by binding to nucleic acids. However, traditional nucleic acid dyes pose great environmental and economic challenges due to their high price, high toxicity, long dyeing time, low sensitivity and insufficient stability. To overcome these problems, we developed a new nucleic acid dye based on carbon dots, which were generated through hydrothermal synthesis with liquorice components as precursors and a system containing ethylenediamine. This new type of carbon dot can effectively replace traditional dyes and can be used to efficiently visualize DNA, RNA and plasmids via agarose gel electrophoresis. Then, we studied the interaction mechanism between carbon dots and nucleic acids by UV–visible spectroscopy, Fourier transform infrared spectroscopy and circular dichroism spectroscopy. The interaction between the carbon dots and nucleic acids mainly occurred through groove binding and was accompanied by a slight electrostatic interaction. Carbon dots-based nucleic acid dyes, with their low cost, simple synthesis process and high stability, have opened a new path for the field of nucleic acid detection. Its research and development not only promote the frontier progress of biological science and medicine but also introduces innovative strategies and tools for scientific research and clinical practice.
研究领域:
生物化学
·
分子生物学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 21
·46312
·
IF 1.901
Yangyang Zhao,Fuwei Nian,Hao Pang,Jianheng Huang,Hongwei Zhao,Kun Wang,Bing Liao
Star-shaped superplasticizers, which incorporated polyol ester with unsaturated bond at their cores and bore comb-type structures as their arms were synthesized via esterification-copolymerization in aqueous phase from pentaerythritol, acrylic acid (AA), and isopentenyl oxy poly(ethylene glycol ether) (TPEG). The monomer ratios of AA and TPEG were varied and comonomer sodium methallyl sulfonate (SMAS) bearing short side chains was added to regulate the arm structure of star-shaped polycarboxylate superplasticizers (SPCEs). The effects of the SPCEs on cement paste were investigated and the cement dispersion as well as early hydration mechanism were explored. As a main result, SPCEs with SMAS and certain molar ratios for anchoring groups and PEO side-chains in their arm structure exhibited good paste dispersion and fluidity retention, which also delayed the early hydration process and prolonged both the initial and the final setting time. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46312.
研究领域:
材料科学
·
土木工程
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 9
·1095-1108
·
IF 4.927
Xiaoqi Zhao,Wentao Wu,Jian Zhang,Wenxue Dai,Youliang Zhao
Multicomponent miktoarm stars with multifunctional Y junctions may provide us with new insights into their physicochemical properties and prospective applications. Considering the unique role of a gas stimulus in smart materials and the promising gradient-type properties induced by combined stimuli, this study aims at the synthesis, thermoresponsive and self-assembly behaviors of an O2-, redox-, thermo-, and pH-responsive 3-miktoarm star quarterpolymer. A robust method involving controlled polymerization, amine–thiol–ene conjugation and hydrolysis was developed to achieve a poly(N-isopropylacrylamide-co-4-(2-(2,2,2-trifluoroethylcarbamoyl)ethylthio)-2-(acrylamido)-N-(2-hydroxyethyl)butanamide)-arm-poly(ε-caprolactone)-arm-poly(acrylic acid) star. Owing to the changes in amphiphilicity, chemical composition and mutual interactions, a single stimulus or various stimuli combinations could lead to switchable LCSTs and morphological transformations. Upon increasing pH, O2 treatment and oxidation, the copolymer solution was liable to exhibit enhanced LCST due to the improved hydrophilicity. The star quarterpolymer could self-assemble into multicompartment vesicles (pH 3.0), vesicles (pH 5.9) and small micelle/vesicle mixtures (pH 10) at ambient temperature. Upon thermo, redox and O2 stimuli, the assemblies formed at different pHs could be further converted into some other morphologies such as compound micelles and nanocapsules with hollow caves. Our research affords a general route to synthesize MMSs with tailored Y junctions, and the combination of the O2 stimulus with other stimuli may potentially expand the scope of multi-triggered properties and applications of star copolymers.
研究领域:
高分子化学
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材料科学
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 10
·1321-1330
·
IF 1.906
Chen Jun,Ding Amin,Zhou Yifeng,Chen Pengpeng,Xu Ying,Nie Wangyan
Star-shaped copolymers based on star-shaped poly (L-lactide) (s-PLLA) and tocopheryl polyethylene glycol 1000 succinate (TPGS) (s-PLLA-TPGS) were synthesized with structural variation on arm numbers in order to investigate the relationship between the arm numbers of s-PLLA-TPGS copolymers and their micelle properties. The structure and M w of s-PLLA-TPGS were characterized with 1 H NMR, GPC, DSC, and XRD. The indometacin(IMC)-loaded s-PLLA-TPGS micelles were obtained by dialysis method. The effects of arm numbers of s-PLLA-TPGS copolymers on surface morphology, particle size, zeta potential, drug loading content (LC), drug encapsulation efficiency (EE), and in vitro drug release behavior of prepared micelles were studied. The results indicated that the average diameters, LC, and EE of IMC-loaded s-PLLA-TPGS micelles gradually increased in the order of 4-arm, 5-arm, and 6-arm s-PLLA-TPGS copolymers. The in vitro release studies showed that the IMC accumulative release can be decreased by increasing the arm numbers of the s-PLLA-TPGS copolymers, and the release profiles of IMC from the s-PLLA-TPGS copolymers followed the Baker-Lonsdale model equation. The results suggest that the arm number regulation of s-PLLA-TPGS copolymers can provide a new strategy for designing drug carriers of high efficiency.
Graphical abstract
研究领域:
药剂学
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
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2018
·
IF 6.945
Suli Chen,Fan Feng,Yimei Yin,Haiying Che,Xiao-Zhen Liao,Zi-Feng Ma
A star-like hyperbranched β-cyclodextrin is designed and synthesized for the solid polymer electrolyte of all-solid-state sodium batteries by grafting β-cyclodextrin with multiple oligo(methyl methacrylate)- block -oligo(ethylene glycol) methyl ether methacrylate short chains. Complexing this star-like hyperbranched β-cyclodextrin with sodium trifluomethanesulfonate salt leads to a self-standing, transparent, and flexible solid polymer electrolyte film. It is found that this solid polymer electrolyte exhibits superior thermal stability, excellent mechanical properties at the even elevated temperature and good interfacial stability against Na metal electrode. Especially, ascribing to the unique three-dimensional structure of the star-like hyperbranched β-cyclodextrin, a solid polymer electrolyte formed with the optimized star-like hyperbranched β-cyclodextrin containing 69.3 wt.% oligo(ethylene glycol) methyl ether methacrylate shows an ionic conductivity of 1.3 × 10 −4 S cm -1 at 60 °C and a wide electrochemical window of 5.2 V vs. Na + /Na, which are superior to those of the previously reported solid polymer electrolytes. The all-solid-state Na/NaNi 1/3 Fe 1/3 Mn 1/3 O 2 cell shows high first discharge capacity (102.4 mAh g −1 at 0.1C), good reversibility and excellent cycling performance (with 87.8% capacity retention after 80 cycles at 0.1C) at 60 °C. All the results indicate that the star-like hyperbranched β-cyclodextrin is a promising polymer for the solid polymer electrolyte of all-solid-state sodium batteries.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
Oncotarget
·
2016
·
IF 5.008
Tao Liu,Xidong Wu,Yigang Wang,Tao Zhang,Ting Wu,Fang Liu,Wansong Wang,Gang Jiang,Minqiang Xie
The co-delivery of drug and gene has become the primary strategy in cancer therapy. Based on our previous work, to co-deliver docetaxel (DOC) and MMP-9 siRNA more efficiently for HNE-1 nasopharyngeal carcinoma therapy, a folate-modified star-shaped copolymer (FA-CD-PLLD) consisting of β-cyclodextrin (CD) and poly(L-lysine) dendron (PLLD) was synthesized, and then used for DOC and MMP-9 co-delivery. Different from commonly used amphiphilic copolymers micelles, the obtained CD derivative could be used directly for the combinatorial delivery of nucleic acid and hydrophobic DOC without a complicated micellization process. In vitro and in vivo assays are carried out to confirm the effectiveness of the target strategy and combined treatment. It was found that the conjugation of CD-PLLD with FA could enhance the DOC/MMP-9 delivery effect obviously, inducing a more significant apoptosis and decreasing invasive capacity of HEN-1 cells. In vivo assays showed that FA-CD-PLLD/DOC/MMP-9 could inhibit HNE-1 tumor growth and decrease PCNA expression effectively, indicating a promising strategy for nasopharyngeal carcinoma therapy. Moreover, the in vivo distribution of DOC and MMP-9, blood compatibility and toxicity are also explored.
研究领域:
药剂学
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肿瘤学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Ailian Wang,Hao Xu,Qian Zhou,Xu Liu,Zhengyao Li,Rui Gao,Na Wu,Yuguo Guo,Huayi Li,Liaoyun Zhang
A new hyperbranched multi-arm star polymer with hyperbranched polystyrene (HBPS) as core and polymethyl methacrylate-block-poly(ethylene glycol) methyl ether methacrylate(PMMA- b -PPEGMA) as arms was firstly synthesized by atom transfer radical polymerization. The obtained hyperbranched multi-arm star polymer (HBPS-(PMMA- b -PPEGMA) x ) exhibited good thermal stability with a thermal decomposition temperature of 372 °C. The transparent, free-standing, flexible polymer electrolyte film of the blending of HBPS-(PMMA- b -PPEGMA) x and lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) was successfully fabricated by a solution casting method. The ionic conductivity of the hyperbranched star polymer electrolyte with a molar ratio of [EO]/[Li] of 30 could reach 8.3 × 10 −5 S cm −1 at 30 °C (with the content of PPEGMA of 83.7%), and 2.0 × 10 −4 S cm −1 at 80 °C (with the content of PPEGMA of 51.6%). The effect of the concentration of lithium salts on ionic conductivity was also investigated. The obtained all-solid-state polymer electrolyte possessed a wide electrochemical stability window of 4.7 V ( vs. Li + /Li), and a lithium-ion transference number ( t Li + ) up to 0.31. The interfacial impedance of the fabricated Li│polymer electrolyte│Li symmetric cell based on hyperbranched star multi-arm polymer electrolyte exhibited good interfacial compatibility between all-solid-state polymer electrolyte and electrodes. The excellent properties of the hyperbranched star polymer electrolyte made it attractive as solid-state polymer electrolyte for lithium-ion batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Zhiqiang Guo,Hongli Wang,Liang Wang,Bin Zhao,Yiran Qian,Hongwei Zhang
Pharmaceuticals and personal care products (PPCPs) are universally detected in natural waters, posing potential risks to drinking water safety. Nanofiltration (NF) is an advanced technology for water purification; however, its removals of PPCPs are unsatisfying, especially for hydrophobic species. In this study, the 3D architecture of nanomaterials were used to manipulate the performance the polyamide (PA) thin-film nanocomposite (TFN) membrane. In-situ addition of polyethyleneimine (PEI) successfully induced the assembly of ZIF-8 nanocrystals into star-shaped clusters (ZIF-8-PEI) due to the coordination between PEI and Zn 2+ . Together with the improved hydrophilicity, these ZIF-8-PEI clusters became excellent scaffolds for water drop retention after discretely loading onto the porous substrate. The conical protrusions of the ZIF-8-PEI clusters supported the defect-free PA film produced by the interfacial polymerization (IP), leaving big interfacial cavities underneath. These cavities worked as gutters for water transport, and the water permeance of the optimal TFN was 79% higher than that of the pristine thin-film composite (TFC) membrane. Moreover, the water impregnated cavities markedly alleviated the hydrophobic interaction between the PA film and hydrophobic PPCPs, impeding the transport of PPCPs across the membrane. Our results demonstrated the importance of the 3D architecture of nanofillers for the improving membrane performance.
研究领域:
水处理
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膜科学
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环境工程
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材料科学
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产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2017
·Vol. 19
·期 34
·23024-23033
·
IF 4.123
Yuxiu Xing,Jun Peng,Kai Xu,Shuxi Gao,Xuefeng Gui,Shengyuan Liang,Longfeng Sun,Mingcai Chen
A well-defined pH-responsive star-shaped polymer containing poly(N,N-dimethylaminoethyl methacrylate) (PDMA) arms and a cage-like methacryloxypropyl silsesquioxane (CMSQ-T10) core was used as an interfacial stabilizer for emulsions consisting of m-xylene and water. We explored the properties of the CMSQ/PDMA star-shaped polymer using the characteristic results of nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC), dynamic light scattering (DLS), and zeta potential and conductivity measurements. The interfacial tension results showed that the CMSQ/PDMA star-shaped polymer reduced the interfacial tension between water and oil in a pH-dependent manner. Gelled high internal phase emulsions (HIPEs) including o/w and w/o types were formed in the pH ranges of 1.2–5.8 and 9.1–12.3 with the CMSQ/PDMA star-shaped polymer as a stabilizer, when the oil fractions were 80–90 vol% and 10–20 vol%, respectively. The soluble star-shaped polymer aggregated spontaneously to form a microgel that adsorbed to the two immiscible phases. Images of the fluorescently labeled polymers demonstrated that there was a star-shaped polymer in the continuous phase, and the non-Pickering stabilization based on the percolating network of the star-shaped polymer also contributed to the stabilization of the HIPE. This pH-dependent HIPE was prepared with a novel stabilization mechanism consisting of microgel adsorption and non-Pickering stabilization. Moreover, the preparation of HIPEs provided the possibility of their application in porous materials and responsive materials.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 12
·2252-2261
·
IF 5.342
Li Zhang,Dongjian Shi,Yunyun Gao,Tianyang Zhou,Mingqing Chen
To overcome the thermodynamic instability of polymeric micelles in an extremely high dilution bio-environment, unimolecular micelles with covalently-bound molecular architectures have been widely studied for drug delivery. In this work, an amphiphilic multi-arm star random copolymer, polyamidoamine-poly(butenyl phospholane-co-methoxy phospholane) with phenylboronic acid end groups (abbreviated as PAMAM-P(BEP-co-MP)-PBA), was synthesized by a simple one-pot ring-opening polymerization with the fourth-generation PAMAM dendrimer as a macro-initiator. Then, unimolecular micelles (UMs) were formed by the obtained copolymers in a dilute aqueous solution. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) results showed that the UMs possess uniform spherical structures and stable hydrodynamic sizes (ca. 20 nm). Besides, further information on polymer repeat unit numbers could be theoretically calculated by comparison of hydrodynamic sizes and contour lengths. Doxorubicin (DOX) could be encapsulated into the inner hydrophobic regions of the UMs. The obtained DOX-loaded UMs exhibited a slow and sustainable release behavior in an intracellular simulated environment. Furthermore, in vitro cytotoxicity and cellular uptake studies demonstrated that the DOX-loaded UMs could specifically recognize and accumulate in HepG2 cells, and then inhibit tumor cell growth effectively. Therefore, this PBA-functionalized unimolecular micelle could be a promising candidate for targeted drug delivery.
研究领域:
聚合物化学
·
药学
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纳米技术
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Jiahao Dong,Jiexiang Tong,Jing Luo,Xiaoya Liu
In this work, a novel kind of temperature-responsive core cross-linked star (CCS) polymer, composing of poly(methoxypolyethylene glycol-co-di(ethylene glycol) ethyl ether acrylate) (P(PEGA-DEGA)) as thermo-responsive arm and poly(2-(dimethylamino)ethyl methacrylate) as functional core, was developed as nanoreactor for immobilizing gold nanoparticles for smart catalyst with facile recovery. The protonated imino groups in CCS polymer core could capture AuCl 4 - and simultaneously reduce it to Au NPs in aqueous solution, leading to the formation of P(PEGA-DEGA) CCS@Au composite. The whole procedure was carried out in aqueous media without using any toxic reducing agent, which is facile, efficient and green. The as-prepared CCS@Au composite exhibit a superior high catalytic activity for the reduction of 4-nitrophenol (4-NP), owing to that the soluble polymeric arms of the CCS polymers provides a homogeneous reaction system with fast mass transfer and thus facilitates interactions between Au NPs in the core and 4-NP. In addition, temperature-responsive catalyzing behavior was observed for the CCS@Au composite: the reaction rate enhanced with the elevation of the reaction temperature at first, but decreased when the temperature increased close to the LCSTs of the CCS@Au catalysts.
研究领域:
材料科学
·
纳米技术
·
催化
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 11
·1-18
·
IF 2.8
Li Xin,Zhan Shiping
Poly (L-lactic acid) (PLLA) is a bio-based biodegradable polymer with minimal immunogenicity, non-toxicity and excellent mechanical properties and has widely used in medical, pharmaceutical, food packaging and other fields. However, linear PLLA has the characteristics of high melting point, strong crystallinity, weak flowability and poor thermal stability, which cannot meet the requirements of various industrial processes and novel pharmaceutical formulations. With its low viscosity, controlled degradation cycle, and excellent melt flowability, star-shaped PLLA can be used in the fields of biocomposites, biomedical devices, drug delivery, and intelligent packaging. Presently, metal catalysts and organic solvents are frequently used in PLLA synthesis industries, and both residues continue to pose a safety risks. In existing studies, the performance of bioenzymes as optimal green catalysts in organic solvents is not satisfactory, and they are predominantly used to synthesise oligomers with low yields and lengthy reaction times. In this study, a four-armed star-shaped poly (L-lactic acid) (4s-PLLA) with a porous structure favourable for drug loading was synthesised using supercritical carbon dioxide (Sc-CO 2 ) as a solvent, lipase as a catalyst, and erythritol as a nucleus. Using Sc-CO 2 as a solvent the reaction activity and stability of the enzyme were increased so that the reaction yield could reach 83% and the reaction time was only 24 h, which provided a possibility for the practical application of the enzymes catalyze green process. Both the random copolymerization product four-armed star-shaped poly(L-lactic-glycolic acid) (4s-PLGA) and the block copolymerization product four-armed star-shaped poly (L-lactic-glycolic acid) (4s-PLLA-PGA) were subsequently synthesized by copolymerization modification, and their porous structures retained and hydrophilicity were enhanced. The response surface analyses were performed about the reaction time, reaction temperature and yield of synthetic reactions by using Design-Expert 12 software and the prediction equations were generated.
研究领域:
生物材料学
·
绿色化学
·
医药工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）