NEW JOURNAL OF CHEMISTRY
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2025
·
IF 2.5
Qiuyao Jiao,Yan Liu,Ran Yu,Lei Li
For supported heterogeneous catalyst, metal-support interaction (MSI) is very important factors for catalytic performance. Commercial γ-alumina was reduced with hydrogen in advance, providing strong anchoring sites for metal (metal oxide) species. This research demonstrates the use of pre-reduced alumina as catalyst carrier to anchor metal Co species in FTS compared with unreduced one. The defective alumina supported catalyst displayed a supeior performance. The Co/RAl2O3-550 catalyst showed surprisingly high CO conversion of 56.0%, C5+ hydrocarbons selectivity of 93.2%, and a low methane selectivity of 2.7% at a remarkable high activity (CTY = 1.1 × 10-5 molCO gCo-1 s−1). It revealed the strong reduction of alumina generated more defective sites, which was strongly anchored with metal cobalt species under MSI. Besides, the reduction of alumina also boosted the number of surface L-acidity, promoting the CO absorption rate through CO dissociation. These results reveal the unique property of defective Al2O3 supported cobalt catalysts, and provide a practical strategy to explore stable and efficient FTS catalysts.
研究领域:
催化化学
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材料科学
·
化学工程
·
表面化学
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2026
·
IF 10.5
Han Pan,Murilege Chao,Miao He,Jinhua Chen,Feifan Yin,Yongliang Cai,Wenting Cheng,Zhongyun Wang,Yang Xiang
A single-base mutation in the CHCHD10 gene can impair thermogenic responses, and inhibit the efficient conversion of white adipose tissue to beige adipose tissue. However, achieving high-fidelity detection of such low-abundance single nucleotide polymorphisms (SNPs) within complex biological matrices remains a critical technological challenge. This study developed a novel method for detecting a single-base mutation in CHCHD1 0 by integrating the specific recognition of flap endonuclease 1 (FEN1) with the cascade amplification of an entropy-driven circuit reaction (EDCR), supplemented with magnetic separation to suppress background interference. In this process, the mutant target (MT) hybridizes with the upstream probe (UP) and a hairpin downstream probe (DP) to form a specific three-base overlapping structure. FEN1 recognizes and cleaves this structure, releasing a cleavage sequence (CS). Following magnetic purification, the CS activates the EDCR, enabling dual-signal amplification. The hairpin DP design effectively conceals the CS, significantly reducing background noise. The method achieves a detection limit of 0.23 pM, discriminates mutation abundances as low as 0.01% in mixed DNA samples, and demonstrates robust performance in complex matrices such as human serum and high-background genomic DNA. This work provides an innovative and reliable methodological tool for the detection of low-abundance point mutations in complex samples.
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PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2017
·Vol. 43
·期 15
·13020-13024
·
IF 2.986
Yanfei Wang,Huan Yang,Rongjun Liu,Yingbin Cao,Siqing Wang
The poor fracture toughness of La 2 Zr 2 O 7 hinders its practical application as a thermal barrier coating topcoat material. To toughen La 2 Zr 2 O 7 , metastable tetragonal 8 wt% yttria-stabilized zirconia ( t ’-8YSZ), has been introduced into the La 2 Zr 2 O 7 matrix by plasma spray quenching of 8YSZ powders and spark plasma sintering . An evident fracture toughness improvement has been achieved due to ferroelastic domains switching. The resulting toughness increase has a quadratic relationship with t ’ phase volume fraction below a critical value (30 vol%), beyond which it is far smaller to what expected owing to the residual stress being smaller than the ferroelastic coercive stress.
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高影响因子
SOLID STATE SCIENCES
·
2020
·
IF 2.434
Muyan Zhou,Yong Wu,Lingyi Shi,Shiyu Hu,Huanhuan Li,Yinyan Gong,Lengyuan Niu,Xinjuan Liu,Can Li
The large work function difference between two semiconductors will effectively adjust the interfacial electronic distribution and catalytic performances of heterojunction . In this work, a novel t -ZrO 2 /g-C 3 N 4 composite photocatalyst was prepared by integrating t -ZrO 2 nanoparticle with graphitic carbon nitride (g-C 3 N 4 ) film considering the large work function of tetragonal ZrO 2 ( t -ZrO 2 ). With the aid of experimental measurements and density functional theory calculations, the electronic distributions of g-C 3 N 4 film were explicitly adjusted by the supporting t -ZrO 2 nanoparticle on account of the large interfacial internal electric field , which leaded to the improvement of photogenerated carriers mobility and lifetime, the enhancement of reduction ability and the increase of oxidation active sites. Results showed that the photocatalytic activity of the composite sample was increased by 9.4 and 2.9 times compared with g-C 3 N 4 sample for Rhodamine B and tetracycline hydrochloride degradation under visible-light. This modification strategy shall be applied to devise other high-efficient catalysts by selecting semiconductor with suitable work function.
研究领域:
材料科学
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光催化
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环境化学
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计算材料科学
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纳米技术
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高影响因子
ENERGY
·
2023
·
IF 9
Yang Xiao,Yanqiong Bao,Linfeng Yu,Xiong Zheng,Guangzhao Qin,Meijie Chen,Maogang He
Nanofluids have potential application as spectral beam splitters (SBSs) in photovoltaic/thermal (PV/T) systems due to their tunable spectral absorption properties, while current nanofluid SBSs have some disadvantages, which limit their large-scale application in practice. In this work, carbon quantum dot (CQD) nanofluids have been proven to be excellent SBSs in PV/T systems. CQD-nanofluid filters can be synthesized by a simple microwave heating method and show ultra-stability for a long period. Meanwhile, the optical property of CQD nanofluids was fine-tuned by changing the heating time and PEG concentration. The absorption of nanofluids can be enhanced in the whole spectrum by increasing heating time, and the absorption of nanofluids to specific wavelengths can be regulated by adjusting the PEG concentration. The nanofluid filter with 50% PEG concentration and 20 min heating time shows the best performance with a merit function (MF) value of 1.904 when the worth factor ( w ) is 3, which outperforms the reported nanofluid filters in the literature. This work paves the way for the application of ultra-stable CQD nanofluids as SBSs for large-scale utilization in solar energy power generation stations.
研究领域:
纳米材料
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可再生能源
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光伏/热系统
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光学工程
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太阳能转换
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高影响因子
JOURNAL OF FLUORESCENCE
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2026
·
IF 3.4
Hu Xuan,Zhang Jingyi,Shen Fei,Yang Qian,Xing Changrui,Yuan Jian,Li Guanglei
Endotoxin (lipopolysaccharide, LPS), a major toxic component of Gram-negative bacteria. It shows high stability and resistance to conventional sterilization. Therefore, rapid and effective detection of LPS is crucial to mitigate its threats to human health. This study developed a sensitive, simple, and rapid LPS detection method. It uses a label-free fluorescent aptamer sensor based on an LPS-specific aptamer and the commercial fluorescent probe Thioflavin T (ThT). A novel LPS-detecting aptamer (G4-LA47) was synthesized by attaching guanine-rich DNA sequences to both ends of the LPS-specific aptamer LA27. The G4-LA47 aptamer retained high affinity for LPS, while its terminal guanine-rich sequences formed a G-quadruplex structure. Upon binding with ThT, the G-quadruplex/ThT complex exhibited strong fluorescence. The presence of LPS unfolds of the G-quadruplex, releases free ThT and reduces the fluorescence intensity. LPS was quantitative detected by monitoring fluorescence intensity changes. The linear range was 10–80 ng/mL. The LOD and LOQ were 3.26 ng/mL and 10.86 ng/mL, respectively. The sensor was successfully applied to juice and drinking water samples, with recoveries ranging from 93.34% to 113.29%. This label-free fluorescent aptamer sensor demonstrates high sensitivity, specificity, and simplicity, showing promising potential for practical applications.
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PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Lingzhu Zhao,Guoqing Zhao,Jiaxin Fu,Yan Liu,Jinteng Feng,Guangjian Zhang,Feng Xu,Hui Guo,Min Lin
Programmed cell death protein 1 (PD-1) is a critical immune checkpoint that suppresses T cell activation and cytotoxicity, yet its mechanistic role in regulating T cell mechanotransduction remains unclear. Here, we reveal that PD-1 engagement attenuates T cell activation by impairing cytoskeletal force generation and nuclear mechanotransduction in a mechanically defined microenvironment. Using tunable poly(ethylene glycol) (PEG)-based hydrogels that mimic the stiffness of target cells, we show that PD-1 suppresses T cell receptor (TCR)-mediated activation in a stiffness-dependent manner, requiring immobilized ligand presentation. Mechanistically, PD-1 ligation disrupts actin polymerization, reduces traction forces, and prevents nuclear deformation, thereby impairing the nuclear translocation of mechanosensitive transcription factors yes-associated protein (YAP) and nuclear factor 1 of activated T cells (NFAT1). This inhibition is mediated by the dephosphorylation of cofilin, an actin-severing protein that restricts actin assembly and downstream mechanotransduction. Consequently, PD-1 engagement diminishes the cytokine production and effector cytotoxicity of T cells. Pharmacological or genetic restoration of actin polymerization or nuclear transport rescues nuclear YAP/NFAT1 localization and partially restores T cell activation and function. Our findings suggest PD-1 as a mechanical checkpoint that suppresses T cell immunity by dampening cytoskeletal dynamics and nuclear mechanotransduction, offering insights into the biophysical regulation of immune suppression.
研究领域:
免疫学
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细胞生物学
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生物物理学
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机械生物学
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癌症免疫治疗
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PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Xiang Jin,Jie Xie,Zuojun Ding,Zhi Li,Xuerui Wang,Xuechao Gao,Xuehong Gu
N, N-dimethylacetamide (DMAc) is a typical strongly polar aprotic organic solvent, and its recovery by pervaporation (PV) dehydration is important for production sustainability. However, maintaining a stable permeation flux remains challenge because of the pronounced competitive adsorption of DMAc versus water on membrane surfaces. To address this issue, hollow fiber supported T-type zeolite membrane was modified in AgNO 3 solution to tune its intrinsic pore structure and surface properties. The optimal modification conditions were determined as 0.5 M AgNO 3 concentration with an 8 h exchange time. The PV results demonstrated that the Ag + -modulated membrane could effectively improve the stability in DMAc dehydration. Compared to a dramatic 69% flux loss observed in the original membrane at 373 K, the flux loss of the Ag + -modulated membrane was only 7% after 30 h in dehydrating a 5 wt% water/DMAc mixture. At a lower operation temperature of 353 K, the dehydration flux remained completely stable. The improvement is attributed to the weakened competitive adsorption of DMAc molecules, achieved by reducing surface polarity after Ag + modulation. In addition, the simulated results further revealed that Ag + modulation enhanced water adsorption, thereby creating a steric hindrance for DMAc molecules near the pore entrances. These results suggested that Ag + modulation effectively improves the long-term stability of T-type zeolite membrane for DMAc dehydration, and presents a promising strategy for dehydrating the similar solvents.
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Chengyi Si,Yawen Zhang,Le Li,Tian Zhang,Hongyu Liu,Ao Men,Xiaoqiang Fan,Minhao Zhu
Despite methylphenylsiloxane (MPS) possesses heat-resistance and corrosion resistance , the brittleness hinders its widespread application. Herein, the polyimide (PI) and Ti 3 AlC 2 were introduced for modifying MPS, thereby preparing the T-PI-MPS coating. The bilayer structure of surface-enriched MPS and internal-enriched PI was achieved by controlling the addition amount along with the density difference. The results indicate that the T-PI-MPS coating achieved a contact angle of 95.1° and exhibited corrosion resistance to salt spray for 28 days. Compared to PI-MPS, the wear rate of T-PI-MPS was reduced by 85 % and the friction coefficient declined from 0.75 to 0.58. As expected, T-PI-MPS exhibited exceptional excellent heat-resistance. The exceptional performance is attributed to the following three factors: I. the MPS-enriched layer is characterized by a stable Si O chain organization. This structure gives the corrosion resistance and water resistance, and prevents the hydrolytic swelling of PI. II. the PI-enriched layer is constructed from imide bonds, which give the coating superior friction performance due to its high load-bearing capacity. III. the incorporation of Ti 3 AlC 2 plays a role in mitigating internal defects, prolonging the corrosion path, and inhibiting cracks due to its unique nanolayered structure, high temperature resistance, and hardness.
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高影响因子
Applied Materials Today
·
2023
·
IF 8.3
Weimin Yin,Jiao Chang,Jiuyuan Sun,Yuge Zhao,Shiyu Chen,Hui Zhi,Jie Zang,Tingting Zhang,Yongyong Li,Haiqing Dong
Poor efficacy in solid tumor immunotherapy mainly ascribed to few CD8 + T cells infiltration with low activity in tumor immunosuppressive microenvironment (TIME). Ferroptosis can be harnessed for activating system immune response for more CD8 + T cells infiltration. However, the activity of infiltrated CD8 + T cells will be heavily weakened by the nutrient barrenness and immunosuppressive microenvironment, which formidably impaired the biologically closed-loop reciprocal process between active CD8 + T cells and cellular ferroptosis. Considering the above two key influence factors, we herein elaborately labeled l -Arginine (Arg) with 3,4-dihydroxybenzaldehyde (PA) via reversible Schiff-base bond, and then drive nanoassembly of PA-Argby iron ions mediation (Fe@PA-Arg NPs). Iron released from Fe@PA-Arg NPs in acidic tumor environment could produce reactive oxygen species (ROS) and thus successfully induce immunogenic ferroptosis of cancer cells. Subsequently, promoting the dendritic cells maturation and CD8 + T cells infiltration. Meanwhile, ROS could also induce the lipid peroxidation of tumor associated macrophages that contributed to mitochondrial dysfunction, thereby repolarized M2 to M1 phenotype to relieve the immunosuppression. Arg released from Fe@PA-Arg NPs as nutrient supply to restore infiltrated T cells’ activity by combining Arg metabolic adaption with immunosuppressive mitigation. Reciprocally, restored activated CD8 + T cells could secrete high levels of Interferon-γ, which in turn enhances ferroptosis, thereby successfully initiating and forming a closed-loop, and the tumor inhibition rate of 63.5% was achieved. This study highlights a novel and facile strategy to improve the immunotherapeutic efficiency of murine 4T1 solid tumors.
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高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 41
·14532-14536
·
IF 4.39
Yang Zhang,Yakun Tang,Lang Liu,Yue Zhang,Zhiguo Li
A T-Nb2O5/CNT nanohybrid with short transmission paths, many active sites, and favorable mechanical flexibility can achieve the fast transportation of ions/electrons. The obtained nanohybrid with continuous conductive networks exhibited better lithium storage performance than sodium storage performance, due to lower resistance to the diffusion of Li+ ions crossing the carbon matrix.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Long Wang,Huali Jin,Min Wei,Wenjie Ren,Yurong Zhang,Liying Jiang,Tao Wei,Baoshan He
Herein, an electrochemical aptasensor was constructed for ultra-sensitive determination of T-2 toxin based on Silver ion (Ag + ) -dependent DNAzyme-assisted signal amplification and Gold nanoparticles/Graphene oxide @ manganese dioxide (AuNPs/MnO 2 @GO) nanocomposites. In the presence of Ag + , the secondary structure of the T-2 aptamer is altered via the Ag + mediated coordination of C–Ag + –C base pairs. When T-2 toxin is added, the secondary structure of DNA is changed again, and the trapped Ag + are released. Then, the DNAzyme could repeatedly bind and cleave methylene blue (MB)-modified substrate DNA (S-DNA) in the assistance of Ag + , which leads to a decrease in the electrochemical signal. With the optimal conditions, there is a good linear relationship between the current value and the logarithm of T-2 toxin concentration in the range from 2 fg mL −1 to 20 ng mL −1 , and a detection limit of 0.107 fg mL −1 is obtained. Moreover, the proposed method was successfully applied to measure T-2 toxin in beer, thus showing great potential of this system for food safety and quality control.
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