JOURNAL OF APPLIED POLYMER SCIENCE
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2017
·Vol. 134
·期 14
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IF 1.86
Hongjiao Wang,Shunli Liu,Aokai Zhang,Kewen Li,Olayinka Oderinde,Fang Yao,Guodong Fu
A series of N-succinyl Chitosan (NSCS) hydrogel derived from different substitution degree of NSCS were fabricated through the zinc ions crosslinking. Subsequently, a light-weight, transparent, and hierarchical NSCS-Zn(II) film was obtained by drying the hydrogel. The hierarchical structure of NSCS-Zn(II) film was confirmed by scanning electron microscopy. The NSCS-Zn(II) film exhibited excellent mechanical strength because of the preferential formation of the alignment structure. The tensile strength and Young's modulus reaches 119.3 MPa and 2.67 GPa when the NSCS substitution degree was 91.95%. Furthermore, a remarkable and enhanced broad-spectrum bactericidal properties of the NSCS-Zn(II) film was revealed through E. coli and S. aureus exposure, respectively. These features indicated that NSCS-Zn(II) film is a promising material that can be used in biomedical engineering. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44664.
研究领域:
材料科学
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生物医学工程
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ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
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2018
·Vol. 99
·期 2
·e21499
·
IF 1.316
Lin Zhu,De-Qing Zou,Zuo-Qing Fan,Na Wang,Ying-Ying Bo,Yu-Qing Zhang,Guang Guo
In this study, a carboxymethyl chitosan derived from silkworm pupa (SP-carboxymethyl chitosan) was prepared. The physical characteristics of the SP chitin, chitosan, and carboxymethyl chitosan were analyzed. The scanning electron microscopy results showed that the surfaces of the samples from SP were more uneven, with more surface fractures compared with those of the reference substance (RS). Thermal analysis, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis showed that the main molecular chain structures of SP samples and RSs had no substantial differences. However, the crystallinity and thermal decomposition temperature of the SP samples were lower compared with those of the RSs. All of these results provide a theoretical basis for the development of applications for the SP-carboxymethyl chitosan.
研究领域:
生物材料学
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化学工程
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CARBOHYDRATE POLYMERS
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2019
·
IF 6.044
Xu Liu,Yang Wang,Zheng Cheng,Jie Sheng,Rendang Yang
Bacterial cellulose is an attractive material due to its outstanding biocompatibility, nanometer size and high purity, but the difficulty of dispersing has restricted its wide applications. In this study, chitosan was grafted onto bacterial cellulose by Schiff base reaction, and then obtained the nano-sized fibrils by ultrasonic dispersion process. Different concentrations of NaIO 4 with various time and temperature were applied, and the maximum grafting amount of chitosan was 12.38%. The obtained products were characterized by FTIR, XRD, SEM and TEM. From the dispersibility and stability behavior research, the suspension containing chitosan was more uniform and showed better acid and temperature stability. It can also be observed in SEM and TEM images that the bacterial cellulose were dispersed into single ones and the diameter of the isolated fibril was 30–80 nm.
研究领域:
材料科学
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生物医学
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Polymer Chemistry
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2019
·Vol. 10
·期 18
·2305-2315
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IF 4.76
Xiacong Zhang,Lin Cheng,Letian Feng,Yu Peng,Zhimin Zhou,Guoyong Yin,Wen Li,Afang Zhang
Stimulus-responsive injectable hydrogels with self-healing properties are promising materials for the delivery of bioactives owing to their protection of the payloads, minimally invasive procedures and site-specific administration. In this work, we report on a type of thermoresponsive dendronized chitosan-based (G1-CS) injectable hydrogel and its potential as scaffolds for stem cell delivery. G1-CS was synthesized through dendronization of chitosan with dendritic oligoethylene glycols (OEGs) to afford characteristic thermoresponsiveness, and its further crosslinking through dynamic covalent Schiff-base chemistry generated the hydrogels. The mechanical properties of the obtained hydrogels are weak with a storage modulus around 0.2 kPa at room temperature, which can be significantly improved to about 1.4 kPa at 37 °C. This feature comes remarkably from thermally induced aggregation and a simultaneously enhanced Schiff-base reaction in an aqueous phase, resulting in promoted crosslinking of the hydrogel network and immediate gelation under physiological conditions. The Schiff-base linkage also endows the hydrogels with shear-thinning and self-healing properties, which facilitate the injection process of the hydrogels and maintenance of their stability. G1-CS hydrogels were examined to encapsulate stem cells. After long term (14 days) culture, the cells exhibited high viability and well maintained their differentiation potential. We therefore believe that hydrogels from this dendronized chitosan, featuring biocompatibility, thermoresponsiveness, self-healing ability, and enhanced mechanical properties, can serve as promising scaffolds for drug delivery and tissue engineering.
研究领域:
材料科学
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生物材料
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组织工程
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干细胞研究
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Biomaterials Advances
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2023
·
IF 0
Yue Wang,Kun Liu,Kai Huang,Wenying Wei,Ye Huang,Honglian Dai
Pathological bacterial infection poses a serious threat to public health security. The excessive use of antibiotics has resulted in a serious decline in treatment effect and bacterial resistance. For the treatment of infected wounds, we compounded dopamine-assisted exfoliated molybdenum disulfide (MoS 2 @PDA) into lipoic acid modified chitosan (LAMC) to obtain a composite hydrogel dressing (LAMC-MoS 2 @PDA). LAMC-MoS 2 @PDA hydrogels exhibited excellent photothermal conversion ability and the LAMC-MoS 2 @PDA2 group (0.3 wt%) has a photothermal conversion efficiency of 26.29 %. Meanwhile, they showed good biocompatibility and ROS scavenging activity in vitro. Photothermal therapy usually utilizes photothermal agents to convert near-infrared light into heat energy for bacterial cell membrane destruction and bacterial protein inactivation. Under the near-infrared light irradiation, the antibacterial ratio of LAMC-MoS 2 @PDA hydrogels against Staphylococcus aureus and Escherichia coli reached nearly 100 %, and the morphology of the bacteria showed obvious contraction and cleavage. The hydrogels also showed an excellent antibacterial effect and wound healing promotion in the infected wound of rats. In particular, the LAMC-MoS 2 @PDA2 (+) group (with NIR) showed almost complete wound closure after 14 days, indicating that the LAMC-MoS 2 @PDA hydrogels have great potential in clinical anti-infected treatment.
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Soft Matter
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2012
·Vol. 9
·期 6
·1835-1843
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IF 4.39
Lei Jin,Yonggang Shangguan,Tao Ye,Hu Yang,Quanfu An,Qiang Zheng
A remarkable shear induced self-thickening of chitosan-graft-polyacrylamide aqueous solution was observed. After the polyelectrolyte solution presenting shear thinning was subjected to a high-rate shear for several minutes, their viscosities recovered and then a much higher zero shear viscosity than the original one appeared. Obviously, the self-thickening differs from conventional shear thickening or viscous recovery, as reported previously. The mechanism of self-thickening was investigated by rheological methods together with TEM, 1H NMR and DLS, etc. It was found that some aggregates exist in original chitosan-graft-polyacrylamide aqueous solution and the scale of such aggregations would become larger within several minutes after a strong shear. The thickening was proven to be the result of an enhanced scale of GPAM aggregation in aqueous solution, and the mechanism of aggregation was proven to be intermolecular hydrogen bonding effects. Besides, the shear-induced self-thickening appears to be facile, maintainable and easily controllable by changing the shear conditions.
研究领域:
材料科学
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生物化学
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Materials Science & Engineering C-Materials for Biological Applications
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2013
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IF 2.404
Luzhong Zhang,Sufeng Dou,Yan Li,Ying Yuan,Yawei Ji,Yaling Wang,Yumin Yang
The films of poly(glycolic acid) grafted chitosan were prepared without using a catalyst to improve the degradable property of chitosan. The films were characterized by Fourier transform-infrared spectroscopy and X-ray photoelectron spectroscopy (XPS). The degradation of the poly(glycolic acid) grafted chitosan films were investigated in the lysozyme solution. In vitro degradation tests revealed that the degradation rate of poly(glycolic acid) grafted chitosan films increased dramatically compared with chitosan. The degradation rate of poly(glycolic acid) grafted chitosan films gradually increased with the increasing of the molar ratio of glycolic acid to chitosan. Additionally, the poly(glycolic acid) grafted chitosan films have good biocompatibility, as demonstrated by in vitro cytotoxicity of the extraction fluids. The biocompatible and biodegradable poly(glycolic acid) grafted chitosan would be an effective material with controllable degradation rate to meet the diverse needs in biomedical fields.
研究领域:
生物材料学
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医学工程
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生物医学
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2017
·
IF 1.174
Linlin Zhai,Zhishan Bai,Yong Zhu,Bingjie Wang,Wenqiang Luo
In this article, morphology, structure and size controllable chitosan microspheres with high mechanical strength were synthesized by microfluidic technology combining chemical crosslinking and used as an adsorbent for methyl orange. The synthesized adsorbents were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and an Energy Dispersive Spectrometer (EDS). The effect of pH revealed that the adsorption process depended on pH and the pH variation of methyl orange solution after adsorption indicated that adsorption capacity was affected through the associated role of chitosan nature and pH variation. Experimental results suggested that the as-prepared chitosan microspheres were controlled within a narrow size distribution (coefficients of variation is 1.81%), whose adsorption capacity reached to 207 mg·g − 1 and mechanical strength was suitable to resist forces. In addition, the adsorption isotherm was well fitted with the Langmuir model, and the adsorption kinetic was best described by the pseudo-second-order kinetic model. The high performance microfluidic-synthesized chitosan microspheres have promising potentials in the applications of removing dyes from wastewater.
研究领域:
环境科学
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材料科学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Mehdihasan I. Shekh,Jhaleh Amirian,Florian J. Stadler,Bing Du,Yanxia Zhu
Developing a novel scaffold carrier with a sustained and controllable release profile of drug is essential to promote the effective transdermal delivery for acyclovir (ACY). In this work, electrospun polyacrylonitrile nanofibers (PAN NFs) was chemically modified with oxidized chitosan (OC). The modified fibrous scaffold was further loaded with the ACY for drug released investigation. FT-IR and NMR results revealed that the conversion of the functional group for each step has successfully occurred on the surface of the fibers. Through the in-vitro drug release and kinetic study, it demonstrated that ACY could be sustainably and controlled released from the OC modified scaffold following the Korsmeyer-Peppas model with a Fickian diffusion mechanism. The human adipose-derived stem cells and the blood combability evaluation confirmed the obtained scaffold possessed excellent cell biocompatibility and hemocompatibility. It could be concluded that the resultant OC modified scaffold based on electrospun PAN NFs opened a new potential option for the topical/transdermal drug delivery of ACY.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yanfei Gao,Pingxiong Cai,Lei Zhong,Ruixian Zhang,Xueyi Hou,Xiuxiu Ren,Junzhong Wang,Xiaokun Chu,Yanyue Lu,Zeguang Zhou
Dye pollution in the aquatic environment can harm ecosystems and human health. Here, we developed a new green adsorbent by applying an improved drying process. Diatomite was embedded in a network structure formed between chitosan and polyvinyl alcohol without using any crosslinking agent to prepare chitosan-polyvinyl alcohol-diatomite hydrogel beads through alkali solidification. The beads were tested for removing a cationic dye (methylene blue (MB)) from water. The structure of the adsorbent beads was analysed using scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy. The adsorption capacity was investigated, and the results indicated excellent MB adsorption properties. The adsorbents had a rough surface and high swelling capacity of 66.9 g/g. The maximum MB adsorption capacity was 414.70 mg/g, and the adsorption followed the Freundlich isothermal and quasi-second-order kinetic models. The adsorption was an endothermic spontaneous process governed by both intra-particle and external diffusion processes. The proposed adsorption mechanisms involved hydrogen bonding and electrostatic interactions. These adsorbent beads have considerable application potentials owing to their high adsorption capacity, green composition, and non-polluting nature.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
·
IF 8.6
Xin Liu,Zhujun Zou,Dong Wang,Dongyu Du,Zhuo Li,Weiyi Li
A key to the sustainable development of membrane technology is the green fabrication of biopolymer membranes, whose filtration performance is comparable to that made from petroleum-based polymers. In this study, chitosan membranes were fabricated via wet precipitation of the alkaline dope; both the composition and temperature of the coagulation bath were regulated to optimize the filtration performance for ultrafiltration. It is revealed by comparing the morphological characterization with the filtration-performance evaluation that the use of pure ethanol as the coagulant at a subzero temperature would be in favor of the formation of a laminated substructure, which can enhance the water permeance not at the cost of decreasing the rejection of micron-sized particles and macromolecules. Optical coherence tomography (OCT) was employed to in-situ characterize the film formation in an effort to understand how the variation in coagulating conditions could change the geometrical and topological characteristics of the resulting membrane. The OCT-based characterization highlights the key role of the Liesegang phenomenon in forming the hierarchical substructures, while resolving the synergistic effects emanating from the ethanol-induced film shrinkage and the structural preservation in the subzero environment.
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Polymers
·
2023
·Vol. 15
·期 19
·4024
·
IF 5
Lixia Huang,Yifei Jiang,Xinying Chen,Wenqi Zhang,Qiuchen Luo,Siyan Chen,Shuhan Wang,Fangqing Weng,Lin Xiao
Supramolecular responsive microcarriers based on chitosan microspheres were prepared and applied for nonenzymatic cell detachment. Briefly, chitosan microspheres (CSMs) were first prepared by an emulsion crosslinking approach, the surface of which was then modified with β-cyclodextrin (β-CD) by chemical grafting. Subsequently, gelatin was attached onto the surface of the CSMs via the host–guest interaction between β-CD groups and aromatic residues in gelatin. The resultant microspheres were denoted CSM-g-CD-Gel. Due to their superior biocompatibility and gelatin niches, CSM-g-CD-Gel microspheres can be used as effective microcarriers for cell attachment and expansion. L-02, a human fetal hepatocyte line, was used to evaluate cell attachment and expansion with these microcarriers. After incubation for 48 h, the cells attached and expanded to cover the entire surface of microcarriers. Moreover, with the addition of adamantane (AD), cells can be detached from the microcarriers together with gelatin because of the competitive binding between β-CD and AD. Overall, these supramolecular responsive microcarriers could effectively support cell expansion and achieve nonenzymatic cell detachment and may be potentially reusable with a new cycle of gelatin attachment and detachment.Keywords:chitosan;microcarrier;cell culture;cell detachment;host–guest interaction
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