JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Xingyuan Wang,Xiansong Shi,Zhe Zhang,Congcong Yin,Zhipeng Zhang,Yong Wang
Intrinsically charged covalent organic frameworks (COFs) afford specific ionic nanochannels for mass transport, and thus become promising platforms to design membranes with unique selectivity. However, internal electrostatic repulsion and large-pore frameworks cause significant barriers that greatly limit membrane performances. Herein, we report a novel strategy to synchronously crystallize and upgrade cationic COF membranes by ion-pairing design. Ion-paired guest molecules are involved in electric-driven interfacial crystallization to offset the charges of the ionic monomers and host frameworks. This host-guest neutralization promotes the crystallization of compact COF membranes. Lateral dimension and charge nature of guest molecules fundamentally affect the ion-pairing efficiency. Tight encapsulation of the large-sized electronegative molecules effectually narrows the molecular sieving channels, yielding a significant elevation in membrane selectivity. The membrane rejection of organic ions with a size larger than 1.2 nm thus can be improved from below 50 % to above 85 % with a water permeance of ∼10 L m −2 h −1 bar −1 . Prominently, our membranes demonstrate efficient recovery and pH-dependent release of bioactive pharmaceuticals, with a release rate that is 12 times higher in an acidic solution compared to a neutral environment. This work provides an ion-pairing strategy to regulate COF membranes for pharmaceutical industries and beyond.
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高影响因子
Advanced Composites and Hybrid Materials
·
2019
·Vol. 2
·期 3
·462-470
·
IF 0
Dai Lin,Lu Jinshun,Kong Fangong,Liu Kefeng,Wei Huige,Si Chuanling
Development of biomass-based and some other sustainable biomedical materials is a key subject and effective approach to biomass high-value utilization. In this work, we used cellulose resources to develop a photoresponse hydrogel (PR-gel) by integrating 4arm-PEG and azobenzene into cellulose nanofibrils (CNFs). This novel PR-gel exhibited good mechanical strength (storage modulus over 10 3 Pa), structure stability, reversible recoverability between sustained step strain of 1% and 1000%, and excellent biocompatibility. Under UV irradiation ( λ = 365 nm, 10 mW/cm 2 , 10 min), the azobenzene cross-linker in PR-gel as photoswitch can cause the trans-cis isomerism and a softening effect of the hydrogel, thus realized the photo-controlled release of bovine serum albumin (BSA) (5-fold higher release rate under UV light irradiation). This work provided a new approach to design cellulose-based photoresponsive hydrogels. It is also can expand the application of cellulose-based hydrogels and some other sustainable materials in the biomedical field.
Cellulose nanofibrils-4arm-polyethylene glycol-azobenzene (PR-gel) exhibited good mechanical strength, reversible recoverability, excellent biocompatibility, and reversible photoresponse for protein release.
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POLYMER JOURNAL
·
2019
·Vol. 51
·期 11
·1211-1222
·
IF 2.639
Liu Guanghua,Lin Guanquan,Tan Mingyi,Zhou Hongjun,Chen Huayao,Xu Hua,Zhou Xinhua
To improve the utilization of pesticides and reduce the amount of pesticides used, sustained-release nanoparticles were prepared. Soybean protein isolate (SPI) and carboxymethyl cellulose (CMC) were modified to obtain hydrazine-modified SPI and aldehyde-modified CMC, respectively, and SPI-CMC was prepared by the condensation of hydrazine and aldehyde groups, forming a hydrazone bond. SPI-CMC was heated and loaded with avermectin (AVM) to obtain AVM/SPI-CMC. The encapsulation efficiency property, anti-ultraviolet property, sustained-release characteristics, pH responsiveness, and toxicological profiles were studied. The particles in the formulation were spherical-like, with sizes ranging between 150 and 250 nm. The encapsulation efficiency increased with the addition of SPI, which reached 44.49% when SPI was added in a mass ratio of m SPI-HYD : m CMC-ALD = 2:1. The percentage of remaining AVM in AVM/SPI-CMC was 31.47% higher than that in the AVM solution after UV irradiation for 43 h. Moreover, the nanoparticles were responsive to pH. SPI-CMC had no significant effect on the insecticidal toxicity of AVM. Environmental friendly SPI-CMC could protect and release pesticides continuously, which could improve the efficiency of pesticides.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Ruquan Zhang,Yongzhen Tao,Weilin Xu,Shili Xiao,Simin Du,Yingshan Zhou,Anwarul Hasan
A hyperbranched polysaccharide , coded as TM3a, was extracted from the Pleurotus tuber - regium sclerotia . TM3a was hybridized with xanthan gum (XG) by chemical crosslinking using sodium trimetaphosphate (STMP) to obtain new hydrogels with self-healing and release-controlled properties. The oscillatory rheological measurements indicated that chemically crosslinking was happened immediately on mixing STMP solutions into the XG-TM3a solutions, and the crosslinked network developed slightly as time increased. The resultant hydroges were disturbed into the loose structures and regrouped the microstructure in 2 min when a large and a small amplitude oscillation were applied in turn, suggesting a self-healable property. The XG-TM3a-STMP hydrogels exhibited shear-thinning behavior with yield stress. The storage modulus of the XG5-TM3a-STMP hydrogel was 445.2 Pa at 1% strain and 243.3 Pa at 100% strain, and yield stress was 160.6 Pa, which was higher than the corresponding value of the XG5-STMP hydrogel. The morphological observation indicated the aggregates of double helical XG chains exhibited directional arrangement, and were combined with the TM3a aggregates to constitute a network of hierarchical structures. The hybrid hydrogels with enhanced mechanical properties displayed good drug loading efficiencies and sustained drug release properties.
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PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 8
·1041
·
IF 4.7
Teng Sun,Dekang Zhan,Xiangzhu Wang,Qingjie Guo,Mingzhou Wu,Pu Shen,Man Wu
This study aims to improve the slow-release performance of a film material for a controlled-release fertilizer (CRF) while enhancing its biodegradability. A water-based biodegradable polymer material doped with biochar (BC) was prepared from modified polyvinyl alcohol (PVA) with polyvinylpyrrolidone (PVP) and chitosan (CTS), hereinafter referred to as PVA/PVP–CTSaBCb. An environmentally friendly novel controlled-release phosphate fertilizer (CRPF) was developed using PVA/PVP-CTS8%BC7%as the film. The effect of the PVA/PVP-CTS8%BC7%coating on the service life of the CRPF was investigated. The film was characterized via stress–strain testing, SEM, FTIR, XRD, and TGA analyses. The addition of the CTS modifier increased the stress of PVA/PVP-CTS8%by 7.6% compared with that of PVA/PVP owing to the decrease in the crystallinity of PVP/PVP-CTS8%. The hydrophilic –OH groups were reduced due to the mixing of CTS and PVA/PVP. Meanwhile, the water resistance of the PVA/PVP-CTS8%BC7%was improved. And the controlled-release service life of the CRPF was prolonged. Moreover, the addition of BC increased the crystallinity of the PVA/PVP-CTS8%by 10%, reduced the fracture elongation of the material, and further improved the biodegradability of the PVA/PVP-CTS8%BC7%. When the amount of BC added was 7%, the phosphorus release rate of the CRPF was 30% on the 28th day. Moreover, the degradation rate of the PVA/PVP-CTS8%BC7%polymer film was 35% after 120 days. This study provides basic data for applying water-based degradable polymer materials in CRFs.
研究领域:
农业科学
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材料科学
·
环境科学
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高影响因子
Wood Material Science & Engineering
·
2024
·
IF 2.2
Li Jin,Xin Ren,Fei Wang,Zhiwei Fan,Shuaibo Han,Yan Zhang,Hui Wang,Xinxing Wu,Fangli Sun
Disodium octoborate tetrahydrate (DOT) is a well-received and eco-friendly preservative. However, it is prone to leaching from wood in humid conditions or rainy seasons, causing problems such as decreased efficiency in resisting fungi and poor surface performance in surface finishing. To obtain enhanced leaching resistance and simultaneously achieve controlled release of DOT, a pH and temperature dual responsive poly (2-hydroxyethyl methacrylate/2-(Dimethylamino) ethyl methacrylate) (PDH) was prepared and optimized for in situ construction of DOT-loaded PDH (PDHD) in wood. Results showed that PDH displayed obvious pH and temperature-responsive swelling, and when loaded with DOT, the PDHD consequently released DOT in a pH and temperature-responsive way. Fourier transform infrared spectroscopy, Solid-13C NMR analysis and Dynamic mechanical analysis confirmed the copolymerization of 2-Hydroxyethyl methacrylate (HEMA) and 2-(Dimethylamino) ethyl methacrylate (DMAEMA), as well as the presence of crosslinked structure formed from hydrogen bond between the hydroxyl group of HEMA and the N,N-dimethylamino groups of DMAEMA. After that, the PDHD was in situ constructed in wood for controlled release of boron. During the water leaching test, the modified wood exhibited a boron fixation rate of 49.05% compared with 0.72% of the neat DOT-treated wood. Besides, it presented controlled release activity in response to pH and temperature. This work provides new approaches to the fixation of boron preservatives and notably realizes responsive releasing of boron compounds for long-term wood preservation.
研究领域:
材料科学
·
林学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jia Xu,Qing Wu,Jing Wang,Yingjie Liu,Ke Liu,Ming Xia,Dong Wang
The development of materials with high lysozyme adsorption is critical for drug delivery and skin wound applications, as it enhances antibacterial properties, stability, and controlled release of therapeutic agents, thereby improving treatment efficacy and safety. Alginate-based nanofiber scaffolds, featuring high surface area and multiple adsorption sites, can efficiently absorb lysozyme and regulate its release through tunable pore channels, offering a promising approach to chronic wound management. In this study, we fabricated poly (vinyl al co hol-co-ethylene) (EVOH) nanofiber-based sodium alginate (ENSA) aerogels using a simple two-step crosslinking procedure. The resulting aerogels, with controllable porosity formed via high-pressure spraying techniques (aerogel film) and molding (aerogel sponge), were evaluated for their high-loading capacity and controllable release of lysozyme. The aerogel film exhibited a remarkable lysozyme adsorption capacity of 1965 ± 36 mg/g, while the aerogel sponge sustained lysozyme release over 14 days. Analysis of the drug-release mechanism through four kinetic models revealed two distinct processes: cation exchange and matrix diffusion. The aerogel's pore structure influenced the diffusion processes, enabling tailored drug release profiles. Additionally, the ENSA aerogels demonstrated good mechanical properties, non-cytotoxicity, and potent antibacterial activity, positioning them as promising materials for skin wound dressings.
研究领域:
材料科学
·
生物医学工程
·
药剂学
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PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jiang Yang,Rongrong Fan,Yingcheng Li,Xiujuan He,Xiaolong Zhao
Surfactants are widely used as foaming agents to remove liquid accumulation in gas wells, enhancing natural gas production. The surfactant used in traditional foam sticks was dissolved and released as foam in a short period, especially at elevated downhole temperatures. This often requires the addition of foam sticks to maintain foam. To solve this problem, this study studies the utilization of nano silica to incorporate the amphoteric surfactant, cocamidopropyl betaine (CAB), into the mesoporous structure of silica nanocomposite as foam sticks for controlled release of CAB. Mesoporous nano silica was prepared by a sol–gel acid-catalyzed process with a silica precursor. The formation of nanocomposite solid sticks containing the amphoteric surfactant was achieved by aging and drying. The composite was characterized by various techniques: infrared spectroscopy, thermogravimetric analysis, energy-dispersive spectrometry, scanning electron microscopy, transmission electron microscopy, and small-angle X-ray diffraction. Results showed that 49.3% of CAB was encapsulated within the mesoporous structure of 30–50 nm nano silica. CAB release over time in aqueous solution at 130 °C exhibited 10.1% surfactant left in the nanocomposite after 72 h, as determined by thermal analysis. Surfactant release was systematically evaluated through foam performance tests. The study revealed that CAB could be control-released over 168 h via CAB diffusion from mesoporous silica. This study provides a longer-lasting foam method to enhance gas production by utilizing mesoporous silica as a control release medium for gas well deliquification.
研究领域:
材料科学
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石油工程
·
化学工程
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高影响因子
Food Bioscience
·
2024
·
IF 4.8
Zenghong Xing,Wenxin Han,Taotao Dai,Deming Gong,Guowen Zhang
In this study, the potato protein (PP)-pectin (PC) nanoparticles were constructed to encapsulate ferulic acid (FA). The effects of FA additive amount, addition order and pH value on the properties of PP-FA-PC/PP-PC-FA nanocomplexes were investigated. It was found that when the mass ratio of PP to FA was 25:1, the PP-FA-PC nanocomplex had the smallest particle size, turbidity and the highest FA encapsulation efficiency. At pH 5.0, the addition order of FA had an effect on the properties of the nanocomplexes, and the formed nanocomplexes had larger particle size, higher turbidity and better encapsulation efficiency than the nanocomplexes formed at pH 7.0. Additionally, the nanocomplexes formed at pH 5.0 also possessed lower ABTS + and DPPH free radical scavenging rates, indicating that FA was successfully encapsulated by PP-PC nanoparticles. The results of Z-average diameter and fourier transform infrared spectra confirmed PP-FA-PC nanocomplex at pH 5.0 encapsulated FA based on hydrogen bonding, hydrophobic and electrostatic interactions. The scanning electron microscopy showed that the PP-FA-PC nanocomplex exhibited irregular and segregated small particles at pH 5.0. Moreover, the PP-FA-PC nanocomplexes at pH 5.0 had the best encapsulation ability and protection effect on FA, and the environmental stability was the best. The release rate of FA loaded by PP-PC nanoparticles was greatly reduced in simulated gastric fluid, while increased in simulated intestinal fluid compared to free FA. This study may provide valuable information for PP-PC nanoparticles as a food-grade delivery system, signifying the potential application in the health food industry.
研究领域:
食品科学
·
纳米技术
·
生物技术
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高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Hui-Ming Xiang,Xiao-Hong Wei,Yi-Ran Li,Bo-Jun Zhang,Min Li,Rui-Yan Ma
BACKGROUND As sex pheromones are environmentally friendly and specific, they are often used to monitor and control oriental fruit moths (OFMs). Currently, non-biodegradable polymers are commonly employed as carriers to prepare controlled sex pheromone release systems for plant protection. Electrospinning is a relatively simple technique for preparing biodegradable nanofibers that allows for the controlled release of sex pheromones. This study aimed to develop a biodegradable controlled release system for the combination of OFM pheromone and codlemone via electrospinning, in which codlemone was used as a synergist for OFM pheromone. RESULTS New systems for the controlled release of combined pheromones from OFM and colding moths were developed using electrospun nanofibers from polycaprolactone (PCL), cellulose acetate (CA), and polylactic acid (PLA). In the indoor experiments, the load ratio and release stability of CA nanofibers loaded with combined pheromones (CA-SP) were superior to those of the other two nanofiber types. In the field experiments, among all the treatments, 10 mg of CA-SP was the most attractive to OFMs, and its effective duration was approximately 6 weeks. The optimum storage temperature for all nanofibers was −20 °C. CONCLUSION Electrospun CA-SP nanofibers were biodegradable and environmentally friendly, with stable release. This study presents a new technique that could be beneficial for the monitoring and control of OFMs. © 2025 Society of Chemical Industry.
研究领域:
昆虫学
·
环境科学
·
材料科学
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PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Hongyu Tian,Zeli Li,Panfang Lu,Yong Wang,Cong Jia,Huaili Wang,Zhiguang Liu,Min Zhang
Due to the poor controlled release ability, bio-based materials are difficult for large scale application on controlled release fertilizers (CRFs). Starch-based polyol (SP) and castor oil (CO) were mutually modified, and a cross-linked polymer film was formed on the surface of urea by in-situ reaction, which improved the slow release ability of the bio-based material. The results showed that increasing the CO ratio reduced porosity of coating and prolonged the nitrogen (N) release period, while the SP changed the high-temperature wrinkle characteristics and regulated the early N release rate. The mutual modification achieved an ultra-long release period of bio-based CRUs for 7 months. The degradation rate during nine months of bio-based coatings (5.05 %) was significantly higher than that of petroleum-based (3.74 %), and the coating was non-toxic to rice seeds. Mutual modification provided a safe and effective solution for the preparation of bio-based CRFs with long-term controlled release capability.
研究领域:
材料科学
·
农业科学
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2018
·
IF 7.877
Lei Wang,Yujie Hu,Yongwei Hao,Li Li,Cuixia Zheng,Hongjuan Zhao,Mengya Niu,Yanyan Yin,Zhenzhong Zhang,Yun Zhang
Combination therapy with multiple drugs or/and multiple assistant treatments has become a hot spot in cancer therapy. In this study, a new type of core-shell structured dual-drug delivery system based on poly (lactic- co -glycolic acid) (PLGA, inner cores) and hyaluronic acid (HA, outer shells) was constructed. Firstly, HA was conjugated to PLGA for preparation of HA-PLGA block copolymer . Secondly, 5-amino levulinic acid (ALA) was connected to PLGA through a pH-sensitive hydrazone bond for synthesization of PLGA-HBA-ALA. Finally, the core-shell structured nanoparticles ( [email protected] /ALA NPs) were constructed by self-assembled method for artemisinin (ART) loading in PLGA cores. In this co-delivery system, ALA and ART can be released in a manner of procedural controlled release. ALA was released from the NPs at first though the pH sensitive hydrazone bond cleavage in order to generate protoporphyrin IX (PpIX) for heme formation. And the increase of heme can effectively improve the curative effect of the subsequent released ART. Furthermore, this system has also shown obvious sonodynaimc activity which can be used for cancer sonodynamic combination therapy. The in vitro and in vivo anticancer results demonstrate that [email protected] /ALA delivery system could provide a prospective comprehensive treatment strategy for cancer therapy.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物医学工程
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PubMed
高影响因子
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