JOURNAL OF SEPARATION SCIENCE
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2017
·Vol. 41
·期 2
·540-547
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IF 2.557
Junjie Zhang,Benqiang Li,Huijuan Yue,Jing Wang,Yuansuo Zheng
With the combined surface imprinting technique and immobilized template strategy, molecularly imprinted magnetic nanoparticles were successfully prepared and coupled with high-performance liquid chromatography to selectively separate and determine gallic acid from the pomegranate rind. On the surface of carboxyl-functionalized magnetic nanospheres, thin imprinting shells were formed using dopamine as monomer and crosslinker. The characteristics, polymerization conditions, and adsorption performances of the resultant nanomaterials were investigated in detail. In addition of good crystallinity, satisfactory magnetism, and uniform morphology of the obtained polymers, they had rapid binding kinetics, high adsorption capacity, and favorable reusability. In the mixed solution of four hydroxybenzoic acids, the prepared nanomaterials have an excellent selectivity to gallic acid with an imprinting factor of as high as 17.5. Therefore, the polymers have great potentials in specific extraction and enrichment of gallic acid from the complex natural resources.
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SENSORS AND ACTUATORS B-CHEMICAL
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2015
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IF 4.097
Zhixian Liang,Haiyun Zhai,Zuanguang Chen,Haihang Wang,Shumei Wang,Qing Zhou,Xiaoting Huang
A facile and ultrasensitive sensor based on gold microclusters (AuMCs) electrodeposited on sulfonate functionalized graphene (SF-GR) was fabricated, and applied for the simultaneous determination of gallic acid (GA) and uric acid (UA). Taking advantage of the unique plane structure of the functionalized graphene (GR), the AuMCs were successfully electrodeposited on functionalized GR immobilized on the surface of a GCE. The results of scanning electron microscope (SEM) and energy spectrum analysis illustrated that AuMCs were deposited on the functionalized GR film. In comparison with the bare GCE, the pristine AuMCs and the pristine SF-GR modified electrode, AuMCs/SF-GR/GCE exhibited excellent electrochemical oxidation toward GA and UA. In addition, the two compounds were separated completely in 0.10 M citric acid-sodium citrate buffer (pH 4.0) by differential pulse voltammetry (DPV) under optimum conditions. The anodic current was linearly related with 0.05–8.0 μM GA and 0.2–50.0 μM UA, with the detection limit of 10.7 nM and 0.12 μM, respectively. Furthermore, AuMCs/SF-GR/GCE was successfully applied to the independent determination of GA in black tea and Cortex moutan as well as the simultaneous determination of GA and UA in urine samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ran Sun,Lei Lei,Jiamin Ji,Yuan Chen,Weiliang Tian,Fan Yang,Qian Huang
In abdominal wall defect repair, surgical site infection (SSI) remains the primary cause of failure, while complications like visceral adhesions present significant challenges following patch implantation. We designed a Janus multifunctional hydrogel patch (JMP) with antibacterial, anti-inflammatory, and anti-adhesive properties. The patch comprises two distinct layers: a pro-healing layer and an anti-adhesion layer. The pro-healing layer was created by a simple mixture of polyvinyl alcohol (PVA), quaternized chitosan (QCS), and gallic acid (GA), crosslinked to form PVA/QCS/GA (PQG) hydrogels through GA's self-assembly effect and hydrogen bonding. Additionally, the PVA anti-adhesive layer was constructed using a drying-assisted salting method, providing a smooth and dense physical barrier to prevent visceral adhesion while offering essential mechanical support to the abdominal wall. The hydrogel patch demonstrates widely adjustable mechanical properties, exceptional biocompatibility, and potent antimicrobial properties, along with a sustained and stable release of antioxidants. In rat models of skin and abdominal wall defects, the JMP effectively promoted tissue healing by controlling infection, inhibiting inflammation, stimulating neovascularization, and successfully preventing the formation of visceral adhesions. These compelling results highlight the JMP's potential to improve the success rate of abdominal wall defect repair and reduce surgical complications.
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FOOD CONTROL
·
2024
·
IF 5.6
Shuqi Zhang,Jing Yi,Zhilong Zhang,Xuanxuan Yuan,Zhongguo Shan,Haihua Wang
The growing concerns over food contamination caused by microorganisms, coupled with the worsening environmental impact of petroleum-based plastics have drawn significant attention to eco-friendly materials in food packaging. Herein, cyclodextrin-metal-organic framework (CD-MOF) was prepared as promising nanocarrier for the natural product gallic acid (GA). Then, the prepared material (GA@CD-MOF) was incorporated into zein matrix to obtain Zein-GA@CD-MOF films. Further studies showed that the composite films possessed great potential for food packaging, offering excellent UV-light blocking, water resistance , and mechanical properties. Notably, Zein-GA@CD-MOF films demonstrated superior antimicrobial activity (44.56%–77.97% against Escherichia coli O157:H7 and 28.36%–59.49% against Salmonella enterica ) and sustained antioxidant properties for 100 days, which correlated with the sustainable release effect of GA. Furthermore, the exceptional biosafety of GA@CD-MOF has been confirmed through cytotoxicity and hemolysis assays. Pork preservation experiments illustrated that the obtained films could retard protein degradation, microorganism growth, and lipid oxidation, extending the shelf-life by 9 days at 4 °C. These findings suggest that Zein-GA@CD-MOF films has promising application prospects in pork preservation packaging.
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CHEMISTRY OF NATURAL COMPOUNDS
·
2025
·
IF 0.9
Popov S. A.,Qi Z.,Yang G.,Wang C.,Semenova M. D.,Shpatov A. V.,Shults E. E.
New conjugates of lupane triterpenoids bound through a 1,2,3-triazole linker with gallate derivatives were prepared via Cu-catalyzed cycloaddition reactions of [3 β ,28-diacetoxy-20(29)-lupen-30-yl]azide and 3 β -acetoxylup-20(29)-en-30-azido-28-oic acid with gallate derivatives with propargyl substituents in various positions. Conjugate 4 based on betulin with a modified gallate substituent containing a dioxolane moiety possessed potent antioxidant properties and anti-inflammatory activity (suppression of NO hyperexpression).
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Mengchu Sun,Chenglong Zhang,Xichao Yin,Hongjin Tang
With the escalating environmental impact of petroleum-based plastics, natural polysaccharide-protein composite films have demonstrated significant potential as eco-friendly materials for food packaging. However, research on integrating bioactive metal-organic frameworks (MOFs) with Zein-based matrices to develop multifunctional active packaging remains underexplored. This study developed a novel composite film by encapsulating cinnamaldehyde (CA) within a magnesium-gallic acid-MOF (Mg-GA-MOF) and incorporating it into an ethyl cellulose (EC)/Zein matrix for pork preservation. The optimized CA@Mg-GA-MOF/EC/Zein-4% film with a thickness of 0.14 mm demonstrated remarkable mechanical properties, including a tensile strength of 55.75 MPa and an elongation at break of 5.46%. It exhibited low water vapor permeability at 5.87 × 10 −7 g·m −1 ·s −1 ·Pa −1 . The film also showed strong antibacterial activity, inhibiting growth by up to 99.73% against Escherichia coli and 89.26% against Staphylococcus aureus , as well as notable antioxidant properties with DPPH and ABTS scavenging rates of 59.70% and 49.71%, respectively. Furthermore, the composite film demonstrated sustained release characteristics for CA and GA and excellent biocompatibility. Non-covalent interactions between the components contributed to the improvement of functional properties of the film. In pork preservation trials, the composite film effectively delayed microbial growth, protein degradation, and lipid oxidation. Based on the total viable count safety limit (6 log CFU/g, GB 4789.2–2016), the film extended the shelf life of pork by 7 days compared to the control group. This study presents the first use of Mg-GA-MOF for the co-delivery of CA and GA within the EC/Zein film, offering a novel strategy for high-performance active food packaging.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
·
IF 5.4
Zheyu Huang,Jingzhong Kuang,Tingsheng Qiu,Mingming Yu
The similarity in surface properties between scheelite and calcite makes their flotation separation particularly challenging, thereby severely limiting the efficient utilization of tungsten resources. In this paper, Fe-SYA and Fe-GA colloidal complexes were synthesized via a metal-organic coordination strategy using Fe³⁺ with salicylic acid (SYA) and gallic acid (GA), respectively, and their structure-dependent flotation regulation mechanisms were systematically investigated. The structural stability, interfacial adsorption behavior, and their relationship with flotation selectivity were elucidated through contact angle measurements, zeta potential analysis, XPS, TEM and DFT calculations. The results showed that Fe-SYA and Fe-GA preferentially adsorbed on the calcite surface at pH=4 and a ratio of 1:1/2, significantly reducing calcite hydrophobicity and collector adsorption, while exerting only a minor effect on scheelite, thereby enabling selective separation. Owing to its abundant phenolic hydroxyl groups, Fe-GA formed a stable reticulated polydentate coordination structure with enhanced electronegativity and spatial stability, facilitating the formation of a dense inhibition film on calcite and yielding superior flotation performance, with a WO₃ concentrate grade of 71.03% and a recovery of 86.54%. In contrast, Fe-SYA exhibited lower structural stability and was prone to hydrolysis into Fe(OH)₃ colloids under alkaline conditions, resulting in non-selective inhibition. This work elucidates the structure–selectivity relationship of metal-organic colloidal complexes and provides a green and efficient strategy for the flotation separation of calcium-bearing minerals.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jinyu Chen,Siyang Wang,Zhirui Ji,Xianji Yi,Jiaqi Guo,Guofeng Jin,Zijian Wu
For purpose of overcoming the negative impact of high-dose phenols on meat quality, xanthan gum (XG), a natural anionic polysaccharide, was employed to prevent the undesirable interaction between myofibrillar protein (MP) and gallic acid (GA, 150 μmol/g) and ameliorate the gel and emulsification characteristics of MP. XG dose-dependently alleviated the structural damage of MP caused by GA and reduced protein aggregation, manifested as the decrease in surface hydrophobicity, turbidity and aggregate size ( p < 0.05) and increase in α-helix content and intrinsic fluorescence. As a result, more proteins participated in establishing an ordered cross-linked network, favoring the entrapment of immobilized water and imparting the gel with improved rheological properties and gel strength (from 2.2 N·mm to 3.1–5.5 N·mm) and a decreased cooking loss (from 13.6 % to 3.2 %–7.7 %). In addition, the presence of XG reduced oil–water interfacial tension of MP, promoting uniform distribution of emulsion droplets in a smaller size. The emulsifying activity and stability increased from 6.5 m 2 /g to 8.1–8.4 m 2 /g, and 41.5 % to 81.2 %–93.2 %, respectively, and the creaming index decreased from 52 % to 0 %–24 %. The multiple light scattering and microrheology results further demonstrated the enhancement of emulsion stability. The competition mechanism of XG, along with its hydrophilicity, electronegativity and viscosity, collectively contributed to the improvement of gel and emulsion quality. Our paper exploited the potential of dual application of polysaccharides and polyphenols in meat products for simultaneously reducing protein oxidation and quality deterioration.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Yuzhen Lu,Cong Zhang,Yingying Song,Liang Chen,Xin Chen,Guohua Zheng,Yuan Yang,Peng Cao,Zhenpeng Qiu
Accumulating evidence suggests that de novo lipogenesis is a typical characteristic facilitating nonalcoholic fatty liver disease (NAFLD) progression. Gallic acid (GA) is a naturally occurring phenolic acid with metabolic disease-related clinical significance and preclinical benefits. This study aimed to evaluate the anti-steatotic potentials of GA in a fructose-induced NAFLD mouse model featuring a hepatic lipogenic phenotype. The results revealed that GA alleviated hepatic steatosis , oxidative stress , and inflammatory response in fructose-fed mice. Mechanistically, GA treatment restored AMP-activated protein kinase α (AMPKα) phosphorylation, resulting in downregulations of pro-lipogenic factors, including sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FASN), and acetyl-CoA carboxylase (ACC), in hepatocytes of mice and in vitro . Furthermore, computational docking analysis indicated that GA could directly interact with AMPKα/β subunits to stabilize its activation. These results suggest that GA ameliorates fructose-induced hepatosteatosis by restraining hepatic lipogenesis via AMPK-dependent suppression of the SREBP-1/ACC/FASN cascade. Altogether, this study demonstrates that GA supplement may be a promising therapeutic strategy in NAFLD, especially in the subset with enhanced hepatic lipogenesis.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2022
·Vol. 57
·期 3
·1718-1728
·
IF 3.612
Ying Luo,Ao Li,Miao Shen,Man-Man Yu,Zi-Xuan Wu,Xiao-Yang Liu,Fa-Wen Yin,Da-Yong Zhou
Summary The process of lipid oxidation in fresh and fried oysters during in vitro digestion and the relationship between the antioxidant ability of phenolic esters with different chain lengths were investigated through co-digestion of fresh and fried oysters with gallic acid (GA) and its alkyl esters. Lipid oxidation in fresh and fried oysters during simulated digestion in vitro was observed according to increased conjugated diene value, conjugated triene value, thiobarbituric acid reactive substances and fluorescence intensity of aldehydes. Lipid oxidation in oysters was inhibited by GA and its alkyl esters during in vitro digestion effectively. As the alkyl chain length increased, the antioxidant effect first increased and then decreased, and butyl gallate achieved the highest effect among the GA and its alkyl esters we studied, which suggests that the antioxidant efficiency of GA and its alkyl esters in the digestive system may follow the ‘cut-off’ effect.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2022
·Vol. 57
·期 4
·2435-2446
·
IF 3.612
Man-Tong Zhao,Zhong-Yuan Liu,Guan-Hua Zhao,De-Yang Li,Guang-Hua Xia,Fa-Wen Yin,Da-Yong Zhou
Summary The antioxidant capacity of gallic acid (GA) and its fatty alkyl esters such as butyl gallate, octyl gallate (OG), lauryl gallate and hexadecyl gallate in freeze-dried oyster was investigated. During ambient storage, the significant increase of peroxide value and thiobarbituric acid value together with the decline for docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) contents indicated the occurrence of lipid autoxidation in freeze-dried oysters. Meanwhile, the oxidative degradation of glycerol phosphocholine (GPC), glycerol phosphoethanolamine (GPE) and triacylglycerols (TAG) molecular species carrying DHA or EPA in oyster ranked as: TAG > GPE > GPC. GA and its alkyl esters could effectively be prevented dried oyster lipid from oxidation. Among them, OG stood out as the most effective individual. This work implied that the chain lengths of GA alkyl esters affect their antioxidant ability for dried oysters, which provides the information for selecting eligible antioxidants to enhance the oxidative stability of freeze-dried seafood.
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COLORATION TECHNOLOGY
·
2022
·Vol. 139
·期 1
·45-56
·
IF 2.049
Na-won Baek,Dan Wang,Xun Zhang,Jie Wang,Xue-rong Fan
Silk fabrics treated with gallic acid/pyrrole (PGA/PPy) complexes polymerised using horseradish peroxidase have higher electrochemical activity than silk fabrics dyed with gallic acid alone. However, the degree of polymerisation decreases. As a result, the ultraviolet (UV) protection and fastness of the silk fabric were lowered. To solve this problem, we studied the degree of polymerisation of the complex and the functionality of dyed silk fabrics by applying a polyethylene glycol (PEG) template to the enzymatic polymerisation of PGA/PPy. The polymerisation mechanism of the complexes was analysed in detail using UV-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and high-performance liquid chromatography electrospray ionisation mass spectrometry (HPLC-ESI-MS). Consequently, the PGA/PPy/PEG complex has a higher degree of polymerisation than the PGA/PPy prepared without PEG, indicating that the PEG template can promote the polymerisation of PGA and PPy. As a result, we found that the presence of the PEG template improved the thermal stability and UV protection function of the dyed silk fabric, but did not impair the electrochemical activity of silk fabric. As a result of analysing the colour depth, it exhibited a higher K/S value compared to the dyed silk fabric in the absence of PEG. Additionally, its colour fastness was improved.
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