CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Juan Xu,Hongpo Zhou,Kun Li,Jinju Ma,Wenwen Zhang,Lanxiang Liu,Yanlin Sun,Hong Zhang,Kai Li
The smart polyphenol material could be designed to form two competitive interactions related to same one polyphenol molecule with different objects that could easily adhere to one surface through the weak interaction, and also could be entirely removed from the same surface by the strong interaction. In this study, the multi-scale pectin beads were fabricated by crosslinking with ions that could be acted as polyphenol loading agent through electrostatic force between the ions loading on the surface of pectin beads and polyphenol. The two effects on the size and appearance of pectin beads were detected. Because of the hydrogen bond between polyphenols loading on the beads and the surface of target, fluorescence-functionalized beads could easily adhere on target surfaces. Meanwhile, attributing to stronger electrostatic force between surface ions on beads and polyphenol, the thin membrane made of the beads can be entirely removed from the target surface to avoid the pollution of fluorescence probes.
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DOI
PubMed
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Nanbo Liu,Shuoji Zhu,Yuzhi Deng,Ming Xie,Mingyi Zhao,Tucheng Sun,Changjiang Yu,Ying Zhong,Rui Guo,Keluo Cheng,Dehua Chang,Ping Zhu
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) . It could also promote the proliferation and migration of L929 fibroblasts. In vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group. The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.
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DOI
PubMed
高影响因子
PROCESS BIOCHEMISTRY
·
2022
·
IF 4.885
Chaoting Wen,Dandan Song,Linwu Zhuang,Guoyan Liu,Li Liang,Jixian Zhang,Xiaofang Liu,Youdong Li,Xin Xu
This study aimed to isolate, purify and identify phenols from the celery leaves and further evaluate the antioxidant activities of the monomers in chemical system. Seven polyphenol monomers (a-g) were identified by HPLC-ESI-MS/MS after being separated by D101 macroporous resin, semi - preparative reversed-phase high-performance liquid chromatography (RP-HPLC) and sephadex LH-20. Interestingly, chrysoeriol 7-O-glucoside was identified from celery leaves by UV, IR, one dimensional nuclear magnetic resonance (NMR) and two-dimensional NMR for the first time. In addition, these polyphenol monomers manifested desirable DPPH• scavenging capacity (EC 50 : 39.55 ± 1.43–612 ± 8.45 μM) and ABTS+• scavenging capacity (EC 50 : 32.12 ± 0.58–512 ± 25.12 μM), respectively. Among them, the polyphenol monomers (a and b) with two hydroxyl groups (-OH) on the B ring in flavone skeleton had the strongest antioxidant activities. Moreover, the analysis of the structure-activity relationship showed that the position and quantity of -OH on the B-ring and the methylation degree of 3-OH played an important role in regulating antioxidant activities.
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高影响因子
Foods
·
2021
·Vol. 10
·期 6
·1320
·
IF 4.35
Junping Liu,Jiayan Zhang,Tao Liao,Lei Zhou,Liqiang Zou,Yafei Liu,Li Zhang,Wei Liu
The thermal inactivation kinetics of kudzu (Pueraria lobata) polyphenol oxidase (PPO) were investigated in model and food systems. PPO in kudzu tissue (tPPO) showed a higher thermostability than that of PPO in crude extract (cPPO) and purification fractions (pPPO). The PPO inactivation rate constant (k) increased with an increase in temperature, and tPPO showed the lowestkvalue, followed by that of cPPO and pPPO at the same temperature, indicating that PPO in the food system was more resistant to thermal treatment. Food constituents (pectin, starch, sucrose, and bovine serum albumin) in the food system decreased the activity of PPO but increased the thermostability of PPO, among which pectin exhibited the strongest protective effect against thermal inactivation, and the influence of sucrose was much slighter than that of other macromolecules. Fluorescence emission spectra indicated that pPPO exhibited stronger interactions with pectin than sucrose, and pPPO with pectin showed a more stable conformation under thermal treatment.Keywords:polyphenol oxidase;kudzu;thermostability;thermal inactivation kinetics;food constituents;conformation
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Kaibo Yu,Lei Zhou,Yuefang Sun,Zicong Zeng,Huiwen Chen,Junping Liu,Liqiang Zou,Wei Liu
Enzymatic browning control of cloudy fruit juice with natural substances has received much attention for improving its nutritional and commercial value. This study explored the anti-browning potential of Rosa roxburghii in apple juice. The anti-browning effects and mechanisms were evaluated by serial measurements of appearance, browning index, polyphenol oxidase (PPO) activity, UPLC-QE-Orbitrap-MS identification, inhibition kinetics and molecular docking. The results showed that Rosa roxburghii juice (0.25%-1.25% w/w) could effectively inhibit browning and PPO activity of apple juice. Ascorbic acid (1.67 g/100 g) as a reducing agent was a main anti-browning factor. Furthermore, seven phenolic compounds in Rosa roxburghii were screened as PPO inhibitors. Representative phenolic inhibitors induced mixed or competitive inhibition of PPO, mainly driven by hydrophobic forces and hydrogen bonds. This work demonstrates that Rosa roxburghii is a promising natural anti-browning ingredient to control the browning of cloudy apple juice due to abundant ascorbic acid and PPO inhibitors.
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2020
·
IF 5.774
Junda Wu,Zhiqiang Hou,Zhixin Yu,Jihui Lang,Jiuyun Cui,Jin Yang,Jiangdong Dai,Chunxiang Li,Yongsheng Yan,Atian Xie
Owing to the complex application environments, designing and fabricating emulsion separation membrane via facile preparation method with high separation efficiency and superior chemical stability are necessary. Herein, the TA-Ti@PVDF composite membranes via facile layer-by-layer self-assembly process with the merits of low-cost and eco-friendly have been reported. The property of TA-Ti@PVDF composite membrane can be regulated via changing the times of coating process, shows great experimental flexibility and practicability. Additionally, the separation efficiency of prepared membrane is as high as 99.35%, and the permeation flux is 689.6 L m -2 h −1 bar −1 . Most importantly, the prepared TA-Ti@PVDF composite membrane exhibits superior chemical stability (acid/alkali/salt resistance) and outstanding underwater oil repellence property. The separation efficiency of the composite membrane which treated by acid/alkali solutions are all above 97.39%. Generally, the low-cost and eco-friendly TA-Ti@PVDF composite membrane via facile coating process is appropriate for oily water treatment in the practical complicated environment, and possesses great potential in oil/water emulsion separation.
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高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 45
·10428-10438
·
IF 5.344
Yue Ren,Fei-Yu Wang,Zi-Jian Chen,Ri-Tong Lan,Ren-Huan Huang,Wan-Qun Fu,Rizwan M. Gul,Jing Wang,Jia-Zhuang Xu,Zhong-Ming Li
Periprosthetic joint infection (PJI) is one of the main causes for the failure of joint arthroplasty. In view of the limited clinical effect of oral/injectable antibiotics and the drug resistance problem, there is a pressing need to develop antibacterial implants with therapeutic antimicrobial properties. In this work, we prepared a highly antibacterial ultrahigh molecular weight polyethylene (UHMWPE) implant by incorporating tea polyphenols. The presence of tea polyphenols not only improved the oxidation stability of irradiated UHMWPE, but also gave it the desirable antibacterial property. The potent antibacterial activity was attributed to the tea polyphenols that produced excess intracellular reactive oxygen species and destroyed the bacterial membrane structure. The tea polyphenol-blended UHMWPE had no biological toxicity to human adipose-derived stem cells and effectively reduced bacteria-induced inflammation in vivo. These results indicate that tea polyphenol-blended UHMWPE is promising for joint replacement prostheses with multifunctionality to meet patient satisfaction.
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Tao Liao,Lei Zhou,Junping Liu,Liqiang Zou,Taotao Dai,Wei Liu
Salicylic acid is generally considered to combine with polyphenol oxidase (PPO) to inhibit activity and enzymatic browning, while its acidification effect on PPO activity was usually neglected. In this study, the inhibitory mechanism of salicylic acid on PPO was examined from acidification and binding effects by altering the buffer conditions. As the buffer concentration increased, contribution of acidification decreased while the binding effect became more predominant. Salicylic acid exhibited competitive inhibition on PPO, inducing the changes in secondary structure with a reduction in α-helix. Molecular docking results showed that salicylic acid interacted with residues HIS61, HIS85, HIS259, HIS263 and VAL283 through hydrogen bond and hydrophobic interaction. Furthermore, acidic pH enhanced the binding of salicylic acid to PPO with lower binding energy, additional hydrogen bond and electrostatic interactions. Therefore, both acidification and binding effects were important for salicylic acid on PPO inhibition and enzymatic browning control in fruit and vegetables.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Tianbao Wang,Jiahui Yang,Hongmei Kang,Liangke Zhang,Huan Chen
Photothermal therapy (PTT) is a potentially effective and non-invasive tumor therapy that has attracted the attention of many researchers. This study systematically investigated the formation of metal-polyphenol nanoparticles and their photothermal properties. A simple physical self-assembly method was used to embed hyaluronic acid (HA) into metal-polyphenol nanoparticles, and a novel type of HA-modified ferrous baicalein nanoparticle (HFBNP) was successfully prepared for the first time. Unlike most current methods that utilize positive and negative charge attraction or chemical bonding, the method proposed in this study is to embed HA into nanostructures to reduce the risk of HA shedding in the circulation, thereby improving the tumor targeting efficiency while avoiding the use of other chemical reagents. HFBNP had a suitable size distribution and good biosafety meanwhile efficiently converting near-infrared (NIR) laser energy into thermal energy. The active targeting capability mediated by HA significantly increased the uptake of nanoparticles by tumor cells, and HFBNP exhibited a strong growth inhibitory effect on tumor cells under NIR laser irradiation. With the combination of PTT and chemotherapy, HFBNP significantly inhibited tumor growth in tumor-bearing mice. In conclusion, the nanosystem prepared in this study provides a new strategy for tumor therapy.
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DOI
PubMed
高影响因子
Journal of Future Foods
·
2025
·
IF 7.2
Guanfeng Deng,Heng Liang,Qilu Xue,Tao Chen,Lijun Zhou,Ming Yuan,Chunbang Ding,Shiling Feng
Lethariella cladonioides (Nyl.) Krog (EE) proved to be a prolific source of polyphenols. UHPLC-Q-TOF-MS/MS was used to identify 38 polyphenolic compounds in L. cladonioides and determined the fragmentation pathways of its unique compounds (Vermicularin). The chosen polyphenols were utilized in the COSMO-RS method to tailor the most appropriate deep eutectic solvent (DES) for L. cladonioides . The Materials Studio program was used to construct virtual cluster molecules from 34 types of DESs and the 8 chosen polyphenols. The 17 DESs were configured and used to extract the polyphenols. The results indicated that choline chloride-ethanol amine exhibited outstanding dissolution effects. Furthermore, ultrasound-assisted DES extraction process parameters were optimized using response surface methodology, including ultrasound time, ultrasound power, and temperature and the optimization significantly increased the total phenol content to 41.17 ± 0.24 mg GAE/g. In the study, 38 polyphenol components in L. cladonioides were analyzed by mass spectrometry and ChCl-Eth was successfully screened out as the optimal extraction solvent based on the modeling, providing new ideas for the application of molecular simulation in the field of polyphenol extraction.
研究领域:
天然产物化学
·
绿色化学
·
计算化学
·
分析化学
·
植物化学
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高影响因子
Polymers
·
2025
·Vol. 17
·期 24
·3305
·
IF 4.9
Ruolan Du,Shuyan Liu,Yuanzhe Li
Hydrogen peroxide (H2O2) is a key oxidant for green chemical processes, yet its catalytic utilization and activation efficiency remain limited by material instability and uncontrolled radical release. Here, we report a dual-functional, hollow conductive polymer nanostructure that enables selective modulation of H2O2reactivity through interfacial physicochemical design. Hollow polypyrrole nanospheres functionalized with carboxyl groups (PPy@PyCOOH) were synthesized via a one-step Fe2+/H2O2oxidative copolymerization route, in which H2O2simultaneously served as oxidant, template, and reactant. The resulting structure exhibits enhanced hydrophilicity, rapid redox degradability (>80% optical loss in 60 min (82.5 ± 4.1%, 95% CI: 82.5 ± 10.2%), 10 mM H2O2, pH 6.5), and strong electronic coupling to reactive oxygen intermediates. Subsequent tannic acid–copper (TA–Cu) coordination produced a conformal metal–polyphenol network that introduces a controllable Fenton-like catalytic interface, achieving a 50% increase in ROS yield (1.52 ± 0.08-fold vs. control, 95% CI: 1.52 ± 0.20-fold) while maintaining stable photothermal conversion under repeated NIR cycles. Mechanistic analysis reveals that interfacial TA–Cu complexes regulate charge delocalization and proton–electron transfer at the polymer–solution boundary, balancing redox catalysis with energy dissipation. This work establishes a sustainable platform for H2O2-driven redox and photo-thermal coupling, integrating conductive polymer chemistry with eco-friendly catalytic pathways.
研究领域:
材料化学
·
环境催化
·
纳米材料
·
能量转换
·
绿色化学
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DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Sha Li,Keting Li,Chao Yang,Lansha Song,Lian Shuai,Xingyi Chen,Lei Wang
This research aimed to fabricate and characterize low-methoxyl citrus pectin films crosslinked respectively with Ca 2+ , Mg 2+ and Zn 2+ in chloride or gluconate salt, and optionally incorporated with polyphenol from Rosa roxburghii Tratt (RRT) leaves (RTLP) for potential in active food packaging, through the solution casting method. Although RRT has been proven with health benefits due to the renowned abundance of polyphenols, there remains a research paucity on RRT leaf-derived polyphenol for the biological functionalities in vitro to achieve an economic added value . Specifically, it has been determined that two-step method of cellulose hydrolysis and ultrasonication, as compared to the single step and their simultaneous combination, was observed with the remarkable capability of scavenging free radicals and suppressing carbohydrate digestion as evidenced by α-glucosidase/α-amylase inhibitory activities in a dose-dependent manner, which was accordingly incorporated into pectin film. Generally, the ionic cross-linker observably increased the tensile strength especially for 18.49 MPa of P-Mg(Cl) as compared to 1.34 MPa of P-water. Interestingly, both cation and anion are responsible for ionic cross-linking performance, for example the altered anionic group of Mg 2+ from chloride to gluconate decreased the tensile strength by ∼73 %. On another hand, the RTLP incorporation could not only contribute to the packaging performance of films with excellent antioxidant capability, but also significantly alter their physico-chemical properties assessed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, X-ray diffraction and thermo-gravimetric analysis etc. These results showed a promising venue to prepare pectin-based film with great potential in food packaging industry.
研究领域:
食品科学与技术
·
高分子科学
·
材料科学
·
功能食品
·
天然产物化学
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高影响因子
危险品化学品经营许可证（带存储）