POLYMER COMPOSITES
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2025
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IF 4.7
Hu Jiang,Rongkun Bai,Lingling Zhang,Haoyang Lou,Xiacong Zhang,Ye Chen,Mingming Yu
A resveratrol-based epoxy resin was synthesized and applied as a novel bio-based sizing agent for the surface treatment of carbon fibers (CF). This paper investigated the effects of different sizing concentrations on the surface morphology of carbon fibers, the interfacial properties, and the mechanical performance of carbon fiber/epoxy (CF/EP) composites. X-ray Photoelectron Spectroscopy (XPS) tests showed that the functional groups and π-π* bonds of CFs significantly increased. Compared to untreated CF/EP composites, the interfacial shear strength (IFSS) of the sized composites increased by almost 69.7%, the tensile strength and modulus increased by 32.7% and 19.5%, and the flexural strength and modulus increased by 24.9% and 9.6%, respectively. A strong positive correlation was observed between the tensile and flexural properties of the composites and their interfacial bonding strength. This sizing agent effectively enhanced the interfacial properties of CF/EP composites. The CF/EP composites with sizing treatment exhibited ductile fracture characteristics which might have the potential to delay structural cracking.
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BIOLOGICAL & PHARMACEUTICAL BULLETIN
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2015
·Vol. 38
·期 10
·1658-1662
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IF 1.828
Lu-yang Lu,Yuan Liu,Zhi-feng Zhang,Xiao-jun Gou,Jun-hao Jiang,Ji-zhong Zhang,Qian Yao
Pomegranate seed oil (PSO) has diverse bioactivities. It was hyphothesized that if PSO were employed to construct a trans-resveratrol-loaded self-nanoemulsifying drug delivery system (RES SNEDDS-PSO), not only could PSO serve as an oil phase but also exert synergistic effects with resveratrol to yield better therapeutic outcomes. In this study, we prepared RES SNEDDS-PSO for the first time to validate that hypothesis. The anti-inflammatory and anticancer activities of RES SNEDDS-PSO were compared with another SNEDDS composed of oil phase isopropyl palmitate (RES SNEDDS-IP). The results showed that upon exposure to a 10-fold amount of water, RES SNEDDS-PSO was converted into nanoemulsions with a mean size of 44 nm. Nanoemulsions enhanced the water solubility of resveratrol by 20-fold, significantly improved resveratrol stability in intestinal fluid, and slowed the decomposition of resveratrol in water by 1-fold. An in vivo anti-infection test showed that the degree of inflammatory swelling in mice given RES SNEDDS-PSO was only 60 and 76% that of the group fed with RES SNEDDS-IP at doses of 10 and 20 mg/kg, respectively. An in vitro anticancer study showed that the inhibitory rate of RES SNEDDS-PSO against MCF-7 breast cancer cells was 2.03- and 1.24-fold that of RES SNEDDS-IP at a concentration of 12.5 and 25 µg/mL, respectively. This study demonstrated that the newly developed SNEDDS may be a prospective formulation in the functional food and clinical fields.
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FOOD CHEMISTRY
·
2019
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IF 5.399
Can-Peng Li,Shuang Tan,Hanzhang Ye,Jun Cao,Hui Zhao
A label-free fluorescence assay for resveratrol determination is presented for the first time. The approach was based on fluorescence resonance energy transfer (FRET), via competitive supramolecular recognition, between p-sulfonated calix[6]arene (CX6)-modified reduced graphene oxide (CX6@RGO) and a probe-resveratrol complex. The probe molecule (Rhodamine B or rhodamine 123) had a strong fluorescence signal, and its fluorescence was quenched by CX6@RGO, based on FRET. When the target molecule was added to CX6@RGO, the probe molecule was displaced by resveratrol, and a host-guest complex, CX6@RGO-resveratrol formed, turning-on the fluorescence signal. Fluorescence intensity of the CX6@RGO-probe complex increased linearly with increased resveratrol concentrations (2.0–40.0 μM). The proposed approach was used to determine resveratrol in red wine with satisfactory detection limits and recoveries. Compared with traditional determination methods, our procedure is advantageous because it saves time, is easy to operate, and does not require sample pretreatment.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Fazhu Li,Tingting Yang,Guanghua Xia,Zhongyuan Liu,Dawei Yu,Zhidong Liu,Liming Zhang,Jiamei Wang
ACP treatment enhanced encapsulation and controlled release of curcumin / resveratrol. • ACP promoted hydrogen bonding and electrostatic interactions in nanoemulsions • ZCR/SA-NE-3 min showed excellent emulsifying and antioxidant activity. • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles effectively reduced TVC and MDA levels in refrigerated tilapia • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles extended the shelf life of refrigerated tilapia from 4 to 8 days. Oxidative degradation and microbial contamination cause quality deterioration of aquatic products under refrigeration, posing a major challenge to their preservation. In this study, zein-curcumin-resveratrol‐sodium alginate nanoparticles (ZCR/SA NPs) were pretreated with atmospheric cold plasma (ACP) for 1–4 min. The ACP-modified NPs were further fabricated into antioxidant nanoemulsions (NEs), and the influences of ACP pretreatment on the physicochemical properties, encapsulation efficiency, and sustained-release performance of the resultant NEs were systematically explored. The ACP treatment significantly improved the loading efficiency and controlled release of curcumin and resveratrol ( P < 0.05). FT-IR and XRD analyses indicated the formation of stronger hydrogen bonding and electrostatic interactions within the NEs system, which improved structural stability. Among all samples, ZCR/SA-NEs-3 min exhibited the best emulsifying properties (ESI = 358.57 ± 14.60 min, EAI = 30.51 ± 1.52 m 2 /g) and strong antioxidant activity (DPPH: 74.7 ± 1.67%, ABTS: 76.4 ± 2.17%). Importantly, ZCR/SA-NEs-3 min could significantly delay the spoilage process of tilapia fillets during 8 days of storage. Compared with the control group, the total viable count decreased from 8.07 ± 0.04 to 5.20 ± 0.04 lg₁₀ CFU/g, the malondialdehyde content dropped from 1.57 ± 0.03 to 0.49 ± 0.01 mg MDA/kg, and the shelf life was extended from 4 days to 8 days. This study not only revealed the mechanism underlying property improvement of NEs by ACP-modified NPs, but also provided an eco-friendly and innovative strategy for efficient preservation of aquatic products. Download: Download high-res image (265KB) Download: Download full-size image
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Drug Design Development and Therapy
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2026
·
IF 6.1
Chao Song,Xiaofei Wu,Chaoqi Chen,Baoxin Shen,Yuheng He,Fei Liu,Feng Chen,Zhijiang Fu,Zongchao Liu
Background: Intervertebral disc degeneration (IVDD), characterized by inflammation, cell death, and matrix dysregulation, involves ferroptosis and autophagy interactions, though the role of ferritinophagy remains unclear.Methods: This study integrated bioinformatics analysis of clinical transcriptomes, single-cell sequencing, and experimental models to identify molecular targets linking ferritinophagy to IVDD progression.Results: Multi-omics analysis revealed 10 ferroptosis-related hub genes (eg, NCOA4, TP53, SLC7A11) enriched in hypoxia, autophagy, and ferroptosis pathways. Single-cell profiling demonstrated dynamic shifts in nucleus pulposus cell (NPCs) phenotypes during degeneration, with increased pro-inflammatory monocyte/macrophage infiltration. Clinical and experimental validation showed elevated NCOA4 and ACSL4 (ferroptosis drivers) alongside reduced GPX4 and FSP1 (anti-ferroptotic factors) in degenerated discs. Mechanistically, NCOA4-mediated ferritinophagy promoted iron overload and lipid peroxidation by degrading ferritin, exacerbating oxidative damage. Resveratrol, a natural anti-inflammatory compound, mitigated IVDD in rat models by restoring disc height, suppressing IL1β, TNF-α, and IL6, and reversing ferroptosis/autophagy imbalance via NCOA4 downregulation. Cellular studies confirmed that resveratrol attenuated LPS-induced NPCs degeneration by blocking NCOA4-dependent ferritinophagy, reducing lipid peroxidation and cell death.Conclusion: This work identifies NCOA4 as a critical nexus coordinating ferroptosis-autophagy crosstalk in IVDD and establishes ferritinophagy as a novel pathological mechanism. Resveratrol’s therapeutic efficacy, mediated through multi-target modulation of inflammatory and iron homeostasis pathways, provides a promising strategy for IVDD treatment. The findings advance precision medicine approaches by elucidating ferritinophagy’s role and proposing resveratrol as a targeted intervention to disrupt this self-amplifying cycle of oxidative damage in disc degeneration.
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ACS Applied Bio Materials
·
2026
·
IF 5.6
Zhengrong Chen,Jiaxin Yan,Qingshuang Wang,Yutong Wang,Chunshuang Qi,Xue Jiang,Xincui Shi,Xiangru Feng
Diabetic bacterial infected wounds are severe complications in diabetic patients, posing significant challenges to clinical management. The wound site is prone to bacterial colonization and biofilm formation, triggering a persistent inflammatory response and forming a vicious cycle of “hyperglycemia−infection−inflammation”. Therefore, the development of antibacterial materials that are efficient, safe, and less likely to induce drug resistance is of great significance for improving wound repair. In this study, a thermosensitive composite hydrogel based on chitosan (CS) and poloxamer (P407/P188), named CPP, was developed for the codelivery of berberine (BBR) and resveratrol (RES). This system undergoes a phase transition at physiological temperature to form a porous network structure, enabling controllable and sustained drug release. In vivo experiments using a diabetic mouse model with infected wounds showed that the CPP@BBR@RES hydrogel effectively inhibited bacterial colonization, alleviated the inflammatory response, and significantly promoted collagen deposition, angiogenesis, and wound closure. This study innovatively combines the thermogelling and sustained-release properties of the material with the synergistic antibacterial, anti-inflammatory, and repair-promoting functions of the dual drugs, providing a multifunctional integrated therapeutic strategy for diabetic infected wounds.
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ULTRASONICS SONOCHEMISTRY
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2026
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IF 10.2
Xinyu Shen,Chunmin Ma,Yang Yang,Guang Zhang,Jiawang Wang,Xinyu Xu,Bing Wang,Yue Xu,Na Zhang
This study focused on black rice starch as the research subject, constructing different ultrasonic power-based black rice starch–resveratrol (BRS–RE) composite systems to explore the correlation between structural changes, physicochemical properties, and in vitro digestion behavior. Ultrasound increased the complexation index (CI) to a maximum of 80.38 % at 400 W. Particle size initially increased and then decreased with ultrasonic power, indicating power-dependent molecular reorganization. FT-IR and Raman analyses indicated changes in the hydrogen-bonding environment and short-range order, while high-power ultrasound induced partial local reordering. Molecular docking suggested hydrogen-bonding and hydrophobic interactions between resveratrol and starch chains, with a potentially more favorable interaction with amylopectin than amylose. These structural changes improved hydration properties (maximum WAI, 2.61 g·g −1 ) and gel strength, accompanied by increases in bound water and immobile water content. Additionally, thermal and rheological properties were altered (maximum ΔH, 10.11 J/g), and setback values indicated a reduced retrogradation tendency. In vitro digestion results showed a decrease in RDS and an increase in RS (up to 26.87 %). Correlation analysis linked structural disorder and reorganization to changes in hydration, gel network reinforcement, and digestion resistance. Based on these observations, the BRS–RE system exhibited property-dependent responses to ultrasonic power, reflecting varying contributions of starch-chain disruption, resveratrol association, and molecular reorganization across different structural and functional attributes. This work offers mechanistic insights and theoretical support for designing starch-based functional foods with reduced digestibility and potential glycemic benefits. Download: Download high-res image (164KB) Download: Download full-size image
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Frontiers in Pharmacology
·
2026
·
IF 5.4
Dongxin Chen,Hailun Xia,Lu Cao,Haoxin Fu,Yan Chen,Shiqi Jiang,Runjuan Zhan
Introduction Vorolanib is a new-generation multi-targeted kinase inhibitor (MTKI) whose drug-drug interaction (DDI) profile remains largely unexplored. This study combined in vitro and in vivo approaches to systematically investigate the effect of resveratrol on vorolanib metabolism. Methods Using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), the concentrations of vorolanib and its primary active metabolite X297 were quantified in rat liver microsomes (RLM), human liver microsomes (HLM), recombinant human CYP3A4 (rCYP3A4), and Sprague-Dawley rats. Molecular docking simulations were performed to investigate the binding poses of vorolanib and resveratrol within the active site of CYP3A4. Results In vitro assays revealed that resveratrol inhibited vorolanib metabolism with half-maximal inhibitory concentration (IC 50 ) values of 6.28 ± 0.27, 33.86 ± 0.65 and 6.70 ± 0.32 μM in RLM, HLM and rCYP3A4, respectively. The specific mechanisms were identified as non-competitive inhibition in HLM, and mixed inhibition in both RLM and rCYP3A4. IC 50 shift experiments indicated that the inhibition of vorolanib by resveratrol was non-time-dependent. Furthermore, metabolic stability assays in RLM showed that resveratrol substantially prolonged the in vitro t 1/2 of vorolanib from 39.02 ± 2.02 to 186.24 ± 58.99 min. Molecular docking confirmed that both compounds bind within the catalytic pocket of CYP3A4 with binding energies of −7.29 and −7.23 kcal/mol, respectively. The in vivo pharmacokinetic study demonstrated that co-administration with resveratrol significantly increased the AUC (0-t) and AUC 0 ‐ ∞ of vorolanib by 1.70- and 1.82-fold, respectively, while significantly decreasing its CL z/F by 56.1%. Similarly, for the metabolite X297, the AUC (0-t) , AUC 0 ‐ ∞ , and C max were increased by 2.00-, 2.22-, and 1.18-fold, respectively, accompanied by a 63.9% decrease in CL z/F . Conclusion Both in vitro and in vivo results consistently demonstrate that resveratrol profoundly inhibits the metabolism and elimination of vorolanib, driven by its interference with the CYP3A4 catalytic domain as corroborated by docking analysis. These findings highlight a potential risk of herb-drug interactions, suggesting that close clinical monitoring for adverse reactions is required when vorolanib and resveratrol are used in combination.
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高影响因子
Current Traditional Medicine
·
2024
·Vol. 11
·期 6
·E22150838296794
·
IF 0.6
Jie Huang,Chong Xie,Zhi Pan,Mengya Lin,Qingsheng Chen,Shengzhao Gong,Yadong Huang
BackgroundPlant extracts have wide applications in food, nutrition, and cosmetics, which results in a deeper investigation of natural ingredients. Numerous natural ingredients have been demonstrated to exhibit multiple activities, including antioxidation, anti-inflammation, and anti-melanogenesis. However, their combinations have not been well investigated, which could provide stronger performance with less toxicity and easier applications.MethodsWe used B16F10 cells treated with alpha-melanocyte stimulating hormone (αMSH) for melanogenesis-related studies, including cellular melanin content, tyrosinase activity, and gene or protein expression. MTT assay was used to evaluate cell viability. DPPH scavenging activity was measured for antioxidation. Nitric oxide (NO) content was evaluated in lipopolysaccharide (LPS) treated RAW264.7 cells to indicate the performance on anti-inflammation.ResultsIn this study, six different compounds and their combinations were tested for melanogenesis. The results showed that the combination of glabridin, resveratrol, and ellagic acid (GRE) exhibited the highest efficiency, which was mainly manifested as inhibition of melanin production and tyrosinase activity, higher DPPH scavenging rate, and inhibition of nitric oxide (NO) production. Meanwhile, our results showed that GRE could significantly downregulate the expression of microphthalmia-associated transcription factor (MITF) related genes and proteins and could also inhibit the phosphorylation of cyclic AMP response element-binding protein (CREB), which was the upstream signal of MITF.ConclusionThe results suggest GRE exhibits high efficiency in inhibiting anti-melanogenesis, antioxidation, and anti-inflammation. Furthermore, GRE could downregulate the phosphorylation of the CREB and MITF signal pathway, which provides a theoretical basis for its application in pigmentation disorder disease and cosmetics.
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高影响因子
CARBOHYDRATE POLYMERS
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2026
·
IF 12.5
Tingting Ma,Yiran Li,Aolong Li,Siluo Dai,Zhengyang Qin,Yubao Li,Jidong Li
The core difficulty in bone defect repair lies in the simultaneous regulation of immunity, angiogenesis and osteogenesis. In this study, hydrophobic resveratrol (Res) was encapsulated in liposomes (LP), and then co -spun with polyvinyl alcohol-chitosan (PVA-CS) to construct a “drug-liposome-fiber” multi-level drug-controlled-release scaffold (RL/PVA-CS). Physicochemical characterization confirmed that this scaffold could sustain the release of Res, and CS incorporation significantly enhanced mechanical properties of the PVA-based fiber scaffold. In vitro studies confirmed that the RL/PVA-CS scaffold not only efficiently scavenged free radicals, regulated macrophage polarization to M2 type to improve the immune microenvironment, but also demonstrated a significant potential for promoting angiogenesis. Moreover, this scaffold could effectively recruit bone marrow mesenchymal stem cells (BMSCs) and drove their osteogenic differentiation and matrix mineralization by activating the autophagy pathway. In a rat cranial defect model, the implantation of the RL/PVA-CS scaffold demonstrated excellent angiogenic ability and osteogenic performance, significantly accelerating bone defect repair. The main innovation of this study is the development of a dual-release and multi-functional synergistic RL/PVA-CS fiber scaffold. This system effectively protects drug activity, overcomes single-function limits of traditional materials, coordinates immunity, angiogenesis and osteogenesis via autophagy, offering an integrated solution for complex bone defects.
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高影响因子
EXPERIMENTAL EYE RESEARCH
·
2026
·
IF 3.1
Meiyu Wang,Xiangyu Liu,Zhenzhen Ji,Yingxin Chen,Jun Cai,Mei Dong,Ziwen Xu,Jingxin Ju,Zhijian Li
Background As the predominant cause of blindness, cataract pathogenesis centrally involves oxidative stress-induced damage and apoptosis in lens epithelial cells. Although resveratrol possesses recognized antioxidant and antiapoptotic activities, its functional role in cataract development and its specific impact on TXNIP require further elucidation. This study aimed to investigate whether resveratrol delays cataract progression by regulating the TXNIP/Trx2 pathway, improving mitochondrial function, and inhibiting apoptosis. Methods In vitro , an oxidative stress model was established using the hydrogen peroxide (H 2 O 2 )-induced human lens epithelial cell line B3 (HLE-B3), whereas in vivo , a cataract model was constructed in sodium selenite-induced SD rats. Evaluations included cell viability, ROS levels, mitochondrial function (mitoROS and ΔΨm), antioxidant markers (GSH, SOD, and CAT), expression of TXNIP, Trx2, and apoptosis-related proteins (cleaved-caspase-3, Bax, Bcl-2), and apoptosis detection. Lenticular opacity and histopathological changes were assessed in vivo . Results In vitro experiments demonstrated that resveratrol and SRI37330 comparably suppressed H 2 O 2 -induced TXNIP expression and mitochondrial translocation, thereby upregulating Trx2, reducing ROS production, improving mitochondrial membrane potential, enhancing antioxidant capacity, and attenuating apoptosis. In vivo experiments revealed that resveratrol alleviated lens opacity and tissue abnormalities in rats, restored antioxidant function, regulated the expression of TXNIP, Trx2, and apoptosis-related proteins, and inhibited apoptosis. Conclusion Resveratrol delays cataract formation and progression by inhibiting TXNIP expression and mitochondrial translocation, restoring the mitochondrial antioxidant protein Trx2 expression, thereby reducing mitochondrial oxidative stress-related damage and blocking the mitochondrial apoptotic pathway.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Zhaolun Li,Hongyan Wu,Jianan Liu,Hongshun Hao,Jingran Bi,Hongman Hou,Gongliang Zhang
This study aimed to investigate the synergistic effects of benzyl isothiocyanate (BITC) and resveratrol (RS) on Listeria monocytogenes and their application in chicken meat preservation. BITC combined with RS (BR) significantly enhanced the antimicrobial activity and inhibited the growth of Listeria monocytogenes within 24 h compared to individual treatment, as well as suppressing bacterial swimming and swarming motility, reducing biofilm formation by 56.4%, increasing cell membrane disruption, and inducing intracellular ROS surges. Synergistic effects were associated with the inhibition of biofilm formation, cell membrane destruction, and ROS production. Biofilm removal facilitated the direct antimicrobial action of BR. RS disrupted cell membrane permeability, allowing more BITC into the cells, resulting in increased intracellular antibacterial levels, cell membrane hyperpolarization, and rapid ROS accumulation. Furthermore, BR visibly slowed the microbial growth in chicken flesh stored at 25 °C and 4 °C. Therefore, BR is expected to be a new strategy for food preservation.
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