INTERNATIONAL JOURNAL OF THERMOPHYSICS
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2021
·Vol. 42
·期 6
·1-24
·
IF 1.608
Liu Ping,Liu Zimin,Zhao Tianxiang,Liu Fei,Liao Quanlan
Densities and viscosities for the binary system of tetraethylene glycol (1) + water (2) at T = (298.15 to 323.15) K were measured as a function of composition under atmospheric pressure. The excess properties, including excess molar volumes ( \(V_{{\text{M}}}^{{\text{E}}}\) ), viscosity deviations (Δ η ), and the excess Gibbs free energy of activation for viscous flow (Δ G * E ) were calculated by using density and viscosity data, respectively. Excess properties indicated that there are hydrogen bonding interactions between tetraethylene glycol and water molecules, which are investigated in detail by FTIR and UV–Vis spectra.
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Catalysts
·
2021
·Vol. 11
·期 11
·1268
·
IF 4.146
Shucheng Wang,Chuanzhao Wang,Houlin Yu,Wei Yu,Yongnan Liu,Wucan Liu,Feixiang Zhou,Wanjin Yu,Jiuju Wang,Jianjun Zhang,Wenfeng Han
A BaF(p-BDC)0.5catalyst was prepared by solid state reaction at room temperature with Ba(OH)2as precursor, NH4F as F source, and H2(p-BDC) as organic ligand. The calcined samples were used as catalysts for dehydrochlorination of 1-chloro-1,1-difluoroethane to generate vinylidene fluoride (VDF) at 350 °C. Commercial production of VDF is carried out at 600–700 °C. Clearly, pyrolysis of the BaF(p-BDC)0.5catalyst provided a promising way to prepare VDF at low temperatures. Prior to calcination, the activity of the BaF(p-BDC)0.5catalyst was low. Following calcination at high temperatures, BaF(p-BDC)0.5decomposed to BaF2and BaCO3, and then the catalyst was chlorinated and fluorinated to BaClF, which showed high activity and stable VDF selectivity for dehydrochlorination of 1-Chloro-1,1-Difluoroethane to VDF.Keywords:barium fluoride;catalytic pyrolysis;dehydrochlorination;1-chloro-1,1-difluoroethane;vinylidene fluoride
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Lin Zhang,Lei Xing,Jie Liu,Tieyue Qi,Meng Li,Lidong Wang
Cobalt-based catalysts can promote sulfite oxidation to recover the valuable byproducts formed during wet magnesia desulfurization. However, Hg(II) in the desulfurization slurry degrades the quality of reclaimed products and poses considerable environmental risk. Here, a bifunctional sulfur-doped catalyst/adsorbent, Co-TUD-1/S, is prepared through one-pot synthesis, in which the sulfur site is designed for trapping aqueous Hg 2+ . The catalytic rate of Co-TUD-1/S for MgSO 3 is 0.083 mmol/L/S, which is 10.4 times of that under non-catalytic condition, the removal efficiency of Hg 2+ is higher than 90%. The isothermal models and kinetic models for the adsorption of Hg 2+ are well-fitted to the Langmuir model and pseudo-second-order model, respectively, and the maximum adsorption capacity of experimental data is 96 mg/g. The characterization results confirm that Co 3 O 4 is functioned as the active catalysis site, and the formation of S–Hg bonds plays a crucial role in Hg 2+ capture. Density functional theory calculations reveal that the Co site is more likely to combine with sulfite rather than Hg 2+ , which reduces the interference of absorbed Hg 2+ on the catalytic activity of Co. Specialization and cooperation between the catalysis site of –Co and adsorption site of –S are realized. The results reveal that the use of Co-TUD-1/S is a feasible strategy for improving wet desulfurization efficiency.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Tongtong Wang,Xuedan Song,Hailong Xu,Miaomiao Chen,Jie Zhang,Min Ji
A recyclable and magnetic nanocomposite catalyst (IL/Fe3O4@HKUST-1) was synthesized via grafting ionic liquid (IL) [AEMIm]BF4 into magnetically functionalized metal–organic framework Fe3O4@HKUST-1 in a water–ethanol media. The properties of IL/Fe3O4@HKUST-1 were fully characterized by powder X-ray diffraction, electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption–desorption, density-functional theory, and a magnetic property measurement system. IL/Fe3O4@HKUST-1 showed high activity in the solvent-free cycloaddition of CO2 with epoxides under mild conditions. Furthermore, the catalyst can be easily separated from the reaction mixture, and the recycled catalyst maintained high performance for several cycles. The synergistic effect of the Lewis acid and base sites in IL/Fe3O4@HKUST-1 contributes to its greater reactivity than individual IL or HKUST-1.
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PubMed
高影响因子
FEBS Open Bio
·
2021
·Vol. 11
·期 8
·2118-2126
·
IF 2.693
Na Wei,Tan Lu,Libin Yang,Yonghan Dong,Xiaotan Liu
Ferroptosis is an iron-dependent programmed cell death, which participates in the pathogenesis of spinal cord injury (SCI). Our previous study has revealed that Lipoxin A4 (LXA4) exerts a protective role in SCI. Here, we investigated whether LXA4 can protect SCI through inhibiting neuronal ferroptosis. We treated primary spinal cord neurons with Erastin (ferroptosis activator) to induce ferroptosis. Erastin treatment reduced cell viability and enhanced cell death of primary spinal cord neurons, which was rescued by ferrostatin-1 (ferroptosis inhibitor). Moreover, Erastin repressed glutathione peroxidase 4 (GPX4) expression and the levels of glutathione and cysteine in primary spinal cord neurons. Erastin also enhanced the expression of ferroptosis biomarkers (PTGS2 and ACSL4) and the levels of reactive oxygen species (ROS) in primary spinal cord neurons. The influence conferred by Erastin was effectively abolished by LXA4 treatment. Furthermore, LXA4 enhanced the protein expression of p-AKT, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and haem-oxygenase-1 (HO-1) in primary spinal cord neurons. LXA4-mediated inhibition of ferroptosis of primary spinal cord neurons was prohibited by LY294002 (AKT inhibitor), brusatol (Nrf2 inhibitor) or zinc protoporphyrin (HO-1 inhibitor). In conclusion, this work demonstrated that LXA4 exerted a neuroprotective effect in Erastin-induced ferroptosis of primary spinal cord neurons by activating the Akt / Nrf2 / HO-1 signaling pathway. Thus, this work provides novel insights into the mechanisms of action of LXA4 in ferroptosis of primary spinal cord neurons and indicates that LXA4 may be a potential therapeutic agent for SCI.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2021
·
IF 2.694
Houchun Yan,Wenyang Fan,Shiwei Sun,Hongyue Guo,Yuanyuan Han,Qingsong Li
Liquid–liquid equilibrium (LLE) data for the ternary mixture of water + 2,2,3,3-tetrafluoro-1-propanol (TFP) + {1-pentanol or 2-ethyl-1-hexanol or n-propyl acetate or dichloromethane} was measured in 101.3 KPa and 303.2 K. The distribution coefficient and separation factor appraised utility for extracting TFP from water. The experimental LLE data were related by the nonrandom two liquid and universal quasichemical models for which the absolute average deviation and root means square deviation were no more than 0.0029 and 0.0035, respectively.
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ACS Omega
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2020
·
IF 2.87
Yumeng Yang,Dan Gao,Rui Qian,Yuyang Jiang
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using conventional organic matrices for detection of small molecules has some limitations, such as heterogeneous analyte/matrix co-crystals, as well as interference of matrices in the low-molecular-weight range. In this work, a zeolite framework nanomaterial, TS-1, was applied as a MALDI matrix for the analysis of small molecules by MALDI-MS for the first time. To improve the signal intensity and reproducibility, TS-1 was modified with polydopamine (TS-1@PDA). Using TS-1@PDA as a matrix, organic substances in the low-molecular-weight region such as amino acids, nucleosides, peptides, oligosaccharides, and fatty acids can be detected by MALDI-MS in positive ion mode. Compared with traditional organic matrices like 2,5-dihydroxybenzoic acid (2,5-DHB) and α-cyano-4-hydroxycinnamic acid (CHCA), TS-1@PDA has the advantages including the formation of uniform sample spots, small background interference at low molecular weight, and better salt tolerance. Furthermore, this matrix was employed for the analysis of endogenous glucose in urine samples, and the level of glucose was quantified with a linear range of 0–10 mM (R2 > 0.98). The results demonstrated that TS-1@PDA has the potential to be used as an effective MALDI matrix for the analysis of small molecules in biological samples with excellent reproducibility and moderate sensitivity.
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DYES AND PIGMENTS
·
2020
·
IF 4.613
Chunping Ma,Gaoyi Xie,Yangchun Tao,Hongni Zhu,Yi Zhang,Zhenguo Chi,Siwei Liu,Jiarui Xu
Three diblock copolymers ( PTPEE-PNns ) with controllable polymer structures were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, combining 1-ethenyl-4-(1,2,2-triphenylethenyl)-benzene (TPEE) and N-isopropylacrylamide (NIPAM). All PTPEE-PNns copolymers showed remarkable aggregation-induced emission (AIE) characteristic. Due to the amphiphilic structure of the copolymers, PTPEE-PNn micelles (mainly hollow) were prepared with either “precipitation” or “dialysis” method, respectively. Scanning electron microscopy, transmission electron microscopy , dynamic light scattering and fluorescence methodology were performed to investigate the morphology, size distribution and stability of the micelles, revealing the effects of molecular weight and micelle preparation method on the nanostructure of the micelles. The PTPEE-PN2 hollow micelles prepared by the “dialysis” method had the advantages of small particle size, extremely narrow particle size distribution , remarkable thermal sensitivity, excellent particle stability, and showed good biocompatibility and fluorescence emission capability in cell imaging . This work would inspire more approaches to prepare novel AIE-active, thermoresponsive and biocompatible polymers for biomedical application .
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Food & Function
·
2020
·Vol. 11
·期 12
·10852-10863
·
IF 4.171
Mingbao Gu,Jie Jin,Chenghao Ren,Ximiao Chen,Weiyang Gao,Xiangyang Wang,Yaosen Wu,Naifeng Tian,Zongyou Pan,Aimin Wu,Yifei Zhou,Xiaolei Zhang
As an ordinary joint vestigial disease, osteoarthritis (OA) contributes to a considerable proportion of disability cases worldwide. Inflammation, as the main pathological factor, mediates the occurrence and development of OA. Akebia Saponin D (ASD), also known as Asperosaponin VI, is one of the active components extracted from Dipsaci Radix and is rich in Dipsacus loose tea. It has shown sound therapeutic effects on various diseases; nevertheless, its role in OA therapy is not completely understood. This study demonstrated the anti-inflammatory activity of ASD in OA through a series of in vivo and in vitro experiments. In vitro experiments revealed that ASD might prohibit the production of inflammatory mediators in IL-1β treated chondrocytes such as COX-2, iNOS, NO, PGE2, IL-6, and TNF-α. Meanwhile, it may also inhibit the production of ADAMTS-5 and MMP13 and promote the production of Aggrecan and Collagen II. The mechanism study demonstrated that ASD exerted an anti-inflammatory effect by activating the NRF2 target, upregulating the expression of HO-1, and preventing P65 from binding to DNA. In vivo experiments demonstrated that ASD might improve the progression of OA in a DMM mouse model. These research results provide evidence for the potential application of ASD in OA therapy.
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JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Yutian Lei,Xiao Liu,Li Lu,Cuihua Liu,Rongrong Xu,Shengfeng Huang,Yuan Shen,Chunping Deng,Jinchen Yu,Tingting Zhang,Jacques Crommen,Qiqin Wang,Zhengjin Jiang
There is an urgent need for developing advanced purification techniques with the merits of low cost and satisfactory capacity in order to meet the challenges in the current downstream purification of monoclonal antibodies (mAbs). Herein, a simple and inexpensive nitrogen heterocycle molecule, 1-vinylimidazole (VIM), was proposed as the capture ligand of antibodies for the first time. The corresponding VIM-based non-affinity polymeric material (polyVIM) was then fabricated via a one-step polymerization for use in the highly selective purification of antibodies. Compared to the previously reported materials, this novel material exhibited many advantages without clearly sacrificing selectivity , such as a simpler and faster fabrication (within 1.5 h), comparable or even higher binding capacity (saturated static adsorption capacity > 190 mg/g polymer, dynamic binding capacity about 31.62 mg/g polymer), lower non-specific protein adsorption, and much lower cost. Notably, the polyVIM can effectively purify the antibodies from multiple biological sources with high purity (95.4% for mAbs in the cell culture medium, 93.3% for hIgG in the human serum), with an acceptable recovery (91.6% for mAbs, 77.0% for hIgG), and good reusability (> 10 times). Moreover, the target ELISA binding assay and NFAT-luc reporter gene assay demonstrated that the enriched antibodies can well maintain their binding activity and bioactivity during the whole purification process. The excellent performance of the polyVIM material may be attributed to the high recognition ability of VIM for antibodies, as well as the biocompatible and antifouling properties of the porous polymer . This study provides a promising alternative material for the purification of mAbs in downstream processes and the enrichment of hIgG in human serum.
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JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Meng Li,Yuanyong Ouyang,Wenzhong Yang,Yun Chen,Kegui Zhang,Zhaoshun Zuo,Xiaoshuang Yin,Ying Liu
This work tests the anti-corrosion ability of three imidazolium-based ionic liquids with different anions—bis(fluorosulfon)imide ([FSI] − ), bis(trifluoromethylsulfonyl)imide ([NTF 2 ] − ) and bis(pentafluoroethylsulfon)imide ([BETI] − )—on carbon steels in 1 M HCl solution at 298 K. Electrochemical impedance spectroscopy (EIS) indicated that increasing the number of –CF 2 groups in the anion vastly enhanced the corrosion-inhibition efficiency ( η ). Even at small concentrations (1.25 mM), [(OHC 2 )MIm][BETI] achieved an η of 86%. The polarisation curve verified that [(OHC 2 )MIm][BETI] acted as a mixed-type inhibitor and that its adsorption followed the EI-Away adsorption model. Scanning electron microscope (SEM) imaging intuitively confirmed the superior inhibition performance of [(OHC 2 )MIm][BETI]. X-ray photoelectron spectroscopy (XPS) showed that [(OHC 2 )MIm][BETI] was stably absorbed on the carbon-steel surface. Contact angle measurements indicated that adding the –CF 2 groups effectively decreased the hydrophilicity and surface energy of carbon steel from 69.39 to 19.93 mJ/m 2 , hindering the adsorption of water molecules. Moreover, a frontier molecular orbital theory (FMOT) study confirmed that the –CF 2 groups enhanced the donation and drawing of electrons, and molecular dynamics (MD) simulations revealed that they reduced the interaction energy (E interact ) values between the corrosion inhibitor molecule and the iron surface (from −321.08 to −612.74 kJ·mol −1 ). It was inferred that among the three ionic liquids, [(OHC 2 )MIm][BETI] absorbed most strongly to the carbon-steel surface.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2020
·
IF 2.627
Xiaoda Wang,Wenkai Li,Shiwei Wang,Qinglian Wang,Ling Li,Hongxing Wang,Ting Qiu
Producing 2-ethyl-1-hexyl thioglycolate (ETE) via esterification reaction with thioglycolic acid (TGA) aqueous solution as raw material by reactive-separation coupling technology is a promising process intensification method. To choose suitable reactive-separation coupling strategy, the kinetic studies of the esterification of TGA with 2-ethyl-1-hexanol (EHL) were carried out in a batch system. The commercial ion exchange resin was employed as an eco-friendly catalyst. The effects of temperature, catalyst concentration and molar ratio were determined. It was interesting to observe that the equilibrium conversion of TGA increased with the increase of catalyst mass fraction due to the adsorption of product water onto resin surface. The activity-based pseudo-homogeneous (PH), Eley-Rideal (ER) and Langmuir-Hinshelwood-Hougen-Watson (LHHW) models were used to fit the kinetics data of the resin-catalyzed reaction. The models of ER and LHHW performed better than the PH model. The kinetics of the TGA-self-catalyzed reaction was also determined. An activity-based homogeneous kinetics model could well describe this self-catalyzed reaction. These results would be meaningful to the selection and design of an appropriate reaction-separation strategy for the production of ETE, to realize the process intensification.
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