Food & Function
·
2025
·
IF 5.4
Mengzhen Jia,Xiaorui Wang,Fangjie Ning,Wenxiu Wang,Xinyu Hu,Kexin Geng,Junqing Wen,Shan Wu,Bin Wang,Zhigang Liu
Alzheimer's disease (AD) is mainly manifested by cognitive dysfunction, accompanied by excessive β-amyloid (Aβ) deposition and neuroinflammation. The regulation of vagus nerve (VN) signal transmission is crucial for influencing the pathological progression of AD and exploring new therapeutic approaches. Two doses of 2'-FL (500 &1000 mg/kg) were administered orally to AD model mice. The 2'-FL rescued spatial and recognition memory deficits in AD mice. Moreover, 2'-FL reduced Aβ deposition and neuroinflammation. The 2'-FL enhances c-Fos expression in the NTS. This suggested that 2'-FL alleviated AD related cognition by enhancing VN afferent activity. Vagotomy demonstrated that the alleviation of AD related cognition by 2'-FL depended on the presence of VN. Moreover, 2'-FL enhanced gut barrier function, alleviated gut inflammatory. Notably, 2'-FL also reshaped the gut microbiota composition, increasing the relative abundance of Intestinimonas, Muribaculum, and others. Moreover, 2'-FL promoted the production of SCFAs. Correlation analysis showed that propionate was highly correlated with other related indicators. After vagotomy, although 2'-FL promoted the SCFAs production, it didn't alleviate cognitive impairment. This suggested that the neuroprotective effect of SCFAs could also be partially dependent on the VN. 2'-FL rescued the cognitive deficits in AD mice, which was partly explained by changes in gut microbial composition, production of SCFAs, and the presence of VN.
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ACS Applied Energy Materials
·
2025
·
IF 5.5
Huanjun Su,Weili Shi,Yumeng Zhang,Ying Lin,Yani Liu
Mg3Sb2 Zintl compounds have emerged as promising thermoelectric materials due to their favorable electronic structures and low lattice thermal conductivity. However, strong carrier scattering, including ionized impurity and grain boundary scattering, suppresses mobility and limits the power factor. This study reveals that Zn doping plays a crucial role in tuning carrier scattering mechanisms in n-type Mg3(Sb,Bi)2. The substitution of Mg with Zn weakens ionized impurity scattering, facilitating charge transport and increasing carrier mobility from ∼72 to ∼135 cm2 V–1 s–1. As a result, a high power factor of ∼2089 μW m–1 K–2 is achieved at 573 K in Mg3.155Zn0.045Sb1.5Bi0.49Te0.01. Furthermore, Zn incorporation introduces localized lattice distortions and promotes the formation of high-density dislocations, which intensify phonon scattering and significantly suppress lattice thermal conductivity to ∼0.54 W m–1 K–1 at 773 K. These synergistic enhancements contribute to an optimized thermoelectric performance, yielding a peak ZT of 1.71 at 773 K and an average ZT of 1.21. The estimated conversion efficiency reaches 13% under a 470 K temperature gradient, highlighting Zn doping as an effective strategy for advancing Mg3(Sb,Bi)2-based thermoelectric materials toward high-temperature energy harvesting applications.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Mahmoud Mohamed Mohamed Ahmed,Chen Cheng,El-Sayed R.E. Hassan,Jiang Yu,Guangyi Liu
The flotation separation of galena from its ores with traditional xanthate collectors needs the high alkaline media maintained by lime which production releases CO 2. In this study, a novel collector, 5-heptyl-1,3,4-oxadiazole-2-thione (HPODT), was investigated in flotation separation of galena from pyrite under a moderate alkaline pulp without addition of lime. The micro-flotation results demonstrated that at pH ∼10.0, 6 × 10 −6 mol·L −1 HPODT and octyl xanthate sodium (OXS) floated out 99.3 % and 83.8 % galena, as well as 5.3 % and 75.6 % pyrite from their mixture, respectively, deducing the much better selectivity of HPODT for flotation separation of galena against pyrite than OXS. UV spectra exhibited that under pH ∼10.0, the adsorption amount of HPODT on galena was much bigger than that on pyrite, which supported their flotation and contact angle results. In situ AFM gave out clear evidences that HPODT formed self-assembled aggregates on galena surface. XPS confirmed that the exo -S and endo -N atoms of HPODT’s oxadiazole-thione group bonded with the Pb atom(s) on galena to deliver the Pb(II)-HPODT complexes. As a big conjugated configuration, the oxadiazole-thione group possessed the weak electron-donating and strong electron-accepting ability through electron delocalization effect, which improved the selective affinity of HPODT towards Pb(II) on galena against Fe(III)/Fe(II) on pyrite.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Jia Fang,Jun Li,Long Gao,Xiwang Jiang,Jingwen Zhang,Aihua Xu,Xiaoxia Li
The octahedral molecular sieve manganese oxide (OMS-2) and graphite (Gt) composites (OMS-2/Gt) were prepared by a facile refluxing approach. The structure and morphology of the obtained materials were systematically investigated. The results reveal that OMS-2 nanofibers are uniformly dispersed on the surface of Gt, and the ratio of Mn 3+ species in OMS-2 increases lineally with the increase of Gt dosage. The catalytic activity of OMS-2/Gt was evaluated by the degradation of Acid Orange 7 (AO7) in the presence of peroxymonosulfate (PMS). It is found that the OMS-2/Gt composites show enhanced catalytic performance with the degradation rate lineally correlated with the content of OMS-2 in the catalyst, and even with the ratio of Mn 3+ /Mn 4+ . XPS and radical scavenger experiments further indicated that the oxidation of Mn 3+ by PMS system occurs in the system with the formation of hydroxyl radicals contributed to the dye degradation . The catalysts also exhibit good stability and reusability during consecutive cycles. Thus, the environmental friendly OMS-2/Gt composites with low cost, facile synthesis process and high efficiency are very promising catalysts for PMS activation and pollutants degradation.
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
·
2025
·
IF 4.7
Qianying Shen,Yue-Yue Zhou,Yan-Lin Wang,Yao Qi,Dong-Bo Lian,Zhe-Hong Li,Meng-Fei Chen,Xiao-Li Zhang,Yue Zhang,Jin Song,Li-Fei Zheng,Jin-Xia Zhu
Long-term infection with Helicobacter pylori (H. pylori) leads to elevated serum gastrin levels, which are closely related to gastric cancer. Eradication of H. pylori to treat the high gastrin levels is increasingly challenged by antibiotic resistance. Dopamine (DA) receptor 1 (D1R) is expressed on G cells in the gastric antrum. Parietal cells produce DA, which inhibits somatostatin (SOM) release through D2R on D cells in the gastric mucosa. Whether targeted intervention in DRs can improve high gastrin levels after H. pylori infection remains to be explored. In this study, human gastric tissue, H. pylori-infected mice, D1R and D2R knockout mice, RT‒qPCR, ELISA, IHC, Western Blot, HE staining and ex vivo incubation of gastric mucosae were used. We found that H. pylori infection destroyed the mitochondria of parietal cells and reduced DA content in the gastric mucosa at 10 weeks after infection. Moreover, gastrin-positive cell numbers and serum gastrin levels were increased. D1R, but not D2R, was observed in G cells. DA promoted gastric gastrin secretion. Interestingly, both D1- and D2-like agonists mimicked the effect of DA on the gastrin secretion, which was antagonized by their antagonists. Blocking D2R with domperidone or knocking out D2R resulted in decreased gastrin-positive cell numbers and gastrin levels but increased SOM levels at 10 weeks after H. pylori infection. Our findings highlight the key regulatory effect of D2R on gastrin secretion and elucidate the role of domperidone in reducing the elevated gastrin level associated with H. pylori infection.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Bin Zhang,Xiaodong Guo,Xin Feng,Xiaoxia Duan,Guilong Wang,Chao Yang
The debenzylation reaction of hexabenzylhexaazaisowurtzitane (HBIW) and 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADBIW) to synthesize 2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazaisowurtzitane (TAIW) is the major challenge in the production of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (HNIW). This is primarily attributed to the reaction needing a lot of palladium catalysts, which tend to deactivate rapidly during the process. In this work, a series of Pd(OH)2/C catalysts were successfully prepared through a convenient deposition-precipitation method by controlling the flow rate of the PdCl2 solution. Employing the 10% Pd(OH)2/C–F0.5 sample, the debenzylation reaction was successfully completed with a lower usage of Pd and shorter time of reaction. For the HBIW debenzylation reaction, the yield of TADBIW was 87.4% at low temperature (25 °C) when 1‰ Pd/HBIW was used, and the higher yield was 89.8% at high temperature (45 °C) when 3‰ Pd/HBIW was used. The TADBIW/Pd/h values of them were 42.5 and 95.7, respectively. For the TADBIW debenzylation reaction, the complete conversion of the reactant was realized when Pd/TADBIW was 2‰. The value of TAIW/Pd/h was 154.6 when Pd/TADBIW was 4‰, which was higher than the reports. Compared to the reported catalysts, the dosage of Pd used in the debenzylation reactions of HBIW and TADBIW was significantly decreased. Furthermore, the 10% Pd(OH)2/C–F0.5 sample was recycled six times with similar performance, demonstrating excellent stability. Based on the analysis of characterization results, it is effortless to find that the flow rate of the PdCl2 solution plays a key role in controlling the adsorption behavior of palladium species on activated carbon. The lower flow rate is beneficial to obtaining Pd nanoparticles with a smaller size, a higher proportion of Pd2+, and a higher metal distribution. This study may provide a simple way to develop palladium catalysts with high performance for related applications.
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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2024
·Vol. 41
·期 1
·1-14
·
IF 4
Tan Xiaoli,Jiang Xiaobing,Chen Xiumei,Reymick Okwong Oketch,Zhu Chen,Tao Nengguo
Neofusicoccum parvum is one of the most hazardous pathogens causing mango fruit decay. The present study utilized trans -2-hexenal (TH), a typical antifungal component of plant essential oils (EOs), to control N. parvum both in vivo and in vitro, and attempted to explore the mechanisms involved. The findings showed that at concentrations greater than 0.4 µL/mL, TH exhibited exceptional antifungal activity against N. parvum in vitro. TH application led to the disruption of the structural integrity of both cell walls and cell membranes, with a particular impact on the latter, as evidenced by the dramatically increased propidium iodide level, as well as reduced total lipids and ergosterol content. Further DCFH-DA staining experiments showed that TH induced mycelial reactive oxygen species (ROS) accumulation, which exacerbated cell membrane lipid peroxidation. For easier application of TH, we fabricated aerogel-loaded TH (ALTH) materials, which demonstrated excellent antifungal activity in vitro. Infestation studies on fruits demonstrated that ALTH mitigated mango stem-end rot in a dose-dependent fashion, with a concentration of 40 µL/L showing efficacy comparable to the conventional fungicide prochloraz, while maintaining fruit quality. In light of these results, TH works by inducing ROS buildup and oxidative damage to the cell membrane of N. parvum , and is a particularly promising preservative for preventing postharvest infections in mangoes.
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Molecular Catalysis
·
2024
·
IF 3.9
Yuqing Wang,Miao Jiang,Tian Tian,Zhao Sun,Gangqiang Wu,Yanming Wang,Xiaohui Guo,Wenxiu He,Jian Ding,Li Yan,Yunjie Ding
The development of earth-abundant catalysts with high activity and selectivity is important yet challenging in hydroformylation. In this work, a stable and efficient phosphine-oxide group containing porous organic polymer was afforded, which served as a ligand and a support to fabricate a heterogeneous Co catalyst (Co/POL-POPh 3 ) for hydroformylation of 2-octene under mild condition. A 2-octene conversion of 94.6 % and at least three recycles were achieved using Co/POL-POPh 3 in the hydroformylation with a 51.1 % aldehyde selectivity under 423 K and 3.0 MPa. The experimental and characterization results elucidated that the highly dispersed Co ions was coordinated with the phosphine-oxide groups in the polymer, which was beneficial for the 2-octene isomerization and in turn led to the excellent performance for synthesis of oxygenates. Furthermore, a reaction mechanism was also suggested for 2-octene hydroformylation over the Co/POL-POPh 3 catalyst. The current study delivers valuable insights into the adjustment of the catalytic efficiency of non-previous metal catalysts in the heterogeneous hydroformylation of internal olefins.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2025
·Vol. 29
·期 16
·e70800
·
IF 4.2
Xiangling Yi,Liming Wang,Xiao-yue Wang,Yu Fang,Jiarui Liu,Kehong Chen,Ya-ni He,Jia Chen
Renal recovery following acute kidney injury (AKI) is a key determinant of long-term prognosis, while non-recovery significantly increases the risk of chronic kidney disease and progression to end-stage renal disease. Although cell cycle arrest is implicated in renal non-recovery and fibrosis, its association with decoy receptor 2 (DcR2) remains unclear. In this study, we evaluated 139 patients with biopsy-confirmed AKI, defining renal non-recovery as a ≥ 50% increase in baseline serum creatinine (Cr) or the initiation of dialysis. Patients were divided into recovery ( n = 79) and non-recovery ( n = 60) groups. Urinary DcR2/creatinine (uDcR2/Cr) levels were significantly higher in non-recovery cases, with an area under the curve of 0.733 and a diagnostic cut-off of 378 ng/gCr. Elevated uDcR2/Cr predicted poor renal survival and was independently correlated with non-recovery. In mouse models of ischemia–reperfusion-induced AKI, increased urinary and tubular DcR2 levels were also associated with impaired recovery. Proteomics analysis revealed GSK3b enrichment in cell cycle pathways. Functional studies showed that DcR2 mediated cell cycle arrest through GSK3b/cyclin D1 signalling. In conclusion, DcR2 functions as a biomarker of cell cycle arrest and renal recovery, offering both diagnostic and mechanistic insights, and may serve as a potential therapeutic target in AKI.
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Food Frontiers
·
2025
·
IF 6.9
Xiaoli Qin,Yan Lu,Yawen Luo,Yafang Cui,Kai Zhao,Yang He,Muhammad Aziz ur Rahman,Shengnan Min,Wenfang Wang,Fuyu Yang,Binghai Cao,Huawei Su
Alfalfa is rich in flavonoid compounds, which are known for their antioxidative and anti-inflammatory properties, suggesting therapeutic potential for alfalfa flavonoids (AF) in inflammation-related diseases. This study investigated the effects of AF on Salmonella -induced colitis, a severe inflammatory bowel disorder characterized by oxidative damage and inflammatory response. In vitro, antioxidant assays revealed AF's concentration-dependent radical scavenging, significantly reducing electron paramagnetic resonance (EPR) signals for HO • and O 2 •− by 42% and 54%, respectively. In vivo, AF treatment significantly mitigated body weight (BW) loss by 6%, increased colon length by 11%, and reduced liver and spleen weights by 19% and 81%, respectively, compared to the colitis group. Mechanistically, AF suppressed inflammation by downregulating the Toll-like receptor 4 (TLR4)/IκB/nuclear factor-κB (NF-κB)/cyclooxygenase-2 (COX-2) pathway and inhibiting nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation, thereby lowering levels of pro-inflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin 6 [IL-6], interleukin 1 beta [IL-1β]). Concurrently, AF enhanced antioxidant defense via the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while increasing catalase (CAT) (69%), glutathione peroxidase (GPx) (83%), and superoxide dismutase (SOD) (21%) activities. Moreover, AF preserved epithelial and mucosal barriers by reducing apoptosis and upregulating tight junction proteins (Claudin1, ZO-1, E-cadherin) and goblet cell marker Ulex europaeus (Gorse) Agglutinin I (UEA-1). Microbiota analysis revealed that AF significantly enriched beneficial bacteria, including Akkermansia , Oscillibacter , and butyrate-producing taxa, thereby counteracting Salmonella -induced dysbiosis. Furthermore, AF restored the disrupted profile of short-chain fatty acids (SCFAs), strengthening the relationship between symbiotic microbiota and mucosal defense. Overall, AF exerted multifaced protection against Salmonella -induced colitis by alleviating oxidative stress, stabilizing intestinal homeostasis, and thus attenuating inflammation. These findings make AF a promising phytopharmaceutical for the prevention and treatment of inflammatory diseases.
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BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Lixin Niu,Yun He,Xing Zhang,Yanfei Peng,Ding Wang,Tao Wang,Zunting Zhang
A concise and efficient photo-induced rearrangement and oxidation of 2-(3-methylbenzofuran-2-yl)-3-phenyl-1 H -indoles 1 for the synthesis of 5-(2-hydroxyphenyl)-5-methyl-5,7-dihydro-6 H -benzocarbazol-6-ones 2 is described. Irradiation of compounds 1 in anhydrous dichloromethane solution, using 313 nm UV light in an air atmosphere, resulted in the formation of compounds 2 with yields ranging from 55% to 98%. Using the 6π-electrocyclization strategy of compounds 1 containing a methyl, a quaternary carbon stereocenter was introduced in the compounds 2 . The carbonyl group of compounds 2 was formed by the photo-induced oxidation of C-H bond to C-OH and hemiketal-keto tautomerization. Additionally, the antitumor activities of compounds 2 were evaluated and found to demonstrate equivalent or superior activity compared to Cisplatin against various tumor cell lines, including leukemia HL-60, lung cancer A549, liver cancer HepG2, breast cancer MDA-MB-231 and colon cancer SW480. The anticancer activity of compound 2f was particularly significant, with IC 50 values of 2.99, 9.06, 6.81, 9.29, and 14.93 μM respectively, and its IC 50 value of normal cells 11.18 μM. Compound 2k had a relatively high IC 50 values against cancer cells, whereas its IC 50 value greater than 40μM for normal cells.
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Korean Journal of Materials Research
·
2025
·Vol. 35
·期 7
·266-276
·
IF 0.3
Yao Liu,Yilei Sun,Haixia Wang,Zeda Meng,Won-Chun Oh
Sodium-ion batteries (SIBs) offer a viable alternative to partially or fully replace lithium ion batteries (LIBs) due to their lower cost and increased safety. This paper outlines the compositional optimizations, crystallographic evaluations, and electrochemical behavior of a novel mixed NASICON polyanionic compound, NaFe2PO4(SO4)2 (NFPS). X-ray photoelectron spectrometry (XPS) results showed that cobalt doping produces a higher concentration of oxygen defects compared to undoped samples. Scanning electron microscopy (SEM) analysis results revealed that the modified sample has more uniform pores and pore distribution. Brunauer-Emmett-Teller (BET) measurements showed that doping of Co2+ reduces the specific surface area of NFPS-Co0.08 compared to NFPS. This shortens the sodium ion diffusion pathway and promotes ion dynamics. The addition of Co2+ to the sample significantly improved its performance during galvanostatic charge-discharge tests. The electrochemical activity also is significantly enhanced by Co2+ doping. Na0.84Co0.08Fe2PO4(SO4)2 exhibits superior rate and cycling performance compared to pristine NFPS. After 80 cycles at 25 mA g-1, NFPS-Co0.08 retained discharge specific capacity of 60.8 mA h g-1, which is 1.24 times greater than that of NFPS.
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