MACROMOLECULES
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2012
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IF 5.167
Aiguo Sui,Xincui Shi,Shupeng Wu,Hongkun Tian,Yanhou Geng,Fosong Wang
A new catalyst system, i.e., nickel acetylacetonate/1,3-bis(diphenylphosphino)propane (Ni(acac)2/dppp), was explored to catalyze the Kumada catalyst transfer polycondensation (KCTP) of three fluorene monomers with different substituents at 9-position. The “living” nature of the polymerization was confirmed by polymerization kinetic studies, “monomer addition” experiment and block copolymerizations. As a result, poly(9,9-dioctylfluorene)s (PF8s) with the number-average molecular weights (Mns) in the range 2.8–62.2 kDa and polydispersity indices (PDIs) of ∼1.20 were successfully synthesized in a controlled manner. The syntheses of fluorene-fluorene and fluorene-thiophene diblock copolymers with Mns up to 46 kDa were also demonstrated. A complex, i.e. Ni(dppp)(acac)2, with an octahedral coordination geometry was isolated and confirmed by X-ray crystallographic analysis. The polymerization experiments indicated that the in situ formed Ni(dppp)(acac)2 should be the active catalyst. To the best of our knowledge, this is the first report on the controlled synthesis of polyfluorenes (PFs) via KCTP.
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ORGANOMETALLICS
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2016
·
IF 4.186
Wenlong Luo,Antai Li,Shaofeng Liu,Hongqi Ye,Zhibo Li
A series of chromium(III) complexes, LCrCl3 (Cr1–Cr4: L = 2-(N-R2-benzimidazol-2-yl)-6-(3,5-R1-pyrazol-1-yl)pyridine; Cr1: R1 = H, R2 = H; Cr2: R1 = Me, R2 = H; Cr3: R1 = Me, R2 = Me; Cr4: R1 = Me, R2 = Bn), were synthesized and characterized by IR spectroscopy and elemental analysis. The studies of the solid state of Cr2 and Cr3 revealed distorted octahedral geometries around the chromium centers by X-ray diffractions. In the presence of MAO, Cr1–Cr4 exhibited high activities toward ethylene oligomerization (up to 2.17 × 106 g·mol–1(Cr)·h–1) and ethylene polymerization (up to 6.78 × 105 g·mol–1(Cr)·h–1). The oligomers were produced with high selectivity for α-olefins (>99%), confirmed by FT-IR and 13C NMR, and the distributions followed the Schulz–Flory equation. Various reaction parameters including the amount of cocatalyst, reaction temperature, and time were evaluated in detail, and it was evident that the title complexes had good thermal stability and the substituents on imidazole-N of the ligands dramatically impacted the catalytic activities as well as the distribution of the products.
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CARBON
·
2022
·
IF 11.307
Zhe Zou,Mingqiang Ning,Zhenkuang Lei,Xueheng Zhuang,Guoguo Tan,Jianhua Hou,Hui Xu,Qikui Man,Jingbo Li,Run-Wei Li
Ti 3 C 2 T x is considered a candidate for high-efficiency microwave absorption materials due to its adjustable electrical conductivity , low density and high specific surface area in recent years. However, the single absorption mechanism could not meet the practical requirements as the functional microwave absorbers. Herein, 0D/1D/2D architectures of Co@C/MXene with 0D Co nanoparticles , 1D carbon nanotubes (CNTs) and 2D Ti 3 C 2 T x MXene nanosheets were rationally fabricated to enhance the microwave attenuation performance, in which Co@CNTs were in situ grown on Ti 3 C 2 T x MXene nanosheets . By changing the amount of Ti 3 C 2 T x MXene to optimize the impedance matching properties, the Co@C/M − 10 absorber exhibits excellent microwave attenuation performance with a minimum reflection loss of −50.5 dB at 5.9 GHz under a thickness of 4.0 mm. Meanwhile, the maximum effective absorption bandwidth (<−10 dB) of Co@C/M − 10 absorber can reach 5.8 GHz under 2.0 mm. The remarkable absorption performance can be ascribed to the synergistic effects of interface polarizations and magnetic loss. Moreover, the radar cross section (RCS) simulation was also performed via CST. Under the incident angle of 0°, the RCS reduction value of Co@C/M − 10 can reach 33.5 dBm 2 . This work provides a strategy for synthesizing MXene-based composite materials with tunable electromagnetic attenuation and wide absorption bandwidth performance .
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CRYSTENGCOMM
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2023
·Vol. 25
·期 36
·5085-5091
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IF 3.1
Zhi-Yuan Yue,Rong-Meng Liao,Wang Luo,Na Wang,Le-Ping Miao,Heng-Yun Ye,Chao Shi
Organic–inorganic hybrid molecular ferroelectrics have attracted broad attention in the field of research of ferroelectric materials. Following the surge of stable candidates, hybrid bimetal molecular-based materials have been recently explored to achieve excellent ferroelectricity. However, rare hybrid bimetal molecular ferroelectrics were reported. Inspired by “ferroelectrochemistry”, a chiral nitrite-based hybrid bimetal molecular ferroelectric material, [(R)-3-quinuclidinol]2[LiCo(NO2)6] (1), was reported. The ferroelectric-paraelectric phase transition (C2 ↔ P321) behaviour of 1; was found at 343 K (Curie temperature, Tc) with a spontaneous electronic polarization (Ps) of 0.52 μC cm−2 and a coercive field (Ec) of 48 kV cm−1 at 298 K. Various-temperature single crystal structural analysis and dielectric constant measurements reveal that the rapid rotation of the organic cation and slight order–disorder transition of the NO2− anion are the origin of the ferroelectricity. To our knowledge, 1 is the first example of a nitrite-based hybrid bimetal molecular ferroelectric material that is triggered by an external electric field. This finding establishes a clear stimulus–structure–response relationship in advanced hybrid ferroelectric materials.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
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IF 2.323
Gaoyin He,Liping Wang,Midong Shi,Qingsong Li,Yunfang Wang
This work reveals experimental liquid–liquid equilibria (LLE) for ternary systems of (2-methoxyethanol + water + solvents) with methyl tert-butyl ether, ethyl acetate, and trichloromethane at 313.15 K and dichloromethane as solvent at 298.15 K under 101 kPa. The extraction capacity of the aforementioned solvents has been tested when it comes to the distribution ratio and separation factor according to the experimental data. The calculation results demonstrate that trichloromethane is an available solvent for extraction applications. Simultaneously, the reliability of the experimental LLE data was checked by Othmer–Tobias and Hand correlations, and all of the linear correlation coefficients were greater than 0.98. The experimental LLE values were regressed to obtain binary interaction parameters with both NRTL and UNIQUAC activity coefficient models. Both models shows satisfactory agreement with all of the root-mean square deviation values below 0.50.
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ChemistrySelect
·
2023
·Vol. 8
·期 40
·e202303078
·
IF 2.1
Yixin Tong,E. Mi,Li Zhou,Xiabin Wang,Biao Xiong
Graphical The synthesis of 2-acylindoles from sulfoxonium ylides with o-aminoaryl aldehydes via iridium-catalyzed N−H insertion and intramolecular condensation has been demonstrated. 2-Acylindoles possess widespread applications in functional chemicals. However, the convenient and selective synthesis of such important substructures has to date remained a challenge. Herein, a method to achieve 2-acylindoles from sulfoxonium ylides with o-aminoaryl aldehydes catalysed by Iridium has been developed with the merits of broad substrate scope, good functional tolerance, high efficiency and operational simplicity, which provides an alternative way to access functionalized indoles.
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RSC Advances
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2014
·Vol. 4
·期 45
·23853-23860
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IF 3.708
Pranav K. Tripathi,Mingxian Liu,Lihua Gan
Synthesis of carbon materials with enhanced surface areas, and regular and tuned pore diameters is always a great challenge. In this report, ordered mesoporous carbons (OMCs) were synthesized by the one-step assembly of tri-constituents, and the OMCs were applied as an adsorbent for the removal of the highly hazardous water pollutant di(2-ethylhexyl)phthalate (DEHP). Phloroglucinol–formaldehyde based carbon precursor was in situ prepared during the assembly of the tri-constituents, and the surface area and mesopore diameter of the OMCs were tuned by variation of the molar ratio of formaldehyde to phloroglucinol. Small angle X-ray diffraction patterns revealed that the obtained carbons are highly ordered, which is in agreement with the measuring results of transmission electron microscopy at low and high resolution. Scanning electron microscopy images demonstrate that OMC-F2.0 has a hierarchical morphology. Nitrogen adsorption–desorption measurements revealed that the surface area of the OMCs (956–1801 m2 g−1) was dependent on the molar ratio of the carbon precursor constituents (formaldehyde to phloroglucinol). By varying the molar ratio of formaldehyde to phloroglucinol from 1.0 to 4.0, the mesopore diameter of the OMCs was shifted to the higher side, from 2.1 to 3.1 nm. DEHP was efficiently removed from a model water pollutant by the OMCs. OMC-F2.0 achieved the highest adsorption capacity of 364 mg g−1 for the removal of DEHP. The adsorption equilibrium data were treated with the two mathematical models of Langmuir and Freundlich, and the results revealed that decontamination was more favorable with the Langmuir model. This concludes that the removal of DEHP by OMCs depends on the surface area, and the DEHP molecules occupied the porous space of the OMCs in a monolayer manner.
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Food Frontiers
·
2025
·
IF 6.9
Xiaoli Qin,Yan Lu,Yawen Luo,Yafang Cui,Kai Zhao,Yang He,Muhammad Aziz ur Rahman,Shengnan Min,Wenfang Wang,Fuyu Yang,Binghai Cao,Huawei Su
Alfalfa is rich in flavonoid compounds, which are known for their antioxidative and anti-inflammatory properties, suggesting therapeutic potential for alfalfa flavonoids (AF) in inflammation-related diseases. This study investigated the effects of AF on Salmonella -induced colitis, a severe inflammatory bowel disorder characterized by oxidative damage and inflammatory response. In vitro, antioxidant assays revealed AF's concentration-dependent radical scavenging, significantly reducing electron paramagnetic resonance (EPR) signals for HO • and O 2 •− by 42% and 54%, respectively. In vivo, AF treatment significantly mitigated body weight (BW) loss by 6%, increased colon length by 11%, and reduced liver and spleen weights by 19% and 81%, respectively, compared to the colitis group. Mechanistically, AF suppressed inflammation by downregulating the Toll-like receptor 4 (TLR4)/IκB/nuclear factor-κB (NF-κB)/cyclooxygenase-2 (COX-2) pathway and inhibiting nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation, thereby lowering levels of pro-inflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin 6 [IL-6], interleukin 1 beta [IL-1β]). Concurrently, AF enhanced antioxidant defense via the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while increasing catalase (CAT) (69%), glutathione peroxidase (GPx) (83%), and superoxide dismutase (SOD) (21%) activities. Moreover, AF preserved epithelial and mucosal barriers by reducing apoptosis and upregulating tight junction proteins (Claudin1, ZO-1, E-cadherin) and goblet cell marker Ulex europaeus (Gorse) Agglutinin I (UEA-1). Microbiota analysis revealed that AF significantly enriched beneficial bacteria, including Akkermansia , Oscillibacter , and butyrate-producing taxa, thereby counteracting Salmonella -induced dysbiosis. Furthermore, AF restored the disrupted profile of short-chain fatty acids (SCFAs), strengthening the relationship between symbiotic microbiota and mucosal defense. Overall, AF exerted multifaced protection against Salmonella -induced colitis by alleviating oxidative stress, stabilizing intestinal homeostasis, and thus attenuating inflammation. These findings make AF a promising phytopharmaceutical for the prevention and treatment of inflammatory diseases.
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ORGANIC & BIOMOLECULAR CHEMISTRY
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2025
·
IF 2.7
Fei Yuan,Yiyuan Xin,Caifeng Yuan,Zhuo Chen,Tongling Qin,Wenxia Hu,Jiahuan Duan,E Tang
A simple, exogenous-base-free, and NBS-mediated C-selenocyanation/cyclization reaction of enaminones with KSeCN under mild conditions, providing a facile route to 2-aminoselenazole products, has been developed. This efficient protocol is postulated to first undergo the NBS-oxidated polarity reversal of the reactive SeCN- anion to form N-selenocyanosuccinimide as an electrophilic selenium source, which can induce the C-selenocyanation of enaminones and enamino esters, followed by a nucleophilic cyclization promoted by in-situ yielded HBr.
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PubMed
高影响因子
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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2025
·Vol. 29
·期 16
·e70800
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IF 4.2
Xiangling Yi,Liming Wang,Xiao-yue Wang,Yu Fang,Jiarui Liu,Kehong Chen,Ya-ni He,Jia Chen
Renal recovery following acute kidney injury (AKI) is a key determinant of long-term prognosis, while non-recovery significantly increases the risk of chronic kidney disease and progression to end-stage renal disease. Although cell cycle arrest is implicated in renal non-recovery and fibrosis, its association with decoy receptor 2 (DcR2) remains unclear. In this study, we evaluated 139 patients with biopsy-confirmed AKI, defining renal non-recovery as a ≥ 50% increase in baseline serum creatinine (Cr) or the initiation of dialysis. Patients were divided into recovery ( n = 79) and non-recovery ( n = 60) groups. Urinary DcR2/creatinine (uDcR2/Cr) levels were significantly higher in non-recovery cases, with an area under the curve of 0.733 and a diagnostic cut-off of 378 ng/gCr. Elevated uDcR2/Cr predicted poor renal survival and was independently correlated with non-recovery. In mouse models of ischemia–reperfusion-induced AKI, increased urinary and tubular DcR2 levels were also associated with impaired recovery. Proteomics analysis revealed GSK3b enrichment in cell cycle pathways. Functional studies showed that DcR2 mediated cell cycle arrest through GSK3b/cyclin D1 signalling. In conclusion, DcR2 functions as a biomarker of cell cycle arrest and renal recovery, offering both diagnostic and mechanistic insights, and may serve as a potential therapeutic target in AKI.
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PubMed
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2025
·
IF 3.4
Yan Jiang,Jiayu Zhou,Shusen Fang,Yufei Liu,Yueting Shao,Yiguo Jiang
Smoking, a pivotal environmental risk factor, drives diseases including lung cancer through genetic and epigenetic alterations. While 2-Naphthylamine (2-NA), a tobacco-derived carcinogen, is established as a bladder carcinogen via DNA damage, its role in lung carcinogenesis remains mechanistically uncharacterized despite epidemiological associations. This study identifies bronchial epithelium as a direct target of 2-NA, demonstrating dose-dependent DNA damage in 16HBE cells (peak at 250 μM, 12 h; P < 0.05), accompanied by S-phase arrest, apoptosis, reduced proliferation, and reactive oxygen species (ROS) generation. 2-NA exposure upregulated the expression of circSHOC1, which is a circular RNA derived from the SHOC1 gene, in a dose-dependent manner. Functional assays revealed that circSHOC1 overexpression exacerbated 2-NA-induced DNA damage by enhancing ROS production and 8-hydroxy-2′-deoxyguanosine (8-OHdG) accumulation, whereas knockdown attenuated these effects. Mechanistically, circSHOC1 interacted with mitochondrial protein SLC25A3 (Solute Carrier Family 25 Member 3), a key oxidative stress regulator; SLC25A3 knockdown mitigated DNA damage ( P < 0.01), and co-transfection experiments confirmed SLC25A3 as a critical mediator of circSHOC1-driven genotoxicity. Collectively, this work provides the first experimental evidence that 2-NA induces bronchial epithelial DNA damage via a circSHOC1-SLC25A3-ROS axis, supporting a novel mechanism for tobacco-associated lung carcinogenesis and highlighting 2-NA as a potential pulmonary carcinogen.
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PubMed
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Eco-Environment & Health
·
2026
·
IF 13.4
Kongdong Li,Yichao Zhang,Yingying Zhan,Rongtian Zhang,Ziting Zhao,Kezhuang Chen,Hong Shen,Quanyi Wang,Chang Liu,Wenxiang Zhang,Siyu Chen
DBP-orchestrated liver transcriptional targets are largely associated with HCC. • DBP stabilizes hepatocyte-derived LCN2 to activate cancer cell proliferation. • 24p3R-MMP-9 axis is involved in such a LCN2-triggered cancer cell activation. • Stable DBP-LCN2 complex formation prevents ubiquitin-mediated degradation of LCN2. Dibutyl phthalate (DBP) is a ubiquitous environmental contaminant whose exposure is positively associated with the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the underlying mechanisms by which DBP promotes MASLD progression remain unclear. In this study, high-throughput RNA sequencing revealed that the DBP-orchestrated liver transcriptome is enriched in target clusters associated with hepatocellular carcinoma (HCC), an advanced complication of MASLD. DBP promotes HCC progression in murine models but does not directly affect HCC cell proliferation, indicating that hepatocytes may be the primary target cells for DBP signaling. To identify a molecular target in hepatocytes that transduces DBP signals to HCC cells, we performed label-free proteomic analyses, molecular docking, and the Cancer Genome Atlas (TCGA) database analyses, which identified hepatocyte-derived lipocalin-2 (LCN2) as a candidate target of DBP. Elevated LCN2 expression is negatively associated with overall survival in HCC patients. Inhibition of LCN2 partially attenuates the tumor-promoting effect of DBP-treated hepatocytes on HCC cells. Mechanistically, molecular docking and molecular dynamics simulations demonstrate that DBP directly binds to LCN2 to form a stable complex, which disrupts ubiquitin-proteasome-mediated degradation of LCN2 and thereby enhances its protein stability. Functionally, hepatocyte-derived LCN2 promotes HCC cell proliferation through activation of the 24p3R–matrix metalloproteinase-9 (MMP-9) signaling axis. Our findings demonstrate that DBP acts as a progression promoter in pre-existing HCC via hepatocyte LCN2 stabilization, rather than an initiator of hepatocarcinogenesis. This mechanistic insight addresses a critical gap in understanding how environmental toxicants modulate established HCC progression, complementing epidemiological associations between phthalates and liver disease. Download: Download high-res image (228KB) Download: Download full-size image
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