MATERIALS CHEMISTRY AND PHYSICS
·
2026
·
IF 5.2
Rawiyah Alkahtani,Ahmad Iqbal,M.S. Al-Buriahi,Muhammad Ali Hamza Shahbaz,Amir Muhammad Afzal,Nora Mobark Farhan,Sohail Mumtaz,Abhinav Kumar
A MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO was successfully synthesized through hydrothermal and modified Hummers' methods. • The integration of porous MIL-53(Al) and conductive rGO enhanced charge transport and electroactive site accessibility. • The MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO electrode delivered a high specific capacity of 1189.23C g −1 . • The hybrid SC achieved an energy density of 45 Wh kg −1 and a power density of 2773 W kg −1 . • The ternary electrode showed a low overpotential of 46 mV and a Tafel slope of 49 mV dec −1 . The rising requirement of sustainable and multifunctional electrodes for energy storage and production has stimulated significant interest in advanced electrode architectures. In this study, a MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO composite was fabricated by means of combined hydrothermal and modified Hummers approach. The composite was rationally designed by integrating the MIL-53(Al), the favorable ionic transport characteristics of NASICON-type KTi 2 (PO 4 ) 3 , and the highly conductive network of rGO, there by promoting efficient charge and ion transport. Electrochemical evaluation in a three-electrode cell demonstrated a high specific capacity of 1189.23C g −1 . When assembled into a two-electrode supercapacitor device, the material delivered an energy density of 45 Wh kg −1 at a power density of 2773 W kg −1 . The device also maintained 92% of its initial capacity with a Coulombic efficiency of 97% after 10,000 consecutive charge–discharge cycles, indicating strong electrochemical durability. In addition to its energy storage performance, the MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO electrode demonstrated promising catalytic activity for the hydrogen evolution reaction, requiring only 46 mV overpotential to achieve the targeted current density and exhibiting a Tafel slope of 49 mV dec −1 . These results highlight the synergistic contribution of the MOF, NASICON phosphate, and rGO components and establish MIL-53(Al)@KTi 2 (PO 4 ) 3 @rGO as a promising multifunctional platform for advanced supercapacitor systems and electrocatalytic hydrogen production.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Haichao Zhang,Fei Yao,Zhihong Lyu,Keqin Xie,Rui Ge,Xinru Zhao,Guocheng Wang,Zijin Yang,Hanxiao Zhang,Boyan Li,Yumei Qin,Jianzhong Han,Yanpei Gu
Structurally distinct human milk oligosaccharides differentially regulate intestinal epithelial homeostasis in aged mice. • 3′-Sialyllactose and lacto- N -neotetraose exhibit superior effects on intestinal barrier function and intestinal stem cell function. • Gut microbiota is required for the beneficial effects of human milk oligosaccharides on intestinal epithelial homeostasis in aged mice. Intestinal epithelial homeostasis undergoes progressive functional decline during aging and contributes to systemic age-related dysfunction. Human milk oligosaccharides (HMOs) have well-documented prebiotic and immunomodulatory properties; however, their effects on the aging gut and functional differences among distinct structures remain largely unexplored. Here, we show that structurally distinct HMOs differentially regulate intestinal epithelial homeostasis in naturally aged male mice, with 3′-sialyllactose (3′-SL) and lacto- N -neotetraose (LNnT) showing broader effects than 2′-fucosyllactose (2′-FL). 3′-SL and LNnT supplementation improved barrier-related markers, including Muc2 and ZO-1, and attenuated age-associated epithelial hyperproliferation while maintaining intestinal stem cell (ISC)-related function. Antibiotic-mediated microbiota depletion markedly weakened these effects, supporting an important role of the gut microbiota. Multi-omics analyses further revealed distinct microbiome-metabolome alterations associated with 3′-SL and LNnT supplementation. Specifically, 3′-SL increased the relative abundance of Alistipes and was accompanied by higher levels of metabolites such as spermine. LNnT was associated with increased Allobaculum abundance and elevated acetylcholine levels in colonic contents. Collectively, our findings indicate that specific HMO structures ameliorate age-related decline of the intestinal epithelium in association with alterations in the microbiota–metabolite axis, providing a basis for further investigation of 3′-SL and LNnT as candidate dietary strategies for intestinal aging. Download: Download high-res image (162KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Li Ming,Ning Li,Hongyan Zhang,Xiaobo Zou,Can Zhang
A “all-in-one” nanolabel APZ was constructed. • High Nbs coupling, dual spectral overlap, visible absorption, pH-triggered catalysis. • The three orthogonal signals enhance reliability and enable flexible applicability. • ZIF-8 “enrichment–confinement–pH-triggered collapse” synergy boosts catalysis. • Stabilize Au Pt heterostructure via ZIF-8–enabled physical isolation and protection. Conventional lateral flow immunoassay (LFIA) suffers from limited sensitivity due to single-signal readout, low antibody conjugation efficiency, and steric hindrance associated with bulky conventional antibodies. Herein, we developed a multimodal LFIA employing Au@Pt@ZIF-8 (APZ) as a multifunctional nanolabel, prepared by encapsulating flower-like Au@Pt nanoparticles (Au@Pt NPs) within a ZIF-8 framework. Benefiting from its high specific surface area and mesoporous structure, APZ significantly enhanced the coupling efficiency and stability of anti-3-phenoxybenzoic acid nanobodies (3-PBA Nbs), achieving a coupling efficiency of 94.75% under identical conditions, compared with 69.61% for Au@Pt NPs. APZ further exhibits a broad absorption spectrum, fluorescence quenching due to dual spectral overlap, and high catalytic activity arising from the intrinsic peroxidase-mimicking activity of Au@Pt, synergistically enhanced by ZIF-8 enrichment/confinement and pH-triggered framework collapse. These features enabled the integration of three orthogonal readout modes, namely aggregation-induced coloration, catalysis-induced chromogenesis, and fluorescence quenching, into a single test strip. The resulting multimodal APZ-LFIA attains limits of detection (LOD) for 3-PBA of 0.004 ng/mL, 0.001 ng/mL, and 0.0003 ng/mL, respectively. By integrating multiple complementary signals, this strategy offers a flexible and reliable platform for trace 3-PBA analysis and shows great promise for on-site food safety monitoring. Download: Download high-res image (87KB) Download: Download full-size image
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Frontiers in Pharmacology
·
2026
·
IF 5.4
Yifan Guo,Fang Hu,Allan Zijian Zhao,Yingjuan Zeng,Haoying Chen,Ai Wang,Xiaoxi Li,Li Cong
Introduction Omega-3 polyunsaturated fatty acids (PUFAs) have been widely reported to exert beneficial effects in type 1 diabetes mellitus (T1DM). However, the mechanisms by which Omega-3 PUFAs influence pancreatic islet function through the gut-islet axis remain incompletely understood. This study aimed to investigate whether Omega-3 PUFAs-associated alterations in gut microbiota composition and their metabolites are involved in the modulation of the pancreatic islet microenvironment in T1DM, and to explore the potential immunological mechanisms underlying these effects. Methods Fecal microbiota transplantation (FMT) was performed to evaluate the effects of Omega-3 PUFAs-associated gut microbiota in non-obese diabetic (NOD) mice. Immune cell composition and inflammatory status within pancreatic islets were analyzed using transcriptomic profiling, flow cytometry, and immunohistochemistry. Metabolomics analysis was performed to investigate the association among Omega-3 PUFAs, gut microbiota, and microbiota-related metabolites. In vitro co-culture systems were further established to evaluate the effects of selected metabolites on macrophage polarization and insulin production and secretion in pancreatic β-cells. Results Omega-3 PUFAs treatment and FMT were associated with reduced islet inflammation and a marked enrichment of the Eubacterium coprostanoligenes group ( E. coprostanoligenes ). Enhanced M2 macrophage polarization was observed in the islet microenvironment of FMT mice. Among gut microbiota metabolites, 18β-glycyrrhetinic acid (18β-GA) showed a strong association with E. coprostanoligenes , and in vitro experiments suggested a potential involvement of E. coprostanoligenes in the metabolic conversion process related to 18β-GA. In co-culture systems, 18β-GA promoted macrophage polarization toward an M2-like phenotype, which was accompanied by increased insulin production and secretion in pancreatic β-cells. Conclusion These findings suggest that Omega-3 PUFAs-associated alterations in gut microbiota composition and 18β-GA-related metabolic changes may contribute to the modulation of the pancreatic immune microenvironment and β-cells function in T1DM. This study provides additional insights into lipid-microbiota-immune interactions relevant to T1DM and supports further investigation of microbiota-associated immune regulation.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 30
·23495-23508
·
IF 6.7
Huang Zheng,Zhang Qing,Zhao Jianxin,Stanton Catherine,Ross R. Paul,Chen Wei,Yang Bo
Atopic dermatitis (AD) is a prevalent
early childhood inflammatory
skin disease frequently linked to gut dysbiosis. While Bifidobacterium longum subsp. infantis is a pioneer infant gut colonizer driving immune maturation, its
role in AD prevention remains unclear. Here, we investigated early
life intervention with B. longum subsp. infantis CCFM1269 using a 2,4-dinitrofluorobenzene
(DNFB)-induced murine AD model. Oral administration of CCFM1269 significantly
ameliorated AD symptoms, reducing skin/ear thickness, dermatitis scores,
and serum IgE. Mechanistically, CCFM1269 modulated the systemic Th1/Th2
balance by downregulating TSLP, IL-4, and IL-13, while upregulating
IFN-γ. Notably, CCFM1269 produced indole-3-lactic acid (ILA).
Via the gut–skin axis, ILA activated the aryl hydrocarbon receptor
(AHR) and its target CYP1A1 in skin tissues, strengthening the epidermal
barrier. Additionally, AD mitigation was associated with gut microbiota
reshaping. Ultimately, CCFM1269 alleviates AD primarily through the
ILA- AHR signaling pathway, highlighting its potential as a functional
food ingredient for early life AD prevention.
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高影响因子
ORAL DISEASES
·
2026
·
IF 3.1
Jiaying Shi,Shuxian Lin,Jiayu Yan,Wanyi Tang,Xiaohua Wu,Shuwen Ding,Siyi Chen,Ruowen Zhao,Junhua Wu
Background Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown. Methods An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was analyzed and validated in vivo. Irradiated jaw bone marrow mesenchymal stem cells (JBMMSCs) were characterized. p21 was inhibited using UC2288 and siRNA. A UC2288-loaded AlgMA hydrogel was developed for local delivery. Results Bone healing was compromised in ORNJ. Radiation induced p21 upregulation in osteogenic lineage cells, which promoted Rb dephosphorylation and aberrant Smad2/3 phosphorylation, thereby suppressing Runx2-mediated osteogenesis. p21 inhibition reversed this cascade and restored osteogenic differentiation. Local delivery of UC2288@AlgMA significantly enhanced bone regeneration. Conclusion p21-related signaling impairs bone healing after irradiation, and local UC2288 delivery via AlgMA hydrogels represents a viable strategy to enhance ORNJ regeneration.
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Plants-Basel
·
2025
·Vol. 14
·期 12
·1866
·
IF 4.1
Yaxing Yan,Mei Jiang,Pengjie Han,Xiaohu Lin,Xiao Wang
The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene plays a pivotal role in the glycolysis/gluconeogenesis process, contributing significantly to glycosyl donor synthesis, plant growth and development, and stress responses.Gastrodia elataBl., a heterotrophic plant in the Orchidaceae family, has its dried tubers used as the traditional Chinese medicine. This study identified threeGeGAPDHgenes inG. elata, all encoding basic, stable, hydrophilic proteins. Phylogenetic analysis and subcellular localization predictions categorizedGeGAPDH1as a plastid subtype, whileGeGAPDH2andGeGAPDH3were classified as cytoplasmic subtypes. Prokaryotic expression experiments demonstrated successful expression of the GeGAPDH1 protein inEscherichia coli, which exhibited significant GAPDH enzymatic activity. Subcellular localization experiments showed that GeGAPDH1 was localized in the plastid. Expression analysis indicated that the threeGeGAPDHgenes were predominantly expressed in tubers. Under low-temperature stress, although the total GAPDH enzyme activity in tubers did not change significantly, the expression ofGeGAPDH1was significantly up-regulated, whileGeGAPDH2andGeGAPDH3were significantly down-regulated. This suggests that different subtypes ofGeGAPDHmay regulate cold resistance through different pathways. Upon pathogen infection, theGeGAPDHgene family exhibited pathogen-specific regulatory patterns. During infection byFusarium oxysporum, both the expression levels of all threeGeGAPDHgenes and the total GAPDH enzyme activity in tubers increased significantly; however,F. solaniinfection induced a significant increase in total GAPDH enzyme activity without significant changes in gene expression. These results suggest that theGeGAPDHgene family may respond to different pathogen infections through transcriptional or translational regulation mechanisms. This study systematically identified and characterized theGeGAPDHgene family inG. elata, providing a theoretical foundation for understanding the functional differentiation ofGAPDHin heterotrophic plants.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Nana Zhao,Chen Zhou,Weiqi Liu,Fukang Hao,Mengjie Han,Zhicheng Pan,Jinfeng Yuan,Mingwang Pan
Dumbbell-shaped Janus particles with asymmetric morphology, completely separated hydrophilic and lipophilic regions, and acidic/basic dual pH-responsive functional groups (DHL-ABR JPs) are in high demand because they can endow Pickering emulsions with excellent stability and flexible switching ability between emulsification and demulsification by simply changing pH value of the system. Herein, we propose a novel “oil–water interface growth” strategy to directly access 3-aminophenol- co -formaldehyde@SiO 2 (3-APF@SiO 2 ) DHL-ABR JPs with average particle size of ∼250 nm and size distribution index of 0.012. The formation mechanism was systematically investigated. Interestingly, the particle morphology could be precisely tuned from dumbbell to hamburger, and then to popcorn by simply changing the dropping time of tetraethyl orthosilicate. Additionally, the snowman-shaped particles, consisting of SiO 2 and poly (acrylic acid- co -butyl acrylate) at two ends respectively, were prepared via this method. Remarkably, the Pickering emulsion stabilized by 3-APF@SiO 2 DHL-ABR JPs showed excellent emulsification effect, i.e. the oil droplet diameter and emulsification index of the Pickering emulsion remained almost unchanged even after storage for one year and sensitive dual pH-response characteristics, i.e., emulsified at pH = 7, and demulsified at pH = 4 and 10. It is believed that this work paves a new avenue for synthesis and application of various asymmetric nanoparticles.
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LANGMUIR
·
2026
·
IF 4.4
Ziyi Wan,Chunxi Hai,Yanxia Sun,Shengde Dong,Luxiang Ma,Qi Xu,Xin He,Yuan Zhou
Na3V2(PO4)3 has garnered significant attention as a promising cathode material for sodium-ion batteries due to its excellent ionic conductivity and robust structural stability. However, its further large-scale practical application has been hindered by its low electrical conductivity and poor interface kinetics. Therefore, it is reported in this study that the discharging/charging cycling and rate performance of Na3V2(PO4)3 cathodes are dramatically improved by the uniformly formed 3D carbon networks. Evidently, the Na3V2(PO4)3 cathode material prepared under the optimized conditions exhibited a relatively high initial capacity of 109.30 mAh/g at 0.1C with an initial Coulombic efficiency (ICE) of 99% and achieved an appreciable capacity of 99.42 mAh/g with a capacity retention of 96.39% after 400 cycles at 2C. Based on different characterizations and electrochemical performances, both the formation and sodium storage mechanism of Na3V2(PO4)3-based composite cathodes were initially concluded, which is significant and important for improving electrical conductivity and designing practical carbon-cladding strategies for Na-ion batteries.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2026
·
IF 7.1
Axue Wang,Bingbing Lai,Xiaobo Wang,Huaigang Su,Wenjing Lou,Shengmao Zhang
Biobased lubricants have garnered significant attention due to their environmentally friendly characteristics. In this study, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) was employed as a thickener to successfully prepare four biobased greases with identical NLGI consistency grades. Scanning electron microscopy (SEM) characterization revealed that the P34HB thickener formed a three-dimensional lamellar network microstructure, elucidating the grease formation mechanism of the P34HB thickener. Rheological tests demonstrated that this grease system exhibited typical non-Newtonian fluid behavior and pronounced shear-thinning effects. Tribological performance evaluation indicated that the grease formulated with acetyl triethyl citrate (ATEC) as base oil displayed optimal friction-reducing and anti-wear properties. This research provided expanded base oil options for developing eco-friendly lubricants, extended the application scope of biobased materials in grease technology, and held substantial engineering value for promoting innovative development in green lubrication technologies
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Caimei Lu,Rongrong Song,Junhui Wang,Kun Liu,Tian Fu,Rui Tang,Luying Jiang,Zhangfa Tong,Hanbing Zhang
Effective removal of hazardous and low biodegradable benzophenone-3 (BP-3) has been a challenging problem. In this study, a new Vis/TiO 2 /PDS/Cu 2+ system was constructed to evaluate the catalytic performance of BP-3 during the co-induced ligand-to-metal charge transfer (LMCT) process by Cu 2+ , PDS and TiO 2 . Under visible light irradiation, trace Cu 2+ efficiently triggering LMCT process from PDS to TiO 2 via Cu–O bridging effect was firstly reported. In this LMCT-mediated photocatalysis process, Cu 2+ was not only involved in the formation of visible-light responsive TiO 2 -Cu-PDS complexes but also inhibited the back electron transfer and promoted PDS activation by accelerating the electron transfer from the conductive band (CB) of TiO 2 to PDS via Cu 2+ /Cu + cycle. Compared with BP–3 removal in Cu 2+ /PDS system (18%) and Vis/TiO 2 system (48%), that in Vis/TiO 2 /Cu 2+ system (58%) and Vis/TiO 2 /PDS system (54%) exhibited a slight improvement. It was worth noting that BP-3 removal in Vis/Cu 2+ /TiO 2 /PDS system reached 91% within 30 min and the corresponding TOC removal was up to 76% in 120 min, which proved that the significantly enhancement of BP-3 degradation in Vis/Cu 2+ /TiO 2 /PDS system. Meanwhile, this system could maintain efficient catalytic performance in a wide pH range from 3 to 8. The formation of an interfacial charge transfer complex of Cu-PDS on TiO 2 , and the boosted generation of O 2 – , SO 4 − and HO radicals over the Vis/Cu 2+ /TiO 2 /PDS system were confirmed. Notably, visible light excited Cu-PDS complexes to distribute electrons to TiO 2 (CB) via Cu–O bridge action, thereby inducing the enhanced visible-light activity of TiO 2 and achieving superior catalytic performance for various pollutants in Vis/Cu 2+ /TiO 2 /PDS system. Furthermore, enhanced activation mechanisms of TiO 2 and PDS by visible-light induced LMCT process were proposed in detail. Hydroxylation, demethylation and ring-opening dominated BP-3 degradation, and the weakened toxicity of BP-3 in Vis/TiO 2 /PDS/Cu 2+ system was confirmed via the distinct increase of E.coli colonies numbers at the introduction of intermediates. This study offers new insights into LMCT activation approach and broadens the understanding of the ability of Cu 2+ to be applied in photo-activated persulfate-based advanced oxidation processes for environmental remediation.
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高影响因子
ACS Sensors
·
2023
·
IF 8.9
Siqi Xie,Cheng Zhao,Jiabin Shen,Jing Wei,Haiquan Liu,Yingjie Pan,Yong Zhao,Yongheng Zhu
Listeria monocytogenes, which is abundant in environment, can lead to many kinds of serious illnesses and even death. Nowadays, indirectly detecting the metabolite biomarker of L. monocytogenes, 3-hydroxy-2-butanone, has been verified to be an effective way to evaluate the contamination of L. monocytogenes. However, this detection approach is still limited by sensitivity, selectivity, and ppb-level detection limit. Herein, low-cost and highly sensitive and selective 3-hydroxy-2-butanone sensors have been proposed based on the bimetallic AuPd decorated hierarchical flower-like WO3 nanospheres. Notably, the 1.0 wt % AuPd-WO3 based sensors displayed the highest sensitivity (Ra/Rg = 84 @ 1 ppm) at 250 °C. In addition, the sensors showed outstanding selectivity, rapid response/recovery (8/4 s @ 10 ppm), and low detection limit (100 ppb). Furthermore, the evaluation of L. monocytogenes with high sensitivity and specificity has been achieved using 1.0 wt % AuPd-WO3 based sensors. Such a marvelous sensing performance benefits from the synergistic effect of bimetallic AuPd nanoparticles, which lead to thicker electron depletion layer and increased adsorbed oxygen species. Meanwhile, the unique hierarchical nanostructure of the flower-like WO3 nanospheres benefits the gas-sensing performance. The AuPd-WO3 nanosphere-based sensors exhibit a particular and highly selective method to detect 3-hydroxy-2-butanone, foreseeing a feasible route for the rapid and nondestructive evaluation of foodborne pathogens.
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高影响因子
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