ORAL DISEASES
·
2026
·
IF 3.1
Jiaying Shi,Shuxian Lin,Jiayu Yan,Wanyi Tang,Xiaohua Wu,Shuwen Ding,Siyi Chen,Ruowen Zhao,Junhua Wu
Background Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown. Methods An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was analyzed and validated in vivo. Irradiated jaw bone marrow mesenchymal stem cells (JBMMSCs) were characterized. p21 was inhibited using UC2288 and siRNA. A UC2288-loaded AlgMA hydrogel was developed for local delivery. Results Bone healing was compromised in ORNJ. Radiation induced p21 upregulation in osteogenic lineage cells, which promoted Rb dephosphorylation and aberrant Smad2/3 phosphorylation, thereby suppressing Runx2-mediated osteogenesis. p21 inhibition reversed this cascade and restored osteogenic differentiation. Local delivery of UC2288@AlgMA significantly enhanced bone regeneration. Conclusion p21-related signaling impairs bone healing after irradiation, and local UC2288 delivery via AlgMA hydrogels represents a viable strategy to enhance ORNJ regeneration.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 30
·23495-23508
·
IF 6.7
Huang Zheng,Zhang Qing,Zhao Jianxin,Stanton Catherine,Ross R. Paul,Chen Wei,Yang Bo
Atopic dermatitis (AD) is a prevalent
early childhood inflammatory
skin disease frequently linked to gut dysbiosis. While Bifidobacterium longum subsp. infantis is a pioneer infant gut colonizer driving immune maturation, its
role in AD prevention remains unclear. Here, we investigated early
life intervention with B. longum subsp. infantis CCFM1269 using a 2,4-dinitrofluorobenzene
(DNFB)-induced murine AD model. Oral administration of CCFM1269 significantly
ameliorated AD symptoms, reducing skin/ear thickness, dermatitis scores,
and serum IgE. Mechanistically, CCFM1269 modulated the systemic Th1/Th2
balance by downregulating TSLP, IL-4, and IL-13, while upregulating
IFN-γ. Notably, CCFM1269 produced indole-3-lactic acid (ILA).
Via the gut–skin axis, ILA activated the aryl hydrocarbon receptor
(AHR) and its target CYP1A1 in skin tissues, strengthening the epidermal
barrier. Additionally, AD mitigation was associated with gut microbiota
reshaping. Ultimately, CCFM1269 alleviates AD primarily through the
ILA- AHR signaling pathway, highlighting its potential as a functional
food ingredient for early life AD prevention.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Nana Zhao,Chen Zhou,Weiqi Liu,Fukang Hao,Mengjie Han,Zhicheng Pan,Jinfeng Yuan,Mingwang Pan
Dumbbell-shaped Janus particles with asymmetric morphology, completely separated hydrophilic and lipophilic regions, and acidic/basic dual pH-responsive functional groups (DHL-ABR JPs) are in high demand because they can endow Pickering emulsions with excellent stability and flexible switching ability between emulsification and demulsification by simply changing pH value of the system. Herein, we propose a novel “oil–water interface growth” strategy to directly access 3-aminophenol- co -formaldehyde@SiO 2 (3-APF@SiO 2 ) DHL-ABR JPs with average particle size of ∼250 nm and size distribution index of 0.012. The formation mechanism was systematically investigated. Interestingly, the particle morphology could be precisely tuned from dumbbell to hamburger, and then to popcorn by simply changing the dropping time of tetraethyl orthosilicate. Additionally, the snowman-shaped particles, consisting of SiO 2 and poly (acrylic acid- co -butyl acrylate) at two ends respectively, were prepared via this method. Remarkably, the Pickering emulsion stabilized by 3-APF@SiO 2 DHL-ABR JPs showed excellent emulsification effect, i.e. the oil droplet diameter and emulsification index of the Pickering emulsion remained almost unchanged even after storage for one year and sensitive dual pH-response characteristics, i.e., emulsified at pH = 7, and demulsified at pH = 4 and 10. It is believed that this work paves a new avenue for synthesis and application of various asymmetric nanoparticles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Plants-Basel
·
2025
·Vol. 14
·期 12
·1866
·
IF 4.1
Yaxing Yan,Mei Jiang,Pengjie Han,Xiaohu Lin,Xiao Wang
The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene plays a pivotal role in the glycolysis/gluconeogenesis process, contributing significantly to glycosyl donor synthesis, plant growth and development, and stress responses.Gastrodia elataBl., a heterotrophic plant in the Orchidaceae family, has its dried tubers used as the traditional Chinese medicine. This study identified threeGeGAPDHgenes inG. elata, all encoding basic, stable, hydrophilic proteins. Phylogenetic analysis and subcellular localization predictions categorizedGeGAPDH1as a plastid subtype, whileGeGAPDH2andGeGAPDH3were classified as cytoplasmic subtypes. Prokaryotic expression experiments demonstrated successful expression of the GeGAPDH1 protein inEscherichia coli, which exhibited significant GAPDH enzymatic activity. Subcellular localization experiments showed that GeGAPDH1 was localized in the plastid. Expression analysis indicated that the threeGeGAPDHgenes were predominantly expressed in tubers. Under low-temperature stress, although the total GAPDH enzyme activity in tubers did not change significantly, the expression ofGeGAPDH1was significantly up-regulated, whileGeGAPDH2andGeGAPDH3were significantly down-regulated. This suggests that different subtypes ofGeGAPDHmay regulate cold resistance through different pathways. Upon pathogen infection, theGeGAPDHgene family exhibited pathogen-specific regulatory patterns. During infection byFusarium oxysporum, both the expression levels of all threeGeGAPDHgenes and the total GAPDH enzyme activity in tubers increased significantly; however,F. solaniinfection induced a significant increase in total GAPDH enzyme activity without significant changes in gene expression. These results suggest that theGeGAPDHgene family may respond to different pathogen infections through transcriptional or translational regulation mechanisms. This study systematically identified and characterized theGeGAPDHgene family inG. elata, providing a theoretical foundation for understanding the functional differentiation ofGAPDHin heterotrophic plants.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2026
·
IF 7.1
Axue Wang,Bingbing Lai,Xiaobo Wang,Huaigang Su,Wenjing Lou,Shengmao Zhang
Biobased lubricants have garnered significant attention due to their environmentally friendly characteristics. In this study, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) was employed as a thickener to successfully prepare four biobased greases with identical NLGI consistency grades. Scanning electron microscopy (SEM) characterization revealed that the P34HB thickener formed a three-dimensional lamellar network microstructure, elucidating the grease formation mechanism of the P34HB thickener. Rheological tests demonstrated that this grease system exhibited typical non-Newtonian fluid behavior and pronounced shear-thinning effects. Tribological performance evaluation indicated that the grease formulated with acetyl triethyl citrate (ATEC) as base oil displayed optimal friction-reducing and anti-wear properties. This research provided expanded base oil options for developing eco-friendly lubricants, extended the application scope of biobased materials in grease technology, and held substantial engineering value for promoting innovative development in green lubrication technologies
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 12
·期 1
·576-592
·
IF 1.5
Zhe Zhang,Le Ruan,Xiaodong Huang,Yuzeng Lyu,Shuhua Zhang,Wei Shang,Xiuying Li,Ling Wu
4H-1,2,4-triazol-3-amine and itsaldehyde Schiff bases self-assembled films were formed on carbon steel surface.Electrochemical impedance spectroscopy and polarization curvesmeasurements showed that the self-assembled films could protect carbon steel from corrosion in 0.5M HCl solution. X-ray photoelectron spectroscopy (XPS) analyses indicated that the chemisorption of triazol-3-ylamine and three Schiff bases molecules on carbon steel surface through N atom and ring. Quantum chemical calculation and dynamic simulation were used to further investigate the inhibition mechanism.
✓ 已验证
DOI
高影响因子
Journal of Energy Storage
·
2026
·
IF 9.8
Kaiqi Wu,Chengjin Peng,Fanglin Wu,Liyuan Huang,Liang Lan,Liqiang Kang,Yecheng Liu,Xin Ao,Shan Fang
NASICON-type solid electrolytes exhibit substantial potential for application in all-solid-state lithium metal batteries (ASSLMBs) with a high energy density, attributed to their broad electrochemical window, high ionic conductivity, and excellent air stability. Nevertheless, the practical application is severely limited by inadequate chemical stability upon interaction with lithium metal. To address this challenge, a multifunctional interlayer was developed to suppress the detrimental reaction between Li metal and Li 1.5 Al 0.5 Ge 1.5 (PO 4 ) 3 (LAGP). The interlayer exhibits outstanding interfacial compatibility and minimized interfacial This interlayer was fabricated through the in-situ solidification of poly(ethylene glycol) methyl ether acrylate with cerium trifluoride, combined with ionic liquid (named as PCEIL). The interlayer exhibits outstanding interfacial compatibility and minimized interfacial resistance, which enables the Li|PCEIL-LAGP-PCEIL|Li symmetric battery to achieve stable cycling over 1000 h at 0.1 mA cm −2 without short-circuiting. Additionally, this interlayer enables superior performance in Li|PCEIL-LAGP-PCEIL|LiFePO 4 cells, with a remarkable capacity retention of 96.5 % after 250 cycles at 0.2C, and an impressive average Coulombic efficiency of 99.8 %. Therefore, this work provides effective strategies to stabilize NASICON-type solid electrolytes and lithium metal, promoting the development of high-performance ASSLMBs.
✓ 已验证
产品关联
DOI
高影响因子
Acta Crystallographica Section E-Crystallographic Communications
·
2018
·Vol. 74
·期 1
·28-33
·
IF 0
Li X.-Y.,Peng Y.-Q.,Li J.,Fu W.-W.,Liu Y.,Li Y.-M.
Two new coordination polymers, namely, poly[[μ3-3-(1H-benzimidazol-2-yl)propionato]zinc(II)], [Zn(C10H8N2O2)]n, (1), and poly[bis[μ2-3-(1H-benzimidazol-2-yl)propionato]cadmium(II)], [Cd(C10H8N2O2)2]n, (2) have been synthesized from 3-(1H-benzoimidazol-2-yl)propanoic acid ligands through a mixed-ligand synthetic strategy under a solvothermal environment, and studied by single-crystal X-ray diffraction. Complex 1 crystallizes in the orthorhombic space group Pbca and features a two-dimensional structure formed by a binuclear Zn2O4 core. Complex 2, however, crystallizes in the monoclinic space group P21/c and forms a one-dimensional chain structure. The ZnII and CdII ions have different coordination numbers and the 3-(1H-benzoimidazol-2-yl)propanoate ligands display different coordination modes. The structures reported here show the importance of the selection of metal ions and suitable ligands.
✓ 已验证
DOI
Frontiers in Pharmacology
·
2026
·
IF 5.4
Yifan Guo,Fang Hu,Allan Zijian Zhao,Yingjuan Zeng,Haoying Chen,Ai Wang,Xiaoxi Li,Li Cong
Introduction Omega-3 polyunsaturated fatty acids (PUFAs) have been widely reported to exert beneficial effects in type 1 diabetes mellitus (T1DM). However, the mechanisms by which Omega-3 PUFAs influence pancreatic islet function through the gut-islet axis remain incompletely understood. This study aimed to investigate whether Omega-3 PUFAs-associated alterations in gut microbiota composition and their metabolites are involved in the modulation of the pancreatic islet microenvironment in T1DM, and to explore the potential immunological mechanisms underlying these effects. Methods Fecal microbiota transplantation (FMT) was performed to evaluate the effects of Omega-3 PUFAs-associated gut microbiota in non-obese diabetic (NOD) mice. Immune cell composition and inflammatory status within pancreatic islets were analyzed using transcriptomic profiling, flow cytometry, and immunohistochemistry. Metabolomics analysis was performed to investigate the association among Omega-3 PUFAs, gut microbiota, and microbiota-related metabolites. In vitro co-culture systems were further established to evaluate the effects of selected metabolites on macrophage polarization and insulin production and secretion in pancreatic β-cells. Results Omega-3 PUFAs treatment and FMT were associated with reduced islet inflammation and a marked enrichment of the Eubacterium coprostanoligenes group ( E. coprostanoligenes ). Enhanced M2 macrophage polarization was observed in the islet microenvironment of FMT mice. Among gut microbiota metabolites, 18β-glycyrrhetinic acid (18β-GA) showed a strong association with E. coprostanoligenes , and in vitro experiments suggested a potential involvement of E. coprostanoligenes in the metabolic conversion process related to 18β-GA. In co-culture systems, 18β-GA promoted macrophage polarization toward an M2-like phenotype, which was accompanied by increased insulin production and secretion in pancreatic β-cells. Conclusion These findings suggest that Omega-3 PUFAs-associated alterations in gut microbiota composition and 18β-GA-related metabolic changes may contribute to the modulation of the pancreatic immune microenvironment and β-cells function in T1DM. This study provides additional insights into lipid-microbiota-immune interactions relevant to T1DM and supports further investigation of microbiota-associated immune regulation.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Li Ming,Ning Li,Hongyan Zhang,Xiaobo Zou,Can Zhang
A “all-in-one” nanolabel APZ was constructed. • High Nbs coupling, dual spectral overlap, visible absorption, pH-triggered catalysis. • The three orthogonal signals enhance reliability and enable flexible applicability. • ZIF-8 “enrichment–confinement–pH-triggered collapse” synergy boosts catalysis. • Stabilize Au Pt heterostructure via ZIF-8–enabled physical isolation and protection. Conventional lateral flow immunoassay (LFIA) suffers from limited sensitivity due to single-signal readout, low antibody conjugation efficiency, and steric hindrance associated with bulky conventional antibodies. Herein, we developed a multimodal LFIA employing Au@Pt@ZIF-8 (APZ) as a multifunctional nanolabel, prepared by encapsulating flower-like Au@Pt nanoparticles (Au@Pt NPs) within a ZIF-8 framework. Benefiting from its high specific surface area and mesoporous structure, APZ significantly enhanced the coupling efficiency and stability of anti-3-phenoxybenzoic acid nanobodies (3-PBA Nbs), achieving a coupling efficiency of 94.75% under identical conditions, compared with 69.61% for Au@Pt NPs. APZ further exhibits a broad absorption spectrum, fluorescence quenching due to dual spectral overlap, and high catalytic activity arising from the intrinsic peroxidase-mimicking activity of Au@Pt, synergistically enhanced by ZIF-8 enrichment/confinement and pH-triggered framework collapse. These features enabled the integration of three orthogonal readout modes, namely aggregation-induced coloration, catalysis-induced chromogenesis, and fluorescence quenching, into a single test strip. The resulting multimodal APZ-LFIA attains limits of detection (LOD) for 3-PBA of 0.004 ng/mL, 0.001 ng/mL, and 0.0003 ng/mL, respectively. By integrating multiple complementary signals, this strategy offers a flexible and reliable platform for trace 3-PBA analysis and shows great promise for on-site food safety monitoring. Download: Download high-res image (87KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Haichao Zhang,Fei Yao,Zhihong Lyu,Keqin Xie,Rui Ge,Xinru Zhao,Guocheng Wang,Zijin Yang,Hanxiao Zhang,Boyan Li,Yumei Qin,Jianzhong Han,Yanpei Gu
Structurally distinct human milk oligosaccharides differentially regulate intestinal epithelial homeostasis in aged mice. • 3′-Sialyllactose and lacto- N -neotetraose exhibit superior effects on intestinal barrier function and intestinal stem cell function. • Gut microbiota is required for the beneficial effects of human milk oligosaccharides on intestinal epithelial homeostasis in aged mice. Intestinal epithelial homeostasis undergoes progressive functional decline during aging and contributes to systemic age-related dysfunction. Human milk oligosaccharides (HMOs) have well-documented prebiotic and immunomodulatory properties; however, their effects on the aging gut and functional differences among distinct structures remain largely unexplored. Here, we show that structurally distinct HMOs differentially regulate intestinal epithelial homeostasis in naturally aged male mice, with 3′-sialyllactose (3′-SL) and lacto- N -neotetraose (LNnT) showing broader effects than 2′-fucosyllactose (2′-FL). 3′-SL and LNnT supplementation improved barrier-related markers, including Muc2 and ZO-1, and attenuated age-associated epithelial hyperproliferation while maintaining intestinal stem cell (ISC)-related function. Antibiotic-mediated microbiota depletion markedly weakened these effects, supporting an important role of the gut microbiota. Multi-omics analyses further revealed distinct microbiome-metabolome alterations associated with 3′-SL and LNnT supplementation. Specifically, 3′-SL increased the relative abundance of Alistipes and was accompanied by higher levels of metabolites such as spermine. LNnT was associated with increased Allobaculum abundance and elevated acetylcholine levels in colonic contents. Collectively, our findings indicate that specific HMO structures ameliorate age-related decline of the intestinal epithelium in association with alterations in the microbiota–metabolite axis, providing a basis for further investigation of 3′-SL and LNnT as candidate dietary strategies for intestinal aging. Download: Download high-res image (162KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2025
·Vol. 27
·期 45
·24273-24283
·
IF 2.9
Jin Zou,Daoyun Zhu,Zhongfei Mu,Song Xu,Nurahmat Wali,Fugen Wu,Huafeng Dong,Xin Zhang,Xiao Wu,Yifei Luo,Yuchun Zhan
Near-infrared (NIR) spectroscopic technology has shown extensive application prospects. However, developing NIR phosphors with tunability and high thermal stability is a huge challenge. In this work, a highly promising phosphate compound, K3Ga2(PO4)3, has been successfully synthesized. When doped with Cr3+ ions, it is particularly noteworthy that Cr3+ exhibits highly efficient and thermally stable broadband NIR luminescence in the tetrahedral coordination environment. This unique property makes K3Ga2(PO4)3:Cr3+ a compelling candidate for advanced photonic applications. Therefore, studying the luminescent properties of Cr3+ rare earth ions doped into tetrahedral sites is of great significance. In the tetrahedral coordination environment of K3Ga2(PO4)3:Cr3+ ions exhibit broadband near-infrared emission spanning from 700 to 1100 nm (λem = 822 nm, FWHM = 124 nm) under 452 nm blue light excitation. Remarkably, the quantum efficiency reaches as high as 70.9%, demonstrating its exceptional potential for advanced photonic applications. In addition, the phosphors demonstrated exceptional thermal stability with near-zero thermal quenching. The NIR luminescence intensity at 373 K and 423 K retained 109.0% and 90.4% of its initial room-temperature value, respectively. This remarkable performance can be attributed to the material's ultra-wide band gap, and minimal electron–phonon coupling. The NIR pc-LED devices, fabricated by integrating the optimized K3Ga1.93(PO4)3:0.07Cr3+ phosphors with a blue LED chip (λex = 455 nm), achieved a near-infrared output power of 274 mW with a conversion efficiency of 5.42% under a driving current of 100 mA. Experimental results demonstrate that the fabricated NIR pc-LED exhibits significant potential for applications in night vision and vein imaging technologies. This study provides a strategic framework for designing high-performance NIR pc-LED devices, utilizing K3Ga2(PO4)3:Cr3+ as an efficient phosphor-converted light source, and offers valuable insights for practical implementation in advanced optical systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）