Science China-Life Sciences
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2026
·
IF 9.6
Wang Bao,Fu Junpeng,Qian Jian,Wei Yuang,Bao Meiling,Miao Haoqi,Zhao Xinzhe,Shao Kezheng,Song Yuan,Tan Ruoyun,Li Jie,Shao Pengfei
Clear cell renal cell carcinoma (ccRCC) exhibits aberrant lipid synthesis, yet how this metabolic reprogramming influences ferroptosis—a form of regulated cell death driven by lipid peroxidation—remains poorly understood. This study demonstrates that the key lipid transcription factor SREBP1 acts as a master regulator that promotes ccRCC progression by suppressing ferroptosis. Using SREBP1-knockdown cell models, we found that SREBP1 depletion enriches ferroptosis-related pathways and enhances ferroptosis sensitivity, as evidenced by elevated mitochondrial ROS, labile iron pool, PE-OOH levels, and characteristic mitochondrial alterations. Mechanistically, SREBP1 transcriptionally represses the pro-ferroptotic gene ACSL4 while simultaneously activating the lipid-synthesis gene FASN . Rescue experiments revealed that modulating either ACSL4 or FASN alone only partially reverses the ferroptosis phenotype induced by SREBP1 loss, whereas dual manipulation of both genes fully restores ferroptosis resistance. Metabolomic analyses showed that ACSL4 and FASN converge to regulate the cellular PUFAs/MUFAs ratio, which in turn feeds back to modulate SREBP1 nuclear translocation, thereby establishing a self-reinforcing positive-feedback loop. Clinically, low ACSL4 expression correlates with advanced tumor stage and poor patient survival. In vivo, SREBP1 promotes tumor growth by inhibiting ferroptosis via the ACSL4 / FASN axis. Collectively, our findings reveal that SREBP1 drives ccRCC malignancy through a dual-pronged mechanism—repressing ACSL4 and activating FASN—to alter the PUFAs/MUFAs balance and establish a feed-forward loop that sustains ferroptosis suppression. ACSL4 represents a potential prognostic biomarker, and targeting the SREBP1-ACSL4 / FASN axis offers a promising therapeutic strategy for ccRCC.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Na Yang,Chunli Wang,Jiaxi Wang,Jikai Xia,Qingyong Cao,Henan Cao,Yingying Wang,Chunmin Bo,Shukai Ge,Chengjie Sun,Zhongyuan Cai,Hongyu Lin,Kun Liu
Real-time and accurate detection of drug-induced liver injury is critical for early intervention and treatment, yet clinically applicable visualization methods remain scarce. Based on the difference in glutathione (GSH) content between the normal liver and the livers with different-grade injury, we report a GSH-activated T 1 -weighted magnetic resonance imaging (MRI) nanoprobe (C-MnO), which can be used for non-invasive real-time in vivo magnetic resonance imaging (MRI) of the consumption of GSH in the liver, thereby being applied for the graded diagnosis of liver injury. Due to the presence of abundant disulfide bonds in C-MnO, the T 1 MRI signal around it remained "quenched" until encountering GSH. When C-MnO enters the body and is efficiently absorbed by the liver, it will disassemble and degrade under the action of GSH, thereby activating the T 1 MRI signal. Therefore, this nanoprobe provides an effective visual method for capturing the changes in GSH content during different degrees of liver damages at an early stage, which is beneficial for the graded diagnosis and precision treatment of drug-induced liver injury. Comprehensive in vitro and in vivo studies demonstrate that C-MnO, as a GSH-activated T 1 MRI nanoprobe, enables real-time monitoring and graded diagnosis of drug-induced liver injury, effectively addressing current clinical limitations in the detection of liver injury.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2026
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IF 3.4
Li Xiao,Sun Hanju,Nagassa Merga,Gao Lingyan,Pei Hui,Liu Shuyun,Gu Yingying,He Xinzhou,He Shudong
In this study, a kind of instant kudzu root powder was prepared by twin-screw extrusion combined with ultrafine grinding. Extruded kudzu root powder (EK) and ultrafine extruded kudzu root powder (UEK) were prepared by twin-screw extruder and vibrating ultrafine pulverizer respectively. The effects of extrusion and ultrafine grinding on physicochemical properties, starch composition and instant solubility of kudzu root were revealed. Compared with that of raw powder, the gelatinization degree of EK increased, and that of RDS increased by 5.41%. The content of RS and SDS decreased by 1.25% and 9.18%, respectively. The particle size of UEK decreased significantly after ultrafine grinding, with an average particle size of 11.29–20.99 μm. The particle size was minimum (11.29 μm) after ultrafine grinding for 10 min. The microstructure diagram indicated that after extrusion and ultrafine grinding, the particles of EK and UEK presented in many amorphous flake structures. Infrared spectrum implied that kudzu root was transformed into amorphous structure. Compared with the control, the ΔH and T p of EK and UEK decreased. Compared with control, the instant solubility of the powder was improved after extrusion and ultrafine grinding.
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2026
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IF 3.3
Chen Buxin,Li Yehui,Chen Mao,Liu Lingling,Ma Kaihui,Bai Chenguang,Hu Meilong
To support green transition of vanadium titanomagnetite blast furnace smelting, various low-carbon blast furnace atmospheres, including oxygen-enriched air injection (CO–N 2 ), oxygen-enriched H 2 -rich air injection (CO–H 2 ), and H 2 -rich air injection (CO–H 2 –N 2 ) were investigated to gain insight on the Ti(C,N) formation mechanisms. In this study, thermogravimetric analysis was first employed to investigate the kinetics of the TiO 2 reaction. Arrhenius-based kinetic modeling revealed that these reactions are primarily controlled by solid-state diffusion, and N 2 directly nitrides titanium oxides to TiN, and the activation energy decreases with increasing N 2 content. In contrast, H 2 lowers the activation energy of the reaction and promotes the reduction of TiO 2 to lower-valence oxides. Then, the carbothermic reduction of TiO 2 -bearing slags was investigated. Chemical composition analysis, XRD, and EPMA-WDS mapping demonstrated pronounced atmosphere-dependent variations in the formation of TiC/N phases. In CO–N 2 atmospheres, Ti(C,N) content decreases with increasing CO content and Ti(C,N) tends to agglomerate. With pure CO, only a few, sparsely dispersed TiC particles were detected. Whereas in CO–H 2 atmospheres, increasing the H 2 concentration markedly enhanced TiC formation, yielding uniformly dispersed particles with slight clustering. Therefore, the overall atmosphere effect on the amount of TiC/N formation follows the order: 100 pct CO < 80 pct CO–20 pct H 2 < 80 pct CO–20 pct N 2 < 60 pct CO–40 pct H 2 < 60 pct CO–40 pct N 2 < 30 pct CO–70 pct N 2 atmosphere (conventional blast furnace atmosphere). Graphical
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 3
·76
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IF 2.5
Khan Khyrullah,Wang Wei,Chang Zhidong,Dong Bin
The innovation for highly effective solid acid catalysts that resist impurities is crucial for enhancing sustainable esterification and transesterification processes, which are vital for biofuel production and green chemistry. In this work, tungsten-modified sulfated titania (WO₃/SO₄ 2 ⁻/TiO₂) catalyst was prepared through the impregnation method and subsequently calcined at 550 °C to assess the impact of tungsten impurity on its structural and catalytic properties. The catalyst was characterized through FT-IR, XRD, NH 3 -TPD, and BET surface area analysis. These analyses revealed that the presence of sulfate and tungsten species inhibited TiO₂ crystallization, improving the textural properties and increasing surface acidity. The 5 wt.% WO₃/SO₄ 2 ⁻/TiO₂ catalyst demonstrated the largest surface area (35.99 m 2 /g) and total acidity (1.20 mmol NH₃/g). This catalyst achieved 86.4% conversion in the reaction of transesterification of ethyl acetate and n-butanol at 100 °C for 3 h. The enhanced catalytic performance and selectivity were attributed to the synergistic interaction between WO₃ and SO₄ 2 ⁻, resulting in the formation of Lewis-Bronsted acid sites. This study provides important insights into how tungsten affects the structure and acidity of sulfated titania, which could guide the design of more efficient, impurity-tolerant solid acid catalysts for environmentally sustainable chemical processes. Graphical
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Science China-Life Sciences
·
2026
·
IF 9.6
Liu Li,Gu Chengxiang,Feng Xiaoyuan,Li Meng
Asgard archaea are a group of archaea found in various natural environments such as deep-sea sediments and mangrove wetlands, garnering significant attention for the presence of eukaryotic signature proteins and close phylogenetic links to the origin of eukaryotes. However, as most Asgard archaea have not yet been successfully cultured, research into their biological characteristics and metabolic mechanisms remains in its early stages, primarily relying on genomic data obtained from environmental samples. Here, we report that the classical pentose bisphosphate pathway of nucleoside degradation is also widely distributed in Asgard archaea. This pathway, which links nucleotide recycling to central carbon metabolism, has been proposed as a relic of ancient heterotrophy, with its ribose moiety representing one of the first abundant fermentable sugars available to early heterotrophs. To functionally validate this pathway, we conducted a biochemical examination of the three key enzymes involved in this pathway—nucleoside-5′-monophosphate phosphorylase, ribose-1,5-bisphosphate isomerase, and ribulose-1,5-bisphosphate carboxylase/oxygenase—from Promethearchaeum syntrophicum MK-D1, the first cultured representative of Asgard archaea. Our results strongly suggest that these enzymes play a role in the conversion of nucleoside monophosphates to 3-phosphoglycerate in P. syntrophicum . These findings provide new experimental insights into the metabolism and physiology of Asgard archaea.
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CELLULOSE
·
2026
·
IF 4.6
Cheng Xiaowen,Liu Shuping,Wei Qiaofeng,Zhang Ru,Li Shujing,Liao Xilin,Liu Rangtong
The inherent flammability and poor Ultraviolet (UV)-blocking properties of cotton fabric make it fail to meet the growing demands for health protection and functional apparel. To broaden its applications, imparting dual functionality, both flame retardancy and UV protection, has become a research hotspot in the functionalization of cotton fabrics. Using biomass-derived wool keratin (WK), tea polyphenols (TP), and phenyl-phosphonic acid (PPOA) as raw materials, a simple “dipping and spraying” method is employed to endow cotton fabrics with flame retardant and UV-resistant properties in this paper. The thermal stability, combustion performance, flame retardancy and UV resistance of fabrics before and after finishing are analyzed using synchronous thermal analyzer, micro combustion calorimeter, limiting oxygen index tester, vertical burning tester and fabric UV protection factor analyzer. More importantly, a characterization method was proposed to evaluate the synergistic effects (SE) of three raw materials in the composite finishing of phosphorus-nitrogen biomass materials on the f flame retardant and UV-resistant functions of cotton fabrics. The results indicate that both single/dual/triple-component finished cotton fabrics exhibit a decrease in the initial decomposition temperature (T 5% ), an increase of char residue and a higher limiting oxygen index (LOI), demonstrating a notable trend of low-temperature dehydration. In addition, the finished cotton fabrics containing WK component all display a four-stage thermal degradation characteristic, and the cotton fabric finished with five-dip-five-nip process using triple-component WK/TP/PPOA presents significant improvement in flame-retardant and anti-UV function, with LOI value and UV protection factor (UPF) of up to 31.03% and 35.4, respectively. Moreover, in the dual-component system, the TP/PPOA combination exhibits a more pronounced LOI SE in flame retardancy, while the WK/TP combination demonstrates a more prominent UPF SE in UV-resistance. In the triple-component system, the comprehensive SE in flame retardancy and UV-resistance is much more obvious for the cotton fabric finished with a one-dip-one-nip process. This study can be applied into these products such as outdoor sportswear, sunshade tents and hats, etc., providing a reference for the development of textiles with durable flame retardant and UV resistant integrated functions.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·324
·
IF 38.5
Guo Yinfeng,Xu Yuxiang,Jia Yaduo,Zhu Xiaoqing,Zhang Tao,Zhang Jia,Cao Changyong Chase,Gu Qilin,Xu Guiyin
Achieving Zn anode stability is critical for advancing commercialization of aqueous zinc-ion batteries. However, the instability of zinc metal anodes driven by dendritic growth, hydrogen evolution, and interfacial passivation remains a critical obstacle for advancing aqueous zinc-ion batteries. In this paper, we report a synergistic interfacial engineering strategy that integrates in situ-grown zincophilic copper nanorod arrays with a self-assembled layer of 1-dodecanethiol to regulate ion flux and suppress side reactions simultaneously. The water-poor electric double-layer microenvironment derived from this dual-function “zincophilic–hydrophobic” architecture (denoted as HS-Cu@Zn) promotes uniform Zn deposition along the (100) plane, enhances desolvation kinetics (Zn 2 + transference number increased from 0.47 to 0.75), and effectively excludes electroactive water molecules from the anode surface. As a result, the symmetric cells exhibit ultra-long cycling stability over 3500 h at 1 mA cm −2 , while Zn||Cu half-cells maintain a Coulombic efficiency of 99.65% for 900 cycles. ZnVO||HS-Cu@Zn full cell demonstrates exceptional cycling stability, achieving 2000 stable cycles at 5 A g −1 with an average Coulombic efficiency of 99.8%.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·294
·
IF 5.4
Xu Xiaowen,Liu Tiandi,Ma Tenghe,Li Tengfei,Wang Jing
A smartphone-assisted colorimetric sensing platform was developed for the sensitive detection of sulfites based on a cobalt single-atom nanozyme (Co-N-C). The nanozyme was synthesized via high-temperature pyrolysis of bimetallic Zn/Co-ZIF precursors, resulting in atomically dispersed Co active sites anchored on a nitrogen-doped carbon framework. Benefiting from the well-defined catalytic centers, Co-N-C exhibits exceptional oxidase-like activity, efficiently catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) into a blue product (oxTMB). The presence of sulfites triggers rapid discoloration through a dual mechanism involving reactive oxygen species (ROS) scavenging and the direct reduction of oxTMB. Under optimized conditions, the proposed assay demonstrates a wide linear range of 0.5–80 µM with a low detection limit of 0.066 µM. To eliminate potential interference from biothiols such as glutathione, a selective masking strategy using N-(2-hydroxyethyl)maleimide (HEMI) was introduced. Furthermore, integration with smartphone-based RGB analysis enables portable and instrument-free quantification. The platform was successfully applied to real food samples (white sugar, liquor, and bean vermicelli), yielding satisfactory recoveries of 92.6%-104.0%. This work highlights the potential of single-atom nanozymes in developing low-cost, portable sensing platforms for practical food safety monitoring.
Section
Graphical abstract
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Communications Chemistry
·
2026
·
IF 6.9
Wang Fei,Li Qi,Zhou Han,Liu Chanjuan,Yu Guangli,Li Guoyun
Marine sulfated polysaccharides (SPs) are promising candidates for new anticoagulant drug development, necessitating efficient method to evaluate their anticoagulant activity at the molecular level. In this work, a heparin microarray-based competitive strategy was developed to investigate the specific interactions between SPs and antithrombin Ⅲ (AT). The strategy is based on the principle that SPs competitively bind to the active domain of AT, reducing the signal of AT binding to immobilized heparin on microarrays. Validation was performed using established anticoagulants heparin and enoxaparin as model analytes. After optimizing key experimental conditions, the method successfully determined the IC 50 values for three SPs: fucoidan derived from Ascophyllum nodosum (AnF, 50.55 ± 2.79 μg‧mL −1 ), fucosylated chondroitin sulfate derived from Holothuria tubulosa (FCS ht , 44.18 ± 4.05 μg‧mL −1 ), and its selectively degraded sulfation product (S-dFCS ht , 16.99 ± 6.56 μg‧mL −1 ). The reliability of these results was confirmed by surface plasmon resonance assay. The strategy’s versatility was further demonstrated by assessing SP interactions with side effect-related proteins, providing valuable insights into both efficacy and safety profiles. Although currently applicable primarily to heparin-interacting anticoagulant targets, this strategy can be extended to other targets by fabricating specialized glycan microarrays, enabling comprehensive evaluation of SP interactions with various anticoagulant targets.
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Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Zhao Xiaohan,Wang Liling,Yin Xianggang,Wu Linlin,Zheng Ying,Shao Qingsong,Zhou Yifeng,Huang Jun
Saffron ( Crocus sativus L. ) is a valuable perennial bulbous medicinal herb, often referred to as the “golden spice”. Although previous studies have investigated the non-volatile components and bioactive constituents in various parts of saffron, comprehensive profiles of its volatile organic compounds (VOCs) remained limited. This study employed headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) combined with cluster heatmaps, principal component analysis (PCA), and orthogonal partial least squares-discriminant analysis (OPLS-DA) to analyze and compare the VOCs in seven parts of Zhejiang-cultivated saffron, namely stigma (SS), petal (SP), pollen (SPO), filaments (SF), corms (SC), buds (SB), and leaves (SL). A total of 72 VOCs of saffron were identified, comprising 10 alcohols, 7 esters, 19 ketones, 7 aldehydes, 17 alkenes, and 12 other compounds. Among these, fatty acid methyl esters were the predominant VOC components in SC, whereas safranal or isophorone exhibited relatively higher abundances in the other six parts, which were also enriched in trimethylcyclohexane or cyclohexene derivatives. Cluster heatmaps and PCA grouped the seven saffron parts into three major clusters: SS, SPO and the remaining five parts. Furthermore, 15 significantly differential compounds were screened using the scatter loading plot (S-plot) of the OPLS-DA model combined with variable importance in the projection (VIP) values. Isophorone, 2,2,6-trimethylcyclohexane-1,4-dione (DOIP), and 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde (safranal) were identified as common key discriminant compounds across all comparisons, and while SS, SP, SF, SB and SL each contain unique marker compounds. These findings provide a scientific foundation for the authentication, quality assessment and comprehensive utilization of saffron resources.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2026
·
IF 4
Liu Man,Wu Songze
Myocardial infarction (MI) is recognized by its rapid onset and higher mortality rate. The intricate nature of its pathological process has rendered targeted therapy for MI a persistent issue. Hesperidin (HES) has been identified that may protect cardiac cells and promote myocardial tissue regeneration. Nonetheless, its effectiveness in addressing MI-related ischemia situations is hindered by its insufficient angiogenesis and poor bioavailability. This present investigation demonstrates that the effective therapy of HES is augmented by mesoporous copper carbonate (MCC) microspheres, owing to their superior drug-delivery capacity and consistent release of angiogenic degradation (Cu). The cellular examinations demonstrated that HES and Cu could produce synergic effects on endothelial cell angiogenesis and anti-cardiomyocyte apoptosis. Additionally, an in vivo MI model showed that the HES-loaded MCC (MCC@HES) significantly reduced cardiomyocyte apoptosis, decreased infarct size, and enhanced vascularization in myocardial tissue. Overall, the present study is groundbreaking for indicating the benefits of integrating HES with MCC nanocarriers for myocardial remodeling and for presenting an innovative, meticulously designed MCC@HES system as a prospective treatment approach for MI.
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