PHYTOTHERAPY RESEARCH
·
2026
·
IF 8.1
Huaiying Tang,Qin Xiang,Yue Zhang,Yu Zhang,Xiangxiang Fu,Liming Tan,Yongli Zhang,Siqi Li,Dong Gong,Xu Guo,Yonghong Zhang,Li Chen,Tao Zheng,Qibin Wang
Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage. Cinnamic acid (CA), a natural compound with anti-diabetic and hepatoprotective effects, shows therapeutic potential, but its role in mitigating ET-exacerbated hepatocyte injury in diabetes remains unclear. This study thus investigated whether CA protects against ET-induced hepatocyte pyroptosis under diabetic conditions and explored the underlying mechanisms. In vitro, HepG2 cells cultured under high-glucose (HG) conditions were exposed to ET to simulate a diabetic state with concomitant alcohol intake. Pyroptosis was evaluated by morphological examination and annexin V/PI staining. The involvement of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3)/gasdermin D (GSDMD) pathway and AMP-activated protein kinase (AMPK) activation was assessed via immunoblotting, reactive oxygen species (ROS) detection, and molecular docking. In vivo, a T2DM mouse model was established using a high-fat diet combined with streptozotocin injection, followed by ET exposure and CA treatment. Metabolic parameters, histopathological changes, and hepatic signaling pathways were analyzed. Our results showed that ET exposure significantly increased pyroptotic body formation, ROS production, and NLRP3/GSDMD pathway activation in HG-treated HepG2 cells—all of which were reversed by CA in a concentration-dependent manner. Mechanistically, CA directly bound to and activated AMPK, and the protective effects were abolished by the AMPK inhibitor Compound C. In T2DM mice, ET exposure aggravated insulin resistance, dyslipidemia, hepatic steatosis, and histopathological abnormalities, whereas CA intervention ameliorated these adverse effects and modulated the AMPK-NLRP3/GSDMD signaling axis in liver tissue. Collectively, these findings demonstrate that CA alleviates ET-exacerbated hepatocyte pyroptosis under diabetic conditions by activating AMPK and subsequently inhibiting the NLRP3/GSDMD signaling cascade. This study provides novel insights into the therapeutic potential of CA in T2DM complicated by alcoholic hepatocellular injury.
✓ 已验证
DOI
高影响因子
Acta Pharmaceutica Sinica B
·
2019
·
IF 5.808
Yahui Huang,Shuqiang Chen,Shanchao Wu,Guoqiang Dong,Chunquan Sheng
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) dual inhibitors were successfully identified, which showed potent in vitro and in vivo antitumor potency. Particularly, compound 30a was orally active and possessed excellent in vivo antitumor activity in the HCT116 xenograft model (TGI = 75.2%, 150 mg/kg, p.o .) without significant toxicity, which was more potent than HDAC inhibitor vorinostat, TOP inhibitor evodiamine and their combination. Taken together, this study highlights the therapeutic advantages of evodiamine-based HDAC1/TOP2 dual inhibitors and provides valuable leads for the development of novel multi-targeting antitumor agents.
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Shiyao Shen,Ying Tang,Jie Li,Weishuang Fang,LaiYuan Ao,Xiangguang Zhao,Liang Fang
Substitution of Ga 3+ by [Zn 0.5 Ti 0.5 ] 3+ in MgGa 2 O 4 improved the comprehensive properties of the resultant spinel. A continuous solid solution with a spinel structure was formed in Mg(Zn 0.5 Ti 0.5 ) 2 x Ga (2−2 x ) O 4 (0 ≤ x ≤ 1); here, Zn 2+ occupied the tetrahedral 8 a site while Ti 4+ occupied the octahedral 16 d site, resulting in a decrease in the degree of inversion λ from 0.86 to 0. The optimal sintering temperature decreased from 1460 °C to 1220 °C, and the dielectric constant ( ε r ) increased from 8.8 to 14.9; these changes could be ascribed to the greater polarizability of [Zn 0.5 Ti 0.5 ] 3+ relative to that of Ga 3+ . The temperature coefficient of resonant frequency ( τ f ) of the material remarkably increased from −64.1 ppm/°C to −16.8 ppm/°C, which may be attributed to the increase in dielectric polarizability/molecular volume, bond energy, and bond valence in B-sites. The high-quality factor ( Q × f ) slightly decreased from 89,253 GHz to 73,432 GHz with decreasing λ and packing fraction. Optimal microwave dielectric properties were obtained from the sample with x = 1 and sample sintered at 1220 °C; in this case, ε r = 14.9, Q × f = 73,432 GHz, and τ f = −16.8 ppm/°C.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Junyun Huang,Xiaofang Li,Mengjie Ma,Dinglong Li
Di-(2-ethylhexyl) phthalate (DEHP) is an annexing agent that is widely used in the plastics industry. Due to the endocrine-disrupting effect of this compound, the development of an efficient method for degrading DEHP is important. In this study, DEHP was degraded by UV-activated peroxymonosulfate (PMS) oxidation. The influences of various parameters, including PMS dose, temperature, pH, metal ions, common anions and humic acid (HA), were examined. An increase in PMS dose and the presence of metal ions and common anions was observed to accelerate the reaction, while high pH and the presence of HA inhibited the reaction. In addition, seven transformation products were identified by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS), from which the reaction mechanism and degradation pathways were tentatively proposed. Direct oxidation, hydroxylation, cleavage of the ester bond and decarboxylation were observed in the degradation process. These findings may provide useful information for the treatment of this pollutant.
✓ 已验证
DOI
高影响因子
CHEMICAL PAPERS
·
2024
·
IF 2.1
Lin Yan,Ren Yu,Lin Xiaoyun
Reduced graphene oxide (RGO) loaded with sodium anthraquinone-2-sulfonate (AQS) was prepared using one-pot hydrothermal synthesis. The phase, composition and structure of the prepared materials were characterized by transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and powder X-ray diffraction (XRD). The AQS, RGO and AQS/RGO on functionalized carbon cloth (FCC) electrodes were established. The performance of AQS/FCC, RGO/FCC and AQS/RGO/FCC were tested by galvanostatic charge–discharge (GCD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The specific capacitance ( C s ) of AQS/FCC, RGO/FCC and AQS/RGO/FCC is 9.29, 194.8 and 402.5 F g −1 at the current density ( C d ) of 0.5 A g −1 , respectively. After 1000 cycles of charging and discharging, the capacity retention of AQS/RGO/FCC remained at 92.6%. Therefore, the AQS/RGO/FCC electrode exhibits excellent rate performance, excellent charging and discharging performance and cycling stability in supercapacitors (SCs).
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xin Wang,Yiyang Bi,Chengqian Wang,Ke Li,Yu Zhang,Qun Liu
In this research, we report a simple and cost-effective method for the preparation of two-dimensional (2D) Ni 2 P-Ni(PO 3 ) 2 derived from metal-organic frameworks (MOFs) via a one-step thermal phosphorization strategy. The resulting material is employed to significantly enhance the photocatalytic hydrogen evolution performance of zero-dimensional (0D) CdS nanoparticles. Through an ultrasonic-assisted strategy, the CdS nanoparticles are uniformly dispersed on the surface of Ni 2 P-Ni(PO 3 ) 2 , leading to the successful fabrication of a Ni 2 P-Ni(PO 3 ) 2 /CdS composite with substantially enhanced photocatalytic performance. Under visible light irradiation (λ ≥ 420 nm) using Na 2 S-Na 2 SO 3 as sacrificial agents, the 3 wt% Ni 2 P-Ni(PO 3 ) 2 /CdS composite demonstrated a remarkable photocatalytic hydrogen evolution rate of 2235 µmol g −1 h −1 , which is approximately 7.5 times higher than that of pristine CdS (297 µmol g −1 h −1 ). Over a 20 h cycling experiment, the composite catalyst demonstrated remarkable stability, maintaining around 78 % of its initial hydrogen generation efficiency. The enhanced performance of the composite is ascribed to the role of Ni 2 P-Ni(PO 3 ) 2 in facilitating the separation of photoinduced charge carriers from CdS and improving electrical conductivity. A possible electron-hole transfer mechanism is proposed based on the experimental findings. This work is expected to be helpful in fabricating efficient CdS photocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yuchi Dong,Yalan Liang,Haoyu Gao,Xianyu Jiang,Linbo Zhang,Liangjun Yin,Le Yuan,Xin Wang,Guo Jing
Magnetic metal absorbers will inevitably suffer from corrosion and aging failure in actual application environments (air, salt spray, acid/alkali, etc.), resulting in serious deterioration of their performance. Using inert, densified materials to modify absorber surface is an effective and feasible solution. Herein, a core-shell structure carbonyl iron composite absorbent (CIP@2-MI/MBI/EP) was prepared by in-situ polymerization with 2-methylimidazole (2-MI), 2-mercaptobenzimidazole (MBI), epoxy resin (EP) as the precursor, and carbonyl iron powder (CIP) as the core. The core-shell structure has enhanced both of corrosion resistance and microwave absorbing performance due to the effect of alleviating the intrusion of corrosive media and low dielectric characteristics of the corrosion inhibitors MBI and EP. The results of electromagnetic parameter test exhibited the minimum reflection loss(RL) of the modified absorbent at 13.78 GHz is -69.57 dB, and the thickness is only 1.65 mm. Electrochemical tests revealed the corrosion potential (E corr )of the composite powder shifted positively from -0.680 V to -0.012 V compared to original CIP. The corrosion current (i corr ) decreased from 59.1 μA/cm 2 to 0.1562 μA/cm 2 , and the annual corrosion rate (CR) decreased by 2 orders of magnitude to 0.0223 mil/year. These results attest to the exceptional corrosion resistance of the composites. In addition, the results of salt spray experiments revealed that the morphology and composition of CIP@2-MI/MBI/EP absorbers remained largely unchanged after 720 H salt spray test. Meanwhile, the acid resistance test (PH=1) further demonstrated the outstanding anti-corrosion performance of the composites. The research offers a new option for the development and design of high-efficiency microwave absorbent with robust corrosion resistance.
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Xinyi Du,Xingfan Li,Minghui Yang,Zhiqiang He,Tianwei Xu,Jia Liu,Xiaorui Guo,Zhonghua Tang
Di(2-ethylhexyl)phthalate (DEHP) is one of the most widely used plasticizers in plastic manufacturing. However, the toxicological effects of DEHP on dandelions remain poorly understood. This study comprehensively analyzed and explored the response mechanisms of dandelions to 1, 10, 50, and 100 mg L −1 DEHP influencing the morphophysiological growth, metabolomics, and molecular docking. DEHP reduced chlorophyll synthesis, inhibited plant growth, and induced oxidative-state-associated stress, which was manifested by the excessive production of reactive oxygen species, an increase in antioxidant enzyme activities, and enhanced synthesis of some osmoregulatory compounds, including proline and soluble protein. An analysis of the integrated biological response index showed that the toxicity was dose-dependent. Molecular docking demonstrated that DEHP could bind stably to three enzymes, and the binding energy was peroxidase (POD) > catalase (CAT) > superoxide dismutase (SOD). Metabolomics revealed that metabolite abundance and metabolic pathways were altered by DEHP, with 88 and 72 primary metabolites identified in shoots and roots, respectively. Amino acid, sugar, and organic acid metabolism were severely disturbed, with the most significant effects being on carbohydrate metabolism, valine, leucine, and isoleucine biosynthesis. Our study elucidated the influence of DEHP exposure on dandelions, providing new insights into the toxicity mechanisms and toxicological risk assessment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Qianqian Zhao,Haiqi Jia,Wenxiong Shi,Shaolu Li,Xiaohui Yi,Siqi Yin,Genghao Gong,Yunxia Hu
Aromatic polyamide (PA) reverse osmosis (RO) membrane has gained widespread usage in desalination and water production. Nevertheless, their surfaces are prone to fouling during practical applications stemming from their inherent physicochemical properties. Therefore, conducting research on enhancing the antifouling properties of PA membranes through surface modification is of significant importance. In this work, high-flux and superior antifouling RO membranes were fabricated via surface grafting and self-crossing of [3-(2-aminoethyl) aminopropyl] triethoxysilane (AEAPTES) on the pristine PA membrane surface. Benefiting from solvent activation by n-hexane/n-decane and the strong hydrophilicity of AEAPTES, the modified membranes showed a significant enhancement in water permeance by approximately 73 % (reaching up to 4.10 LMH/bar) compared to unmodified PA membrane, while maintaining NaCl rejection above 98.67 %. Additionally, the modified membrane exhibited outstanding stability. Dynamic fouling experiments with charged model foulants of varying molecular sizes, supported by molecular dynamics simulation analysis, demonstrated that the surface charge plays a crucial role in resisting small-molecule foulants, while hydrophilicity is more effective against macromolecule foulants. Although AEAPTES incorporation did not improve the antifouling performance to negatively charged sodium dodecyl sulfate (SDS), it significantly improved resistance to positively charged dodecyl trimethyl ammonium bromide (DTAB) and charged protein model foulants, including lysozyme (LYZ) and bovine serum albumin (BSA). These improvements are attributed to the creation of a thick hydration layer, as well as the electrostatic interactions and steric hindrance effects provided by the AEAPTES modified layer. This research offers new perspectives on the antifouling mechanisms of PA membranes modified by organoalkoxysilane molecules.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2024
·
IF 3.2
Jian Li,Shuai-Bing Ma,De-Sheng Wei,Wan-Yi Lan,Ting-Ting Xu,Yu-Teng Zhang,Nan Lv,Shuang-Bao Li
Herein, a novel CF 3 -functionalized zirconium-based metal-organic tetrahedron (ZrT-(CF 3 ) 2 ) was constructed based on 2.5-bis(trifluoromethyl)terephthalic acid (H 2 BDC-(CF 3 ) 2 ) ligand and trinuclear zirconocene building unit. Notably, the single crystals of ZrT-(CF 3 ) 2 was obtained under traditional solvothermal condition, while the yield and purity could be further improved by the microwave-assisted solvothermal method. Subsequently, the adsorption performance of ZrT-(CF 3 ) 2 for salicylic acid (SA) emerging contaminant was systematically evaluated, indicating a maximum adsorption capacity of 99.91 mg/g under optimal conditions. Furthermore, a possible adsorption mechanism was proposed based on experimental results and DFT simulations.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Aynigar Ablat,Min Yin,Shihang Zhou,Aierken Sidike
Ce 3+ -doped Ca 2 BO 3 Cl and Ca 3 (BO 3 ) 2 are presented as promising phosphors for solid-state white light illumination, display, phototherapy, etc. Herein, we combined experimental and first-principles calculations to study the photoluminescence properties of Ce 3+ -doped Ca 2 BO 3 Cl and Ca 3 (BO 3 ) 2 under different preparation environment. The results show that the co-doped Na + ions have little effect on the luminescence of Ce 3+ ions doped Ca 2 BO 3 Cl and Ca 3 (BO 3 ) 2 . However, the luminous intensity of Ce 3+ /Na + ions co-doped Ca 2 BO 3 Cl greatly decreased with increasing oxidizing atmosphere. When sintering at 800 °C in air, the luminescence intensity was more than 10 times lower than that in a reducing atmosphere (5 % H 2 + 95 % N 2 ), whereas the luminescence intensity of Ce 3+ -doped Ca 3 (BO 3 ) 2 hardly changed. First-principles calculations revealed that, within an enhanced oxidizing atmosphere, the formation energy of interstitial oxygen (O i ) in Ca 2 BO 3 Cl:Ce 3+ ,Na + decreased from 2.84 to 0.31 eV, whereas in Ca 3 (BO 3 ) 2 :Ce 3+ , it decreased from 2.11 to 1.51 eV. The small formation energy (0.31 eV) of interstitial oxygen (O i ) in an oxidation atmosphere may lead to the formation of interstitial oxygen defects in Ca 2 BO 3 Cl:Ce 3+ ,Na + , which may result in the luminescence quenching of Ce 3+ ions in Ca 2 BO 3 Cl:Ce 3+ ,Na + ((Ce 3+ )∗+O 0 →Ce 4+ +O 1− ) and cause a decrease in the luminescence intensity. The study of the difference in resistance to oxidation between Ce 3+ -doped Ca 2 BO 3 Cl and Ca 3 (BO 3 ) 2 is highly important for further improving current luminescent materials and developing new functional materials.
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Jia Liu,Senlin Li,Hong Zhou,Mengheng Wang,Chengliang Zhang,Cheng Tian,Yue Xu,Mengxuan Wang,Xin Li,Qing Li,Ming Xiang
Gemcitabine is a widely employed first-line chemotherapeutic drug for pancreatic cancer (PCa). However, the rapid emergence of gemcitabine resistance poses a major clinical hurdle. Here, we identified REG3A as a crucial determinant of poor prognosis in PCa. Notably, REG3A was upregulated in tumor tissues from clinical gemcitabine-resistant PCa patients. Through comprehensive in vitro cellular assays and in vivo studies using Reg3g (the murine homolog of REG3A) knockout mice, we demonstrated that REG3A deficiency sensitized PCa to gemcitabine treatment. Mechanistically, RNA sequencing (RNA-Seq) combined with Protein-Protein Interaction (PPI) analysis revealed that REG3A functioned as an exocytosis protein binds to the novel membrane receptor GPR54. The interaction increased membrane localization of GPR54, which subsequently engaged ARRB2 as a scaffolding molecule, leading to activation of the ERK1/2 pathway and suppression of gemcitabine-induced apoptosis. Moreover, the GPR54 agonist KP10 synergistically enhanced gemcitabine resistance in conjunction with REG3A, while interference with GPR54 or its antagonist KP234 attenuated REG3A-induced gemcitabine resistance. Targeting REG3A or pharmacologically inhibiting its downstream signaling molecules may represent a promising strategy to overcome gemcitabine resistance. Overall, REG3A could serve as a potential biomarker for gemcitabine resistance in PCa, offering a new avenue for therapeutic intervention and patient stratification.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）