Journal of Cachexia Sarcopenia and Muscle
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2022
·Vol. 13
·期 6
·2740-2751
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IF 12.063
Fengju Li,Ting Luo,Honghui Rong,Lu Lu,Ling Zhang,Chuanfeng Zheng,Dali Yi,Yi Peng,Enyu Lei,Xiaotao Xiong,Fengchao Wang,Jose M. Garcia,Ji-an Chen
Background Di-(2-ethylhexyl) phthalate (DEHP) and its metabolites can cross the placenta and may cause birth defects and developmental disorders. However, whether maternal DEHP exposure affects skeletal muscle development in the offspring and the pathways involved are unknown. This study investigated the effects of maternal DEHP exposure and the contribution of myostatin (MSTN) to skeletal muscle development in the offspring. Methods Pregnant wild-type and muscle-specific myostatin knockout (MSTN KO) C57BL/6 mice were randomized to receive vehicle (corn oil) or 250 mg/kg DEHP by gavage every other day until their pups were weaned (postnatal day 21 [PND21]). Body weights of the offspring mice were measured longitudinally, and their hindleg muscles were harvested at PD21. Also, C2C12 cells were treated with mono-2-ethylhexyl phthalate (MEHP), the primary metabolite of DEHP, and proteolysis, protein synthesis, and myogenesis markers were measured. The contribution of myostatin to maternal DEHP exposure-induced muscle wasting in the offspring was determined. Results Maternal DEHP exposure reduced body weight growth, myofibre size, and muscle mass in the offspring compared to controls (Quad: 2.70 ± 0.1 vs. 3.38 ± 0.23, Gastroc: 2.29 ± 0.09 vs. 2.81 ± 0.14, Tibialis: 1.01 ± 0.07 vs. 1.25 ± 0.11, mg/tibial length in mm, all P < 0.01, n = 35). Maternal DEHP exposure significantly increased Myostatin expression (2.45 ± 0.41 vs. 0.03 ± 0.00 DEHP vs. controls, P < 0.01, n = 5), Atrogin-1(2.68 ± 0.65 vs. 0.63 ± 0.01, P < 0.05, n = 5), MuRF1 (1.56 ± 0.51 vs. 0.31 ± 0.01, P < 0.05, n = 5), and Smad2/3 phosphorylation (4.12 ± 0.35 vs. 0.49 ± 0.18, P < 0.05), and decreased MyoD (0.27 ± 0.01 vs. 1.52 ± 0.01, P < 0.05, n = 5), Myogenin (0.25 ± 0.03 vs. 1.95 ± 0.56, P < 0.05, n = 5), and AKT phosphorylation (4.12 ± 0.35 vs. 1.00 ± 0.06, P < 0.05, n = 5), in skeletal muscle of the offspring in MSTN flox/flox , but not in MSTN KO mice. Maternal DEHP exposure resulted in up-regulation of CCAAT/enhancer-binding protein δ (C/EBPδ, 4.12 ± 0.35 vs. 1.00 ± 0.19, P < 0.05, n = 5) in skeletal muscle of the offspring in MSTN flox/flox and MSTN KO mice (4.12 ± 0.35 vs. 4.35 ± 0.28, P > 0.05, n = 5). In vitro, C/EBPδ silencing abrogated the MEHP-induced increases in Myostatin, MuRF-1, and Atrogin-1 and decreases in MyoD and Myogenin expression. Conclusions Maternal DEHP exposure impairs skeletal muscle development in the offspring by enhancing the C/EBPδ-myostatin pathway in mice.
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Nanomaterials
·
2025
·Vol. 15
·期 24
·
IF 4.3
Luan Liu,Hongru Liu,Zikang Chen,Genghua Cao,Xiaoyu Wu,Baorui Jia,Xuanhui Qu,Mingli Qin
A rapid solvent-free microwave-assisted strategy was developed to fabricate Pt- and Ni-modified Co(OH)2catalysts for alkaline hydrogen evolution. Among them, Ni-Pt@Co(OH)2, prepared via sequential Ni-first then Pt loading, exhibited the best performance. Structural analyses confirmed uniform Pt dispersion with dominant Pt(111) facets, while ICP-MS showed reduced Pt usage compared to Pt@Co(OH)2. Electrochemical measurements in 1.0 M KOH revealed an overpotential of 71 mV at 10 mA·cm−2, comparable to Pt/C, and a mass activity 4–6.5 times higher across 25–75 mV. EIS demonstrated lower charge-transfer resistance, and stability tests showed negligible degradation after 3000 CV cycles and 11 h continuous operation. The outstanding performance arises from enhanced Pt utilization, abundant conductive sites, and strong Ni-Pt interfacial synergy, highlighting Ni-Pt@Co(OH)2as a promising catalyst for efficient alkaline HER with reduced Pt consumption.
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JOURNAL OF ORGANIC CHEMISTRY
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2025
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IF 3.6
Lei Xu,Hao Sun,Xuefeng Tan,Dong Li,Gen-Qiang Chen,Xumu Zhang
A series of ferrocene-based chiral multidentate P,P,N,N-ligands were successfully designed and synthesized. They can be directly prepared via a one-step nucleophilic substitution reaction from (S)-1-[(R)-2-(diphenylphosphino)ferrocenyl] ethyl acetate [(SC,RFC)-BPPFOAc]. Their ruthenium complexes were used in the asymmetric hydrogenation of 2-pyridyl ketones under mild conditions, the target chiral 1-aryl- or 1-alkyl-(pyridine-2-yl)methanols were obtained with high yields and excellent enantioselectivities. The synthetic utility of this reaction was demonstrated through its utilization in the preparation of key intermediates for a RAS inhibitor and the antihistamine drug Carbinoxamine.
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Translational Research
·
2021
·
IF 7.012
Shiju Ye,Ke Lin,Gaojun Wu,Ming-Jiang Xu,Peiren Shan,Weijian Huang,Yi Wang,Guang Liang
Activation of the innate immune system represents a vital step in inflammation during cardiac remodeling induced by the angiotensin II (Ang II). This study aimed to explore the role of Toll-like receptors 2 (TLR2) in Ang II-induced cardiac remodeling. We investigated the effect of TLR2 deficiency on Ang II-induced cardiac remodeling by utilizing TLR2 knockout mice, bone marrow transplantation models, and H9C2 cells. Though TLR2 deficiency had no effect on body weight change , cardiac Ang II content and blood pressure, it significantly ameliorated cardiac hypertrophy, fibrosis and inflammation, as well as improved heart function. Further bone marrow transplantation studies showed that TLR2-deficiency in cardiac cells but not bone marrow-derived cells prevented Ang II-induced cardiac remodeling and cardiac dysfunction. The underlying mechanism may involve increased TLR2-MyD88 interaction. Further in vitro studies in Ang II-treated H9C2 cells showed that TLR2 knockdown by siRNA significantly decreased Ang II-induced cell hypertrophy, fibrosis and inflammation. Moreover, Ang II significantly increased TLR2-MyD88 interaction in H9C2 cells in a TLR4-independent manner. TLR2 deficiency in cardiac cells prevents Ang II-induced cardiac remodeling, inflammation and dysfunction through reducing the formation of TLR2-MyD88 complexes. Inhibition of TLR2 pathway may be a therapeutic strategy of hypertensive heart failure.
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 6
·1-11
·
IF 2.8
Han Yu,Wei Chaoquan,Wang Ting,Zeng En
The inevitable damage to paint films during coating applications significantly reduces their protective performance, leaving the underlying substrate vulnerable. Developing self-healing coatings is therefore of critical importance. This study presents the synthesis of polyvinyl alcohol (PVA)/polyurea hybrid microcapsules (MCs) loaded with isophorone diisocyanate via interfacial polymerization in an oil-in-water emulsion, with PVA serving as the emulsifier. These microcapsules were incorporated into acrylic resin, along with a dispersant, co-solvent, and isocyanate curing agent, to formulate a microencapsulated self-healing two-component waterborne polyurethane (2 K WPU) coating. The microcapsules were characterized using TG, FTIR, and SEM. The influence of PVA's polymerization degree and alcoholysis degree on microcapsule properties was systematically analyzed. Results indicate that PVA 1799 as an emulsifier yields microcapsules with minimal surface folds and smooth morphology. When 9 wt% of MC 1799 was added to the 2 K WPU coating, the resulting formulation exhibited optimal performance, achieving an average particle size of 29 μm, along with superior self-healing and anti-corrosion properties. This research offers a novel approach for developing high-performance self-healing coatings with potential industrial applications.
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FUEL
·
2025
·
IF 7.5
Yali Niu,Rui Yao,Shuhui Fan,Jinping Li,Guang Liu
Anion-exchange membrane water electrolyzers (AEMWE) are promising for clean hydrogen production. However, the high energy barriers associated with water adsorption and dissociation combined with the high adsorption energy of hydrogen intermediates (H*) in alkaline environment result in slow kinetics for the hydrogen evolution reaction (HER). To tackle this, we report a catalyst comprising Pt nanoparticles loaded on Co(OH) 2 /PTI nanosheets (Pt/Co(OH) 2 /PTI) for efficient alkaline HER at high current densities. Operando characterization indicates that Co(OH) 2 promotes H 2 O adsorption and dissociation, while the Pt nanoparticles optimize H* adsorption energy, enabling preferential H* adsorption at the Pt site to facilitate H 2 generation and desorption. Furthermore, the ultra-thin poly (triazine imide) (PTI) support prevents the Pt nanoparticles aggregation, thereby enhancing catalyst stability. As a result, the synergistic Pt/Co(OH) 2 /PTI achieves superior HER performance, demanding an overpotential of merely 7 mV to achieve a current density of 10 mA cm −2 and just 220 mV to drive 1 A cm −2 , and it maintains stable for over 220 h under the condition of 1 A cm −2 . Additionally, the electrolyzer assembled using Pt/Co(OH) 2 /PTI as the cathode demonstrates stable operation for 200 h at 0.5 A cm −2 under 70 °C, highlighting its strong potential for industrial applications.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Weiqiang Li,Dandan Wei,Qian Xu,Luyu Yang,Yang Liu,Hengyi Xu
Foodborne pathogens pose serious risks to environmental protection and food safety. The low abundance of foodborne pathogens during the early stage of pollution makes the detection of them a challenge, and combining efficient bacterial enrichment with powerful signal release is a potential proposal. In this study, wulff-type boronate functionalized magnetic nanoparticles (MNPs) (B-N/APBA@MNPs) was designed, the binding pH and affinity of the original boronic acid were improved by teamed boronate affinity strategy. Characterization and capacity performance assessment ensure its successful synthesis and excellent capture performance for 2 bacteria. Meanwhile, controlled explosive release of carbon dots (CDs) nanocapsule was prepared by encapsulating CDs with characterized its successful synthesis and evaluate its fluorescence performance. The nanocapsule encapsulating strategy can effectively enhanced the fluorescent signal and avoided the interference of magnetic nanoparticles (MNPs) on CDs. Taking Listeria monocytogenes and Escherichia coli O157:H7 as a proof of concept, a dual-signal amplification platform based on Wulff-type boronate acids combined with controlled explosive release nanocapsule was established. Results showed an impressively low limit of detection (10 1 CFU/mL) and high recovery rates (84.95 % ∼ 116.27 %). Notably, the proposed dual-signal amplification strategy provides a design template for the detection of low concentration of bacteria in environmental detection and food safety.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 7
·583
·
IF 2.8
Zou Wenqian,Zhang Mengyu,Liu Xichen,Ding Shoujun J.,Zou Yong
Developing highly efficient and stable inorganic narrow-band green-emitting phosphor is crucial for phosphor converted backlighting devices. In this study, trivalent Tb 3+ ions self-actived NaTb(MoO 4 ) 2 (NTM) narrow-band green-emitting phosphor was prepared by a conventional high-temperature solid-state reaction method. The electronic structure, luminescence properties and luminescence thermal stability of NTM were studied through experiments and theoretical calculations. The structure of NTM was determined to be a tetragonal phase with the space group of I41/a (88). Besides, the NTM was confirmed with direct bandgap characteristics with bandgap width of 3.1231 eV. Upon 266 nm and 355 nm ultraviolet (UV) excitation, the narrow-band green-emitting properties of the phosphor were investigated. Importantly, the phosphor was confirmed with well luminescence thermal stability and the thermal activation energy ( E a ) was fitted to be 0.32 eV. The work demonstrates that trivalent Tb 3+ ions self-actived NTM is promising as high luminescence stable narrow-band green-emitting phosphor for backlighting display applications.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Li Weipeng,Xu Weizhuo,Sun Zhaopeng,Tang Linning,Xu Guohao,He Xinyue,Deng Yulin,Sun Wei,Zhou Bingjie,Song Jianfei,Liu Wei
As a promising stationary energy storage device, aqueous redox flow battery (ARFB) still faces the challenge of low open-circuit voltage, due to the limitation of the potential of water splitting (1.23 V theoretically). Herein, we present a low potential anolyte design by using Na substituted phosphotungstic acid (3Na-PW 12 ) for an aqueous redox flow battery with the high open-circuit voltage up to 2.0 V. The 3Na-PW 12 can store 5 electrons in the charging process and simultaneously capture Na + or protons from the dissociation of water, resulting in the increase of electrolyte pH to 11. Because of the high pH value, the hydrogen evolution reaction (HER) is highly suppressed, and the 3Na-PW 12 is partially degraded into a lacunary structured PW 11 with extremely low potential down to −1.1 V (vs. SHE). After discharging, the captured protons are re-released into the solution, therefore, pH and the structure of 3Na-PW 12 are recovered. Based on the cyclic pH change and self-regulation process of 3Na-PW 12 in the charge and discharge process, the aqueous flow battery offered a high-power density of 200 mW cm −2 and 160 mW cm −2 coupled with Br 2 /Br − and I 2 /I − catholyte respectively.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2025
·
IF 6
Tong Yu,Juan Qian,Guangyao Zhang,Xiaoran Zhang,Feichao Han,Jiangsheng Liu
This investigation innovatively develops a water-lean blended amine system through multidimensional performance evaluation and reaction mechanism elucidation. The experimental protocol commenced with screening MAE (2-(Methylamino)ethanol) blended with five organic amines, where M15D15 (15 wt% MAE + 15 wt% DETA) and M15A15 (15 wt% MAE + 15 wt% AEEA) emerged as prime candidates due to their exceptional cyclic capacity and rapid desorption kinetics, respectively. Subsequent phase behavior optimization via n-propanol (PrOH) incorporation revealed critical solvent composition effects. The optimized M15D15P45 formulation (MAE/DETA/PrOH = 15:15:45 wt%) demonstrated remarkable capability metrics: 81.2 % enhancement in CO 2 absorption capacity and 129 % improvement in cyclic capacity compared to benchmark 30 wt% MEA aqueous solution, with regeneration energy consumption reduced to 2.05 GJ·t −1 CO 2 . Post six absorption–desorption cycles, the system retained 95.2 % initial capacity, showcasing exceptional stability. 13 C NMR spectral analysis confirmed PrOH’s dual functionality as both phase separation promoter and active reaction participant through carbamate formation. Kinetic profiling further revealed MAE’s superior regeneration responsiveness over DETA. In conclusion, the M15D15P45 absorbent system demonstrates excellent regeneration capability and outstanding stability, with significant potential for future development.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Chuan-Jun Yue,Xin Sun,Han Xiao,Xin-Yan Jin
In the framework of sustainable development, researchers in both traditional and modern chemistry are compelled to pursue innovation. The inherent drawbacks of conventional ester synthesis methods highlight the urgent need to develop efficient and environmentally benign approaches. This study introduces an electrochemical-intensified heterogeneous catalytic strategy for acrylate synthesis. A distinctive heterogeneous catalyst has been developed by bonding 2-methoxyphenothiazine onto nanosilica surface through the coupling agent 3-chloropropyltrimethoxysilane. The characterization of the catalyst was conducted through Infrared spectroscopy (IR), X-ray diffraction (XRD), scanning electron microscope (SEM), and thermogravimetry (TG), as well as the Kjeldahl method, revealing a 12.86% loading and uniform distribution. The catalyst demonstrated remarkable efficacy in facilitating the esterification of acrylic acid and monohydric alcohols at room temperature, uniformly varying reaction rate processes compared to acid catalysis and achieving a catalytic yield exceeding 85%. Moreover, the catalytic activity largely remained consistent over six cycles. The electrochemical enhancement was instrumental in modifying the traditional esterification process. The electrochemical-intensified heterogeneous catalytic system for the esterification of acrylic acid meets the standards for green production. This research provides novel insights into integrated catalytic technologies for esterification, contributing to the advancement of sustainable chemistry.
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OZONE-SCIENCE & ENGINEERING
·
2018
·
IF 1.232
Siyuan Wang,Xinghao Wang,Jing Chen,Ruijuan Qu,Zunyao Wang
Benzophenone-2 (BP-2) is an important type of UV filter that has been widely used and detected in the aquatic environment with greater estrogenic toxicity. In our work, the removal of BP-2 with the initial concentration of 25 mg L−1 was first carried out by ozone at different pH (ranging from pH 3.0 to 11.0), and we found a positive correlation between the pH values and the degradation efficiency of BP-2, among which the more rapid removal of BP-2 in alkaline condition was observed than acidic and neutral conditions. For the influence of aqueous humic acid (HA, the concentration ranged from 0 ppm to 100 ppm), the degradation rate of BP-2 by ozonation was first increased with the growth of humic acid concentration (from 0 ppm to 5 ppm), reaching to maximum at 5 ppm of HA and subsequently decreased with the growth of HA concentration (from 5 ppm to 100 ppm). Fourteen intermediate products in the ozonation process were distinguished by an electrospray time-of-flight mass spectrometer and then two degradation pathways were proposed. Through the theoretical calculation, we found the carbanyl group of BP-2 has the most reactivity to be easily attacked by ozone, providing us guides and theoretical basis on the supposed intermediate products. Furthermore, the P. phosphoreum acute toxicity test was conducted to evaluate the potential toxicity during the ozonation process.
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