SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Yongjun Sun,Yuanyuan Yu,Shengbao Zhou,Kinjal J. Shah,Wenquan Sun,Jun Zhai,Huaili Zheng
In this study, an amphoteric magnetic chitosan (CS)-based flocculant MFe 3 O 4 @CS-g-PIA was prepared from CS, Fe 3 O 4 , and itaconic acid (IA), and its apparent morphology and characteristic structure were systematically studied. The flocculation performance and mechanism of the fabricated material were also investigated in different pollution systems, and the effects of total monomer concentration, m(CS):m(IA), IA pre-neutralization degree, reaction temperature, reaction time, and initiator concentration on the synthesis of MFe 3 O 4 @CS-g-PIA were studied. Characterization results showed that MFe 3 O 4 @CS-g-PIA forms a three-dimensional network with excellent magnetic induction. The optimal removal rates of Cu(II) and Disperse Blue 56 (DB56; 90.2% and 97.0%, respectively) were obtained under the conditions of 150 mg·L −1 MFe 3 O 4 @CS-g-PIA, pH 6.0, and 300 rpm stirring speed. MFe 3 O 4 @CS-g-PIA maintained removal rates of over 80.0% for Cu(II) and DB56 after five consecutive cycles of regeneration/flocculation and demonstrated excellent acid resistance stability. Changes in the particle size distribution, fractal dimensions, and zeta potentials of the flocs indicated that the relevant flocculation mechanism involves the synergistic functions of chelation, charge neutralization, and adsorption bridging. An artificial neural network model was finally established on the basis of the experimental flocculation data to predict the removal rates of Cu(II) (R = 0.97) and DB56 (R = 0.98) accurately.
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CARBOHYDRATE POLYMERS
·
2023
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IF 11.2
Hanyu Ren,Andi Guo,Chunhui Luo
Developing artificial substitutes that mimic the structures and performances of natural cartilage is of great importance. However, it is challenging to integrate the high strength , excellent biocompatibility, low coefficient of friction , long-term wear resistance, outstanding swelling resistance, and osseointegration potential into one material. Herein, a sandwich hydrogel with cartilage-mimetic structures and performances was prepared to achieve this goal. The precursor hydrogel was obtained by freezing-thawing the mixture of poly vinyl alcohol, chitosan and deionized water three cycles, accompanied by soaking in sodium hyaluronate solution. The top of the precursor hydrogel was hydrophobically modified with lauroyl chloride and then loaded with lecithin , while the bottom was mineralized with hydroxyapatite . Due to the multiple linkages (crystalline domains, hydrogen bonds , and ionic interactions), the compressive stress was 71 MPa. Owing to the synergy of the hydrophobic modification and lecithin , the coefficient of friction was 0.01. Additionally, no wear trace was observed after 50,000 wear cycles. Remarkably, hydroxyapatite enabled the hydrogel osseointegration potential. The swelling ratio of the hydrogel was 0.06 g/g after soaking in simulated synovial fluid for 7 days. Since raw materials were non-toxic, the cell viability was 100 %. All of the above merits make it an ideal material for cartilage replacement.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Jingde Yang,Binjie Zhang,Li Wang,Wenda Song,Bo Li,Zhengzhi Mu,Yufei Wang,Shuang Zhang,Junqiu Zhang,Shichao Niu,Zhiwu Han,Luquan Ren
Ultra-high molecular weight polyethylene (UHMWPE) fibers are broadly applied in lightweight and high-strength composite fiber materials. However, the development of UHMWPE fibers is limited by their smooth and chemically inert surfaces. To address the issues, a modified UHMWPE fibers material has been fabricated through the chelation reaction between Cu 2+ and chitosan coatings within the surface of fibers after plasma treatment, which is inspired by the hardening mechanism, a crosslinked network between metal ions and proteins/polysaccharides of the tips and edges in arthropod-specific cuticular tools. The coatings improve the surface wettability and interfacial bonding ability, which are beneficial in extending the application range of UHMWPE fibers. More importantly, compared to the unmodified UHMWPE fiber cloths, the tensile property of the modified fiber cloths is increased by 18.89% without damaging the strength, which is infrequent in modified UHMWPE fibers. Furthermore, the interlaminar shear strength and fracture toughness of the modified fibers laminate are increased by 37.72% and 135.90%, respectively. These improvements can be attributed to the synergistic effects between the surface activity and the tiny bumps of the modified UHMWPE fibers. Hence, this work provides a more straightforward and less damaging idea of fiber modification for manufacturing desirable protective and medical materials.
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Foods
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2023
·Vol. 12
·期 15
·2898
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IF 5.2
Lingyu Han,Ruiyi Zhai,Bing Hu,Jixin Yang,Yaoyao Li,Zhe Xu,Yueyue Meng,Tingting Li
The synthesis of octenyl-succinylated chitosan with different degrees of substitution resulting from chemical modification of chitosan and controlled addition of octenyl succinic acid was investigated. The modified products were characterized using1H NMR, FTIR, and XRD, and the degree of substitution was also determined. The properties of the modified chitosan oligosaccharide in solution were evaluated by surface tension and dye solubilization, finding that the molecules self-assembled when they are above the critical aggregation concentration. The two methods yielded consistent results, showing that the self-assembly was reduced with higher levels of substitution. The antimicrobial activity of the octanyl-succinylated chitosan oligosaccharide (OSA-COS) derivatives againstStaphylococcus aureus,Escherichia coli, andFusarium oxysporum f.sp cucumerinumwas investigated by the Oxford cup method. While the acetylated COS derivatives were not significantly effective against eitherE coliorS. aureus, they showed significant antifungal activity towardF. oxysporumthat was superior to that of COS. The modified product was found to form a stable emulsion when mixed with whey protein isolate. The emulsion formed by the highly substituted derivatives have a certain stability and loading efficiency, which can be used for the encapsulation and delivery of astaxanthin.Keywords:chitosan oligosaccharide;octenyl succinic anhydride;astaxanthin;emulsions properties
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Bingren Tian,Xia Qiao,Songlin Guo,Aiqin Li,Yanan Xu,Jia Cao,Xu Zhang,Duan Ma
The development of nanoparticles loaded with natural active ingredients is one of the hot trends in the pharmaceutical industry. Herein, chitosan was selected as the base material, and sodium tripolyphosphate was chosen as the cross-linking agent. Chitosan nanoparticles loaded with β-acids from hops were prepared by the ionic cross-linking method. The results of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that chitosan nanoparticles successfully encapsulated β-acids. The loading capacity of chitosan nanoparticles with β-acids was 2.00 %–18.26 %, and the encapsulation efficiency was 0.58 %–55.94 %. Scanning electron microscopy (SEM), transmission electron microscope (TEM), particle size, and zeta potential results displayed that the nanoparticles revealed a sphere-like distribution with a particle size range of 241–261 nm, and the potential exhibited positive potential (+14.47–+16.27 mV). The chitosan nanoparticles could slowly release β-acids from different simulated release media. Notably, the β-acids-loaded nanoparticles significantly inhibited Staphylococcus aureus ATCC25923 ( S. aureus ) and Escherichia coli ATCC25922 ( E. coli ). Besides, β-acids-loaded chitosan nanoparticles were cytotoxic to colorectal cancer cells (HT-29 and HCT-116). Therefore, applying chitosan nanoparticles can further expand the application of β-acids in biomedical fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yan Fang,Jiawen Chen,Qinglin Li,Qinhui Chen
Excessive bleeding and bacterial infection leading to death is a major concern worldwide, particularly in cases of deep and narrow noncompressible hemorrhage. Herein, a novel Janus cryogel with anisotropic surface wettability, antibacterial activity, and rapid shape recovery was designed by constructing a hydrophilic porous cryogel using chitosan (CS), acacia gum (AG), and quaternized mesoporous bioglass (QMBG), with subsequent surface hydrophobic modification using octadecanol. The asymmetric hydrophobic surface modification of octadecanal endowed OCAQ with outstanding antiblood and antibacterial permeability, effectively preventing blood outflow and the invasion of bacteria to the wound. The hydrophilic parts with interconnected macroporous structure give the cryogel with ultra-high water uptake (5167 ± 182 %) and rapid water-trigged shape recover ability (≈2.1 s). The presence of active CS, AG, and QMBG in cryogel contributes to its exceptional blood clotting ability. Janus cryogel presents outstanding hemostatic performance (0.14 ± 0.03 g) in rat's liver injury model. Moreover, Janus cryogel exhibits excellent antibacterial properties due to the combination of its hydrophobic surface and antimicrobial quaternary amine groups. Meanwhile, the Janus cryogel has favorable hemocompatibility and biocompatibility. A Therefore, the Janus cryogel will become a candidate with great potential for clinical application of noncompressible wound as a multifunctional dressing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
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IF 8.2
Yongfei Zhang,Depeng Shi,Wenqian Wang,Weiyi Li,Wenhui Li,Lihua Zhao,Lichun Ma,Zhi Peng,Xianyong Sun,Chao Yang
An effective treatment for some disease, such as the model disease acute retinal necrosis (ARN), requires a combination of different drugs which should be administered at a certain interval. The precise sequential and long-term drug release are the critical questions. In this work, the as-prepared chitosan nanoparticles (CS-NPs) coated with hyaluronic acid (HA) were embedded in the aldehyde β-cyclodextrin (ACD)/aminated hyaluronic acid (NHA) hydrogels to synthesize injectable hydrogels loaded with dual drugs named DEX-CS-NPs/GCV-Gel and HA-DEX-CS-NPs/GCV-Gel. In the first 24 h and 48 h, the releases of DEX from DEX-CS-NPs/GCV-Gel were 128.5 % and 82.8 % faster than those from HA-DEX-CS-NPs/GCV-Gel, respectively. There was no DEX released from HA-DEX-CS-NPs/GCV-Gel at the first 7 h, which has never been reported before, although some hydrogel systems loaded with different drugs release different drugs simultaneously at different rate which have been well studied. This is a good start of a precise sequence release. The composite hydrogels possessed appropriate rheology , gel time, degradation performance, and ideal cytocompatibility. The injectable hydrogel loaded with dual drugs presenting a precise sequential and long-term release has great potential in the treatment of diseases requiring combinations of drugs being released sequentially at different treating stages.
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Chaoyi Shen,Xiangzheng Yang,Da Wang,Jiangkuo Li,Changqing Zhu,Di Wu,Kunsong Chen
Nanofiber packaging has not yet gained practical application in fruit preservation because of some limitations, such as low production rate and utilization, and failure due to poor adhesion to the fruit. Herein, to solve this issue, a novel fruit packaging method based on solution blow spinning (SBS), called in-situ packaging, was pioneered. Specifically, carboxymethyl chitosan (CMCH) and polycaprolactone (PCL) were chosen as substrate materials and cherry tomatoes were selected as demonstration subjects. CMCH/PCL nanofibers were deposited directly onto the surface of cherry tomatoes by SBS, forming a tightly adherent and stable fiber coating in 8 min. Also, this in-situ packaging could be easily peeled off by hand. The in-situ packaging was an excellent carrier for active substances and was effective in inhibiting gray mold on cherry tomatoes. The in-situ packaging film formed a barrier on the surface of cherry tomatoes to limit moisture penetration, resulting in reduced respiration of fruits, which led to reduced weight and firmness loss. In addition, metabolomics and color analysis revealed that the in-situ packaging delayed ripening of cherry tomatoes after harvest. Overall, the in-situ packaging method developed in the present work provides a new solution for post-harvest fruit preservation.
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Science China-Technological Sciences
·
2023
·
IF 4.6
Ren Hui,Zhang Zhen,Lu KaiLun,Shen YuanYuan,He ChaoLiang,Chen XueSi
Burn wounds are destructive skin traumas typically of irregular shape and large area. Prone to infection, they require frequent dressing replacement, and painless removal of dressings from burn wounds remains a major challenge. This study focuses on the dynamic characteristics and treatment difficulty of burn wounds. Hydrogel dressings based on glycol chitosan and propionaldehyde- or benzaldehyde-terminated 4-arm poly(ethylene glycol) were designed on the basis of Schiff base cross-linking networks. The hydrogels exhibited shape-adaptability, self-healing and fast-degradation properties, which makes these hydrogels suitable for burn wounds. Salvianolic acid B (SaB)-loaded hydrogel exhibited good antioxidant properties in vitro . In a rat model of deep second-degree burn wounds, the SaB-loaded hydrogel could quickly reduce wound temperature, regulate wound oxidant microenvironment, promote angiogenesis, and accelerate wound healing. Thus, the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of burn wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Chuang Li,Li Fu,Suqi Deng,Heng Wang,Li Jia
Environmentally friendly and recycled polydopamine-functionalized electrospun poly(vinyl alcohol)/chitosan nanofibers (PVA/CS/PDA) were prepared through a low-energy-consumption procedure. The PDA coating endows PVA/CS/PDA nanofibers with good water stability. The PVA/CS/PDA nanofibers have a fibrillar and porous structure that is favorable for Cu(II) to access the active sites of the nanofibers. The adsorption isotherm and kinetics data preferably conform to the Liu isotherm and pseudo-second-order kinetic models, respectively. The maximum adsorption capacity of Cu(II) ions by PVA/CS/PDA nanofibers from the Liu isotherm model is 326.5 mg g −1 . The PVA/CS/PDA nanofibers exhibit higher adsorption capacity than some other reported adsorbents. The adsorption mechanism study demonstrates that the Cu(II) adsorption is mainly ascribed to the complexation of Cu(II) with the imino, amino, and hydroxy moieties in PVA/CS/PDA nanofibers. The nanofibers can be employed for 5 cycles without significantly deteriorating performance. More interestingly, a fluorometry method based on the oxidation mimic enzyme activity of Cu(II) was developed to detect low concentrations of Cu(II) using the nanofibers as an adsorbent to preconcentrate Cu(II). The limit of detection is 0.42 mg L −1 . The successful removal and detection of Cu(II) in Pearl River and mineral water samples demonstrates the great potential of PVA/CS/PDA nanofibers to remediate Cu(II)-polluted water.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Xi Zhang,Xiangli Kong,Xin Zhou,Yiyan Gao,Yibo Sun,Guanghui Gao,Wei liu,Kai Shi
Conductive hydrogels have great development prospects in the field of flexible strain sensors due to the unique characteristics of sufficient flexibility, comfort and functional diversification. However, long-term direct contact between hydrogel sensors and human skin can cause the phenomenon of bacterial infection, which accelerates the replaceable frequency of hydrogel wearable sensors, hindering the application of hydrogel wearable sensors. Here, the hydrogel with distinguished antibacterial, biocompatibility, frost resistance, water retention and toughness were designed and manufactured by a freeze–thaw method introducing polyvinyl alcohol, quaternary ammonium chitosan salt, polyhexamethylene biguanide hydrochloride, glycerin and lithium chloride. The hydrogel maintains remarkable tensile properties and fatigue resistance in the range from 25 °C to −20 °C, expanding the application of hydrogels as sensors. Meanwhile, the hydrogel was resistant to E. coli and Bacillus subtilis and could be preserved in mice for 14 days. As a result, the hydrogel sensors could be used to detect human movement in real time, such as finger bending, frowning, speaking and other movements. Therefore, the design of the hydrogel provides a simple research idea for implantable sensing devices.
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Advanced Healthcare Materials
·
2023
·
IF 10
Ning Yang,Xiuhua Pan,Xiawei Zhou,Zengyi Liu,Jie Yang,Jun Zhang,Zengguang Jia,Qi Shen
Immunogenic cell death (ICD) shows promising therapeutic potential for tumor regression. However, the low sensitivity and immunosuppressive state of current cell death manners seriously impede tumor immunogenicity. Ferroptosis characterized by excessive lipid peroxidation (LPO), has emerged as a potential strategy to induce ICD and activate antitumor immune responses. However, the effectiveness of ferroptosis is limited by antioxidant regulatory networks, including the glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1) pathways, presenting challenges for its induction. Herein, we propose a novel approach using functionalized chitosan-ferrocene-sodium alginate (CFA) crosslinked nanogels, incorporating pravastatin (PRV) and M1 macrophage membrane (MM) (designing as CFA/PRV@MM). Specifically, ferrocene boots intracellular reactive oxygen species (ROS) levels for efficient glutathione (GSH) depletion through Fenton reaction, thus disrupting the GPX4/GSH axis, while PRV intervenes in the mevalonate (MVA) pathway to inhibit the FSP1/CoQ10 antioxidant axis, thereby synergistically causing pronounced ferroptotic damage and promoting ICD. The CFA/PRV@MM nanogels demonstrate superior therapeutic efficacy in a mouse breast model, resulting in effective tumor ablation and immune response with minimal side effects. RNA transcription analysis reveals that nanogels can significantly affect metabolic progress, as well as immune activation. This research provides valuable insights into the design of ferroptosis induction for cancer immunotherapy. This article is protected by copyright. All rights reserved
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