CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Jun Zhu,Jingjing Chen,Congcong Wang,Dehong Yu,Minghao Chao,Hanrong Yan,Ruqi Huang,Zhenxin Wang,Bin Pan,Fenglei Gao
Insufficient generation of reactive oxygen species and the highly active cholesterol metabolism of tumors are two major barriers limiting the efficacy of conventional ferroptosis-based cancer therapies. Here, we engineered a single-atom iron nanozyme (Fe-NC@TASIN-30@FA, abbreviated as FTF) to overcome ferroptosis resistance and sensitize tumors to apoptosis-coupled catalytic therapy by simultaneously delivering a distal cholesterol synthesis inhibitor and catalytically amplifying ROS production. FTF is constructed by loading a selective 7-dehydrocholesterol (7-DHC) synthesis inhibitor, TASIN-30, onto an iron single-atom nanozyme and further functionalizing it with folate-modified polyethylene glycol (SH-PEG-FA) to confer tumor-targeting capability. Notably, TASIN-30 is incorporated with a drug-loading rate of 22.5%, providing efficient payload delivery without compromising nanozyme activity. The iron active centers in FTF exhibit dual enzyme-mimetic activities. One of them is peroxidase-like activity that breaks down H 2 O 2 into hydroxyl radicals, and the other is glutathione peroxidase-like activity that catalyzes the oxidation of reduced glutathione to oxidized glutathione, thereby increasing intracellular ROS levels and consuming antioxidants to achieve a coordinated iron apoptosis effect. In addition, by inhibiting 7-DHC and cholesterol biosynthesis, FTF accelerates the consumption of excess intracellular cholesterol in tumor cells, disrupts the integrity of lipid rafts, and consequently suppresses tumor cell proliferation. In 143B tumor-bearing nude mice, FTF achieves an in vivo tumor inhibition rate of approximately 82.5%, while exhibiting a maximum tolerated dose of 7.5 mg/kg. Overall, this study proposes a new therapeutic strategy that integrates cholesterol metabolic interference with catalytic nanozyme therapy, providing a potent ferroptosis-apoptosis synergistic modality for tumors refractory to conventional treatments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
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IF 8.7
Ying Yu,Yonggang Peng,Sekar Vijayakumar,Yikai Chen,Yangfan Mao,Meihua Xin,Mingchun Li
This study aims to develop a novel chitosan-based pH-responsive hydrogel for sustained curcumin (Cur) delivery. Chitosan was modified with norbornene dicarboxylic anhydride to introduce reactive double bonds and enhance solubility, while cysteine-modified Pluronic F127 was crosslinked via UV-induced thiol–ene chemistry to form a stable three-dimensional network. The hydrogel structure was tuned by adjusting the CSNB/CPC ratio and characterized using 1 H NMR, solid-state 13 C NMR, FTIR, TGA, XRD, SEM, and rheology. The optimized hydrogel achieved a drug loading capacity of 13.3 mg/g and exhibited pH-responsive release in simulated gastrointestinal fluids, with kinetics well-fitted to the Peppas–Sahlin model (R 2 > 0.98), dominated by Fickian diffusion. Functional evaluation showed that NC4 displayed nearly 90% DPPH radical scavenging efficiency, and its antioxidant potential was further supported by the Folin–Ciocalteu (GAE) assay and the phosphomolybdenum (AAE) assay, indicating enhanced overall reducing capacity and total antioxidant capacity. NC4 also exhibited strong antibacterial activity against Staphylococcus aureus and Escherichia coli . Biocompatibility was confirmed by CCK-8 and hemolysis assays, with cell viability exceeding 90% and hemolysis rates below 0.35%. Collectively, this multifunctional hydrogel integrates sustained release, antioxidant, antibacterial, and excellent biocompatibility, providing a promising material platform for oral controlled drug delivery and wound healing applications.
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Biomaterials Advances
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2026
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IF 6.7
Changxu Wang,Shenghao Shi,Fei Wang,Chong Yuan,Di Liu,Yifei Liu
Osteoporosis is a prevalent metabolic bone disorder characterized by an imbalance between bone resorption and formation. Current therapeutic options are constrained by side effects and low bioavailability. Icariin (ICA), a naturally derived osteotropic flavonoid, exhibits osteogenic and anti-osteoclastogenic properties; however, its clinical application is limited due to poor solubility and low oral bioavailability. This study introduces β-cyclodextrin-modified gold nanoclusters (CGNCs) as a nanocarrier for efficient delivery of ICA. The synthesized ICA-loaded CGNCs (ICA-CGNCs) have a hydrodynamic diameter of approximately 2.16 nm, demonstrating excellent dispersity, sustained release kinetics, and storage stability. In vitro, ICA-CGNCs showed good cytocompatibility in both MC3T3-E1 pre-osteoblasts and RAW264.7 macrophages. In MC3T3-E1 cells, ICA-CGNCs promoted osteogenic differentiation, as indicated by increased ALP activity, enhanced mineralization, and upregulated osteogenic genes (ALP, BMP2, RUNX2, and COL1A1 ); immunofluorescence further showed elevated nuclear β-catenin and RUNX2 signals, supporting the involvement of osteogenic pathway-associated events in this cell model. In RAW264.7 cells, ICA-CGNCs suppressed RANKL-induced osteoclastogenesis by reducing TRAP-positive multinucleated osteoclast formation, disrupting F-actin ring organization, and downregulating osteoclast markers ( TRAP, CTSK, MMP9, and NFATc1 ), which was supported by decreased bone resorption pit formation and attenuated nuclear accumulation of NF-κB p65 and NFATc1·In a glucocorticoid-induced zebrafish osteoporosis model, ICA-CGNCs effectively promoted cranial and vertebral bone mineralization without systemic toxicity, outperforming both free ICA and CGNCs alone. This study establishes the ICA-CGNC platform as a dual-action nanotherapeutic strategy with significant potential for osteoporosis treatment and bone regeneration.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Fengxian Luo,Xinchuang Wang,Tao Chen,Lihang Chen,Dan Zhang,Qingping Shi,Jinling Xu,Jiangning Hu
Inflammatory bowel disease (IBD) represents a chronic inflammatory disorder characterized by excessive reactive oxygen species (ROS) generation, persistent inflammatory response, and gut microbiota dysbiosis. Herein, a novel colon-targeted composite hydrogel (FTS/Gel) consisting of metal-polyphenol nanozymes (FTS) embedded in an inulin-based gel was developed for efficient oral treatment of IBD. This nanozyme (FTS) was synthesized by coordination between Fe 3+ ions and the anti-inflammatory drugs taxifolin (Tax) and L- Se -methylselenocysteine (SeMC), exhibiting remarkable superoxide dismutase (SOD)-like and catalase (CAT)-like activities. Moreover, FTS nanozymes significantly scavenged intracellular ROS and suppressed inflammation in RAW264.7 cells. Incorporating FTS into an inulin hydrogel notably enhanced colon-targeting efficiency, bio-adhesion, and retention time in vivo. Oral administration of FTS/Gel effectively alleviated colitis, as evidenced by increased colon length, reduced splenomegaly, restored intestinal epithelial barrier integrity, and enhanced mucin secretion. Furthermore, FTS/Gel treatment rebalanced gut microbiota composition by promoting beneficial bacteria and suppressing pernicious bacteria. Collectively, this study presents a promising therapeutic strategy combining antioxidant nanozymes and prebiotic-based hydrogel delivery systems for effectively managing and treating IBD.
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Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 2
·227-236
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IF 7.5
Rakotomalala Manda Heriniaina,Xia Chen,Yulian Wu,Wenfeng Liao,He Fei,Peipei Wang,Kan Ding
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), ranks among the most prevalent malignancies and is a leading cause of cancer-related mortality worldwide. Therefore, there is an urgent need to identify novel anti-pancreatic cancer agents. This study reports a newly identified homogeneous polysaccharide, designated ESPPW, isolated from Arthrospira platensis ( A. platensis ). The molecular weight of ESPPW is estimated at 356 kDa, and it consists predominantly of glucose and rhamnose, with minor amounts of mannose, glucuronic acid, galacturonic acid, galactose, xylose, arabinose, and fucose. ESPPW inhibits the proliferation and migration of PDAC cells both in vitro and in vivo . Mechanistic investigations reveal that ESPPW induces apoptosis through activation of caspase-3 and is associated with upregulation of the tumor-suppressor protein p53. Notably, treatment with 2.8 nmol·L −1 of ESPPW leads to significant time-dependent downregulation of galectin-3 (Gal-3) and glypican-6 (GPC-6). These findings are corroborated by immunohistochemical analysis of tumor xenograft tissues. Furthermore, overexpression of Gal-3 and GPC-6 reverses the pro-apoptotic effect of ESPPW, as indicated by restored cycle regulatory proteins (CDK2) expression. In conclusion, these data demonstrate that ESPPW suppresses PDAC cell growth by promoting apoptosis and disrupting the functional activity of Gal-3 and GPC-6.
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DYES AND PIGMENTS
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2026
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IF 3.9
Xuemei Sun,Jiahao Li,Suyu Jiang,Lin Zang,Rong-Mei Kong,Yan Zhao,Weiheng Kong
The escalating incidence of antibacterial resistance presents a formidable challenge in managing bacterial infections. Traditional Zn-based antibacterial agents face limitations due to their reliance on ultraviolet activation and potential neurotoxicity. The combination of nanotechnology and traditional Chinese medicine (TCM) not only reduces the side effects of Zn 2+ but also enhances therapeutic efficacy. In this study, we synthesized Zn-baicalein nanoparticles (Zn-BE NPs) that self-assemble through chemical coordination, offering broad-spectrum antibacterial capabilities. The Zn component exhibited inherent antibacterial properties by disrupting the synthesis of bacterial metabolic enzymes and destroying genetic factors. Baicalein (BE), derived from Scutellaria , enhanced the NPs’ antibacterial efficacy by disrupting bacterial membranes and facilitating Zn 2+ influx, leading to cell wall rupture and metabolic disruption. In addition, Zn-BE NPs exhibited excellent photothermal conversion efficiency, enabling effective bactericidal action under near-infrared irradiation. This triple synergistic mechanism not only overcame the limitations of conventional Zn-based therapies but also sustained long-term antibacterial activity by preventing rapid bacterial metabolism. Our findings demonstrated that Zn-BE NPs could achieve complete bacterial eradication, showcasing expected potential in addressing antibacterial resistance. This research laid a foundation for the development of safer and more effective antibacterial agents, with implications for future applications in combating resistant infections.
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Food Bioscience
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2026
·
IF 6.2
Yini Lin,Xiaohan Ge,Meiru Mao,Jiawen Liu,Zixin Jin,Yi Wang
Coix seed is a medicinal-edible plant rich in bioactive polysaccharides. While coix seed polysaccharide (CSP) exhibits broad pharmacological activities, its neuroprotective potential against neurodegenerative diseases remains underexplored. This study identified CSP as a heteropolysaccharide with two distinct molecular weight peaks (552 Da and 35,011 Da), primarily composed of glucose. It has a triple-helical structure and exhibits strong, dose-dependent antioxidant properties. In vitro antioxidant assays demonstrated strong radical scavenging capacity, with IC 50 values of 2.56 mg/mL for ABTS radical and 2.75 mg/mL for •OH. Crucially, CSP pretreatment significantly protected PC12 cells against H 2 O 2 -induced oxidative damage, evidenced by a 41.56% increase in cell viability at 1.6 mg/mL ( P < 0.05). Additionally, CSP increased the activity of superoxide dismutase (SOD) and catalase (CAT) in a dose-dependent manner, raised glutathione (GSH) levels, and reduced the release of lactate dehydrogenase (LDH) and the content of malondialdehyde (MDA) in PC12 cells exposed to H 2 O 2 . Moreover, CSP significantly reduced reactive oxygen species (ROS) accumulation and attenuated apoptosis. Taken together, these findings elucidate CSP's neuroprotective mechanism via oxidative stress mitigation, supporting its potential development as a therapeutic agent or functional food component for neurodegenerative disorders.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Xiao Liang,Qi Huang,Yang Wu,Deyu Zhu,Zhuangzhuang Wei,Qing Feng,Zhilong Chen,Yibing Chen,Ping Ma,Xu Yang,Cuiyu Bao,Xinyu Bao
Background Polystyrene microplastics (PS-MPs) represent a major environmental contaminant, capable of building up in various organisms, including animals and plants. They can increase through the food chain, ultimately threatening human health. Recent research has indicated a possible association between exposure to PS-MPs in the environment and heart damage; nevertheless, the specific mechanisms behind this connection are not yet fully understood. Objectives This study aimed to investigate the toxic effects of PS-MPs exposure on cardiac health. We specifically elucidated the underlying mechanisms through which PS-MPs exacerbate doxorubicin hydrochloride (DOX)-induced cardiac injury, emphasizing oxidative stress, ferroptosis, and dysregulation of mitochondrial dynamics. Furthermore, we examined the protective effects of two antagonists: Ferrostatin-1 (Fer-1) and luteolin (Lut), against PS-MPs-induced cardiac injury. Methods C57BL/6 mice were categorized into eight distinct groups: the blank control group (saline), the PS-MPs exposure group (PS-MPs), the DOX modeling group (DOX), the combined exposure group of PS-MPs and DOX (PS-MPs+DOX), and the treatment groups with Fer-1 and Lut (PS-MPs+Fer-1, PS-MPs+Lut, PS-MPs+DOX+Fer-1, PS-MPs+DOX+Lut). The entire experimental duration spanned five weeks. We evaluated the effects of PS-MPs and DOX on cardiac function using electrocardiography and assessed their impact on cardiac injury through histopathological analysis of the heart. Concurrently, we examined the effects of PS-MPs and DOX on mitochondrial structure via mitochondrial electron microscopy. Furthermore, we analyzed the heart organ coefficient, myocardial injury markers (CK-MB, CTnT), oxidative stress biomarkers (ROS, MDA, GSH, 4-HNE, Nrf2), ferroptosis-related markers (Fe 2 + , GPX4, SLC7A11), mitochondrial damage markers (ATP, Complex III, Complex V), mitochondrial dynamics-related markers (OPA1, MNF2, DRP1), as well as serum metabolomics. Results Our findings reveal that exposure to PS-MPs exhibits significant cardiotoxic effects, influencing heart rate changes in mice and leading to abnormal in oxidative stress levels and ferroptosis-related proteins within myocardial tissue. Concurrently, exposure to PS-MPs leads to changes in mitochondrial structure and dynamics, further exacerbating oxidative stress and ferroptosis. Ultimately, PS-MPs aggravate DOX-induced cardiac injury. However, Fer-1 and Lut have a good improvement effect on the above situation. Furthermore, metabolomic analyses suggest that pathways and metabolites involved in cAMP signaling, the TCA cycle, tryptophan metabolism, and the metabolism of xenobiotics by cytochrome P450 may also play significant roles. Conclusion PS-MPs exposure can further exacerbate DOX-induced cardiac injury in mice, a process characterized by oxidative damage, activation of the ferroptosis pathway, and alterations in mitochondrial dynamics. Furthermore, luteolin, a naturally occurring active compound, plays a significant role in ameliorating this process.
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JOURNAL OF FLUORESCENCE
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2026
·
IF 3.4
Su Qian,Huang Li,Zhang Youjin,Yang Zhiyong
Carbon dots (CDs) have been broadly employed in many fields due to their excellent fluorescence property, especially in pharmaceutical analysis. Herein, we developed a simple and rapid method to prepare the phosphorus-nitrogen (P, N) co-doped carbon dots via a 3-minute 50-second microwave-assisted synthesis, using N-butyldiethanolamine as the carbon source with phosphoric acid accelerating the CDs formation reaction. The prepared CDs (termed CD1) were characterized by TEM, FT-IR, XPS, XRD and fluorescence spectroscopy. P, N co-doped CDs exhibited notable water solubility, a quantum yield of 19.7% and good photobleaching resistance. Taking advantage of their superior fluorescence, these CDs served as a bright-blue probe for tigecycline detection through fluorescence quenching. The sensor displayed excellent selectivity and anti-interference ability against common coexisting drugs (e.g., voriconazole, ceftazidime, amikacin). Under optimized conditions, a wide linear range (1-936 µM) between F 0 / F and Tigecycline concentration was established, with a correlation coefficient (R) of 0.984, and the detection limit (LOD) was calculated to be 1.10 µM. Furthermore, we clarified the fluorescence quenching mechanism of CD1 toward tigecycline, which was attributed to the internal filtration effect (IFE). Thus, this work demonstrated a novel P, N co-doped CD-based sensing strategy for rapid tigecycline monitoring.
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Journal of the Taiwan Institute of Chemical Engineers
·
2026
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IF 6.9
Yuchen Yang,Yanhua Liu,Qiong Bu,Changjia Gong,Jianbin Zhang,Dianming Li,Ziyuan Yang,Jie Ren,Libang Feng
Background The metallization of carbon fibers (CFs) has become a promising strategy to significantly enhance electrical conductivity, enabling advanced applications in electromagnetic interference (EMI) shielding and electrothermal systems. Nevertheless, conventional metallization techniques often suffer from insufficient interfacial adhesion, intricate processing steps, and unfavorable environmental implications. Method In this study, a rapid and environmentally benign approach is proposed, combining tannic acid (TA)-mediated surface functionalization with microwave-assisted reduction. TA modification (CF@TA) enables the chelation of silver ions onto the CF surface, which are subsequently reduced in situ to generate silver nanocrystals (CF@TA-Ag(N)). Microwave irradiation expedites reaction kinetics and promotes uniform deposition, resulting in a dense, continuous, and strongly adherent silver layer (CF@TA-Ag(L)) within only 5 minutes. Significant finding The CF@TA-Ag(L) specimens exhibit an electrical conductivity of 17,480 S·m -1 , representing a 670-fold increase compared with pristine CFs. These fibers retain mechanical integrity after 200 bending cycles, 30 min of ultrasonication and 100 tape cycles. Moreover, a high EMI shielding effectiveness of 75.2 dB is achieved, accompanied by notable low-voltage electrothermal performance, reaching 59.2 °C at only 1 V. This facile fabrication route offers substantial potential for applications in electromagnetic protection and energy-efficient heating technologies.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhen Zhang,Xiaojian Tian,Yuxiao Sun,Dandan Han,Bang Gu,Dan Wu,Armin Rezayan,Xian Wu,Jingpeng Zhao,Jianshe Wang,Tianliang Lu,Renfeng Nie,Xiaoqin Si,Chunbao Xu,Yongsheng Zhang
Vanadium-based catalysts are widely used in the oxidation of carbohydrates to produce formic acid (FA), a promising liquid organic hydrogen carrier, but still suffers from low yield due to the formation of CO 2 . This study found that the spatially isolated VO x on active carbon (AC) can significantly increase FA yield from 43.5 to 72.9% in glucose oxidation compared with free VO x . Two specific roles of AC were revealed. Firstly, the oxygenated functional groups, high surface area and abundant microporous of AC, play a crucial role in the atomic dispersion of VO x , resulting in a heterogeneous, single-site VO x -AC catalyst. The isolated VO x site favors the oxidative C C bond cleavage in glucose via a stepwise α-cleavage pathway, thus improving FA selectivity. Secondly, the conductive AC acts as an electron buffer, which accelerates the catalytic redox cycle between V 5+ and V 4+ of the isolated VO x sites, thus increasing the reaction activity. The prepared single-site VO x -AC catalyst is reusable and can generate a concentrated FA solution (4.7 wt%) by simple filtration of the solid catalyst. This work presents a simple method for the production of H 2 energy carrier from biomass and provides a fundamental basis for designing efficient catalytic systems for aqueous-phase oxidation reactions.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Weifang Jiang,Xueer Huang,Fengling Tian,Qi Wei,Kaxi Chen,Xuehui Tang,Jinfang Nie,Jianmei Zou,Di Huang,Yun Zhang
This work initially describes a highly sensitive colorimetric assay with smartphone readout that enables instrument-free, determination of hypochlorite (ClO − ) ion. The assay exploited analyte-induced anti-aggregation of Au nanoparticle (AuNP), which attenuated their Tyndall effect (TE). In the absence of the analyte, dithiothreitol (DTT) molecules (each bearing two terminal thiol groups) could form strong Au S bonds with the AuNP to induce the aggregation of these nanoprobes. This not only produced a familiar surface-plasmon-resonance-based red-to-blue color change but also markedly intensified the TE signal of the reaction mixture. In the presence of the ClO − , on the other hand, the analyte rapidly oxidized the thiol groups of DTT, thereby preventing the AuNP aggregation. These nanoprobes thus remained their original dispersed state, giving a red color and a weak TE response. The TE signal was inversely related to the ClO − concentration. Under optimized conditions, this new method, which required only an inexpensive 635 nm laser pointer to generate a red or red-yellow TE, offered far better visual discrimination of analyte concentration than the conventional SPR-based approach, reaching a visual limit of detection (LOD) of ~0.25 μM (~0.02 mg·L −1 ), ten-fold lower than that of the latter. Coupling the new assay with a smartphone for portable TE readout further allowed for linear quantification of ClO − over the 0.05–90 μM (0.0036–6.4 mg·L −1 ) range, lowering the quantitative LOD to ~14.2 nM (~0.001 mg·L −1 ) (3σ), about 30 times lower than that achieved by the traditional UV–Vis spectroscopy. The recovery of ClO − in four types of tested water samples (i.e., tap water, mineral water, pond water and pool water) ranged from 97.64 to 108.38%, additionally confirming the analytical accuracy and practical utility of the TE-enhanced smartphone-assisted equipment-free quantitative method developed herein.
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危险品化学品经营许可证（带存储）