Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
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IF 15.7
Qi Jia-Xin,Gong Jing-Wen,Zhang Cheng-Rong,Peng Zhi-Hai,Cai Yuan-Jun,Liu Xin,Liu Jin-Lan,Chen Xiao-Juan,Liang Ru-Ping,Qiu Jian-Ding
Piezoelectric catalysis possesses the potential to convert ocean wave energy into and holds broad prospects for extracting uranium from seawater. Herein, the Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized through in situ growth of covalent organic frameworks (COFs) on the surface of ZnO and used for efficient uranium extraction. The designed COFs shell enables ZnO with stability, abundant active sites and high-speed electron transport channels. Meanwhile, the interface electric field established in the heterojunctions stimulates electron transfer from COFs to ZnO, which break the edge shielding effect of the ZnO’s metallic state. Additionally, the polarization of ZnO is enhanced by heterogeneous engineering, which ensures the excellent piezocatalytic performance. As a result, ZnO@COF achieves an ultra-high efficiency of 7.56 mg g −1 d −1 for uranium extraction from natural seawater driven by waves. In this work, we open an avenue for developing efficient catalysts for uranium extraction from seawater.
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ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Zhang Chen-chun,Li Yuan,Jiang Chang-you,Le Qiu-min,Liu Xing,Ma Lan,Wang Fei-fei
The O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is a critical post-translational modification that couples the external stimuli to intracellular signal transduction networks. However, the critical protein targets of O-GlcNAcylation in oxidative stress-induced apoptosis remain to be elucidated. Here, we show that treatment with H 2 O 2 inhibited O-GlcNAcylation, impaired cell viability, increased the cleaved caspase 3 and accelerated apoptosis of neuroblastoma N2a cells. The O-GlcNAc transferase (OGT) inhibitor OSMI-1 or the O-GlcNAcase (OGA) inhibitor Thiamet-G enhanced or inhibited H 2 O 2 -induced apoptosis, respectively. The total and phosphorylated protein levels, as well as the promoter activities of signal transducer and activator of transcription factor 3 (STAT3) and Forkhead box protein O 1 (FOXO1) were suppressed by OSMI-1. In contrast, overexpressing OGT or treating with Thiamet-G increased the total protein levels of STAT3 and FOXO1. Overexpression of STAT3 or FOXO1 abolished OSMI-1-induced apoptosis. Whereas the anti-apoptotic effect of OGT and Thiamet-G in H 2 O 2 -treated cells was abolished by either downregulating the expression or activity of endogenous STAT3 or FOXO1. These results suggest that STAT3 or FOXO1 are the potential targets of O-GlcNAcylation involved in the H 2 O 2 -induced apoptosis of N2a cells.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Liu Shengqin,Jin Yangxin,Huang Shuquan,Zhu Qi,Shao Shan,Lam Jason Chun-Ho
The catalytic valorisation of biomass to afford synthetically useful small molecules is essential for sustainable biorefinery processes. Herein, we present a mild cascaded electrochemical protocol for converting furoic acid, a common biomass-derived feedstock, into a versatile platform chemical, gamma-butyrolactone. In the platinum(+)|nickel(−) electrode paired undivided cell, furoic acid is electrochemically oxidised with 84.2% selectivity to 2(5 H )-furanone, the olefin of which is then hydrogenated to yield gamma-butyrolactone with 98.5% selectivity. The final gamma-butyrolactone yield is 69.1% with 38.3% Faradaic efficiency and 80.1% carbon balance when the reaction is performed with 100 mM furoic acid at 80 °C at +2.0 V Ag/AgCl . Mechanistic investigation revealed the critical temperature and electrolyte pH conditions that maximise the production and protection of the key intermediate, furan radical, promoting its transition to 2(5 H )-furanone rather than self-polymerising. The reaction is scalable, as 2.1 g of 98.1% pure gamma-butyrolactone is isolated through a simple solvent extraction.
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CELLULOSE
·
2024
·
IF 4.9
Gan Peng,Zhang Kai,Li Jinze,Xu Qixi,Yang Guihua,Zhang Yunlai,Dong Xinchuang,Wang Baobin,Zhang Lei,Chen Jiachuan
This study focuses on using agricultural straw—specifically sugarcane bagasse—as the raw material and employs single-factor optimization and response surface modeling strategies to develop a low-temperature NACO pulping process. A mathematical prediction model was constructed to explore the leaching patterns of chemical components in sugarcane bagasse, reveal the reaction mechanism of selective lignin removal through the new oxygen-alkali synergistic approach, and elucidate the green pulping mechanism of the low-temperature NACO method. The research findings indicate that at a temperature as low as 114.3 °C and a Na 2 CO 3 / NaOH mass ratio of 1.86, the paper pulp exhibits optimal performance, with a freeness yield of 52.83%, a viscosity of 675.77 ml/g, a whiteness of 40.95% ISO, and a kappa number of 19.85. At this condition, only 43.96% of the silicon element enters the black liquor. Response surface variance analysis shows that the studied variables have statistically significant effects on different response levels, with all correlation coefficients (R 2 ) greater than 0.93, indicating that the model has good predictive capability for the low-temperature NACO pulping process. Finally, the paper produced from the pulp under the optimal conditions exhibits excellent physical properties, with a tear index of 4.9 kPa·m 2 ·g⁻ 1 , burst index of 3.8 mN·m 2 ·g⁻ 1 , tensile index of 70.9 N·m·g⁻ 1 , and ring crush index of 11.6 N·m·g⁻ 1 , which are 1.9, 1.8, 1.6, and 2.3 times, respectively, compared to the performance of paper made by traditional oxygen-alkali chemical pulping methods.
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RARE METALS
·
2024
·
IF 9.6
Zeng Jin-Quan,Qi Jun-Lei,Yang Yue-Yang,Zhang Min-Hao,Lin Yuan-Hua
The practical application of CaSmAlO 4 microwave dielectric ceramics is limited by its low quality factor ( Q × f ) value and non-zero temperature coefficient resonant frequency ( τ f ) value. In this study, we introduced Mg 2+ –Ti 4+ ionic pairs into CaSmAlO 4 , along with an excess of 9% Sm 2 O 3 . The Mg 2+ –Ti 4+ ionic pairs substituted Al 3+ , and two phases simultaneously coexisted in the ceramics: CaSmAlO 4 and Sm 2 O 3 . As the doping concentration of Mg 2+ –Ti 4+ ionic pairs increased, the relative permittivity exhibited an upward trend, while the quality factor and resonant frequency temperature coefficient first rose and then descended. Remarkably, 0.09Sm 2 O 3 –0.91CaSmAl 0.7 Mg 0.15 –Ti 0.15 O 4 sintered at 1450 °C yielded excellent dielectric properties: ε r = 19.72, Q × f = 72,936 GHz, and τ f = –0.044 ppm·°C − 1 . The factors influencing the microwave dielectric properties of 0.09Sm 2 O 3 –0.91CaSmAlO 4 ceramics were further examined by considering the crystal structure, grain size, Lichtenecker logarithmic rule, tolerance factor and packing fraction. Graphic abstract
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 2
·1-11
·
IF 21.8
He Qin-yu,Chen Fu-ming,Hu Shu-ting,Zhai Wangjian,Tang Zhilie
Current heavy-metal wastewater treatment methods face significant limitations, creating a need for new technologies. Zero-valent iron (ZVI) shows potential, but the core-shell structure of ZVI is an obstacle due to the low electrical conductivity ( σ ) of its shell, limiting electron transfer from the core to the surface for metal removal reactions. In this study, we enhance the shell’s σ in a pre-magnetized decimeter-sized ZVI plate (MMDZVIP) through reinforced negative magnetoresistance (NMR) effect. Magnetoresistance measurements reveal that MMDZVIP exhibits an NMR effect. MMDZVIP shows a magnetoresistance ratio ( MR ) of -123%, an σ 1.95 times and removal efficiencies 1.91 to 5.18 times that of unmagnetized plates when magnetized to 449 mT. Heavy-metal removal experiments showed nearly 100% removal efficiency at 354 mT, with performance retention above 99.7% after 9 cycles, demonstrating high durability. The mechanism behind the results is as follows: During the removal process, the migration of releasing electrons is aligned to form a current along the normal direction of the MMDZVIP plate. This current is primarily driven by electron consumption on the plate’s surface, where the removal reaction occurs. With pre-magnetization, NMR and Hall effects acted on the releasing electron current and synergistically and significantly enhance the shell's σ . Our work introduces a novel method for enhancing NMR in materials, advancing heavy-metal treatment technologies beyond current limitations.
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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
·
2024
·
IF 8.6
Song Yangmeihui,Qin Chunxia,Chen Yixiong,Ruan Weiwei,Gai Yongkang,Song Wenyu,Gao Yu,Hu Wenzhu,Qiao Pengxin,Song Xiangming,Lv Xiaoying,Zheng Danzha,Chu Huikuan,Jiang Dawei,Yang Ling,Lan Xiaoli
Purpose The reversibility of early liver fibrosis highlights the need for improved early detection and monitoring techniques. Fibroblast activation protein (FAP) is a promising theranostics target significantly upregulated during fibrosis. This preclinical and preliminary clinical study investigated a FAP-targeted probe, gallium-68-labeled FAP inhibitor 04 ([ 68 Ga]Ga-DOTA-FAPI-04), for its capability to visualize liver fibrosis. Methods The preclinical study employed [ 68 Ga]Ga-DOTA-FAPI-04 micro-positron emission tomography (PET)/computed tomography (CT) on carbon tetrachloride-induced mice model (n = 34) and olive oil-treated control group (n = 26), followed by validation of the probe's biodistribution. Hepatic uptake was correlated with fibrosis and inflammation levels, quantified through histology and serum assays. FAP and α-smooth muscle actin expression were determined by immunohistochemistry, as well as immunofluorescence. The subsequent clinical trial enrolled 26 patients with suspected or confirmed liver fibrosis to undergo [ 68 Ga]Ga-DOTA-FAPI-04 PET/magnetic resonance imaging or PET/CT. Key endpoints included correlating [ 68 Ga]Ga-DOTA-FAPI-04 uptake with histological inflammation grades and fibrosis stages, and evaluating its diagnostic and differential efficacy compared to established serum markers and liver stiffness measurement (LSM). Results [ 68 Ga]Ga-DOTA-FAPI-04 mean uptake in mice livers was notably higher than in control mice, increasing from week 6 [0.70 ± 0.11 percentage injected dose per cubic centimeter (%ID/cc)], peaking at week 10 (0.97 ± 0.15%ID/cc) and slightly reducing at week 12 (0.89 ± 0.28%ID/cc). The hepatic biodistribution and FAP expression showed a consistent trend. In the patient cohort, hepatic [ 68 Ga]Ga-DOTA-FAPI-04 uptake presented moderate correlations with inflammation grades (r = 0.517 to 0.584, all P < 0.05) and fibrosis stages (r = 0.653 to 0.698, all P < 0.01). The average SUVmax to background ratio in the liver showed superior discriminative ability, especially between stage 0 and stage 1, outperforming LSM (area under curve 0.984 vs. 0.865). Conclusion [ 68 Ga]Ga-DOTA-FAPI-04 PET shows significant potential for non-invasive visualization and dynamic monitoring of liver fibrosis in both preclinical experiment and preliminary clinical trial, especially outperforming other common clinical indicators in the early stage. Trial registration NCT04605939. Registered October 25, 2020, https://clinicaltrials.gov/study/NCT04605939
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 12
·1-13
·
IF 5.3
Wang Xue,Zhao Zixuan,An Long,Wang Tianxiang,Yang Xiaojing,Shan Jiajia
An unlabeled electrochemical sensing strategy based on electroactive copper-centered metal–organic framework (Cu-MOF) film coupled with multiwalled carbon nanotubes (MWCNTs) was proposed for the rapid assessment of nanoplastic concentration. The sensing interface was fabricated via the electro-deposition of Cu-MOF on the pre-modified MWCNTs using the cathodic reduction method. The exposed copper active sites in Cu-MOF showed excellent electrochemical activity, which was further enhanced due to rapid electron transfer induced by highly conductive MWCNTs. Through the adsorption functionality of Cu-MOF film towards polystyrene (PS) nanoplastics, the rapid recognition for nanoplastics in aqueous solution was achieved, thereby causing the inhibition of the current response. The results showed a robust dependence of the inhibition rate on the PS mass concentration. The proposed detection method was used for the quantitative determination of PS nanoplastics with the sizes of 100 nm, 500 nm, and 1 μm. The applicability of this electrochemical sensing platform was successfully validated in real-world water sample analysis. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 12
·1-14
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IF 2.8
Zeng Fanen,Tan Zhen,Yang Xun,Wang Xiamei,Xu Bing
The practical application of hierarchical porous carbon materials in supercapacitors is very important. Therefore, the development of a high–performance hierarchical porous carbon material is a huge challenge. The waste coffee grounds–based porous carbon (WBC) was synthesized from waste coffee grounds by carbonization and static air activation. The physicochemical properties of WBC were observed by scanning electron microscopy with energy dispersive X–ray spectroscopy, X–ray diffraction, Raman spectroscopy, X–ray photoelectron spectroscopy, and N 2 adsorption–desorption analysis. The WBC activated at 800 ℃ has a more developed hierarchical porous structure with a specific surface area of 639.01 m 2 g –1 , and an average pore diameter of 2.77 nm. The formation mechanism of the WBC, which has a hierarchical porous structure in static air activation, was illustrated systematically. Within the three–electrode system, the optimal WBC exhibits the highest specific capacitance of 164.4 F g –1 at 0.5 A g –1 in 6 M KOH and an excellent rate capability of 84.85% at 5 A g –1 . The constructed symmetric SC with the optimal WBC as electrode material and 6 M KOH as electrolyte achieved an energy density of 8.15 Wh kg –1 at a power density of 250 W kg –1 and an outstanding cyclic retention rate of 100% over 7000 cycles at 10 A g –1 . The hierarchical porous structure of WBC exhibits high specific capacitance, high energy density, and stable cyclic retention rate, which provides a broad application prospect for realizing energy storage and conversion applications.
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Journal of Translational Medicine
·
2025
·Vol. 23
·期 1
·1-18
·
IF 7.5
Tan Yanzhen,Li Hong,Cao Guojie,Xin Jialin,Yan Dongxu,Liu Yingying,Li Panpan,Zhang Yuxi,Shi Lei,Zhang Bing,Yi Wei,Sun Yang
Background In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.Methods Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitro and in vivo. The role of matrix metalloproteinase-9 (MMP9) in CTRP9 cleavage was examined, and the effects of different CTRP9 domains on cardiac fibrosis and cardiac fibroblast (CF) activation were investigated.Results gCTRP9 exerted better protective effects than fCTRP9 against MI, demonstrating superior anti-apoptotic and anti-fibrotic properties. fCTRP9 was cleaved by MMP9, resulting in gCTRP9 and nCTRP9. MMP9 overexpression enhanced the cardioprotective effects of fCTRP9, while nCTRP9 supplementation aggravated cardiac fibrosis in MI mice. Mechanistically, nCTRP9 activated CFs via an increase in Rap1 expression and MEK 1/2 and ERK1/2 phosphorylation.Conclusion sDifferent domains of CTRP9 have distinct cardioprotective effects. gCTRP9 shows beneficial effects, while nCTRP9 promotes cardiac fibrosis. These findings highlight the importance of CTRP9 in cardiac function regulation and suggest prospective therapeutic options for MI treatment.
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IONICS
·
2024
·Vol. 30
·期 7
·4271-4279
·
IF 2.4
Wang Jianyu,Peng Yin,Wang Liying,Yang Xijia,Gao Yang,Li Xuesong,Lü Wei
Although TiO 2 has been widely used as the illumination anode in quantum dot sensitized solar cells (QDSSCs), its inherent low photovoltaic conversion efficiency remains a challenge. This study designed and prepared black rutile phase TiO 2 (B-R TiO 2 ) using sodium borohydride as a reducing agent, and utilized it as a photoanode in quantum dot-sensitized solar cells (QDSSCs). The findings illustrated that the modification of rutile phase TiO 2 through the reduction method led to changes in its surface structure which in turn affects its band structure and optical absorption properties. The increase in surface oxygen vacancy concentration resulted in an enhancement of light absorption intensity, leading to an enhanced photovoltaic conversion efficiency. Subsequently, when employed as a photoanode in QDSSCs, the photovoltaic conversion efficiency (PCE) increased from an initial 1.77% to 4.27%. X-ray photoelectron spectroscopy (XPS) analysis revealed a significant increase in the oxygen vacancy (Ov) content after reduction, resulting in a rise in short-circuit current density from the original 8.10 (mA/cm 2 ) to 15.33 (mA/cm 2 ) as observed in the J-V curve. In conclusion, the study demonstrated the effectiveness of the reduction method in modifying the black rutile phase TiO 2 , resulting in improved optical properties and improved solar cell efficiency in quantum dot-sensitized solar cells.
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Food Biophysics
·
2024
·Vol. 20
·期 1
·1-16
·
IF 2.8
Yu Cailing,Zhao Yanan,Zu Xinyu,Liang Yan,Wang Hua
This study presents a novel multifunctional hydrogel synthesized by crosslinking Chlorella protein using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/n-hydroxysuccinimide, aimed at extending the shelf life of perishable fruits like cherries. Structural, rheological, and scanning electron microscopy analyses revealed that Chlorella protein hydrogels (CPH) possess excellent solid-like properties and a stable porous structure. The water-holding capacity improved significantly from 67.11 ± 0.72% to 96.53 ± 0.61% with increasing CP concentration (10–22.5%, w/v). Additionally, CPH decomposition temperatures were ~ 150 °C (5% weight loss), demonstrating good thermal stability. Due to the ionization of -COOH and -NH 2 groups, the CPH showed excellent pH sensitivity, with low dissolution rates in acidic environments (64.97%) and significantly higher rates in alkaline environments (448.50%). Furthermore, the CPH inhibited the penetration of Staphylococcus aureus and Escherichia coli , and exhibited good free radical scavenging abilities against DPPH (74.50%) and ABTS •+ (97.92%). In cherries preservation tests, CPH extended preservation time to 15 days compared to 5 days in the control group, effectively inhibiting decay, suggesting CPH is a promising choice for multifunctional fruit preservation. Graphical abstract
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危险品化学品经营许可证（带存储）