Nanoscale
·
2020
·Vol. 12
·期 32
·17064-17073
·
IF 6.895
Jinghua Li,Daoming Zhu,Weijie Ma,Yang Yang,Ganggang Wang,Xiaoling Wu,Kunlei Wang,Yiran Chen,Fubing Wang,Wei Liu,Yufeng Yuan
Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths globally. Advanced nanomaterials have emerged as effective approaches to liver cancer therapy such as photothermal therapy. However, limited penetration depth of photothermal agents (PTAs) activated in the NIR-I bio-window and thermoresistance due to heat shock proteins restrict the therapeutic efficacy of PTT in HCC. Herein, we prepared a Bi@ZIF-8 (BZ) nanomaterial by a simple one-step reduction method. Then, gambogic acid, a natural inhibitor of Hsp90, was efficiently loaded onto the BZ nanomaterial via physical mixing. The characterization of the nanomaterial and release of GA due to pH change or NIR-light irradiation were separately studied. Photothermal conversion efficiency was calculated, and therapeutic studies were carried out in vitro and in vivo. This nanomaterial exhibited a significantly enhanced drug release rate when the temperature was increased under acidic conditions and had good light stability under laser irradiation and a photothermal conversion efficiency of about 24.4%. In addition, this novel nanomaterial achieved good therapeutic effects with less toxicity in vitro. The BZ nanomaterial loaded with GA caused tumor shrinkage as well as disappearance and effectively downregulated Hsp90 expression in tumors in vivo. Moreover, this novel nanomaterial exhibited good biocompatibility and potential for application in low-temperature PTT with excellent tumor destruction efficacy.
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2020
·
IF 3.004
Xiangrong Wu,Beibei Qiu,Yanan Chen,Yuqiong Shi,Jinhua Zhu,Xiuhua Liu,Dongbao Zhao
In this work, α-glucosidase was immobilized on a type of nanoscaled magnetic materials Fe 3 O 4 @ZIF-67 to construct a biomicroreactor for rapid screening α-glucosidase inhibitors. The parameters that affected the immobilization efficiency were investigated. Under optimal conditions, the amount of α-glucosidase loaded was up to 79.07 μg·mg −1 . Then, the enzyme biomicroreactor was immobilized by an external magnetic field in a tube connecting HPLC and micro-injection pump at both ends to form a magnetic online screening system. The screening flow rate and eluent organic solvent ratio during the screening process were optimized. XinYang MaoJian crude tea extract was tested to verify this online screening method, and three inhibitors (catechin, epigallocatechin gallate and epicatechin gallate) were fished by this magnetic online screening system. Based on the classical p NPG method, the inhibitory activities on α-glucosidase were further verified and studied. Compared with the traditional ligand fishing methods, the screening method established in this work can integrate screening, elution and analysis. It can simply, efficiently and directly screen and identify potential α-glucosidase inhibitors from natural sources. This method was expected to provide an effective basis for accelerating the development of new hypoglycemic drugs.
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Nanomaterials
·
2020
·Vol. 10
·期 10
·2044
·
IF 4.324
Weiwei Ye,Yu Zhang,Wei Hu,Liwen Wang,Yu Zhang,Ping Wang
A sensitive fluorescence resonance energy transfer (FRET) biosensor is proposed to detect 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is a typical DNA oxidation damage product excreted in human urine. The FRET biosensor was based on carbon dots (CDs)-modified nanoporous alumina membrane with CDs as fluorescence donors. Gold nanoparticles were encapsulated in zeolitic imidazolate framework-8 to form Au@ZIF-8 nanoparticles as signal quenchers. CDs and Au@ZIF-8 nanoparticles were biofunctionalized by 8-OHdG antibody. The capture of 8-OHdG on the membrane substrates can bring Au@ZIF-8 nanoparticles closely to CDs. With 350 nm excitation, the fluorescence of CDs was quenched by Au@ZIF-8 nanoparticles and FRET effect occurred. The quenching efficiency was analyzed. The limit of detection (LOD) was 0.31 nM. Interference experiments of the FRET biosensor showed good specificity for 8-OHdG detection. The biosensor could detect urinary 8-OHdG sensitively and selectively with simple sample pretreatment processes. It shows applicability for detecting biomarkers of DNA damage in urine or other biological fluids.Keywords:nanoporous alumina membrane;fluorescence resonance energy transfer;Au@ZIF-8 nanoparticles;DNA oxidation damage;8-OHdG detection
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 3
·1-8
·
IF 5.479
Yuan Yue,Xu Xianzhen,Xia Jianfei,Zhang Feifei,Wang Zonghua,Liu Qingyun
Porous carbon was prepared from a zeolitic imidazolate framework (type ZIF-8) by carbonization at 800 °C (Z-800). A hybrid material was then obtained by direct co-electrodeposition of Z-800 with graphene oxide (Z-800/rGO). Z-800 is N-doped with good electrical conductivity and displays electrocatalytic activity. Z-800 readily undergoes mass transfer and also prevents graphene to agglomerate during electroanalysis. The hybrid was placed on a glassy carbon electrode (GCE) to obtain an electrochemical sensor for chloramphenicol (CAP) detection. Under the optimized conditions, the response of the modified GCE (typically measured at a low potential of −0.07 V vs. Ag/AgCl) is linear in the 1 to 180 μM CAP concentration range with a 0.25 μM detection limit (S/ N = 3). In our preception, the method has a wide scope in that it may be applied to the preparation of various kinds of other (doped) porous carbon/rGO composites for use in (bio)chemical sensors.
Schematic presentation of the preparation process of the materials and the electrochemical detection of chloramphenicol.
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Yingying Yang,Zengpei Guo,Wei Huang,Shiyu Zhang,Jingjing Huang,Hongjun Yang,Yingshan Zhou,Weilin Xu,Shaojin Gu
Facile construction of multifunctional fabrics with durability still remains a challenge in the past decade. In this work, we report a facile fabrication of non-fluorinated superhydrophobic and antibacterial cotton fabric surfaces via in situ growing zeolitic imidazolate framework-8 (ZIF-8) nanocrystals on cotton fibers under room temperature condition and subsequently coating with polydimethylsiloxane (PDMS). The surface morphology and chemical composition of treated fabric have been characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction analysis (XRD) and X-ray photoelectron spectroscopy (XPS). The as-prepared cotton fabric showed superhydrophobic property with a water contact angle (WCA) of 151.36° and a sliding angle of 3.6° and excellent antibacterial properties against E. coli and S. aureus. The durability of the superhydrophobic and antibacterial fabrics was evaluated by repeated washing and abrasion cycles. The as-prepared fabrics retained their excellent antibacterial property and superhydrophobicity after 300 cycles of abrasion and 5 cycles of washing. The robustness of superhydrophobicity and antibacterial activity made this method has wild application prospects in biomedical field in the future.
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PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Chenyang Zhao,Yi Huang,Yue Li,Chen Wang,Wenlin Yuan,Di Cheng,Tao Shen,Ji Zhang,Jie Liu,Chao Yang,Chunchun Wu,Qianhong Shen,Hui Yang
Nanocontainers encapsulating corrosion inhibitors are commonly incorporated into organic coatings to enable self-healing effects, thereby ensuring long-term anticorrosion performance. In this study, a novel dual corrosion inhibitor-loaded self-healing nanocontainer with core-shell structure was proposed for fabricating composite waterborne epoxy coatings with both active and passive corrosion prevention properties. The nanocontainer, named BTA-ZIF-8@LDH-Mo, was synthesized through the in-situ growth of molybdate-intercalated ZnAl layered double hydroxide (LDH-Mo) on the surface of 1H-benzotriazole-inbuilt zeolitic imidazolate framework (BTA-ZIF-8). Potentiodynamic polarization results showed that the I corr of bare Q235 carbon steel immersed in a 3.5 wt% NaCl solution decreased from 4.658 × 10 −6 A/cm 2 to 1.274 × 10 −6 A/cm 2 after introducing BTA-ZIF-8@LDH-Mo nanocontainers, resulting in a superior corrosion inhibition efficiency of 72.65 %. Electrochemical impedance spectroscopy further demonstrated that the |Z| f=0.01Hz of epoxy coating doped with BTA-ZIF-8@LDH-Mo reached 4.24 × 10 9 Ω·cm 2 after 42 d of immersion in 3.5 wt% NaCl solution, approximately 30 times higher than that of pure EP coating. Moreover, investigations on artificially scratched coatings indicated that the incorporation of BTA-ZIF-8@LDH-Mo nanocontainers effectively mitigated the corrosion process by forming an inhibiting layer on the metal substrate that impeded the corrosion process. The dual corrosion inhibitor strategy relies on the synergistic action of BTA pre-loaded in ZIF-8 nanoparticles and molybdate ( MoO 4 2- ) intercalated in LDH interlayers for active corrosion protection . Additionally, the nanocontainers enhance passive protection by elongating the diffusion paths of corrosive media and trapping chloride ions. This nanocontainer design offers a facile strategy for fabricating a smart coating with the excellent anticorrosion properties.
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Materials Today Communications
·
2024
·
IF 3.7
Tianlu Li,Aixian Tian,Wei Li,Yun Zhao,Minfang Chen
A one-step hydrothermal method was used to deposit a in situ composite coating on a magnesium alloy by adding ZIF-8 nanoparticles modified by polydopamine (PDA) (PDA@ZIF-8) as a photoabsorbing agent and growing Mg-Al double-layer hydroxide (LDH). The results showed that PDA@ZIF-8 nanoparticles had significant influence on the corrosion resistance, antibacterial properties, and biocompatibility of the LDH coating, and improved the compactness and crystallinity of LDH by regulating the growth of its lamella. Compared with the LDH coating, the corrosion current density of the composite coating by adding PDA@ZIF-8 nanoparticles was reduced from 2.28×10 -5 to 1.86×10 −6 A·cm -2 . And its immersion corrosion rates were 0.89 ± 0.05 mm·year −1 in SBF solution for 8 days. Meanwhile, it had antibacterial efficacy of 99.99% and 99.99% against Escherichia coli and Staphylococcus aureus , respectively, with the in vitro photothermal conversion efficiency of 29.77%. Moreover, besides greatly improving osteogenic activity and biocompatibility in vitro, the composite coating with the addtion of PDA@ZIF-8 nanoparticlescan also drive M1-type macrophages to M2-biased phenotypes after exposure to 808 nm NIR light, changing in macrophage secretion for tissue regeneration, and fulfill the excellent antibacterial properties in vivo antibacterial implantation test. This method can provide an effective way and strategy for regulating and enhancing the antibacterial functionalization and improving the corrosion resistance of the double-layer hydroxide coating on the surface of magnesium alloys.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Guanwen Su,Yue Liu,Yulin Hou,Rui Zhang,Wei Wang,Jie Zhang,Leping Dang
A core–shell–shell sandwich material is developed with silver nanowires as the core, ZIF-8 as an inner shell, and gold nanoparticles as the outer shell, namely, Ag@ZIF-8@Au nanowires (AZA-NW). Then, the synthesized AZA-NW is transformed into a surface-enhanced Raman spectroscopy (SERS) sensor (named M-AZA) by the vacuum filtration method and used to enrich, detect, and inactivate traces of bacteria in the environment. The M-AZA sensor has three main functions: (1) trace bacteria are effectively enriched, with an enrichment efficiency of 91.4%; (2) ultrasensitive detection of trace bacteria is realized, with a minimum detectable concentration of 1 × 101 CFU/mL; (3) bacteria are effectively killed up to 92.4%. The shell thickness of ZIF-8 (5–75 nm) is controlled by adjusting the synthesis conditions. At an optimum shell thickness of 15 nm, the effect of gold nanoparticles and ZIF-8 shell on the sensor’s stability, SERS activity, and antibacterial performance is investigated. The simulation of the SERS sensor using the finite difference time domain (FDTD) method is consistent with the experimental results, theoretically demonstrating the role of the gold nanoparticles and the ZIF-8 shell. The sensor also shows excellent stability, safety, and generalizability. The campus water sample is then tested on-site by the M-AZA SERS sensor, indicating its potential for practical applications.
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RENEWABLE ENERGY
·
2024
·
IF 9
Wenlei Xie,Xiangxiang Wang,Lihong Guo
Improving the reactant mass transfer on the catalyst surface is a feasible approach to fabricate a robust solid catalyst for efficiently promoting the biomass macromolecules-involving reactions, specifically for biodiesel production by using non-edible acidic oils as feedstocks. In this premise, to reduce the mass transfer resistance, the hierarchical porous SOM-ZIF-8 was firstly synthesized using polystyrene spheres (PS) as templates and then employed as catalyst supports for loading of Keplerate-type polyoxomolybdates {Mo 132 } to prepare a novel {Mo 132 }@SOM-ZIF-8 solid acid catalyst. The catalyst characterization results revealed that the active species of {Mo 132 } clusters were well-dispersed on the SOM-ZIF-8 support and the primary framework of the SOM-ZIF-8 support remained nearly unaltered after the preparation processes. This prepared catalyst featured three-dimensional ordered hierarchical porous structure and dual Bronsted-Lewis acid sites, with a large surface area of 736.26 m 2 /g and high acidity of 903 μmol/g, presenting high activities for concurrent triglyceride transesterification and free fatty acids (FFAs) esterification. With the acidic soybean oils as feedstocks, 93.9 % of oil conversion and full FFA conversion to biodiesel were achieved over this solid catalyst at 130 °C for 8 h with a catalyst loading of 2 wt%, thus imparting the great potential for a one-pot efficient biodiesel manufacture from the acidic oils to comply with the demand of green and clean production. The synergy between the hierarchical porous structure and the strong acidity emerged, thus boosting the catalytic performance of this solid catalyst for the heterogeneous biodiesel production. The good FFA and moisture-resistance capacity was shown for this catalyst even in the case of moisture content of 3 % and FFA content of 25 %. Further, this catalyst showed excellent reusability without significantly losing its catalytic performance even after five runs, providing a deeper insight into constructing efficient solid catalysts with hierarchical porous structure that are utilized for cost-effective production of biodiesel from the non-edible acidic oils.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Chunmei Xu,Mengran Lou,Rui Liu,Taotao Lv,Yang Wang,Ruiying Wang,Hongtao Liu,Xia Kong
Metal-nitrogen-carbon (M–N–C) catalysts are promising alternatives to precious metal-based bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in Zn-air batteries (ZABs). Herein, FeCo@nitrogen doped carbon nanotube/nitrogen doped reduced graphene oxide (FeCo@NCNT/N-rGO) catalyst with unique 3D heterostructure was synthesized through one-step pyrolysis of FeCo-ZIF-8 precursor anchored on graphene oxide (FeCo-ZIF-8/GO). Benefiting from the coupling of FeCo dual-metal sites with nitrogen-doped carbon substrates, the FeCo@NCNT/N-rGO catalyst achieved extraordinary bifunctional oxygen electrocatalytic activity, exhibiting a high ORR half-wave potential (E 1/2 ) of 0.881 V (vs. RHE), which was superior to the Pt/C catalyst (0.838 V), and OER overpotential of 343 mV at 10 mA cm −2 , merely inferior to RuO 2 by 33 mV. The resulting ΔE (defined as E j=10 − E 1/2 ) reaches an impressively low value of 0.69 V, highlighting its superior reversible oxygen electrocatalytic performance. Meanwhile, achieving a high-power density of 240 mW cm −2 and open circuit voltage (OCV) of 1.488 V in ZAB applications, superior to that of Pt/C + RuO 2 in ZAB (1.447 V; 143 mW cm −2 ). Flexible solid-state ZAB with FeCo@NCNT/N-rGO achieves 1.416 V OCV and 47.4 mW cm −2 power density, remaining stable even when bent 180°. This study guides design of dual-site non-precious metal bifunctional oxygen catalysts.
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DESALINATION
·
2025
·
IF 9.8
Na Yang,Xu Guo,Jing Yu,Hongsen Zhang,Rumin Li,Lele Wang,Qi Liu,Jun Wang
The effective removal of radioactive Sr 2+ and Cs + ions from wastewater is crucial for environmental remediation. Herein, a novel solar-enhanced adsorption platform based on a CoS 2 /MoS 2 /P-MXene/C composite aerogel has been developed that can efficiently remove Sr 2+ and Cs + ions. The constructed CoS 2 /MoS 2 heterointerface provides abundant active regions, while the hierarchical porous structure of the aerogel promotes the rapid transfer of ions and water molecules. In particular, the superior photothermal conversion ability of the CoS 2 /MoS 2 /P-MXene/C makes it capable of capturing solar energy for local heating effect, thereby increasing ion diffusion and accelerating mass transfer. This photothermal feature can greatly enhance the adsorption kinetics through the evaporation of the solution and the ion concentration at adsorption sites. The equilibrium of both Sr 2+ and Cs + was reached within 1 h under one-sun illumination. The measured maximum adsorption capacities were 98.7 and 150.6 mg/g for Sr 2+ and Cs + ions, respectively. In addition, it has excellent selectivity and recyclability as well as high performance in high-salinity solution. The CoS 2 /MoS 2 /P-MXene/C also shows promising potential in the fields of solar-driven seawater desalination and purification of wastewater containing dyes due to the multi-functionality. This work not only engineers an efficient adsorbent for treating nuclear wastewater, but also presents a generic design strategy for multifunctional adsorption system enhanced by external fields for environmental applications.
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Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 26
·10282-10293
·
IF 8.262
Yidong Zhang,Baoping Lin,Junchuan Wang,Jiahui Tian,Ying Sun,Xueqin Zhang,Hong Yang
Currently, the development of two kinds of materials from a single precursor has been an important frontier in material synthesis. In this study, we have successfully fabricated a single precursor using metal–organic frameworks (MOFs) (zeolitic imidazolate framework, ZIF-8) and carbon nanotubes (CNTs). ZnO quantum dots (QDs)/carbon/CNTs and porous N-doped carbon/CNTs have been selectively synthesized from a single ZIF-8/CNTs template. When the two derived materials were used for supercapacitor electrodes, they showed high capacitance values (185 F g−1 g for ZnO QDs/carbon/CNTs at 0.5 A g−1 and 250 F g−1 g for porous N-doped carbon/CNTs at 1 A g−1, respectively). Further, an all-solid-state asymmetric supercapacitor (ASC) device using ZnO QDs/carbon/CNTs as the positive electrode and porous N-doped carbon/CNTs as the negative electrode was fabricated, and this device could reach a working potential of 1.7 V, delivering a maximum energy density of 23.6 W h kg−1 and a maximum power density of 16.9 kW kg−1, which are better than those of the ZnO-based symmetric or asymmetric supercapacitor devices.
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危险品化学品经营许可证（带存储）