Nature Communications
·
2023
·Vol. 14
·期 1
·1-17
·
IF 16.6
Lei Hong,Alu Aqu,Yang Jingyun,He Xi,He Cai,Ren Wenyan,Chen Zimin,Hong Weiqi,Chen Li,He Xuemei,Yang Li,Li Jiong,Wang Zhenling,Wang Wei,Wei Yuquan,Lu Shuaiyao,Lu Guangwen,Song Xiangrong,Wei Xiawei
Mucosal immunity plays a significant role in the first-line defense against viruses transmitted and infected through the respiratory system, such as SARS-CoV-2. However, the lack of effective and safe adjuvants currently limits the development of COVID-19 mucosal vaccines. In the current study, we prepare an intranasal vaccine containing cationic crosslinked carbon dots (CCD) and a SARS-CoV-2 antigen, RBD-HR with spontaneous antigen particlization. Intranasal immunization with CCD/RBD-HR induces high levels of antibodies with broad-spectrum neutralization against authentic viruses/pseudoviruses of Omicron-included variants and protects immunized female BALB/c mice from Omicron infection. Despite strong systemic cellular immune response stimulation, the intranasal CCD/RBD-HR vaccine also induces potent mucosal immunity as determined by the generation of tissue-resident T cells in the lungs and airway. Moreover, CCD/RBD-HR not only activates professional antigen-presenting cells (APCs), dendritic cells, but also effectively targets nasal epithelial cells, promotes antigen binding via sialic acid, and surprisingly provokes the antigen-presenting of nasal epithelial cells. We demonstrate that CCD is a promising intranasal vaccine adjuvant for provoking strong mucosal immunity and might be a candidate adjuvant for intranasal vaccine development for many types of infectious diseases, including COVID-19.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 24
·65712-65727
·
IF 5.8
Wang Bing,Zeng Yao,Ou Jinghan,Xiong Mingyang,Qiu Ruisi
In recent years, metal-organic frameworks (MOFs) have been employed in numerous applications for adsorption. Researchers synthesize new MOFs by various methods, including the introduction of functional groups. In this study, three different aluminum-based MOFs (with non-functionalized, amino-functionalized, nitro-functionalized) were produced by hydrothermal synthesis and used for investigating typical endocrine disrupting chemicals (EDCs), namely for bisphenol A (BPA) adsorption. We used several methods to characterize the MOFs and conducted batch adsorption experiments to investigate their adsorption properties, and explore the influence of different functional groups on adsorption materials. The specific surface area of Al-MOF-NH 2 is 6 times larger than that of Al-MOF according to the N 2 adsorption and desorption isotherms of the material, that is, the BET of Al-MOF, Al-MOF-NH 2 , and Al-MOF-NO 2 were 109.68, 644.03, and 146.60 m 2 /g. Note that although the same synthesis method is used, pore size is greatly changed because of the different functional groups. Al-MOF and Al-MOF-NO 2 have more mesopores, and Al-MOF-NH 2 is mainly microporous. The BPA adsorption capacities of Al-MOF, Al-MOF-NH 2 , and Al-MOF-NO 2 were 46.43, 227.78, and 155.84 mg/L. The outcomes can also be explained by the improved adsorption performance from the addition of amino functional groups. In this research, the adsorption isotherms and adsorption kinetics of the three Al-MOFs for BPA were also investigated to explain the different adsorption properties of various functional groups. The results show that the amino-functionalized materials have remarkable characterization morphologies, uniform particle distributions, appropriate particle sizes, excellent specific surface areas, and superior adsorption effects. Graphical abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 24
·66303-66313
·
IF 5.8
Xu Zhimin,Ju Shaohua,Gao Peng,Lin Junjian,Niu Yifan,Meng Fei,Li Shunling,Li Fangfang,Du Jiahao,Xu Li,Peng Hongbo,Pan Bo
In this study, ferrous composites (Fe x O 4 ) were prepared by microreactor to activate peroxydisulfate (PDS) for the degradation of bisphenol A (BPA) with visible (Vis) light irradiation. X-ray diffraction (XRD), energy-dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), and scanning electron microscope (SEM) were used to characterize the morphology and crystal phase of Fe X O 4 . Photoluminescence (PL) spectroscopy combined with amperometric tests were used to determine the role of PDS on the performance of photocatalytic reaction. The main reactive species and intermediates for BPA removal were determined by electron paramagnetic resonance (EPR) measurement and quenching experiments. The result indicated that singlet state oxygen ( 1 O 2 ) contributed more to the BPA degradation than that of other reactive radicals (·OH, SO 4 ·− and ·O 2 − ); these reactive radicals and 1 O 2 formed by the reaction between photo-generated electrons (e − ) and holes (h + ) of Fe x O 4 and PDS. During this process, the consumption of e − and h + also improved their separation efficiency and thus enhanced the degradation of BPA. In addition, the photocatalytic activity of Fe x O 4 in Vis/Fe x O 4 /PDS system was 3.2-fold and 6.6-fold higher than that of single Fe x O 4 and PDS under Vis light, respectively. The Fe 2+ /Fe 3+ cycle could effectively drive the photocatalytic activation of PDS through indirect electron transfer and the formation of reactive radicals. This work illustrated that the degradation of BPA was rapidly in Vis/Fe x O 4 /PDS system mainly through 1 O 2 , which further improve our understanding on the efficient removal of organic contaminants in the environment.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 31
·期 9
·4069-4079
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IF 5.3
Yuan Shengrong,Li Jinze,Qi Dongming,Zhang Yan,Chen Fengfeng,Chen Kai
Viscose fabric is susceptible to mold erosion and nourish bacteria, which limit its application. In this study, the efficient and green silver-loaded viscose fabric was prepared by simple liquid phase spray deposition method. The microstructure, physical properties, antibacterial durability of silver-loaded viscose fabric were further evaluated. The result showed that the silver-loaded viscose fabric not only kept their superior comfortability but also had an air permeability that was more than three times higher than the bare viscose fabric. In addition, the silver-loaded viscose fabric showed good antibacterial activity and the antibacterial rate reach to 99.9%. Meanwhile, the silver-loaded viscose fabric still maintained good antibacterial activity after friction treatment. The washing and chemical resistance of the silver-loaded viscose fabric could be further improved through chemical crosslinking with glutaraldehyde. This work provided a feasible way to manufacture green and durable antibacterial viscose fabric, which also improves the application potential of viscose fabric during current respiratory disease pandemic.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·
IF 5.3
Luo Wei,Yang Yang,Han Yu,Weng Yunxuan,Zhang Caili
The development of a heat stabilizer with good thermal stability, plasticizing performance, and migration resistance for polyvinyl chloride (PVC) is still a notable challenge. In this work, two bio-based heat stabilizers, epoxidized cardanol oleate (ECD-OA) and epoxidized cardanol myristate (ECD-MA), were designed and synthesized with different lengths of their alkyl chains and different epoxy contents to provide outstanding compatibility with PVC. After confirming the chemical structures of ECD-OA and ECD-MA by proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy, the thermal stabilizing effects of both epoxidized cardanol esters were compared with those of the traditional CaSt 2 /ZnSt 2 stabilizer and bio-based epoxidized soybean oil. Then, the effects of four different heat stabilizers on the mechanical, thermal, rheological, and optical properties of PVC films were fully studied. The results suggested that the ECD-MA showed the best thermal stability, and the PVC/30DOP/5ECD-MA film did not turn black after 2 h of thermal aging at 200 °C. In addition, the ECD-MA had good compatibility with PVC, and it had a synergistic plasticizing effect, which caused the film to have a high ductility and tensile strength (320.1% and 19.8 MPa, respectively).
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 3
·1-9
·
IF 20.1
Xu Ting,Wang Yaxuan,Liu Kun,Zhao Qingshuang,Liang Qidi,Zhang Meng,Si Chuanling
With the depletion of fossil resources and the gradual intensification of environmental pollution, green and sustainable electrochemical devices have aroused intensive attraction. The supercapacitor, demonstrating fast charging rate, high power densities, and long cycling life, has great application prospects in high power output and backup power supply. Herein, an ultralight and robust MXene/carbon nanotube aerogel is constructed by facile directional freezing and subsequent freeze-drying. Benefiting from the strongly π-π interactions between MXene nanosheets and carbon nanotube, the assembled MXene/carbon nanotube composite aerogel exhibits abundant pore structures, superior conductivity, and good mechanical properties. The electrical conductivity of MXene/carbon nanotube aerogel is up to 1600 S m −1 . The MXene/carbon nanotube aerogel can be subjected to 70% compressive strain and retain 85% initial strain over 1000 compress-release cycles. The as-prepared all-solid-state supercapacitor with MXene/carbon nanotube aerogel shows outstanding electrochemical performance (410.7 mF cm −2 at the current density of 0.8 mA cm −2 ). The supercapacitor is flexible and can be bent from 0 to 90° as the cyclic voltammetry curves are almost consistent. Furthermore, the LED can be lighted by four devices in series.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 31
·期 11
·4752-4769
·
IF 5.3
Yue Xiaopeng,Zhang Siqian,Xu Yang,Wang Zhiwei,Meng Ling
To demonstrate the influence of core-shell structure of microencapsulated ammonium polyphosphate (MCAPPs) on the flame-resistant and smoke inhibition efficiency of polymer composites, four kinds of MCAPPs with unilaminar or bistratal shells were fabricated and used to fabricate flame retarded Poly (butyleneadipate-co-terephthalate) (PBAT) composites. The MCAPP with cross-linked β-cyclodextrin as outer layer (MFAPP-CD 1 ) exhibited the highest flame-resistant efficiency. Accordingly, 75P/25MFAPP-CD 1 showed the highest char residue and densest char layer, also the lowest pHRR and THR, decreasing by 77.4 and 76.9% compared with PBAT, respectively. Meanwhile, the lowest SPR and TSP also demonstrated its excellent smoke inhibition effect due to the weakened catalytic effect of Ammonium polyphosphate (APP) on carbonization agent. As a result, a LOI value (33.2%) and UL-94 V0 rating could be achieved. A reasonable core-shell structure could improve the carbon forming capacity and reduce the release of volatiles during combustion. Polyhydroxy carbonization agent should be designed as the outer layer of bistratal MCAPP. Graphical Abstract
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IRANIAN POLYMER JOURNAL
·
2023
·Vol. 32
·期 8
·979-990
·
IF 3.1
Fu Mengjie,Wang Chun,Lai Xing,Xiao Changfa,Ding Ying
In terms of nanofiltration (NF) membrane development, the properties of membrane substrates and thin-film composite (TFC) structures have become an important factor to determine the separation performances of NF membrane. In this paper, the method of interfacial polymerization assisted by spacer spraying was used to construct the striped structure at nanometer scale. Nanoscale striped structure was prepared successfully on PPTA (poly( p -phenylene terephthamide)) NF surface with 1.3 g/L of UiO-66-NH 2 in the aqueous phase, and the morphology gradually changed to “point shaped” structure when 2.6 g/L of UiO-66-NH 2 in the aqueous phase. The optimized PPTA/UiO-66-NH 2 NF (PU4) membranes were used for dye/salt separation of methylene blue (MB). Compared with the nascent PPTA NF membranes, it showed a higher MB rejection rate of 98.6%, along with permeation flux of 19.79 L/m 2 \(\cdot\) h \(\cdot\) MPa. The salt separation order of the PU4 membrane was Na 2 SO 4 > MgSO 4 > MgCl 2 > NaCl. The rejection rates were 96.3%, 85.4%, 53.2%, and 18.4%, respectively. Under strong acid and alkali conditions, the separation performance was rejected 86.5%, better under alkaline conditions. More importantly, after a six-time recycle, the PU4 membrane showed no significant change in separation performance, suggesting its excellent stability. The novel strategy in this study provided an approach to develop advanced UiO-66-NH 2 membranes toward sustainable molecular separation in environmental applications. Graphical abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 30
·75681-75693
·
IF 5.8
Kang Fei,Lv Qilin,Fan Jingbiao,Zhang Yun,Song Yuling,Ren Xueqin,Hu Shuwen
Soil acidification is a worldwide eco-environmental problem detrimental to plant growth and threatening food security. In this study, calcium poly(aspartic acid) (PASP-Ca) and calcium poly-γ-glutamic acid (γ-PGA-Ca) were obtained through cation exchange and used to mitigate soil acidity owing to high solubility and complexing capability. Three rates at 6.7, 13.4, and 20.1 g kg −1 , denoted as PASP-Ca1, PASP-Ca2, and PASP-Ca3, and γ-PGA-Ca (7.4 g kg −1 ) were surface-applied and compared with conventional lime (CaCO 3 , 2.5 g kg −1 ) along with control in two soil layers (top soil 0–10 cm, subsoil 10–20 cm). After leaching, various soil properties and aluminum fractions were measured to assess their ameliorative performance and mechanisms. Although lime achieved the highest soil pH (6.91) in the topsoil followed by PASP-Ca and γ-PGA-Ca (pH: 5.57–6.33), it had less effect on subsoil increase (5.3) vs. PASP-Ca and γ-PGA-Ca (pH: 5.44–5.74). Surface-applied PASP-Ca demonstrated efficiency in elevating soil pH and reducing exchangeable acidity, mainly as exchangeable Al 3+ , whereas γ-PGA-Ca addition superiorly improved soil pH buffering capacity (pHBC). Moreover, PASP-Ca and γ-PGA-Ca addition improved organic carbon by 34.4–44.9%, available P by 4.80–20.71%, and cation exchange capacity (CEC) by 6.19–29.2%, thus greatly enhanced soil fertility. Ca 2+ from polyAA-Ca promoted the displacement of exchangeable Al 3+ or H + from soil colloid, which were subsequently complexed or protonated and facilitated leaching. Additionally, the transformation into stable organo-aluminum fractions via complexation inhibited further hydrolysis. Under PASP-Ca or γ-PGA-Ca addition, the saturation of aluminum in cation exchange complex was reduced 2.91–7.81% compared to the control without addition amendments. Thus, PASP-Ca and γ-PGA-Ca can serve as potent ameliorants to alleviate soil acidity and aluminum toxicity for sustainable agricultural development.
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JOURNAL OF FLUORESCENCE
·
2023
·
IF 2.7
Xu Zichen,Xu Hedan,Duan Hongliang,Li Junjie,Hu Xiao,Jiang Kaixin,Wang Guixue,Zhang Yuanyuan
Simple and sensitive detection of cardiac biomarkers is of great significance for early diagnosis and prevention of acute myocardial infarction (AMI). Here, a ratiometric fluorescent nanohybrids probe (AuNCs-QDs) was synthesized through the coupling of bovine serum albumin-functionalized gold nanoclusters (AuNCs) with CdSe/ZnS quantum dots (QDs) to realize simple and sensitive detection of cardiac biomarker myoglobin (Mb). The AuNCs-QDs probe shows pink fluorescence under UV light, with two emission peaks at 468 nm and 630 nm belonging to QDs and AuNCs, respectively. Importantly, the presence of Mb caused fluorescence quenching of the blue-emitting QDs, thereby inhibiting the fluorescence resonance energy transfer (FRET) process between QDs and AuNCs, and reducing the fluorescence intensity ratio (F 468 /F 630 ) of AuNCs-QDs probe effectively. As the concentration of Mb increases, the ratiometric fluorescent probe also exhibits a visible fluorescence color change. The detection limit was as low as 4.99 μg/mL, and the response of the probe to Mb showed a good linear relationship up to 0.52 mg/mL. Moreover, the probe has excellent specificity for Mb. Besides, the AuNCs-QDs has been applied to detect Mb of urine samples. More importantly, we also developed an AuNCs-QDs probe modified smartphone-aided paper-based strip for on-site monitoring of Mb. As far as we know, this is the first report of a smartphone-aided paper-based strip for on-site quick monitoring of Mb, which provides a useful approach for AMI biomarker monitoring and may can be extended to other medical diagnostics.
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Drug Delivery and Translational Research
·
2023
·
IF 5.4
Xiao Chuyao,Li Genyun,Li Xiaoyue,Wang Dan,Wu Ya,Sun Minghui,Huang Jiangeng,Si Luqin
Ulcerative colitis (UC) is an idiopathic, chronic, relapsing disease. In most cases, only the distal colon is affected, and the colonic stasis or fast colonic transit through the inflamed colon usually results in reduced exposure of the distal inflamed colon. Although the immunosuppressant cyclosporine A (CsA) has been used in patients with severe colitis who do not respond to corticosteroids, the clinical application of CsA remains limited due to the systemic toxicities and insufficient accumulation at the site of action for the intravenous and oral routes. In this study, we loaded CsA into the amphipathic poly(ethylene glycol)-poly(ε-caprolactone) (PEG-PCL) micelles and then embedded them in hydrogels consisting of chitosan, poloxamer 188, and poloxamer 407 to construct a thermosensitive and mucoadhesive hydrogel drug delivery system (PLCP). The PLCP presented a high drug-loading capacity and showed a stable and rapid gelation rate after rectal administration into the body. Compared to CsA-loaded micelles and Sandimmun (Neoral ® ), the developed thermosensitive gel exhibited prolonged retention on the inflamed colon, as seen from in vitro adhesion and in vivo distribution experiments. It also fast mitigated colitis symptoms in TNBS-treated mice by regulating the expression levels of proinflammatory cytokines (TNF-α, IL-1β, COX-2, and iNOS2), anti-inflammatory cytokines (IL-10, Nrf2, NQO1, and HO-1), and other relevant biochemical factors. Our results suggested that CsA-loaded micelle thermal hydrogel system could be a promising strategy by enhancing the retention in the diseased colon and promoting the relief and recovery of UC. Graphical Abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-10
·
IF 4.6
Pang Honglei,Qiu Yayu,Sheng Weipeng
Hybrid polyvinylidene fluoride-silica-hexadecyltrimethoxysilane (PVDF-SiO 2 -HDTMS) membranes were fabricated via a non-solvent-induced phase-inversion method to create stable hollow-fiber membranes for use in the membrane contact absorption of carbon dioxide (CO 2 ). The surface properties, performance characteristics, and long-term performance stability of the prepared membranes were compared and analyzed. The outer surfaces of the prepared membranes were superhydrophobic because of the formation of rough nanoscale microstructures on the surfaces and their low surface free energy. The addition of inorganic nanoparticles improved the mechanical strength of the PVDF-SiO 2 -HDTMS. Long-term stable operation experiments were carried out with a mixed inlet gas (CO 2 /N 2 = 19/81, v/v) at a flow rate of 20 mL/min. The absorbent liquid in these experiments was 1 mol/L diethanolamine (DEA) at a flow rate of 50 mL/min. The mass transfer flux of CO 2 through the PVDF-SiO 2 -HDTMS membrane decreased from an initial value of 2.39 × 10 –3 mol/m 2 s to 2.31 × 10 –3 mol/m 2 s, a decrease of 3% after 20 days. The addition of highly stable and hydrophobic inorganic nanoparticles prevented pore wetting and structural damage to the membrane. The PVDF-SiO 2 -HDTMS membrane was found to have excellent long-term stable performance in absorbing CO 2 .
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