SCIENCE PROGRESS
·
2024
·
IF 2.6
Samaira Mumtaz,Shaukat Ali,Asim Pervaiz,Uzma Azeem Awan,Tooba Nauroze,Lubna Kanwal,Muhammad Summer,Shumaila Mumtaz,Tafail Akbar Mughal,Hafiz Muhammad Tahir
Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions such as cancer, ageing, and hypertension. Silk sericin (SS) is instrumental in cancer applications due to presence of flavonoids and carotenoids which are natural pigments, present in the layer of sericin that has antioxidant and antityrosinase activity. It reduces oxidative stress and suppresses cancer cytokines while interacting with reactive oxygen species (ROS) to stand against lipid peroxidation. Recent research was focused to calculate the pharmacological intervention of sericin-conjugated silver nanoparticles (S-AgNO3 NPs) against DMBA-induced toxicity. For this purpose, SS protein was extracted from silkworm cocoons by degumming process and the prepared S-AgNO3 NPs via a green synthesis. In female albino mice, a total of 50 mg/kg oral administration of DMBA was used for the induction of toxicity which required almost 8 to 10 weeks approximately. After 60 days of experimentation, mice were dissected, blood samples were collected for further hematological and biochemical analysis and were euthanized via cervical dislocation. There was a significant rise in the level of red blood cells, platelets, lymphocytes, and hemoglobin at the highest applied concentration of sericin and its nanoparticles. Similarly, a reasonable decline was observed in the level of white blood cells, neutrophils, eosinophils, and monocytes as compared to the cancer-inducing group. The level of glutathione, lactate dehydrogenase, and alkaline phosphatase as well as immunoglobulins such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were significantly reduced in all treatment groups as compared to the DMBA-induced group. Substantial effects were demonstrated in response to S-AgNO3 NPs II (T) at the highest concentrations (200 mg/kg, BW) as follows: glutathione (2.42 ± 0.26 μmol/L), lactate dehydrogenase (493.6 ± 5.78 U/L), alkaline phosphatase (158.4 ± 6.35 U/L), IgA (4.22 ± 0.19 g/L), IgG (70 ± 1.70 g/L), and IgM (4.76 ± 0.12). The histopathological study of the liver, kidneys, and brain revealed that the DMBA-induced group showed cytotoxic effects against all selected organs of mice that were recovered by treatment of selective compounds but highly effective recovery was seen in S-AgNO3 NPs II (T). These results concluded that silk S-AgNO3 NPs showed significant pharmacological potential against cancer-inducing toxicity.
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Yifan Zhang,Sylvestre Ndayiragije,Ming Chen,Xiaobo Wang,Lihua Zhu,Nan Wang
Fe- and nitrogen-doped carbonaceous (Fe-N-C) sites supported on MnO 2 (Fe-N-C@MnO 2 ) were prepared by a solvent-free mechanochemical method for peroxymonosulfate (PMS) activation to degrade norfloxacin (NFX). After a 50-min ball milling of iron(II) phthalocyanine (Fe( II )Pc) and MnO 2 at a weight ratio of 7.5 %, the obtained Fe-N-C@MnO 2 exhibited exceptional activity in PMS activation, achieving nearly complete degradation of NFX in 5 min with a rate constant of 0.62 min −1 . This rate constant was 11.5 and 28.2 times higher than that for milled MnO 2 (bm-MnO 2 ) and the mixture of Fe( II )Pc and MnO 2 , respectively. Alternative iron sources (FeSO 4 , FeCl 2 , Fe(III)-EDTA) and phthalocyanine showed no enhancement. Characterization revealed Fe-N-C@MnO 2 possessed abundant Mn 3+ , oxygen vacancies and Fe-N-C sites. Combined experimental and computational studies demonstrated Fe-N-C@MnO 2 simultaneously enhanced the 1 O 2 generation and facilitated the formation of SO 4 •− , •OH and O 2 •− , with contributions to NFX degradation following: 1 O 2 > •OH ≈ O 2 •− > SO 4 •− . This work establishes mechanochemical coordination engineering as a facile strategy for constructing high-performance metal-N-C hybrid catalysts.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Yuan Ziliang,Han Bo,Liu Bing,Sun Jie,Zhou Peng,Mu Rentao,Zhang Zehui
Reductive-coupling of nitro compounds and alcohols is a sustainable route for constructing C = N bonds in organonitrogen chemicals, yet challenging due to the inertness of α-C sp3 -H bond in alcohols and the vulnerability of C = N bonds towards hydrogenation. Here, we report the surprising catalytic activity of ultrafine alkaline-earth metal oxide MgO nanoclusters (0.9 ± 0.3 nm) that efficiently activate α-C sp3 -H bonds, facilitating the transfer hydrogenation and synthesis of value-added chemicals bearing C = N bonds with high to excellent yields (86–99%). Controlled experiments and characterizations showed the crucial role of oxygen vacancies (O v ) and local Mg environment (Mg-O bond) in MgO for substrate adsorption and activation via electronic interactions between substrate’s negatively charged oxygen atoms and O v sites in MgO nanoclusters. Theoretical calculation further confirmed that O v significantly lowered the energy barrier of the hydrogen atom transfer from α-C sp3 -H in ethanol to the nitro group in nitrobenzene (29.3 vs . 52.9 kcal/mol), which is the rate-determining step with the highest energy barrier in reductive-coupling reactions. Our method not only provides an efficient and sustainable pathway for synthesizing organonitrogen chemicals with C = N bonds but also inspires the exploration of main group element catalysts as alternatives to transition metal and noble metal catalysts for organic transformations.
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Science Advances
·
2025
·Vol. 11
·期 29
·
IF 12.5
Zhenyu Li,Kunhong Jiang,Yue Yang,Yijing Pian,Huizhen Liu,Zexuan Zheng,Xiyang Wang,Subhajit Jana,Jiefei Li,Zhuoyuan Ma,Xiaoyun Qiao,Xiaoxin Zou,Xuelu Ma,Bin Zhang,Haibin Chu,Yimin A. Wu
Glycerol oxidation reaction (GOR) represents an economical pathway for transforming renewable feedstock to value-added chemicals. However, the inertness of C(sp 3 )─H bonds of glycerol and intermediates results in the high energy barrier of the dehydrogenation step, relating to poor product selectivity at high glycerol conversion. Here, a carbon nanotube–supported PdBO x @Pd heterostructure catalyst (PdBO x @Pd/CNTs) was synthesized in which in situ–exsoluted PdBO x clusters covalently covered Pd nanoparticles, thus yielding strong electronic interaction between Pd nanoparticles and PdBO x clusters. The strong electronic interaction in PdBO x @Pd/CNTs induces the hybridization between Pd(d), B(s, p), and O(s, p) atom orbits, optimizing the adsorption of reactants and intermediates, thus enhancing the activity for the GOR. The density functional theory calculation result reveals that the strong electronic interaction in PdBO x @Pd/CNTs facilitates the hydrogen transfer in the primary C─H bond of the CH 2 OHCHOHCH 2 O* intermediate, thus reducing the energy barrier of the rate-determining step and improving glyceric acid selectivity toward the GOR.
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ACS Applied Energy Materials
·
2025
·
IF 5.5
Fuyu Chen,Changqing Xiong,Xiangdong Cheng,Ying Shi,Hui Chen,Qinfang Zhang
The electrode is crucial for electrochemical reactions, significantly impacting the vanadium flow battery (VFB) performance. However, their relatively low electrochemical activity remains a major obstacle to developing high-performance VFBs. To overcome this limitation, we introduce a catalyst synthesized by integrating pore-forming agents─specifically, poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer (P123) and polyoxyethylene–polyoxyethylene–polyoxyethylene triblock copolymer (F127)─into MnO@C derived from a metal–organic framework. This study marks the first application of such an approach to VFB enhancement. A comprehensive analysis is conducted to examine the catalyst’s morphology, composition, electrocatalytic activity, and charge–discharge behavior. The results reveal that (i) the prepared catalysts possess a nanoporous structure with MnO nanoparticles uniformly dispersed in amorphous carbon; (ii) pore-forming agent-modified MnO@C, especially P123–MnO@C, exhibits a large specific surface area, an abundance of oxygen-containing functional groups, and exceptional electrochemical activities; (iii) it enhances the energy efficiency of VFBs by 5.7% compared to those utilizing raw carbon felts and by 5.1% over those with MnO@C electrodes at 100 mA cm–2; and (iv) it significantly improves operating voltages, cell capacities, high current density properties, and cycling performance. Thus, this study proposes an innovative electrochemical catalyst for VFBs, enhancing performance and advancing renewable energy storage solutions.
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Energy Storage Materials
·
2025
·
IF 20.2
Dejun Lu,Yunchao Hao,Zhiqiao Wang,Jun He,Xiaojiang Huang,Yunxiang Shi,Shuai Gao,Huiqing Zhang,Yue Ma,Feng Xu,Yao Yao
Wearable biomedical devices require materials that simultaneously integrate energy storage and sensing, function under extreme conditions, and enable battery self-diagnosis. To address this, we developed a novel ZnCl₂-loaded poly(acrylic acid)-based composite hydrogel (Zn-PAA-C) serving as both a flexible Zn-ion battery electrolyte and a high-performance strain sensor. Engineered with poly(acrylic acid) N-hydroxysuccinimide ester (PAA-NHS), gelatin, and ethylene glycol, Zn-PAA-C exhibits exceptional ionic conductivity, mechanical resilience, and freeze-resistance (down to -80 °C). As a strain sensor, it achieves a broad sensing range (0–180 % strain), reliable operation (1–7 Hz), and rapid response (57 ms). As a battery electrolyte, it uniquely incorporates self-diagnostic capability, enabling real-time monitoring of battery expansion and dendrite formation for enhanced safety and longevity, and supports stable operation over 12,000 charge-discharge cycles. Zn-PAA-C thus transcends traditional gel electrolyte limitations, establishing a new standard for multifunctional materials in wearable biomedical devices capable of robust, continuous health monitoring under extreme conditions.
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Advanced Energy Materials
·
2021
·Vol. 11
·期 39
·2101855
·
IF 29.368
Liang Tan,Xuexia Lan,Jinwei Chen,Hanyin Zhang,Renzong Hu,Min Zhu
Lithium-ion batteries (LIBs) suffer dramatic energy reduction, and are even unable to safely charge below -10 °C, due to sluggish Li + transport kinetics in the anode, electrolyte and solid electrolyte interphase (SEI), as well as large overpotential which causes Li plating on the anode surface. Herein, a SnO 2 -LiF-graphite (SLG) composite anode is developed for wide temperature application. The SLG with a propylene carbonate electrolyte delivers a stable capacity of more than 900 mA h g −1 at 60 °C with 100 mA g −1 , maintaining 823.9 mA h g −1 at -10 °C. When matched with a tetrahydrofuran-based electrolyte, the SLG delivers stable capacities of 780.4 mA h g −1 at -40 °C and 637.2 mA h g −1 at -50 °C, respectively. It is demonstrated that the LiF-induced inorganic-rich SEI maintains the nanostructure of the active Sn, and that their interfaces with the electrolyte are highly stable. Furthermore, the formation of α-Sn with higher Li + diffusion kinetics results in a very small overpotential (≈0.18 V) of lithiation for SLG from 30 °C to -50 °C. This work shows that LiF-modified SnO 2 anodes matched with suitable electrolytes can qualify the LIBs for a safe and long-life at wide temperature, which is helpful to further promote these batteries for low-temperature applications.
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Advanced Energy Materials
·
2023
·Vol. 13
·期 10
·2203547
·
IF 27.8
Ying Wei,Te-Huan Liu,Wenjiang Zhou,Hang Cheng,Xueting Liu,Jia Kong,Yue Shen,Henghui Xu,Yunhui Huang
The low ionic conductivity of poly(ethylene oxide) (PEO)-based polymer electrolytes at room temperature and the undesired lithium-dendrite growth at Li|PEO interface impede their further application. Herein, a PEO polymer is regulated at the molecular level through a copper ion (Cu 2+ ) coordination effect with both PEO and Li salts to achieve a high Li + conductivity of 0.2 mS cm −1 and a transference number of 0.42 at 30 °C. Moreover, the Cu-coordinated PEO electrolyte is neither sticky nor hygroscopic because the hydrophilic oxygen groups in PEO are terminated by Cu ions. Furthermore, the in situ formed F/Li-rich inorganic layer induced by CuF 2 additive accelerates Li + transport kinetics and enables uniform Li + deposition during Li plating/stripping. As a result, the Cu 2+ -coordinated PEO electrolytes deliver a high critical current density of 1.5 mA cm −2 at 30 °C. An all-solid-state Li-LiNi 0.83 Co 0.12 Mn 0.05 O 2 (NCM83) battery with such a copper coordinated PEO electrolyte exhibits a long cycle life over 500 cycles with a capacity retention of 71% under 0.6 C at 30 °C. When the mass loading increases to a record high of 7 mg cm −2 , the Li-NCM83 cell delivers a high areal capacity of 1.07 mAh cm −2 under 0.1 C at 30 °C.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yangyang Liu,Fengdi Tu,Ziyu Zhang,Zigang Zhao,Pan Guo,Lixiao Shen,Yunlong Zhang,Lei Zhao,Guangjie Shao,Zhenbo Wang
Iron and nitrogen co-doped carbon (Fe/N/C) electrocatalysts have great potential to catalyze the kinetically slow oxygen reduction reaction (ORR). Unfortunately, the ORR performance of existing Fe/N/C catalysts is seriously hindered by the insufficient density and accessibility of the atomic Fe-N x moieties. Herein, the carboxylate (OAc) molecular scissor is proposed to tailor Fe doped zeolitic-imidazolate-framework-8 (ZIF-8) at atomic scale and construct a multi-dimensional concave Fe@NC catalyst structure (Fe@MNC-OAc). This molecular scissoring strategy imparts Fe@MNC-OAc with dense accessible active sites, multidimensional mass transfer pathways, hierarchical porous structure, and entangled carbon nanotubes network. Therefore, the tailored Fe@MNC-OAc electrocatalyst exhibits excellent ORR activity in acidic media with a half-wave potential of 0.838 V, which is comparable to state-of-the-art non-precious metal catalysts. When assembled as cathode catalyst in a H 2 -O 2 proton exchange membrane fuel cell, it delivers a peak power density of 903 mW cm −2 . This work provides a new approach to tailoring the catalyst architecture and improving the accessibility of active sites.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Deqiang Kong,Yueshuai Wang,Yong Yan,Zongge Li,Yue Lu,Ge Chen
Advancing the two-electron (2e - ) oxygen reduction reaction (ORR) in acidic media is pivotal for sustainable, on-demand hydrogen peroxide (H 2 O 2 ) production, but remains challenged by insufficient activity/selectivity at industrially relevant high current densities. We present a breakthrough catalyst design featuring cobalt atomic sites embedded in curved nitrogen-doped carbon layers (c-Co-N-C). This architecture achieves nearly 90 % H 2 O 2 selectivity across a wide potential window, delivering 11.70 mol g⁻¹ h⁻¹ productivity at 300 mA cm −2 with 80 % Faraday efficiency in flow cell tests. Particularly, the catalyst maintains a stable 300 mA cm −2 operation under 1.9 V cell voltage (surpassing prior-art systems by 0.2 V) for 120 h in a PEM electrolyzer, producing pure-phase H 2 O 2 (4.1 wt%). Through integrated experimental and computational analysis, we reveal two complementary enhancement mechanisms: first, the finite element simulations quantify the enhanced interfacial electric field that concentrates protons and dissolved oxygen; then, the density functional theory (DFT) calculations indicate a downshift in Co d -band center optimizes *OOH adsorption while suppressing O-O bond cleavage. This work establishes curvature engineering as a universal design strategy for advanced catalysts through controlled structural modification, opening new pathways for sustainable chemical synthesis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Pengzhen Jin,Chunyan Hu,Jian Zheng,Zhijia Zhu,Baojiang Liu
Addressing global energy and freshwater scarcity requires sustainable, integrated technologies. Inspired by sunflower's water transport mechanisms, we developed a hydrophilic composite aerogel based on polyvinyl alcohol (PVA), chitosan (CS), and waterborne polyurethane (WPU). Incorporating carboxylated multi-walled carbon nanotubes (c-MWCNTs) yielded the BMPCW aerogel, a bifunctional system for simultaneous solar desalination and hydrovoltaic power generation. This design synergizes the aerogel's interfacial evaporation properties with c-MWCNTs' conductivity and photothermal conversion, significantly enhancing water/ion transport and energy conversion efficiency. Under 1 kW m −2 simulated sunlight, the system achieved a high freshwater evaporation rate of 3.41 kg m −2 h −1 and generated an open-circuit voltage of 125.2 mV in 3.5 wt% sodium chloride (NaCl) solution. The BMPCW aerogel exhibits excellent chemical stability, renewability, and maintains robust performance over multiple cycles. Aerogel array devices successfully demonstrated applicability in seawater desalination and powering small electronics. This work highlights the aerogel's potential for distributed energy, smart agriculture, and offshore applications, offering a novel biomaterial strategy and feasible pathway for sustainable clean water and green energy co-production.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Xin Chen,Jingyao Zeng,Jiahui Wu,Guorong Hu,Ke Du,Zhongdong Peng,Yanbing Cao
Na 4 Fe 3 (PO 4 ) 2 (P 2 O 7 ) (NFPP) is a promising cathode material for sodium-ion batteries due to its low cost, high safety, and long cycle life. However, its poor electronic conductivity and air instability hinder practical application, and the issue of air stability has received limited attention. Herein, the hydrolysis behavior of NFPP/C in humid air is systematically investigated. Based on the identified degradation mechanism, a surface reconstruction strategy is proposed via in situ liquid-phase encapsulation of nanostructured Na 3 (VO) 2 PO 4 F (NVPOF). During heat treatment, VO x in NVPOF catalyzes carbon ordering and enables partial V doping into the NFPP surface lattice, thereby modulating surface chemistry, crystal and electronic structure of NFPP. Additionally, the aligned NVPOF/NFPP heterostructure with minimal lattice mismatch forms a built-in electric field, reducing Na⁺ diffusion barriers and interfacial stress. As a result, the Na3 site is activated, leading to significantly enhanced electrochemical performance. The optimized NFPP/NVPOF/C composite delivers excellent rate capability, with a discharge capacity of 126.55 mAh g −1 at 0.1C and 114.40 mAh g −1 at 10C. This work addresses the overlooked air stability issue of NFPP and highlights the importance of surface reconstruction coupled with interface engineering.
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